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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Pediatric Gastrointestinal and Biliary Diseases: From Molecular Basis to Therapy

edited by

Consolato M. Sergi

submission deadline 20 Mar 2026 | Viewed by 338 | Submission Open

Keywords: pediatrics; gastroenterology; biliary; therapy; genetics; biology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Squamous Cell Carcinoma: From Molecular Mechanisms to Therapeutics

edited by

Nerina Denaro

submission deadline 20 Mar 2026 | Viewed by 337 | Submission Open

Keywords: squamous cell carcinoma; immunotherapy; melanoma; non-melanoma

(This special issue belongs to the Section Molecular Oncology)

Molecular Advances in Chronic Obstructive Pulmonary Diseases

edited by

Evangelia Fouka

submission deadline 20 Mar 2026 | Viewed by 326 | Submission Open

Keywords: COPD; epigenetics; mitochondrial dysfunction; autophagy; proteomics; single-cell sequencing; metabolomics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Pain Chronicity and Relief: From Molecular Basis to Rehabilitation

edited by

Katsuya Kami

submission deadline 20 Mar 2026 | Viewed by 314 | Submission Open

Keywords: exercise-induced hypoalgesia; barrier factor; chronic pain; neuropathic pain; spinal cord dorsal horn; mesocorticolimbic system; myokine; descending pain modulatory system

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Agrifood Waste Valorization: From By-Products to Sustainable Resources

edited by

Elena Dreassi

and

Annalaura Brai

submission deadline 20 Mar 2026 | Viewed by 306 | Submission Open

Keywords: antioxidants; by-products; antimicrobials; nutraceuticals; food industry; circular economy

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in Surfactant Systems: Thermodynamics, Molecular Interactions, and Applications

edited by

Mihalj Poša

submission deadline 20 Mar 2026 | Viewed by 293 | Submission Open

Keywords: micelles; mixed micelles; thermodynamic functions of micellization; micellar solubilization; enthalpy– entropy compensation; boundary surface; Langmuir isotherm; theoretical models

(This special issue belongs to the Section Biochemistry)

Cellular Plasticity in Health and Diseases

edited by

Giovanni Barillari

submission deadline 20 Mar 2026 | Viewed by 286 | Submission Open

Keywords: stem cells; cytokines; extracellular matrix; cell differentiation; cell locomotion; cell growth; tissue repair; chronic inflammation; dysplasia; hyperplasia; premalignant lesions; cancer

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Marine Fungi: From Molecular Biology to Biotechnology Application

edited by

Guang-Lei Liu

submission deadline 20 Mar 2026 | 1 articles | Viewed by 286 | Submission Open

Keywords: marine fungi; marine yeasts; marine filamentous fungi; biosynthesis; metabolic engineering; regulatory mechanism; functional biomolecules; exopolysaccharides; glycolipids; organic acids; biofuel; enzymes; cell factories; gene editing tools; fermentation optimization

(This special issue belongs to the Section Molecular Microbiology)

Bioactive Peptides: Microbial Fermentation-Driven Synthesis and Multifunctional Applications in Health and Industry

edited by

Yongjun Wei

submission deadline 20 Mar 2026 | Viewed by 283 | Submission Open

Keywords: bioactive peptides; foods; probiotics; fermentation; pharmaceutical; herbs

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Autophagy: Novel Insights from Molecular and Chemical Biology

edited by

Prashant R Bharadwaj

submission deadline 20 Mar 2026 | Viewed by 280 | Submission Open

Keywords: Alzheimer’ s disease; amyloid precursor protein; amyloid-β protein; protein aggregation; intracellular clearance pathways; autophagy– lysosomal pathway; ubiquitin-proteasome system; small molecule drugs; autophagy modulators; drug development

(This special issue belongs to the Section Molecular Biophysics)

Host Immunity and Viral Evolution: Dissecting the Molecular Variations of Viral Genomes

edited by Maria Victoria Preciado

submission deadline 20 Mar 2026 | Viewed by 278 | Submission Open

Keywords: virus evolution; immune response; host– virus interaction; vaccine design; antiviral design; virus emergence and reemergence; bioinformatics; immunoinformatics

(This special issue belongs to the Section Molecular Immunology)

Microgravity, Cell Shape and Gene Expression: State of the Art, Challenges and Prospects

edited by Masahiro Terada

submission deadline 20 Mar 2026 | Viewed by 276 | Submission Open

Keywords: microgravity; space radiation; closed environment; space flight; parabolic flight; clinostat; human; rodent; microorganism; countermeasure; artificial gravity

(This special issue belongs to the Section Molecular Biology)

From Plant Genomics Investigations to Plant Biotechnology Exploitation

edited by

Maria R. Ercolano

submission deadline 20 Mar 2026 | Viewed by 273 | Submission Open

Keywords: sequencing; plant genomes; biotechnological applications; translational genomics; new discoveries

(This special issue belongs to the Section Molecular Plant Sciences)

Functional Studies and Deep Phenotyping in Monogenic Forms of Diabetes, Severe Insulin Resistance and Hypoglycemia

edited by Fabrizio Barbetti

submission deadline 20 Mar 2026 | Viewed by 265 | Submission Open

Keywords: monogenic diabetes; neonatal diabetes mellitus; MODY; severe insulin resistance; insulin receptor; lipodystrophy; hyperinsulinemic hypoglycemia; ABCC8/KCNJ11 dominant forms of HH

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Enzymes Involved in Amino Acid Metabolism: Molecular Structure and Function

edited by

Barbara Cellini

and Mirco Dindo

submission deadline 20 Mar 2026 | Viewed by 256 | Submission Open

Keywords: amino acids; enzyme; human disease; protein engineering; protein dynamics

(This special issue belongs to the Section Molecular Biology)

The Immune Regulation of Osteoclasts

edited by

J. Kelly Smith

submission deadline 20 Mar 2026 | Viewed by 248 | Submission Open

Keywords: hematopoietic stem cells; osteoclasts; osteoblasts; osteocytes; stromal cells; T cells; B cells; macrophages; dendritic cells; interleukins; cytokines

(This special issue belongs to the Section Molecular Immunology)

Structure-Based Design of Drugs and Other Bioactive Molecules

edited by

Antonio Carrieri

submission deadline 20 Mar 2026 | Viewed by 248 | Submission Open

Keywords: three-dimensional structure; molecular descriptor; molecular similarity; database searching; drug repositioning; target fishing; novel algorithm; data prediction

(This special issue belongs to the Section Molecular Informatics)

Obesity: Different Perspectives Based on Molecular Physiology and Pathology

edited by Hector I. Rocha-Gonzalez

submission deadline 20 Mar 2026 | Viewed by 243 | Submission Open

Keywords: obesity; rational management; perspectives; new ideas; pharmacology; lifestyle modification; molecular advances

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

HIV Expression in Diverse Cell Types: Mechanisms, Regulation, and Pathogenesis

edited by

Rosemary Kiernan

submission deadline 20 Mar 2026 | Viewed by 243 | Submission Open

Keywords: hiv transcription; latency; reactivation; host transcription factors; chromatin modifications; viral-host protein interactions

(This special issue belongs to the Section Molecular Immunology)

Foundational Studies Using Model Systems for Molecular Insights into Metabolism, Aging, and Disease

edited by

James T. Arnone

submission deadline 20 Mar 2026 | Viewed by 238 | Submission Open

Keywords: Saccharomyces cerevisiae and yeasts; Caenorhabditis elegans and nematodes; Arabidopsis thaliana and plants; Drosophila melanogaster; Mus musculus; established and emerging model systems

(This special issue belongs to the Section Molecular Biology)

Biotransformation and Engineering of Fungals and Microalgae

edited by

Alejandro Chamizo-Ampudia

submission deadline 20 Mar 2026 | Viewed by 234 | Submission Open

Keywords: biotransformation pathways; metabolic engineering; bioactive compound synthesis; enzyme catalysis; microalgae– fungi synergy

(This special issue belongs to the Section Molecular Microbiology)

Emerging Insights into Lymphoid Organ Development, Regulation and Therapeutic Potential

edited by Hélia Neves

submission deadline 20 Mar 2026 | Viewed by 231 | Submission Open

Keywords: thymus; immune; signaling; molecular; pathways; epigenetics; organoids; bioengineering; regeneration; clinical application

(This special issue belongs to the Section Molecular Biology)

Research on Plant Genomics and Breeding: 3rd Edition

edited by

Zhiyong Li

Jian Zhang

and

Dawei Xue

submission deadline 20 Mar 2026 | Viewed by 231 | Submission Open

Keywords: gene cloning and function; genetic engineering; molecular genetics; genome editing; regulatory mechanisms; germplasm enhancement; molecular breeding and marker-assisted selection

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in the Role of Retinoic Acid-Regulated Genes in Cancer Biology

edited by Fuming Tsai

submission deadline 20 Mar 2026 | Viewed by 214 | Submission Open

Keywords: retinoic acid; retinoic acid receptors; retinoic x receptors; tumorigenesis; metastasis; tumor microenvironment; molecular pathways

(This special issue belongs to the Section Molecular Genetics and Genomics)

Responses of Plants to Abiotic and Biotic Stresses: Concepts and Mechanisms

edited by

Ning Liu

submission deadline 20 Mar 2026 | Viewed by 213 | Submission Open

Keywords: plant stress tolerance; abiotic stresses; biotic stresses; molecular mechanisms; signal pathways; multi-omics technologies; epigenetic modifications; crop resilience

(This special issue belongs to the Section Molecular Plant Sciences)

Statin Induced Neurotoxicity

edited by

Iain P. Hargreaves

and

Adam P. Lightfoot

submission deadline 20 Mar 2026 | Viewed by 202 | Submission Open

Keywords: mitochondrial dysfunction; oxidative stress; coenzyme Q10; simvastatin; neurotoxicity; blood brain barrier

(This special issue belongs to the Section Molecular Neurobiology)

Regulation of Gene Expression in Cell Differentiation

edited by

Iole Robuffo

submission deadline 20 Mar 2026 | Viewed by 196 | Submission Open

Keywords: cell differentiation; gene expression regulation; signal transduction; autophagy; nutrigenomics; mechanobiology; longevity; aging mechanism; tumor progression; regenerative medicine; gene therapy; tissue remodeling

(This special issue belongs to the Section Molecular Genetics and Genomics)

Multifunctional Nano-Coatings for Biomedical Applications

edited by

Mikhail Kryuchkov

and Jana Valnohova

submission deadline 20 Mar 2026 | Viewed by 195 | Submission Open

Keywords: nanocoatings; nanomedicine; drug delivery; surface functionalization; diagnostics; therapeutics; prevention; stimuli-responsive materials; biomedical nanotechnology; targeted delivery systems; biocompatible coatings

(This special issue belongs to the Section Molecular Nanoscience)

Advancing Forensic Genetics Through Massive Parallel Sequencing

edited by Daniel Kling

submission deadline 20 Mar 2026 | Viewed by 191 | Submission Open

Keywords: forensic genetics; molecular biology; genetics and aging; biochemistry; population genetics; fo-rensic statistics

(This special issue belongs to the Section Molecular Genetics and Genomics)

From Diet to Health: Which Molecules or Chemicals Are at Work?

edited by Sara Baldelli

submission deadline 20 Mar 2026 | Viewed by 191 | Submission Open

Keywords: balanced diet; functional nutrition; nutraceuticals; disease prevention; bioactive biomolecules

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Novel Immunotherapies for Reshaping the Tumor Immune Microenvironment

edited by

Alessandro Canella

submission deadline 20 Mar 2026 | Viewed by 186 | Submission Open

Keywords: TIME; TME; immunosuppression; inflammation; immune cells; immunotherapy; cancer immune evasion

(This special issue belongs to the Section Molecular Oncology)

Flexible Sensors for Biomedical Application

edited by

Jimin Lee

submission deadline 20 Mar 2026 | Viewed by 185 | Submission Open

Keywords: biomedical applications; molecular diagnostics; molecular recognition mechanisms; biosensors; electrochemical sensing; nanomaterials for sensing; implantable sensors; soft bioelectronics

(This special issue belongs to the Section Biochemistry)

The Interaction Between Tumor Microenvironment and Cancer Stem Cell

edited by

Na Luo

submission deadline 20 Mar 2026 | Viewed by 182 | Submission Open

Keywords: tumor microenvironment; cancer stem cells; innate and adaptive immunity; mesenchymal stromal cells

(This special issue belongs to the Section Molecular Oncology)

Molecular, Genetic, and Omics Approaches to Disorders in Bone–Inflammation Crosstalk

edited by

Paula Sandrin-Garcia

submission deadline 20 Mar 2026 | Viewed by 179 | Submission Open

Keywords: bone physiology; inflammatory; epigenetic regulation; molecular signaling pathways; cellular interactions

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Future of Biomaterials in Dentistry: Innovations in Drug Delivery and Regenerative Medicine

edited by

Victor Martin

submission deadline 20 Mar 2026 | Viewed by 175 | Submission Open

Keywords: dentistry; regenerative medicine; drug delivery; tissue engineering; biomaterials; tooth; periodontal

(This special issue belongs to the Section Materials Science)

Design, Synthesis and Application of Cellulose Materials

edited by

Jian Zhao

and

Yehan Tao

submission deadline 20 Mar 2026 | Viewed by 174 | Submission Open

Keywords: cellulose; polymer materials; biomass

(This special issue belongs to the Section Materials Science)

Light-On Molecular Probes for Biomedical Analysis

edited by Aleksey A. Vasilev

submission deadline 20 Mar 2026 | Viewed by 172 | Submission Open

Keywords: fluorogenic dyes; nucleic acid binders; nucleic acid labels; molecular probes; fluorogenic polymers and nanomaterials

(This special issue belongs to the Section Materials Science)

Molecular Pathways and Mechanisms of Lung Injury: From Environmental Agents to Clinical Implications

edited by

Maria Lisa Garavaglia

and Cristina Porta

submission deadline 20 Mar 2026 | Viewed by 172 | Submission Open

Keywords: lung injury; lung cancer; pulmonary fibrosis; chronic obstructive pulmonary disease; acute respiratory distress syndrome; environmental pollutants and toxins; molecular and cellular mechanisms; biomarkers; therapeutic approaches

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insight into Polymer Dynamics

edited by

Sirui Ge

submission deadline 20 Mar 2026 | Viewed by 171 | Submission Open

Keywords: polymer dynamics; glass transition; segmental relaxation; bulk relaxation; structure– property relationship; functional polymers; spectroscopy; instrumental characterization; simulations and modeling; polymer diffusion

(This special issue belongs to the Section Materials Science)

Health Impacts of Environmental Pollution on the Urogenital and Reproductive Systems

edited by

Anna Perri

and

Silvestro Antonio Ruffolo

submission deadline 20 Mar 2026 | Viewed by 170 | Submission Open

Keywords: pollution; endocrine toxicity; endocrine disruptors; human biomonitoring; infertility; cancer; inflammation; oxidative stress

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Aspects of Retinal Neurodegeneration and Neuroprotection

edited by

Kyriaki Thermos

submission deadline 20 Mar 2026 | Viewed by 166 | Submission Open

Keywords: retinal neurodegeneration; neuroprotection; therapeutic targets; retinal ischemia; excitotoxicity; oxidative stress; mitochondrial dysfunction; neuroinflammation; vascular dysfunction

(This special issue belongs to the Section Molecular Neurobiology)

Recent Molecular Research in Neuroimmunology

edited by Mireya Fernández-Fournier

submission deadline 20 Mar 2026 | Viewed by 165 | Submission Open

Keywords: neuroimmunology; antibodies; virus; multiple sclerosis; progression

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Aging and Alzheimer’s Disease Research: From Molecular Mechanisms to Therapeutics—2nd Edition

edited by Lilach Soreq

submission deadline 20 Mar 2026 | Viewed by 157 | Submission Open

Keywords: aging; Alzheimer’ s disease; bioinformatics; RNA-seq; Parkinson’ s disease

(This special issue belongs to the Section Molecular Neurobiology)

CD8⁺ T Cells in the Cancer Immunity Cycle: Mechanisms, Barriers, and Therapeutic Opportunities

edited by Wael Traboulsi

submission deadline 20 Mar 2026 | Viewed by 153 | Submission Open

Keywords: CD8+ T cell; cancer immunotherapy; checkpoint inhibitor; CAR-T cell therapy; CD8 differentiation; epigenetic regulation; metabolism; exhaustion; dysfonctional CD8+ T cell

(This special issue belongs to the Section Molecular Immunology)

New Advances in Food Allergenicity: From Molecular Mechanisms to Innovative Mitigation Strategies

edited by

Edyta Juszczuk-Kubiak

submission deadline 20 Mar 2026 | Viewed by 151 | Submission Open

Keywords: food allergenicity; food allergen detection; biosensors; mass spectrometry; immunoassays; allergen reduction; hypoallergenic food alternatives; personalized nutrition approaches

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Plant Senescence Under Environmental Stresses

edited by

Agnieszka Ostrowska

submission deadline 20 Mar 2026 | Viewed by 150 | Submission Open

Keywords: plant senescence; environmental stresses; phytohormones

(This special issue belongs to the Section Molecular Plant Sciences)

Activation of the Blood–Brain Barrier and Neurological Dysfunction: 2nd Edition

edited by

Monique F. Stins

submission deadline 20 Mar 2026 | Viewed by 148 | Submission Open

Keywords: blood– brain barrier; neuro-infectious diseases; microbes; traumatic brain injury; Alzheimer’ s disease; Parkinson’ s disease; schizophrenia; cerebral vasculature; vascular heterogeneity; white matter; gray matter; therapeutic delivery; opening the BBB; neuro vascular unit

(This special issue belongs to the Section Molecular Neurobiology)

Advances in the Molecular Biology of Lipids and Mitochondria

edited by

Alejandra Espinosa

submission deadline 20 Mar 2026 | Viewed by 140 | Submission Open

Keywords: lipids; lipid transport mechanisms; lipid peroxidation; mitochondrial integrity; bioenergetics; mitochondrial phospholipid

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advances in Molecular Research on Candida Resistance

edited by

Angela Maione

submission deadline 20 Mar 2026 | Viewed by 135 | Submission Open

Keywords: Candida resistance; antifungal resistance; biofilm; drug repurposing; novel therapies; molecular mechanisms; antifungal agents; Candida albicans; Candida auris; host– pathogen interactions

(This special issue belongs to the Section Molecular Microbiology)

Omega-6 and Omega-3 Fatty Acid Imbalance: Roles in Human Health and Pathogenesis of Diseases

edited by

Jing X. Kang

submission deadline 20 Mar 2026 | Viewed by 121 | Submission Open

Keywords: omega-6/omega-3 ratio; omega-6 fatty acids; omega-3 fatty acids; omega-6/omega-3 imbalance; lipid metabolism; inflammation; chronic diseases; cardiovascular disease; cancer; metabolic syndrome; neurodegenerative diseases; autoimmune diseases; nutritional interventions; polyunsaturated fatty acids (PUFAs); molecular mechanisms; disease pathogenesis; disease management; health promotion

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Displaying special issue 2101-2150 on page 43 of 65.

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