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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Research Progress of Natural Products in Metabolic Disorders

edited by Claudia I. Gamboa Gómez and

Laura Jazel Barragán Zúñiga

submission deadline 25 Sep 2026 | 1 articles | Viewed by 1492 | Submission Open

Keywords: natural products; metabolic disorders; nutraceuticals; functional foods; metabolic health

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Research on Cannabinoids and Cannabinoid Receptors

edited by Valdemiro Amaro Da Silva Junior

submission deadline 25 Sep 2026 | 2 articles | Viewed by 1469 | Submission Open

Keywords: cannabinoids; receptors; endocannabinoidome; degenerative diseases; quality of life

(This special issue belongs to the Section Molecular Pharmacology)

Research on Metal-Based Drugs and Their Mechanisms of Action

edited by Gordana P. Radić

submission deadline 25 Sep 2026 | 2 articles | Viewed by 1276 | Submission Open

Keywords: synthesis of metal-containing compounds; characterization; biological activity; mechanisms of action

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Insight into Mesothelioma

edited by

Fabrizio Celesti

submission deadline 25 Sep 2026 | Viewed by 490 | Submission Open

Keywords: mesothelioma; molecular subtypes; molecular landscape; tumor microenvironment; epigenetics; multiomics; therapeutic strategies; immunotherapy; biomarkers; molecular stratification

(This special issue belongs to the Section Molecular Oncology)

Electron or Ion Transport in Electrochemistry

edited by Simone Sanna

submission deadline 25 Sep 2026 | Viewed by 370 | Submission Open

Keywords: solid oxide fuel cells; mixed ionic and electronic conductors; perovskite; fluorite; hydrogen; CO2 reduction; water splitting; energy conversion and storage

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

The Role of Tumor Microenvironment in Cancer Therapy

edited by

Anca-Maria Cimpean

submission deadline 25 Sep 2026 | Viewed by 327 | Submission Open

Keywords: tumor microenvironment; cancer immunotherapy; immune suppression; tumor angiogenesis; tumor metabolism; extracellular matrix

(This special issue belongs to the Section Molecular Oncology)

A Molecular Dynamics Bridge Between Small and Large Scales

edited by

Denis S. Tikhonov

submission deadline 25 Sep 2026 | Viewed by 315 | Submission Open

Keywords: molecular dynamics; non-adiabatic dynamics; sampling; metadynamics; atomistic simulations

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Breakthroughs in Diagnostic Prediction and Fundamental Therapeutics of Dementia and Movement Disorders, 3rd Edition

edited by

Yasemin M. Akay

submission deadline 25 Sep 2026 | Viewed by 282 | Submission Open

Keywords: Parkinson's disease; dementia with Lewy bodies; Alzheimer's disease; pathogenic protein; biomarker; therapeutic target; drug

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms Regulating Ciliary Motility in Respiratory Health

edited by

Takashi Nakahari

submission deadline 25 Sep 2026 | Viewed by 245 | Submission Open

Keywords: motile cilia; airway; mucociliary clearance; CBF; ciliary waveform; intracellular Cl−; pH; brain ventricle; obiduct; ciliary transport

(This special issue belongs to the Section Molecular Biology)

Molecular Research on Tea Flavor and Chemistry

edited by

Wei Xu

submission deadline 29 Sep 2026 | 1 articles | Viewed by 784 | Submission Open

Keywords: tea processing; tea chemistry; tea functional components; tea sensory evaluation; tea quality control

(This special issue belongs to the Section Biochemistry)

Molecular Mechanisms in Forensic Pathology

edited by

Vittorio Fineschi

submission deadline 29 Sep 2026 | Viewed by 376 | Submission Open

Keywords: molecular investigation; molecular thanatocronology; molecular autopsy; lesion vitality; molecu-lar forensic toxicology; pharmacogenomics; molecular identification

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in the Role of Diet and Nutrition in Metabolic Diseases

edited by Raquel Rocha

submission deadline 29 Sep 2026 | Viewed by 213 | Submission Open

Keywords: metabolic diseases; type 2 diabetes; obesity; cardiovascular health; metabolic dysfunction–associated liver disease; nutrigenomics; gut microbiome; dietary patterns; precision nutrition; bioactive compounds

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Insights in Neurodegeneration

edited by

Oscar Arias-Carrión

submission deadline 30 Sep 2026 | 9 articles | Viewed by 30764 | Submission Open

Keywords: neurodegeneration; molecular mechanisms; protein aggregation; neuroinflammation; oxidative stress; mitochondrial dysfunction; Alzheimer’s disease; Parkinson’s disease; biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Neurobiology)

Genes and Human Diseases: 3rd Edition

edited by

Mikhail I. Churnosov

submission deadline 30 Sep 2026 | 16 articles | Viewed by 25228 | Submission Open

Keywords: genes; human diseases; genetic-epidemiological studies; genetic factors; susceptibility

(This special issue belongs to the Section Molecular Genetics and Genomics)

Common Mechanisms in Gestational Diabetes, Preeclampsia, and Coronavirus Disease 2019

edited by

Sandor G. Vari

submission deadline 30 Sep 2026 | 10 articles | Viewed by 24826 | Submission Open

Keywords: gestational diabetes; preeclampsia; inflammation; immunoglobulins; glycolisation; platelet aggregation; microvascular thrombosis; coronavirus disease 2019

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Aspects of Bacterial Infection

edited by

María Soledad Ramírez

submission deadline 30 Sep 2026 | 5 articles | Viewed by 17238 | Submission Open

Keywords: bacterial pathogenesis; antimicrobial resistance; molecular mechanism of host-pathogen interaction; biofilm; infectious diseases

(This special issue belongs to the Section Molecular Microbiology)

Hearing Loss: Recent Progress in Molecular Genomics

edited by

Chen-Chi Wu

submission deadline 30 Sep 2026 | 4 articles | Viewed by 14940 | Submission Open

Keywords: hearing loss; high-throughput sequencing; prognostic analyses; translational medicine; gene therapy

(This special issue belongs to the Section Molecular Genetics and Genomics)

Mesenchymal Stem/Stromal Cells: Mechanisms and Applications in Tissue Regeneration

edited by

Daiva Bironaite

submission deadline 30 Sep 2026 | 7 articles | Viewed by 13140 | Submission Open

Keywords: MSC isolation, identification, and viability; MSC differentiation mechanisms; extracellular environment modifications; intracellular signalling systems; cytotoxicity investigations; tissue regeneration mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Metabolism in Human Health and Disease

edited by

Abdelnaby Khalyfa

submission deadline 30 Sep 2026 | 7 articles | Viewed by 10042 | Submission Open

Keywords: molecular metabolism; metabolic pathways; insulin resistance; Warburg effect; chronic disease; metabolomics; precision medicine; metabolic dysfunction; cancer metabolism; personalized nutrition; enzyme-targeted therapy; systems biology; cellular energy; metabolic health; preventative healthcare

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Endothelial Cells in Health and Disease

edited by

Alessia Ricci

and

Amelia Cataldi

submission deadline 30 Sep 2026 | 5 articles | Viewed by 8954 | Submission Open

Keywords: endothelial cells; vascular homeostasis; tissue homeostasis; endothelial cell biology; endothelial cells dysfunction; oxidative stress; redox signaling; aging; endothelial regulation of tissue repair

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms Driving Liver Disease: From Cellular Stress to Therapeutic Targets

edited by

Konstantinos Arvanitakis

submission deadline 30 Sep 2026 | 4 articles | Viewed by 8050 | Submission Open

Keywords: liver disease; molecular mechanisms; hepatocellular stress; fibrosis; non-coding RNAs; metabolism; MASLD; liver fibrosis; hepatocellular carcinoma; therapeutics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bone Development and Regeneration—4th Edition

edited by

Kazuo Yudoh

submission deadline 30 Sep 2026 | 4 articles | Viewed by 7959 | Submission Open

Keywords: osteoblast; osteocyte; osteoclast; mesenchymal stem cell; cell differentiation; epigenetics; omics; integrative analysis; biomaterials

(This special issue belongs to the Section Molecular Biology)

Advances in Molecular Biomarkers in Cancer and Metabolic Diseases

edited by

José Antonio Morales-González

and

Angel Morales-González

submission deadline 30 Sep 2026 | 4 articles | Viewed by 7433 | Submission Open

Keywords: biomarkers; cancer; metabolic disease; diagnosis; prognosis; treatment

(This special issue belongs to the Section Molecular Biology)

Oxidative-Stress in Human Health and Diseases

edited by

Ramoji Kosuru

submission deadline 30 Sep 2026 | 2 articles | Viewed by 7319 | Submission Open

Keywords: oxidative stress; ROS; redox signaling; metabolic adaptation; oxidative homeostasis; endothelial dysfunction

(This special issue belongs to the Section Biochemistry)

Advances in Pathogenesis and Treatment of Skin Cancer (2nd Edition)

edited by

Enrica Flori

Giorgia Cardinali

and

Vittoria Maresca

submission deadline 30 Sep 2026 | 3 articles | Viewed by 7155 | Submission Open

Keywords: melanoma; squamous cell carcinoma; basal cell carcinoma; tumor microenvironment; epithelial–mesenchymal transition (EMT) process; ultraviolet radiation; oxidative stress; bioactive modulators; signal transduction pathways

(This special issue belongs to the Section Molecular Oncology)

Natural Products in Drug Discovery and Development: 2nd Edition

edited by Tian-Le Gao

submission deadline 30 Sep 2026 | 8 articles | Viewed by 6974 | Submission Open

Keywords: natural product components; traditional medicine; biological entropy reduction; aromatic drugs; essential oils; gut microbiota modulation; probiotics; drug discovery

(This special issue belongs to the Section Molecular Pharmacology)

Advances in Melatonin Biology and Signaling

edited by Walter Manucha

submission deadline 30 Sep 2026 | 3 articles | Viewed by 6849 | Submission Open

Keywords: melatonin signaling; mitochondrial homeostasis; redox dyshomeostasis; oxidative stress and Inflammation; MT1/MT2 receptors; epigenetic regulation; cytoprotection; translational pharmacology; nanoformulations and drug delivery; lipid rafts and biomolecular condensates

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

The Interaction Between Cell and Virus, 3rd Edition

edited by

Masahiro Fujimuro

submission deadline 30 Sep 2026 | 6 articles | Viewed by 6367 | Submission Open

Keywords: viral replication; gene expression; lytic infection; viral structure; viral assembly; cell signaling pathway; post-translational modification; immune evasion; viral tumorigenesis; antiviral medication

(This special issue belongs to the Section Molecular Microbiology)

Erythrocyte Cell Death: Molecular Insights

edited by

Anton Tkachenko

submission deadline 30 Sep 2026 | 4 articles | Viewed by 6048 | Submission Open

Keywords: cell death signaling; eryptosis; erythrocyte senescence; erythrocytes; necroptosis; regulated cell death

(This special issue belongs to the Section Molecular Biology)

Advancing Liver Health: State of the Art and Recent Research Advances

edited by

Chase Wehrle

submission deadline 30 Sep 2026 | 3 articles | Viewed by 5767 | Submission Open

Keywords: liver; liver cancer and malignancy; liver transplantation; inflammation and immunity; liver health and ageing; molecular genomics; cellular senescence; metabolic dysfunction-associated liver disease; cirrhosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Innate Immunity: New Insights into Genetic and Signaling Networks

edited by

Styliani Sarrou

submission deadline 30 Sep 2026 | 3 articles | Viewed by 5582 | Submission Open

Keywords: innate immunity; innate immune response; signaling pathways; genetic variations

(This special issue belongs to the Section Molecular Immunology)

Genetic, Functional and Therapeutic Aspects of Procoagulant and Anticoagulant Factors (Third Edition)

edited by

Rima Dardik

and

Tami Livnat

submission deadline 30 Sep 2026 | 4 articles | Viewed by 5522 | Submission Open

Keywords: procoagulant factors; anticoagulant factors; hemostasis; inflammation; genetics; therapeutics; cell signaling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Bioactivity and Molecular Mechanisms of Natural Products

edited by

Jingya Ruan

submission deadline 30 Sep 2026 | 8 articles | Viewed by 5496 | Submission Open

Keywords: natural products; bioactivity; molecular mechanisms; anti-inflammatory; anticancer; multi-omics; target identification; structure–activity relationship (SAR)

(This special issue belongs to the Section Bioactives and Nutraceuticals)

DNA Damage and Repair: Current Research

edited by

Mahara A. Valverde Ramírez

and Emilio Rojas

submission deadline 30 Sep 2026 | 8 articles | Viewed by 5494 | Submission Open

Keywords: DNA damage; DNA repair; endogenous compounds; exogenous compounds; therapy

(This special issue belongs to the Section Molecular Genetics and Genomics)

Exploring Molecular Properties Through Molecular Modeling

edited by

Emili Besalu

submission deadline 30 Sep 2026 | 7 articles | Viewed by 5344 | Submission Open

Keywords: molecular modeling; molecular properties; structure–activity relationships; QSAR; prediction; drug design; materials science; virtual screening; in-silico synthesis; computational chemistry; cheminformatics

(This special issue belongs to the Section Molecular Informatics)

Lipid Peroxidation and Protein Carbonylation in Human Diseases

edited by

Galina Nikolova

submission deadline 30 Sep 2026 | 1 articles | Viewed by 4789 | Submission Open

Keywords: free radicals; lipid peroxidation; protein carbonylation; apoptosis; autophagy; ferroptosis; antioxidant enzymes

(This special issue belongs to the Section Biochemistry)

Cardiomyocytes Among Physiology and Pathophysiology: Molecular Insights and Therapeutic Implications

edited by Rosetta Ragusa and

Chiara Caselli

submission deadline 30 Sep 2026 | 3 articles | Viewed by 4765 | Submission Open

Keywords: sarcomere; metabolic stress; epigenetic mechanisms; exercise; aging

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insights into Epilepsy: From Molecular Physiology to Pathology

edited by Paolo Mainardi

submission deadline 30 Sep 2026 | 3 articles | Viewed by 4639 | Submission Open

Keywords: epilepsy; molecular pathology; disease; therapeutic strategies; celluar advance

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biomarkers in Oncology

edited by

Beatriz da Costa Aguiar Alves

submission deadline 30 Sep 2026 | 4 articles | Viewed by 3763 | Submission Open

Keywords: cancer biomarkers; precision oncology; liquid biopsy; circulating tumor DNA; molecular diagnostics; multiomics; translational research; personalized medicine; prognostic and predictive markers

(This special issue belongs to the Section Molecular Oncology)

Recent Research on Optoelectronic Materials

edited by

Meysam Tayebi

submission deadline 30 Sep 2026 | 1 articles | Viewed by 3741 | Submission Open

Keywords: photoelectrochemistry; optoelectronic materials; perovskite materials; semiconductor interfaces; molecular-level catalysis; solar fuel conversion; nanostructured materials; light-harvesting systems

(This special issue belongs to the Section Materials Science)

Current Trends in Gut Microbiota and Food Bioactive Compounds

edited by Uyory Choe

submission deadline 30 Sep 2026 | 2 articles | Viewed by 3624 | Submission Open

Keywords: gut microbiota; food bioactive compounds; polyphenols; microbial metabolism; functional foods; nutritional biochemistry; microbiome; bioavailability; metabolomics; dietary phytochemicals

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Biology of Hypoxia: 2nd Edition

edited by Yuji Arai

submission deadline 30 Sep 2026 | 4 articles | Viewed by 3527 | Submission Open

Keywords: hypoxia; HIFs; normoxic environment

(This special issue belongs to the Section Molecular Biology)

Dynamics of Fascia: Cellular, Molecular, and Biochemical Mechanisms

edited by

Caterina Fede

submission deadline 30 Sep 2026 | 2 articles | Viewed by 3504 | Submission Open

Keywords: fascia; homeostasis and pathology; extracellular matrix remodeling; fibroblast signaling; chronic pain; fibrosis and inflammation; hormonal regulation

(This special issue belongs to the Section Biochemistry)

Phytochemical Insights and Green Extraction Strategies for Bioactive Natural Compounds

edited by

Ana M. L. Seca

and

Gonçalo Pereira da Rosa

submission deadline 30 Sep 2026 | 2 articles | Viewed by 3438 | Submission Open

Keywords: plant and algal bioactive metabolites; phytochemistry; green extraction techniques; natural sustainable solvents (NADES); structural elucidation of natural molecules; molecular characterization

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Exploring UV-Induced Disease: Insights into Mechanisms and Innovative Strategies for Prevention and Therapy

edited by Hui Xu and

Ying Huang

submission deadline 30 Sep 2026 | 2 articles | Viewed by 2997 | Submission Open

Keywords: ultraviolet radiation; skin; DNA damage; DNA repair; immunosuppression; inflammatory disease; autoimmune disease; melanoma; non-melanoma skin cancers; genetic susceptibility; chemopre-vention; tumor immunotherapy; skin organoids for UV study; new animal models

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Extracellular Vesicles in Cancer and Tumor Microenvironment

edited by Celeste Caruso Bavisotto,

Alessandra Maria Vitale

and

Giuseppa D’Amico

submission deadline 30 Sep 2026 | 3 articles | Viewed by 2832 | Submission Open

Keywords: EVs; cancer; tumor cell-derived EVs (TCdEVs); tumor microenvironment (TME); tumor-associated antigens (TAAs)

(This special issue belongs to the Section Molecular Oncology)

Biosynthesis and Regulatory Mechanism of Secondary Metabolites in Medicinal Plants: 3rd Edition

edited by

Shanfa Lu

submission deadline 30 Sep 2026 | 3 articles | Viewed by 2824 | Submission Open

Keywords: biosynthetic pathway; epigenetic regulation; high-throughput sequencing; medicinal plant; metabolic engineering; omics; regulatory mechanism; secondary metabolite; synthetic biology; transcription factor

(This special issue belongs to the Section Molecular Plant Sciences)

Abnormal Production and Structure of Hemoglobin Molecules

edited by Maria Dimopoulou

submission deadline 30 Sep 2026 | 2 articles | Viewed by 2465 | Submission Open

Keywords: hemoglobin; hemoglobinopathies; thalassemias; sickle cell disease; structural hemoglobin variants; alpha globin; beta globin; globin chain genes; unstable hemoglobins; oxygen affinity

(This special issue belongs to the Section Biochemistry)

Advancements and Applications of Phyto-Nanotherapy in Targeted Disease Treatment

edited by

Adewale Fadaka

and

Nicole Remaliah Samantha Sibuyi

submission deadline 30 Sep 2026 | 1 articles | Viewed by 2410 | Submission Open

Keywords: phyto-nanotherapy; medicinal plants; nanoparticles; targeted drug delivery; phytochemicals; phytotherapy; green nanotechnology; chronic diseases; infectious diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neuroblastoma: Advances in Molecular Pathogenesis and Therapy

edited by Paola Fadda and

Simona Dedoni

submission deadline 30 Sep 2026 | 2 articles | Viewed by 2240 | Submission Open

Keywords: neuroblastoma; molecular pathogenesis; MYCN; ALK; epigenetics; non-coding RNAs; tumor microenvironment; immunotherapy; targeted therapy; precision medicine

(This special issue belongs to the Section Molecular Oncology)

Displaying special issue 401-450 on page 9 of 62.

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