Molecular Biology of Hypoxia: 2nd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 30 September 2026 | Viewed by 788
Special Issue Editor
Interests: biology; cartilage; synovium; ligament; meniscus; osteoarthritis; rheumatoid arthritis; HSP; HIF
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue is the second volume of our Special Issue series, entitled “Molecular Biology of Hypoxia”.
Oxygen is essential for the survival of cells and organs in the body, and hypoxic conditions can disrupt a wide range of functional and metabolic systems. However, several types of cells and tissues have a reserve capacity that allows for the mobilization of defense mechanisms for survival in response to relatively acute and less severe hypoxic conditions. In vivo, tissues such as the cornea and articular cartilage lack blood flow and maintain homeostasis in a normoxic environment. The response to these hypoxic conditions results from molecular processes that occur at the cellular level. Central to this response are hypoxia-inducible factors (HIFs), which are downregulated in steady-state oxygen and upregulated in hypoxia, and have also attracted attention as therapeutic targets for various diseases. Intensive studies on the mechanisms that contribute to the development of hypoxia tolerance in cells and tissues are theoretically important as well as necessary to address numerous problems in practical medicine. Studies in this field have significantly advanced our understanding; however, several important questions remain unanswered. Therefore, this Special Issue focuses on the “Molecular Biology of Hypoxia” in various cells and tissues, including the heart, brain, kidneys, articular cartilage, and tumors, and we invite papers that report novel findings and answer questions that currently remain unanswered.
Dr. Yuji Arai
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
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Keywords
- hypoxia
- HIFs
- normoxic environment
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