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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Diabetes and Its Complications: From Molecular Mechanisms to Novel Therapeutic Approaches—2nd Edition

edited by

Andrea Paola Rojas Gil

submission deadline 20 Jan 2026 | 1 articles | Viewed by 6597 | Submission Open

Keywords: diabetes; diabetes complications; environmental factors; endocrine disruptors; nutrition; sleep; therapy; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Virus Infection and Infectious Diseases: Unraveling Mechanisms, Innovations and Therapeutic Strategies—Second Edition

edited by Jung-Hyun Lee

submission deadline 20 Jan 2026 | 5 articles | Viewed by 6591 | Submission Open

Keywords: mechanism of virus infection; host immune responses; innovations in diagnostics and surveillance; therapeutic strategies; epidemiology and global health; data science for infectious disease; zoonotic transmission; virus evolution

(This special issue belongs to the Section Molecular Immunology)

Molecular Mechanism and Pathogenesis of Cardiac Disease

edited by Yu-Hsun Kao

submission deadline 20 Jan 2026 | 3 articles | Viewed by 6493 | Submission Open

Keywords: cardiac diseases; cardiac metabolidm; epigenetics; ER stress; mitochondrial dysfunction; molecular mechanisms; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Herpes Simplex Virus: Immunity, Pathogenicity, Immune Escape Mechanisms, and Antiviral Strategies

edited by

Maria Teresa Sciortino

submission deadline 20 Jan 2026 | 2 articles | Viewed by 6490 | Submission Open

Keywords: herpes simplex virus (HSV); latency; immune evasion; tegument proteins; epigenetic mechanisms; viral pathogenesis; antiviral strategies; molecular mechanisms; therapeutic interventions

(This special issue belongs to the Section Molecular Immunology)

Molecular and Cellular Mechanisms of Skin Diseases (Second Edition)

edited by

Elisabetta Palazzo

submission deadline 20 Jan 2026 | 4 articles | Viewed by 6328 | Submission Open

Keywords: hyperproliferative skin diseases; psoriasis; keratinocyte carcinoma; actinic keratosis; atopic dermatitis; skin inflammation; inflammation-associated skin diseases; epidermal differentiation; epidermal cell metabolism; 3D models; in vivo models

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms of Heart Failure: Insights and Therapeutic Strategies

edited by Emilio Vanoli and Eugenio Caradonna

submission deadline 20 Jan 2026 | 1 articles | Viewed by 6282 | Submission Open

Keywords: heart failure; autonomic nervous system; brain– gut interaction; gut microbiota; neurohumoral treatment; cardiac remodeling; inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Structures, Syntheses of Natural Products, and Their Biological Effects

edited by

Ran Jia

submission deadline 20 Jan 2026 | 3 articles | Viewed by 6187 | Submission Open

Keywords: structures of natural products; syntheses; biological effects; biomedical applications

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Research Landscape of Pulmonary Arterial Hypertension

edited by Cármen Brás-Silva

submission deadline 20 Jan 2026 | 3 articles | Viewed by 5904 | Submission Open

Keywords: pulmonary arterial hypertension; right ventricle; right heart failure; molecular mechanisms; vascular disease; translational research; therapy

(This special issue belongs to the Section Molecular Biology)

Endometriosis Pathophysiology, Diagnosis and Emerging Therapeutic Strategies

edited by

Mariarosaria Boccellino

submission deadline 20 Jan 2026 | 1 articles | Viewed by 5863 | Submission Open

Keywords: endometriosis; pathophysiology; infertility; biomarkers; pharmacological treatments

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Adult Stem Cell Research

edited by Dongsu Park

submission deadline 20 Jan 2026 | 4 articles | Viewed by 5840 | Submission Open

Keywords: tissue-resident stem cells; skeletal stem/progenitor cells; hematopoietic stem cells; tendon/ligament stem cells; musculoskeletal tissue regeneration; stem cell microenvironment; stem cell aging

(This special issue belongs to the Section Molecular Biology)

Molecular Research in Parkinson's Disease

edited by

Yi-Chuan Cheng

submission deadline 20 Jan 2026 | 2 articles | Viewed by 5813 | Submission Open

Keywords: Parkinson's disease; molecular regulation; genetic mutations; epigenetics; protein aggregation; mitochondrial dysfunction; neuroinflammation; biomarkers

(This special issue belongs to the Section Molecular Neurobiology)

New Research Insights in Cystic Fibrosis and CFTR-Related Diseases

edited by Judith A. Coppinger

submission deadline 20 Jan 2026 | 3 articles | Viewed by 5751 | Submission Open

Keywords: cystic fibrosis; CFTR related diseases; COPD; immune cells; extracellular vesicles; neutrophils; therapeutics; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Drug Discovery and Synthesis: 2nd Edition

edited by

Lidia Ciccone

and

Susanna Nencetti

submission deadline 20 Jan 2026 | 2 articles | Viewed by 5745 | Submission Open

Keywords: medicinal chemistry; drug discovery; design and synthesis of bioactive compounds; molecular modeling; X-ray crystallography; structure– activity relationships; structure-based drug design

(This special issue belongs to the Section Molecular Pharmacology)

Recent Developments in Obesity: Metabolism, Pathophysiology and Treatment

edited by

Peteris Tretjakovs

submission deadline 20 Jan 2026 | 1 articles | Viewed by 5743 | Submission Open

Keywords: obesity; adipokines; insulin sensitivity; lipid metabolism; pro-inflammatory cytokines; gut microbiota; GLP-1 receptor agonists; personalized nutrition; lifestyle interventions

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Diagnostics and Treatment Advances in Lung Diseases

edited by Eirini Vasarmidi

submission deadline 20 Jan 2026 | 2 articles | Viewed by 5732 | Submission Open

Keywords: lung diseases; pulmonary; alveolar; diagnosis; treatment; biomarkers; molecular; bronchoalveolar lavage; genetics; pathogenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Melanin and Other Pigments: Function, Synthesis and Characterization

edited by Koen P. Vercruysse

submission deadline 20 Jan 2026 | 3 articles | Viewed by 5722 | Submission Open

Keywords: melanin; eumelanin; pheomelanin; allomelanin; catechol; indole; phenol

(This special issue belongs to the Section Biochemistry)

Biomarkers in Cardiovascular Diseases: Diagnosis, Pathology and Treatment

edited by

Marco Valerio Mariani

submission deadline 20 Jan 2026 | 3 articles | Viewed by 5567 | Submission Open

Keywords: heart failure; myocardial remodeling; ischemic heart disease; myocarditis; cardiomyopathies; prevention; diagnosis; therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neuroinflammation and Cellular Senescence in Brain Aging and Neurodegeneration: From Molecular Mechanisms to Therapeutic Applications

edited by Jordi Olloquequi and M. Emília Juan

submission deadline 20 Jan 2026 | 2 articles | Viewed by 5513 | Submission Open

Keywords: SASP; glial activation; age-related disorders; neurotherapeutics; molecular signaling

(This special issue belongs to the Section Molecular Neurobiology)

Fat and Obesity: Molecular Mechanisms and Pathogenesis

edited by

Seon-Yong Jeong

submission deadline 20 Jan 2026 | 3 articles | Viewed by 5505 | Submission Open

Keywords: obesity; weight gain; adipogenesis; lipolysis; energy balance; hormones; fat oxidation; nutrition; phytomedicine; drug development; cohort studies; genetics and genomics studies

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Neurodegeneration and Neuroinflammatory Processes in Age-Related Diseases

edited by

Barbara Mroczko

submission deadline 20 Jan 2026 | 3 articles | Viewed by 5496 | Submission Open

Keywords: age-related diseases; neurodegenerative diseases; neurodegeneration; neuroinflammation; aging

(This special issue belongs to the Section Molecular Neurobiology)

Neurological Diseases: From Molecular Basis to Therapy

edited by

Claudia Ricci

submission deadline 20 Jan 2026 | 4 articles | Viewed by 5334 | Submission Open

Keywords: neurological diseases; pathogenesis; therapy; personalized medicine; early diagnosis; genetics; neurology; pharmacology

(This special issue belongs to the Section Molecular Neurobiology)

Plant Molecular Regulatory Networks and Stress Responses

edited by

Xiujun Zhang

submission deadline 20 Jan 2026 | 4 articles | Viewed by 5268 | Submission Open

Keywords: plant stress response; stress response gene; regulatory mechanism; gene regulatory network; transcriptional regulation; post-transcriptional regulation; multi-omics integration; single-cell RNA-seq; spatial genomics; bioinformatics

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Immunologic Perspectives on Mycobacterium tuberculosis Infection

edited by

Vishwanath Venketaraman

submission deadline 20 Jan 2026 | 1 articles | Viewed by 5192 | Submission Open

Keywords: M. tb infection; molecular immunology; HIV; AIDS; pathogenesis; host immune responses; adjunctive therapy; immune-enhancing agents; antimycobacterial compounds; host-directed therapies; pathogenesis; modulation of host immune responses

(This special issue belongs to the Section Molecular Immunology)

Tissue Regeneration and Repair in Airway Diseases

edited by Rolf Ziesche

submission deadline 20 Jan 2026 | 2 articles | Viewed by 4891 | Submission Open

Keywords: chronic inﬂammation; structural integrity; regenerative repair; structural disintegration; impact of aging on inﬂammation and repair

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and the Link Between Obesity, Diabetes and Inflammation

edited by

Maria Chiara Pelle

and

Arturi Franco

submission deadline 20 Jan 2026 | 4 articles | Viewed by 4887 | Submission Open

Keywords: adipose tissue; biomarkers; diabetes; inflammation; obesity; cytokine; insulin resistance; signaling pathways; metabolic diseases

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Insights into Antimicrobial Activity

edited by

Liliana Mititelu Tartau

submission deadline 20 Jan 2026 | 2 articles | Viewed by 4878 | Submission Open

Keywords: antimicrobial activity; antimicrobial agents; antimicrobial peptides; phytochemicals with antimicrobial properties; antimicrobial synergy; pathogen-specific targeting; antimicrobial resistance; biomedical science; nanotechnology in antimicrobials; genomic

(This special issue belongs to the Section Molecular Microbiology)

Chronic Kidney Disease: From Molecular Mechanisms to Therapeutic Approaches

edited by

Ligia Petrica

submission deadline 20 Jan 2026 | 3 articles | Viewed by 4868 | Submission Open

Keywords: genetics; epigenetics; inflammation; metabolomics; oxiative stress

(This special issue belongs to the Section Molecular Biology)

New Insights into Satellite DNAs

edited by

Isidoro Feliciello

and

Đurđica Ugarković

submission deadline 20 Jan 2026 | 2 articles | Viewed by 4770 | Submission Open

Keywords: satellite DNA; satellitome; satellite DNA organization; satellite DNA evolution; satellite DNA origin; satellite DNA transcription; satellite DNA function; satellite DNA regulation; satellite RNA; heterochromatin; centromere; telomere; gene regulation; cancer; biomarkers; epigenetics; next-generation sequencing (NGS); nanopore sequencing; PacBio sequencing

(This special issue belongs to the Section Molecular Biology)

New Insights into Male Infertility and Sperm Biology

edited by

Monica Muratori

submission deadline 20 Jan 2026 | 4 articles | Viewed by 4707 | Submission Open

Keywords: male infertility; sperm DNA fragmentation; sperm oxidative stress; sperm nuclear condensation; assisted reproductive technologies; genomics; epigenomics; transcriptomics; proteomics; metabolomics

(This special issue belongs to the Section Molecular Biology)

Diabetic Bone Disease: New Insights into Molecular Mechanisms and Therapeutic Approaches

edited by

Ioannis Kanakis

submission deadline 20 Jan 2026 | 1 articles | Viewed by 4596 | Submission Open

Keywords: diabetic bone disease; molecular mechanisms; therapeutic approaches

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Perspectives in Steroidomics

edited by

Martin Hill

submission deadline 20 Jan 2026 | 2 articles | Viewed by 4581 | Submission Open

Keywords: steroidomics; steroids; pathophysiology; physiology; diagnostics; treatment; prediction; prognosis; LC-MS/MS; GC-MS/MS

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Natural Compounds: Structural Diversity, Modifications, and Biological Activities

edited by Tomasz Pospieszny

submission deadline 20 Jan 2026 | 3 articles | Viewed by 4401 | Submission Open

Keywords: bile acids; molecular research; biological activity; natural products; steroids

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Oral Squamous Cell Carcinoma: Insights into Molecular Pathways and Emerging Therapeutic Approaches

edited by

Silvia Pomella

submission deadline 20 Jan 2026 | 3 articles | Viewed by 4325 | Submission Open

Keywords: oral squamous cell carcinoma; epigenetics; molecular genetics; gene expression targeted therapy; molecular biomarkers

(This special issue belongs to the Section Molecular Oncology)

Applications of Machine Learning in Bioinformatics and Biomedicine

edited by

Fuyi Li

submission deadline 20 Jan 2026 | 3 articles | Viewed by 4290 | Submission Open

Keywords: bioinformatics; computational biology; machine learning; deep learning; AI for biology

(This special issue belongs to the Section Molecular Informatics)

Novel Insights into Molecular Mechanisms of Pulmonary Pathology

edited by Qiaozhen Liu

submission deadline 20 Jan 2026 | 2 articles | Viewed by 4277 | Submission Open

Keywords: fibrosis; infection; COPD; asthma; IPF; pneumonia; lung cancer; molecular mechanism

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Research and Innovations in Green Monomers and Macromolecular Materials

edited by

Joanna Rydz

Marta Musioł

and

Wanda Sikorska

submission deadline 20 Jan 2026 | 3 articles | Viewed by 4253 | Submission Open

Keywords: green monomers and macromolecular material for a sustainable future; current barriers and future needs of green macromolecular materials; latest breakthroughs and approaches in molecular sciences; bio-based and/or biodegradable polymers based on natural; renewable; and synthetic polymers; synthesis; design; characterization; and development of innovative; technologically advanced; adaptable; and multifunctional green polymers in chemistry; biology; and medicine; relationships between structure; properties; functions; and performance of green polymers; sustainability; recycling; and environmental issues of green macromolecular materials; commercial applications: concepts; methodologies; and tools; 3D printing for personalized consumer products

(This special issue belongs to the Section Materials Science)

Cell and Molecular Perspectives in Breast Cancer

edited by Seungbaek Lee

submission deadline 20 Jan 2026 | 1 articles | Viewed by 4239 | Submission Open

Keywords: breast cancer; molecular biology; cell biology; biomarker; novel therapeutics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances and Emerging Trends in Marine Natural Products

edited by Rafael Alexandre Faria da Costa Félix and

Carina Félix

submission deadline 20 Jan 2026 | 4 articles | Viewed by 4132 | Submission Open

Keywords: marine natural products; bioprospecting; circular bioeconomy; bioactive compounds; antioxidant; antimicrobial; anti-inflammatory; polymers; peptides; genome mining; enzyme inhibitors; plant priming; green extraction methodologies

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Insights into Lipodystrophy

edited by

Sofía Sánchez-Iglesias

and

David Araújo-Vilar

submission deadline 20 Jan 2026 | 2 articles | Viewed by 4097 | Submission Open

Keywords: lipodystrophy; adipogenesis; animal models; lipid metabolism; therapeutic targets; insulin signaling pathways; adipose tissue

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Hormone Metabolism and Signaling in Human Health and Disease

edited by

Kuo-Hu Chen

submission deadline 20 Jan 2026 | 1 articles | Viewed by 4065 | Submission Open

Keywords: hormone metabolism; signaling pathways; pathophysiology; molecular and cellular biology; diseases originating from hormone disorders; hormonal therapy

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

The Role of Artificial Intelligence in Cancer Treatment: Molecular Perspective

edited by Andra Valentina Krauze

submission deadline 20 Jan 2026 | 2 articles | Viewed by 4020 | Submission Open

Keywords: cancer treatment; artificial intelligence; machine learning; precision medicine; molecular insights

(This special issue belongs to the Section Molecular Informatics)

Exploring the Complex Interplay Between Metabolic Diseases, MASLD, and Liver Cancer

edited by

Daniela Gabbia

and

Sara De Martin

submission deadline 20 Jan 2026 | 3 articles | Viewed by 3985 | Submission Open

Keywords: hepatocellular carcinoma; MASLD; MASH; obesity; insulin resistance; dyslipidemia; liver cancer

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Pathophysiology and Treatment of Congenital Neuromuscular Disorders

edited by Johan Lindqvist

submission deadline 20 Jan 2026 | 2 articles | Viewed by 3761 | Submission Open

Keywords: nemaline myopathy; hereditary neuromuscular disorder; genetic mutations; pathogenesis; pathophysiology; therapy; myofilament dysfunction; congenital neuromuscular disorders; congenital muscular dystrophy; spinal muscular atrophy; Duchenne muscular dystrophy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Hemophilia: From Pathophysiology to Novel Therapies

edited by

Mingching Shen

submission deadline 20 Jan 2026 | 2 articles | Viewed by 3615 | Submission Open

Keywords: hemophilia; novel therapy in hemophilia; ultra-long half life clotting factor; clotting factor mimics; coagulation rebalancing agent; gene therapy; pathogenesis of hemophilia; molecular biology of hemophilia

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Role of HLA (Human Leucocyte Antigen) in Human Diseases

edited by

Jeane Eliete Laguila Visentainer

submission deadline 20 Jan 2026 | 2 articles | Viewed by 3546 | Submission Open

Keywords: HLA (human leukocyte antigen); molecular immunology; autoimmune diseases; HLA genetics; antigen presentation; HLA and cancer; immunotherapy and HLA; immune responses; immunity and HLA; infectious diseases and HLA; innate and adaptive immunity; organ transplantation and HLA; HLA and immune responses; HLA genotypes and susceptibility; autoimmunity and HLA; HLA and infectious diseases; HLA and personalized therapies; molecular mechanisms of HLA; HLA mutations; experimental models of HLA; HLA and inflammation; HLA biomarkers; HLA and immunosuppression; immune tolerance and HLA; immune evasion by HLA

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Biology and Targeted Therapies in Leukemias

edited by Fabio Stagno and

Stefania Stella

submission deadline 20 Jan 2026 | 2 articles | Viewed by 3437 | Submission Open

Keywords: molecular biology; target therapy; leukemia; TKI; BCL-2; FLT3; CAR-T cells; CML

(This special issue belongs to the Section Molecular Oncology)

Current Research for Heart Disease Biology and Therapeutics (Third Edition)

edited by Claudia Kusmic

submission deadline 20 Jan 2026 | 3 articles | Viewed by 3435 | Submission Open

Keywords: myocardial hypertrophy; cardiac remodeling; heart failure; drug therapy; molecular therapeutic targets; myocardial gene therapy; heart disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Oxidative Stress Responses in Cardiovascular Diseases

edited by Vladimir Jakovljevic

submission deadline 20 Jan 2026 | 1 articles | Viewed by 3417 | Submission Open

Keywords: antioxidant capacity; cardiovascular disease; cell death; endothelial dysfunction; ischemia/reperfusion injury; oxidative stress

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insights into Plant Stress

edited by

Pandiyan Muthuramalingam

Subramani Pandian

and

Hyunsuk Shin

submission deadline 20 Jan 2026 | 3 articles | Viewed by 3406 | Submission Open

Keywords: abiotic stress; biotic stress; bioinformatics; artificial intelligence; biotechnology; breeding; crop plants; horticultural plants; GWAS; CRISPR-Cas; multi-omics; genomics; epigenomics; transcriptomics; proteomics; genetic diversity; gene expression

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Targets in Gastrointestinal Diseases

edited by

Changwon Yang

submission deadline 20 Jan 2026 | 2 articles | Viewed by 3389 | Submission Open

Keywords: molecular pathways; gastrointestinal cancers; inflammatory bowel disease; targeted therapies; microbiota; gene editing

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 851-900 on page 18 of 66.

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