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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Mechanisms in Organ Transplantation

edited by Hirofumi Hirao

submission deadline 25 Nov 2025 | 4 articles | Viewed by 7148 | Submission Open

Keywords: organ transplantation; cellular-specific response to perioperative stress; cold/warm ischemia; innate/adaptive immunity; microcirculatory disturbance

(This special issue belongs to the Section Molecular Biology)

Hallmarks of Cancer: Emerging Insights and Innovations

edited by

Konstantinos Syrigos

submission deadline 25 Nov 2025 | 3 articles | Viewed by 6653 | Submission Open

Keywords: proliferative signaling; growth suppression evasion; epigenetic reprogramming; immune system evasion; replicative immortality; inflammation and cancer; microbiome and cancer; invasion and metastasis; tumor microenvironment; cellular senescence; genomic instability; metabolic reprogramming; therapeutic resistance; molecular diagnostics; targeted cancer therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Pain in Human Health and Disease

edited by

Daniel Pozza

submission deadline 25 Nov 2025 | 2 articles | Viewed by 3526 | Submission Open

Keywords: pain signaling; molecular pathways; chronic pain; neuropathic pain; inflammation neuro– immune interactions; epigenetics pharmacogenetics; precion medicine; sleep disorders

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neuroendocrine Tumors: From Molecular Pathology to Novel Therapeutic Approaches, Including Theranostics

edited by

Behrooz H. Yousefi

submission deadline 25 Nov 2025 | 2 articles | Viewed by 2852 | Submission Open

Keywords: neuroendocrine tumors; NETs; molecular pathology; therapeutic strategies

(This special issue belongs to the Section Molecular Oncology)

Gene Mutations in Cancer

edited by

Lucie Benešová

submission deadline 25 Nov 2025 | 1 articles | Viewed by 1273 | Submission Open

Keywords: oncogenetics; somatic mutations; intratumor mutational heterogeneity; tumor mutational burden; circulating tumor DNA; liquid biopsy

(This special issue belongs to the Section Molecular Genetics and Genomics)

Colorectal Cancer: Molecular and Cellular Basis

edited by Martina Lepore Signorile

submission deadline 25 Nov 2025 | 1 articles | Viewed by 1146 | Submission Open

Keywords: colorectal cancer; molecular and cellular biology; tumor initiation; tumor progression; metastasis

(This special issue belongs to the Section Molecular Oncology)

Oxidative Stress and Disease: Basic and Biochemical Approaches

edited by

Giuseppe Bruschetta

submission deadline 25 Nov 2025 | 1 articles | Viewed by 1056 | Submission Open

Keywords: aging; antioxidant mechanisms; cancer; cytokines; enzymatic pathways; inflammatory processes; oxidative stress; reactive oxygen species (ROS)

(This special issue belongs to the Section Molecular Biology)

Circulating Tumor Cells in Oncology: From Liquid Biopsy to Clinical Decision-Making

edited by

Maria Beatrice Morelli

submission deadline 25 Nov 2025 | 1 articles | Viewed by 971 | Submission Open

Keywords: circulating tumor cells (CTCs); liquid biopsy; cancer biomarkers; precision oncology; metastasis; cancer diagnostics; cancer prognosis; CTC enrichment; CTC isolation techniques; single-cell analysis; tumor microenvironment; CTC culture; immune surveillance; blood-based biomarkers; molecular profiling; CTC-derived cell lines; treatment resistance; personalized cancer therapy; cell reprogramming; anti-tumor immunity

(This special issue belongs to the Section Molecular Oncology)

Bioinformatics Analysis of Single Cell and Spatial Multi-Omics

edited by Fahong Yu

submission deadline 25 Nov 2025 | Viewed by 324 | Submission Open

Keywords: bioinformatics; single-cell omics; spatial multi-omics; matabolomics; genomics; transcriptomics; proteomics; next-generation sequencing techniques

(This special issue belongs to the Section Molecular Informatics)

Valorization of Lignocellulosic Biomass: 2nd Edition

edited by

Haishun Du

submission deadline 25 Nov 2025 | Viewed by 264 | Submission Open

Keywords: lignocellulosic biomass; biorefinery; biomass conversion; bioenergy; biofuels; bioproducts; platform chemicals; cellulose nanomaterials; lignin nanoparticles; functional materials

(This special issue belongs to the Section Materials Science)

Signaling Molecules in Neurological Health and Disease

edited by Venkat Venkataraman

submission deadline 25 Nov 2025 | Viewed by 194 | Submission Open

Keywords: microglia; neuroinflammation; gut– brain axis; neurodegenerative diseases; neuroimmune interactions

(This special issue belongs to the Section Molecular Neurobiology)

T Cell Therapy in Cancer: Molecular Perspectives

edited by Alessio Ottaviani

submission deadline 25 Nov 2025 | Viewed by 135 | Submission Open

Keywords: cancer; immunotherapy; gene therapy; chimeric antigen receptor; tumor-infiltrating lymphocytes; T-reg; gamma delta (γ δ ) T cells; cytokine release syndrome; allogenic transplantation

(This special issue belongs to the Section Molecular Oncology)

From Discovery to Clinic: Overcoming Barriers in Antimicrobial Peptide Development

edited by José M. Pérez De la Lastra

submission deadline 25 Nov 2025 | Viewed by 114 | Submission Open

Keywords: antimicrobial peptides (AMPs); translational challenges; in vivo efficacy; drug delivery and formulation; computational approaches; pharmacokinetics; toxicity prediction; antibiotic resistance; animal models; nanotechnology

(This special issue belongs to the Section Molecular Microbiology)

The Tumor Microenvironment and Targeted Therapy

edited by

Luca Filippi

submission deadline 28 Nov 2025 | Viewed by 137 | Submission Open

Keywords: tumor microenvironment; cancer; immune evasion; novel therapeutic strategies

(This special issue belongs to the Section Molecular Oncology)

Autoimmune Disorders: Molecular Mechanisms and Therapeutic Strategies

edited by

Katarzyna Romanowska-Próchnicka

submission deadline 29 Nov 2025 | Viewed by 258 | Submission Open

Keywords: molecular mechanisms; immune signaling pathways; targeted therapies; biomarkers; autoimmune pathogenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research and Cellular Biology of Breast Cancer

edited by

Andrea Nicolini

and

Cristian Scatena

submission deadline 30 Nov 2025 | 11 articles | Viewed by 23785 | Submission Open

Keywords: molecular mechanisms of tumor growth and diffusion; cancer cell biology; biology of tumor micro-environmental cells; MDR; hormone dependency; HER2 positive breast cancer; TNBC; genetic and epigenetic alterations; pro-tumor and anti-tumor immune responses; conventional and biological therapies; blood and tissue biomarkers

(This special issue belongs to the Section Molecular Oncology)

Plant Extracts and Bioactive Molecules with Potential Benefits for Human Health

edited by

Violeta Popovici

Cerasela Elena Gîrd

and

Emma Adriana Ozon

submission deadline 30 Nov 2025 | 8 articles | Viewed by 20098 | Submission Open

Keywords: medicinal plants; plant extracts; bioactive phytocompound identification and quantification; pharmacological activity; health benefits; phytotherapy; plant-based diet; functional foods

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanisms and Therapies of Pancreatic Cancer: 2nd Edition

edited by

Donatella Delle Cave

submission deadline 30 Nov 2025 | 10 articles | Viewed by 19811 | Submission Open

Keywords: pancreatic cancer; metabolism; cellular plasticity; tumor microenvironment; target therapy

(This special issue belongs to the Section Molecular Oncology)

Medicinal Plants and Bioactive Compounds in Health and Disease

edited by

Sandra Barbalho

and

Sunmin Park

submission deadline 30 Nov 2025 | 9 articles | Viewed by 19307 | Submission Open

Keywords: obesity; diabetes; metabolic syndrome; metabolic-associated fat liver disease; inflammatory processes; free radicals and oxidative stress; phyto-compounds; medicinal plants; nutrition; physical exercises

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Natural Compounds: Advances in Antimicrobial Activity

edited by

Carlo Genovese

and

Francesco Pegreffi

submission deadline 30 Nov 2025 | 8 articles | Viewed by 18871 | Submission Open

Keywords: natural compounds; multidrug-resistant microorganisms; biofilm; synergistic effect; nanotechnologies; delivery systems; machine learning; clinical infections

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Molecular Mechanisms and Markers in Inflammatory Disorders, 3rd Edition

edited by

Elena Vianello

submission deadline 30 Nov 2025 | 8 articles | Viewed by 17066 | Submission Open

Keywords: inflammation; inflammatory disorders; biomarkers; molecular mechanism of inflammation; molecular signaling

(This special issue belongs to the Section Molecular Immunology)

Role of Calprotectin in Human Health and Disease

edited by

Mats B. Eriksson

and

Anders O. Larsson

submission deadline 30 Nov 2025 | 4 articles | Viewed by 15691 | Submission Open

Keywords: acute phase reactants; analysis; bacterial infection; biomarker; calprotectin; critical care; inflammation; turbidimetric

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioinformatics and Machine Learning for Predicting Biological Processes

edited by Hao Lv

submission deadline 30 Nov 2025 | 1 articles | Viewed by 14460 | Submission Open

Keywords: bioinformatics; machine learning; multi-omics integration; gene regulation; biological processes; disease processes; data-driven discovery

(This special issue belongs to the Section Molecular Informatics)

Environmental Stress and Metabolic Responses in Plants

edited by

Tibor Janda

submission deadline 30 Nov 2025 | 5 articles | Viewed by 14266 | Submission Open

Keywords: abiotic stress; acclimation; biotic stress; climate change; light stresses; oxidative stress; photoinhibition; redox regulation; signalling; stress alleviation; stress detection in plants

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Diagnostics and Treatment of Inflammatory Bowel Disease

edited by

Loris Riccardo Lopetuso

submission deadline 30 Nov 2025 | 3 articles | Viewed by 13188 | Submission Open

Keywords: IBD molecular pathogenesis; intestinal mucosal healing; gut microbiota in IBD; fecal microbiota transplantation; target therapy in IBD; stem cell therapy; biologic agents; small molecules; adhesion antagonists; inflammatory cytokines; lymphocyte control

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Nanomaterials and Biomaterials in Biomedicine Application

edited by

Filipa Mascarenhas-Melo

submission deadline 30 Nov 2025 | 6 articles | Viewed by 12734 | Submission Open

Keywords: nanomaterials; biomaterials; biomedicine; drug delivery; regenerative medicine; healthcare technologies; biocompatible platforms

(This special issue belongs to the Section Materials Science)

Molecular Dynamics Simulations and Structural Analysis of Protein Domains (2nd Edition)

edited by

Alexandre G. De Brevern

submission deadline 30 Nov 2025 | 7 articles | Viewed by 11174 | Submission Open

Keywords: protein structures; molecular dynamics; advanced molecular dynamics; variants; pathologies; drug design; allostery; protein domains; secondary structures; methodological development; protein design; ligands; normal mode analysis; machine learning

(This special issue belongs to the Section Molecular Informatics)

Latest Advances in Plant Abiotic Stress

edited by

Kincső Decsi

submission deadline 30 Nov 2025 | 4 articles | Viewed by 9214 | Submission Open

Keywords: abiotic stress factors; priming effects; defense responses; biochemical pathway analyses; transcriptomics; plant conditioners; next-generation sequencing; genome-wide analyses

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular and Clinical Aspects of Migraine and Its Comorbidities: Epilepsy, Stroke, and Restless Leg Syndrome

edited by

Janusz Blasiak

and Michał Fila

submission deadline 30 Nov 2025 | 2 articles | Viewed by 8969 | Submission Open

Keywords: migraine; genetics and epigenetics of migraine; migraine comorbidities; omics in migraine studies; stem cells in migraine studies; epilepsy; stroke; restless leg syndrome

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Nuclear Receptors in Diseases

edited by Roberto Palacios-Ramirez

submission deadline 30 Nov 2025 | 3 articles | Viewed by 8672 | Submission Open

Keywords: nuclear receptors; hormone receptors; orphan receptors; retinoid receptors; metabolic diseases; cancers; drug metabolism

(This special issue belongs to the Section Molecular Biology)

Melatonin: Physiological Effects on Health and Diseases

edited by

Jana Tchekalarova

submission deadline 30 Nov 2025 | 2 articles | Viewed by 8609 | Submission Open

Keywords: hormone melatonin; oxidative stress; sleep; metabolism; neurodegeneration

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Progression of Genome-Related Diseases: 2nd Edition

edited by

Salvatore Saccone

submission deadline 30 Nov 2025 | 3 articles | Viewed by 7887 | Submission Open

Keywords: next-generation sequencing; genetic diseases; multifactorial diseases; diagnostic tolls; human health

(This special issue belongs to the Section Molecular Genetics and Genomics)

Multiple Sclerosis: The Latest Developments in Immunology and Therapy

edited by

Borros Michael Arneth

submission deadline 30 Nov 2025 | 4 articles | Viewed by 7875 | Submission Open

Keywords: multiple sclerosis; sensory disturbances; movement disorders

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Renal Dysfunction, Uremic Compounds, and Other Factors (3rd Edition)

edited by

Giovana S. Di Marco

and

Marcus Brand

submission deadline 30 Nov 2025 | 3 articles | Viewed by 7817 | Submission Open

Keywords: renal dysfunction; acute kidney disease; chronic kidney disease; soluble mediators; uremic toxins; disease progression; organ cross-talk; therapy; new techniques

(This special issue belongs to the Section Molecular Toxicology)

Role of NRF2 Pathway in Chronic Diseases

edited by

Ángel Juan García-Yagüe

submission deadline 30 Nov 2025 | 3 articles | Viewed by 6675 | Submission Open

Keywords: chronic diseases; NRF2; oxidative stress; inflammation; neurodegenerative diseases; cardiovascular disease; autoimmune diseases; chronic kidney diseases; liver disease

(This special issue belongs to the Section Biochemistry)

Mast Cells in Human Health and Diseases—3rd Edition

edited by

Giovanna Traina

submission deadline 30 Nov 2025 | 3 articles | Viewed by 5922 | Submission Open

Keywords: mast cells; human diseases; pain; cardiovascular diseases; microbiome; food allergy; stress; cancer

(This special issue belongs to the Section Molecular Biology)

Hormonal Regulatory Networks in Aging, Cancers, Alzheimer’s Disease, and Therapeutics

edited by

Pulak R. Manna

submission deadline 30 Nov 2025 | 2 articles | Viewed by 5584 | Submission Open

Keywords: hormonal imbalance and aging; endocrinology; physiology and pathophysiology; steroidogenesis; sex hormones and neurosteroids; age-related complications and diseases; tumorigenesis; hormone-dependent cancers; neurodegenrative diseases; Alzheimer’ s disease; therapeutics; healthy aging

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Advances in Biomarkers of Central Nervous System Diseases and Disorders

edited by

David Gurwitz

and

Chiara Villa

submission deadline 30 Nov 2025 | 2 articles | Viewed by 5432 | Submission Open

Keywords: RNA biomarkers; CNS disorders; autism spectrum disorder; precision medicine

(This special issue belongs to the Section Molecular Neurobiology)

Microglia in Neurological Disorders: Potential Therapeutic Targets and Underlying Mechanisms

edited by

Masashi Tanaka

submission deadline 30 Nov 2025 | 3 articles | Viewed by 5407 | Submission Open

Keywords: cerebral amyloid angiopathy; Alzheimer's disease; amyloid-β fibril formation

(This special issue belongs to the Section Molecular Neurobiology)

Mitochondrial Biology and Reactive Oxygen Species

edited by

Wieslawa Jarmuszkiewicz

submission deadline 30 Nov 2025 | 2 articles | Viewed by 5155 | Submission Open

Keywords: mitochondrial biology; mitochondrial dysfunction; mitochondrial coenzyme Q; metabolic homeostasis; oxidative stress; reactive oxygen species

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Soybean Molecular Breeding

edited by Dong Cao

submission deadline 30 Nov 2025 | 4 articles | Viewed by 5126 | Submission Open

Keywords: soybean; plant architecture; adaptation; yield improvement; molecular breeding; nutritional quality traits; stress tolerance

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Research in Hematologic Malignancies

edited by

Rachid Lahlil

and

Anne Aries

submission deadline 30 Nov 2025 | 3 articles | Viewed by 5105 | Submission Open

Keywords: therapeutic targets; leukemogenesis; molecular regulation; cancer stem cells; epigenetics; novel biomarkers; non-coding RNA; DNA methylation; chemotherapy and genetic changes; cancer; hematologic malignancies

(This special issue belongs to the Section Molecular Oncology)

Recent Advances in Iron Metabolism, Ferritin and Hepcidin Research: 3rd Edition

edited by

Edina Pandur

submission deadline 30 Nov 2025 | 3 articles | Viewed by 4511 | Submission Open

Keywords: iron; hepcidin; ferroportin; ferritin; regulation; anemia; therapies; cell signaling; inflammation; disorders

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Cardiovascular Diseases: Aging and Other Risk Factors

edited by

Silvia Liskova

submission deadline 30 Nov 2025 | 2 articles | Viewed by 4202 | Submission Open

Keywords: aging; hypertension; endothelium; vascular smooth muscle cells; pulmonary hypertension; atherosclerosis; hyperlipidemia

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Dermatology: Advances in Pathophysiology and Therapies (3rd Edition)

edited by

Montserrat Fernández-Guarino

submission deadline 30 Nov 2025 | 3 articles | Viewed by 4035 | Submission Open

Keywords: immunodermatology; cutaneous lymphoma; cutaneous drug reaction; erythroderma; psoriasis; atopic dermatitis; eczematous reactions; cutaneous manifestation of systemic diseases; cutaneous vasculitis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Immunophenotyping in Autoimmune Diseases and Cancer, 4th Edition

edited by

Gabor J. Szebeni

and

Attila Balog

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3947 | Submission Open

Keywords: immunophenotyping; immune regulation; multiparameter cytometry; immuno-oncology; anti-tumor immunity; autoimmunity; cancer immunology; protein– protein interactions; structure/function relationships; sulfur amino acids

(This special issue belongs to the Section Molecular Immunology)

Exploring the Cytoskeleton and Its Regulators: From Structure to Function

edited by

Wan Lee

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3821 | Submission Open

Keywords: cytoskeleton; cytoskeleton-binding protein; cytoskeletal protein; cell signaling; mechanotransduction; cell proliferation; cell migration; cellular motility; cell differentiation; structural biology

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms and Treatment of Retinal Diseases

edited by

Deokho Lee

and

Livio Vitiello

submission deadline 30 Nov 2025 | 3 articles | Viewed by 3685 | Submission Open

Keywords: nutritional supplementations; high myopia; optometry; cell therapy; drug delivery; age-related macular degeneration; glaucoma; retinal degeneration; choroidal thinning; scleral remodeling; light therapy; digital healthcare; prematurity of retionopathy; carotid artery occlusion; retinal ischemia; inflammation; eye drop

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Neurological and Psychiatric Disease, 2nd Edition

edited by

Giuseppina Martella

and Maria Meringolo

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3506 | Submission Open

Keywords: Alzheimer's and Parkinson's diseases; epilepsy; migraine; essential tremors; stroke; depression; anxiety disorders; cognitive impairment

(This special issue belongs to the Section Molecular Neurobiology)

Translational Oncology: From Molecular Basis to Therapy

edited by

Mario Cioce

and Gatti Veronica

submission deadline 30 Nov 2025 | 1 articles | Viewed by 3503 | Submission Open

Keywords: cancer; therapy resistance; translational oncology; cancer stem cells; immunotherapy; cancer metabolism; OMICS; patient-derived-organoids; drug repositioning; TKI

(This special issue belongs to the Section Molecular Oncology)

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