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Natural Compounds: Advances in Antimicrobial Activity

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 183

Special Issue Editors

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Guest Editor
Department of Medicine and Surgery, “Kore” University of Enna, 94100 Enna, Italy
Interests: antimicrobial resistance; bacterial adhesion; biofilm; natural extracts; drug delivery systems; clinical infectious diseases
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Medicine and Surgery, “Kore” University of Enna, 94100 Enna, Italy
Interests: osteoarthritis; musculoskeletal pain; orthopedic biomaterials; orthopedic infections; biofilm; antimicrobial resistance

Special Issue Information

Dear Colleagues,

In recent decades, an increase in antimicrobial resistance (AMR) has been observed. AMR is defined as microorganisms' ability to resist antimicrobials' action, making them ineffective. AMR is a consequence of the large and inappropriate use of antimicrobials and the failure to complete the recommended treatment or self-medication. As a result, some microorganisms develop resistance mechanisms that allow them to evade the mechanisms of action of antimicrobial agents. AMR concerns the resistance to antibiotics and other chemotherapeutic agents, including antifungal, antiviral, and antiparasitic drugs. The widespread diffusion of resistant phenotypes explains the increasing prevalence of community-acquired (CA) and hospital-acquired (HA) infections caused by resistant strains. Considering the scarce response to the most common clinically used antimicrobial agents, these infections are extremely difficult and, in some cases, impossible to treat. Accordingly, AMR is associated with high morbidity and mortality rates and implicates increased costs for the management of infections. For these reasons, it represents one of the most important global public health threats. In this context, the research of new and effective natural molecules endowed with a broad spectrum of antimicrobial activities has attracted significant attention.

This Special Issue, entitled “Natural Compounds: Advances in Antimicrobial Activity”, of the International Journal of Molecular Sciences focuses on the antimicrobial effects of natural compounds, emphasizing strategies to make them more selective and effective. Furthermore, research aimed at studying and preventing infectious diseases through an artificial intelligence-based approach will be considered. Specifically, research pertaining to the following topics:

  • Nanotechnology-based delivery systems for natural compounds (polymer nanoparticles, crystal nanoparticles, solid lipid nanoparticles (SLNs), liposomes, dendrimers, and micelles);
  • Natural antimicrobial agents able to inhibit/eradicate biofilm or to block/modulate quorum sensing communication system;
  • Combinational antimicrobial chemotherapies (synergistic interaction of natural compounds and conventional drugs);
  • Machine-learning algorithm to identify natural compounds that could inhibit the growth of multidrug-resistant bacteria (e.g., Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, methicillin-resistant Staphylococcus aureus, and vancomycin-resistant Enterococcus) and predict possible clinical outcomes.

In this Special Issue, original research articles and reviews are welcome.

We look forward to receiving your contributions.

Prof. Dr. Carlo Genovese
Dr. Francesco Pegreffi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • natural compounds
  • multidrug-resistant microorganisms
  • biofilm
  • synergistic effect
  • nanotechnologies
  • delivery systems
  • machine learning
  • clinical infections

Published Papers

This special issue is now open for submission.
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