T Cell Therapy in Cancer: Molecular Perspectives
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 25 November 2025 | Viewed by 24
Special Issue Editor
Special Issue Information
Dear Colleagues,
The immune system plays the important role of protecting the host from malignant cells, and harnessing its potential has been a focus of cancer research for decades. One of the main components of the adaptive immune compartment is represented by T cells due to their ability to recognize and eliminate cancer cells. During the years, several strategies have been developed to employ T cells to make significant advances in cancer immunotherapy. In particular, T cell therapy has reached its higher potential thanks to the advent of genetically engineered T cells as the chimeric antigen receptor T cell.
T cell modification has revolutionized cancer treatment; however, the success of this therapy depends on several factors, such as the choice of T cell subset, target antigen, and genetic modification. The potential of modified T cells to specifically recognize and eliminate cancer cells has opened new avenues for cancer immunotherapy, but there is still a lot to know about the molecular mechanism involved in this recognition, elimination, or inhibition.
This Special Issue will be dedicated to the molecular mechanisms involved in T cell response against cancer, such as activation, memory profile, exhaustion, and inhibition mechanisms, but also to how genetic modification impacts T cell fitness.
Dr. Alessio Ottaviani
Guest Editor
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Keywords
- cancer
- immunotherapy
- gene therapy
- chimeric antigen receptor
- tumor-infiltrating lymphocytes
- T-reg
- gamma delta (γδ) T cells
- cytokine release syndrome
- allogenic transplantation
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