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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Molecular Modeling, Docking and Simulations of Protein Structure, 2nd Edition
edited by
submission deadline 20 Dec 2025 | 5 articles | Viewed by 10725 | Submission Open
Keywords: molecular modeling; protein structure; molecular mechanisms; protein interactomics; ligand design; peptides; molecular dynamics; molecular docking
(This special issue belongs to the Section Macromolecules)
Molecular Research in Infective Mycobacteria
edited by
submission deadline 20 Dec 2025 | 5 articles | Viewed by 10399 | Submission Open
Keywords: infections; mycobacteria; molecular biology; antimicrobials; bacteria biochemistry
(This special issue belongs to the Section Molecular Microbiology)
Nutrition as a Tool for Modulating Cellular Metabolism submission deadline 20 Dec 2025 | 2 articles | Viewed by 10371 | Submission Open
Keywords: cell metabolism; mitochondria; ROS; RNS; proliferation and cell death; metabolic pathways; transporters; natural compounds; bioactive molecules; novel foods; metabolic diseases; human pathology
(This special issue belongs to the Section Biochemistry)
The Role of Enzymes in Metabolic Processes
edited by
submission deadline 20 Dec 2025 | 4 articles | Viewed by 10274 | Submission Open
Keywords: enzyme; metabolism; glycolysis; mitochondria; kinase; cell growth; carcinogenesis
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Pathophysiology of Hair Loss
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 10170 | Submission Open
Keywords: Hair Loss; Pathophysiology; Molecular Mechanisms; Genetic Mutations; Signaling Pathways; Nutrient Interactions; Personalized Therapies; Targeted Drug Delivery
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Role of Natural and Synthetic Sulfur Compounds in Human Health and Diseases
edited by
submission deadline 20 Dec 2025 | 5 articles | Viewed by 10102 | Submission Open
Keywords: sulfur compounds; sulfur metabolism; hydrogen sulfide; H2S-donors; human health; human disease; nutraceuticals
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Recognition and Biosensing
edited by
submission deadline 20 Dec 2025 | 3 articles | Viewed by 9654 | Submission Open
Keywords: molecular recognition; biosensor; nanomaterials; aptamer; nucleic acids; sensitivity
(This special issue belongs to the Section Biochemistry)
High Resolution Mass Spectrometry in Molecular Sciences: 2nd Edition
edited by
submission deadline 20 Dec 2025 | 4 articles | Viewed by 9620 | Submission Open
Keywords: antibodies; astrobiology; biomarkers; drug discovery; drug development; drug metabolism; Fourier transform; glycomics; imaging; ion cyclotron resonance; ion mobility; lipids; lipidomics; mass spectrometry; metabolomics; nucleic acids; Orbitrap; organometallics; polymers; peptides; proteins; proteomics; structural biology; structure elucidation; tandem mass spectrometry; time-of-flight
(This special issue belongs to the Section Biochemistry)
Lymphatic Disorders: From Molecular Mechanisms to Therapies
edited by
submission deadline 20 Dec 2025 | 4 articles | Viewed by 9619 | Submission Open
Keywords: lymphoedema; lipedema; matrix; vascular disorder; ultrasound; lacteal; microbiota; intersitial fluid
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Genetic Research in Neurological Diseases
edited by
submission deadline 20 Dec 2025 | 2 articles | Viewed by 9453 | Submission Open
Keywords: neurodegenerative diseases; genetic risk factor; next-genetation sequencing; genome-wide association studies; disease models
(This special issue belongs to the Section Molecular Neurobiology)
Advanced Research on Nucleic Acids: Therapeutic Potential and Applications, 2nd Edition submission deadline 20 Dec 2025 | 5 articles | Viewed by 9398 | Submission Open
Keywords: aptamer; decoy; DNAzyme; ribozyme; siRNA; miRNA; antisense oligonucleotide; antigene strategy; G-quadruplex; triplex
(This special issue belongs to the Section Biochemistry)
Diabetes: Advances in Molecular Research submission deadline 20 Dec 2025 | 3 articles | Viewed by 9377 | Submission Open
Keywords: type 1 diabetes; type 2 diabetes; retinopathy; nephropathy; neuropathy; molecular pharmacology; cardiovascular disease; cerebrovascular disease; normal physiology; counter-regulatory hormones; hypoglycemia   TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian   //   TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back //     This page is in English   Translate to Simplified Chinese         Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh   Always translate English to Simplified Chinese Never translate English Never translate admin.mdpi.com
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Nonalcoholic Liver Disease: Mechanisms, Prevention, and Treatment submission deadline 20 Dec 2025 | 3 articles | Viewed by 9311 | Submission Open
Keywords: MAFLD; MASH; metabolic syndrome; steatosis; lipid droplets; SNPs; GWAS; therapeutc target; fatty liver; steatohepatitis; HCC; EpigEnetics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Understanding and Treating Amyotrophic Lateral Sclerosis and Related Motor Neuron Diseases
edited by
submission deadline 20 Dec 2025 | 3 articles | Viewed by 9114 | Submission Open
Keywords: neurodegenerative; ALS; motor neuron; genetics; molecular pathways; biomarkers; models; treatments
(This special issue belongs to the Section Molecular Neurobiology)
Insights into Redox Homeostasis and Oxidative Stress
edited by , Zoi Vasiliki Skaperda and
submission deadline 20 Dec 2025 | 4 articles | Viewed by 8918 | Submission Open
Keywords: oxidative stress; redox homeostasis; redox signaling; reactive oxygen species; oxidative damage; diseases
(This special issue belongs to the Section Molecular Pharmacology)
Innovative Therapeutic Approaches in Neuropsychiatric Disorders
edited by Marta Pardo
submission deadline 20 Dec 2025 | 2 articles | Viewed by 8903 | Submission Open
Keywords: neuropsychiatric disorders; pharmacogenomics; pathophysiology; molecular treatment mechanisms; molecular targets for novel drug development; neurotransmitters; synaptic plasticity; epigenetics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Latest Reviews in Molecular Plant Science 2025
edited by and
submission deadline 20 Dec 2025 | 4 articles | Viewed by 8795 | Submission Open
Keywords: gene cloning and gene functional analysis; gene editing; QTL mapping; multi-omics integration analysis; agronomically characteristics; plant development; metabolic pathway; biotic and abiotic stresses
(This special issue belongs to the Section Molecular Plant Sciences)
Innovations in Polymeric Materials: Exploring Advancements and Applications
edited by
submission deadline 20 Dec 2025 | 3 articles | Viewed by 8581 | Submission Open
Keywords: eco-friendly polymers; nanocomposites; biodegradable polymers; smart materials; polymer recycling; drug delivery systems; biocompatible polymers; food industry; wastewater treatment
(This special issue belongs to the Section Materials Science)
New Perspective on Inflammatory Diseases: Role of Natural Compounds submission deadline 20 Dec 2025 | 4 articles | Viewed by 8384 | Submission Open
Keywords: natural compounds; immunomodulatory activity; anti-inflammatory activity; synergistic effect; nanotechnologies; delivery systems; bioinformatic analysis
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Advances in Synaptic Transmission and Plasticity
edited by
submission deadline 20 Dec 2025 | 4 articles | Viewed by 8262 | Submission Open
Keywords: synaptic transmission; synapse; neurotransmitters; synaptic plasticity; memory; learning; neurodegenerative diseases; neuropsychiatric diseases
(This special issue belongs to the Section Molecular Neurobiology)
Cancer Drug Treatment and Cancer Cell Drug Resistance submission deadline 20 Dec 2025 | 3 articles | Viewed by 7958 | Submission Open
Keywords: cellular plasticity; heterogeneity; combinational chemotherapy; metastasis; tumor relapse; novel targets; drug delivery
(This special issue belongs to the Section Molecular Pharmacology)
Cellular and Molecular Mechanisms of Plant Responses to Light (Second Edition) submission deadline 20 Dec 2025 | 4 articles | Viewed by 7632 | Submission Open
Keywords: celluar mechanism; light; molecular mechanism; plant growth; plant development; gene expression; primary and secondary metabolites; photomorphogenesis; photoperiod response; stress resistance; nutrient uptake
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Research of Dystonia and Parkinson’s Disease
edited by
submission deadline 20 Dec 2025 | 4 articles | Viewed by 7594 | Submission Open
Keywords: dystonia; Parkinson’ s disease; molecular mechanism; molecular pathology; cell biology; genetic predisposition to disease; physiopathology; neural plasticity; animal models; biomedical translational science
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Type 2 Diabetes: Molecular Pathophysiology and Treatment
edited by
submission deadline 20 Dec 2025 | 3 articles | Viewed by 7330 | Submission Open
Keywords: type 2 diabetes mellitus and comorbidity; bioinformatics; molecular pathways; genetic background; biomarkers; novel therapies
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Basis and Advances of Targeted Therapy for Breast Cancer: Second Edition submission deadline 20 Dec 2025 | 4 articles | Viewed by 7328 | Submission Open
Keywords: breast cancer; targeted therapy; cancer therapy; resistance; epigenetic modulations
(This special issue belongs to the Section Molecular Oncology)
The Role of Neurons in Human Health and Disease—3rd Edition
edited by
submission deadline 20 Dec 2025 | 5 articles | Viewed by 7134 | Submission Open
Keywords: brain; nervous system; neurons; immune system; human health and disease
(This special issue belongs to the Section Molecular Neurobiology)
Advances in Targeting Macrophages in Immunotherapy
edited by Vinod Nadella
submission deadline 20 Dec 2025 | 1 articles | Viewed by 7097 | Submission Open
Keywords: tumor-associated macrophages; tumor microenvironment; tumor immunology; carcinogenesis; macrophage repolarization; checkpoint inhibitor; immunotherapy; nanomaterials; metabolic reprogramming; epigenetics
(This special issue belongs to the Section Molecular Immunology)
Integrated Approaches, Molecular Mechanism and Therapies in Ocular Surface Diseases
edited by , and
submission deadline 20 Dec 2025 | 4 articles | Viewed by 6892 | Submission Open
Keywords: ocular surface diseases; dry eye; corneal ulcers; persistent epithelial defects; blood-derived products; blood-based therapies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Regulatory Mechanisms of Development and Abiotic Stress Response by Transcriptional Regulators in Plants: 2nd Edition
edited by
submission deadline 20 Dec 2025 | 5 articles | Viewed by 6706 | Submission Open
Keywords: transcriptional regulator; transcription activation; transcription factor; transcription repression; plant development; abiotic stress response; epigenetic regulation; genome-wide analysis
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Insights into Multiple Sclerosis
edited by Yoshio Bando
submission deadline 20 Dec 2025 | 4 articles | Viewed by 6650 | Submission Open
Keywords: multiple sclerosis; molecular mechanism; pathogenesis; biomarkers; therapeutic targets
(This special issue belongs to the Section Molecular Neurobiology)
Cytochrome P450 Mechanism and Reactivity
edited by
submission deadline 20 Dec 2025 | 3 articles | Viewed by 6330 | Submission Open
Keywords: enzyme function; enzyme catalysis; bioengineering; inorganic reaction mechanisms; enzyme inhibition
(This special issue belongs to the Section Biochemistry)
Nanoparticles in Molecular Pharmaceutics
edited by
submission deadline 20 Dec 2025 | 4 articles | Viewed by 6301 | Submission Open
Keywords: nanoparticles; molecular pharmaceutics; drug delivery; nanomedicine; nanoformulation
(This special issue belongs to the Section Molecular Nanoscience)
Nanomedicine in Gene Therapy and Immunotherapy
edited by and Ruixuan Gao
submission deadline 20 Dec 2025 | 3 articles | Viewed by 6275 | Submission Open
Keywords: nanomedicine; drug delivery; gene delivery; genome editing; immunotherapy
(This special issue belongs to the Section Molecular Immunology)
Wnt/β-Catenin Signaling in Cancer submission deadline 20 Dec 2025 | 1 articles | Viewed by 6170 | Submission Open
Keywords: Wnt/β -catenin pathway; tumors; gene expression; molecular targets; tumor microenvironment; carcinogenesis and metastasis; biomarkers; therapeutic approaches
(This special issue belongs to the Section Molecular Oncology)
Voltage-Gated Ion Channels and Human Diseases
edited by María A. Gandini
submission deadline 20 Dec 2025 | 5 articles | Viewed by 6136 | Submission Open
Keywords: channelopathies; voltage gated-ion channels; human diseases; mutations; calcium; sodium; potassium
(This special issue belongs to the Section Molecular Biophysics)
Therapeutic Targets in Pancreatic Cancer: 2nd Edition submission deadline 20 Dec 2025 | 3 articles | Viewed by 6076 | Submission Open
Keywords: pancreatic cancer; translational research; therapeutic targets and novel interventional strategies; mechanisms of anti-tumor reactions; biomarkers
(This special issue belongs to the Section Molecular Oncology)
Anticancer and Chemopreventive Activity of Natural Products and Its Derivatives
edited by
submission deadline 20 Dec 2025 | 2 articles | Viewed by 5999 | Submission Open
Keywords: coumarins; coumarin derivatives; anticancer activity; chemopreventive activity; therapy adjuvant; mechanism of action; in vitro and in vivo studies; molecular research; metabolic pathway; phytochemicals; natural products; apoptosis; bioactivity assessment; chemical composition; therapeutic targets
(This special issue belongs to the Section Bioactives and Nutraceuticals)
New Insight into Extracellular Vesicles in Proliferative Diseases
edited by Sergio Esquivel-Ruiz
submission deadline 20 Dec 2025 | 2 articles | Viewed by 5875 | Submission Open
Keywords: proliferation; extracellular vesicles; intercellular communication; vesicle cargo; therapeutic applications; biomarkers
(This special issue belongs to the Section Molecular Immunology)
Neuroinflammation: Advancements in Pathophysiology and Therapies (2nd Edition) submission deadline 20 Dec 2025 | 2 articles | Viewed by 5842 | Submission Open
Keywords: neuroinflammation; CNS diseases; pathophysiology; therapeutic strategies; pharmacological treatments; neurological disorders; neurodegenerative diseases; cardiovascular diseases; psychiatric disorders
(This special issue belongs to the Section Molecular Neurobiology)
Targeting Metabolic Reprogramming: From Pathogenesis to Therapeutic Strategies submission deadline 20 Dec 2025 | 2 articles | Viewed by 5762 | Submission Open
Keywords: metabolism; therapy; mitochondria; pathogenesis; bioenergetics
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
The Molecular Link Between Nutrition and Obesity
edited by
submission deadline 20 Dec 2025 | 2 articles | Viewed by 5749 | Submission Open
Keywords: hormonal regulation; chronic low-grade inflammation; nutrient sensing pathways; gut microbiota
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Advancing Neurological Disorders via Computational Neuroscience and Neural Networks
edited by
submission deadline 20 Dec 2025 | 2 articles | Viewed by 5717 | Submission Open
Keywords: neurological disorders; neuroimaging analysis; biomarker identification; computational neuroscience; machine learning; brain aging
(This special issue belongs to the Section Molecular Informatics)
Advances in Research on Antifungal Resistance
edited by Anna Tomova
submission deadline 20 Dec 2025 | 4 articles | Viewed by 5594 | Submission Open
Keywords: antifungal resistance; antifungal therapy; drug discovery; molecular mechanisms
(This special issue belongs to the Section Molecular Microbiology)
Preclinical and Translational Research in Thyroid Cancer submission deadline 20 Dec 2025 | 2 articles | Viewed by 5585 | Submission Open
Keywords: thyroid cancers; pathogenesis; molecular bases of thyroid cancer; precision medicine; gender medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Gastrointestinal Disease: Exploring the Interplay Between Inflammation, Autoimmunity, and Cancer
edited by Spyridon Siakavellas and
submission deadline 20 Dec 2025 | 2 articles | Viewed by 5554 | Submission Open
Keywords: gastrointestinal disease; inflammation; autoimmunity; gut microbiota
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Molecular Insights into Ischemia/Reperfusion: 2nd Edition
edited by
submission deadline 20 Dec 2025 | 5 articles | Viewed by 5542 | Submission Open
Keywords: vital organs; ischemic injury; cell and organ dysfunction; oxidative stress; inflammation; excitotoxicity
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
A Commemorative Issue in Honor of Professor Peter A. Ward: World Expert in Sepsis
edited by Peter Ward
submission deadline 20 Dec 2025 | 3 articles | Viewed by 5468 | Submission Open
Keywords: sepsis; neutrophils; macrophages; histones; chemical modifications; apoptosis; complement factors
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
From Nature to Medicine: Exploring Natural Products for New Therapies
edited by
submission deadline 20 Dec 2025 | 3 articles | Viewed by 5352 | Submission Open
Keywords: secondary metabolites; flavonoids; terpenes; hemisynthetic compounds; cytotoxic activity; antimicrobial activity; antioxidant activity; natural products; essential oil; resinous exudate
(This special issue belongs to the Section Molecular Pharmacology)
Lipid Metabolism and Biomarkers in Neural and Cardiometabolic Health
edited by
submission deadline 20 Dec 2025 | 4 articles | Viewed by 5344 | Submission Open
Keywords: lipid species; cardiovascular health; neural health; inflammation; cardiac biomarkers; neural biomarkers
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Allergic Diseases: Molecular Insights into Immunotherapy
edited by Stefania Nicola
submission deadline 20 Dec 2025 | 3 articles | Viewed by 5270 | Submission Open
Keywords: component resolved diagnosis; allergen immunotherapy; molecular diagnostic; basophil activation test; anaphylaxis; allergy diagnosis; in vitro tests; in vivo tests; skin prick test
(This special issue belongs to the Section Molecular Immunology)
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