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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Exploring the Gut-Brain Axis: Mechanisms and Implications for Health and Disease

edited by

Martina Vincenzi

submission deadline 30 Apr 2026 | Viewed by 24 | Submission Open

Keywords: gut– brain axis; enteric nervous system; dysbiosis; gut microbiota; neuroinflammation; one health; microbiota– immune crosstalk; metabolic syndromes; cardiovascular diseases; neurodegenerative diseases; cancer

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances in Brucella Research

edited by

Angel Oñate

submission deadline 30 Apr 2026 | Viewed by 24 | Submission Open

Keywords: Brucella abortus; molecular pathogenesis; host– pathogen interaction; virulence factors; oxidative stress response; intracellular survival; immune evasion; exosomes; vaccine development

(This special issue belongs to the Section Molecular Microbiology)

Molecular Research in Orofacial Pain and Headache

edited by Adriana Elena Bulboaca

submission deadline 30 Apr 2026 | Viewed by 23 | Submission Open

Keywords: neuropathic pain; trigeminal neuralgia; temporomandibular joint disorders; headache; migraine; neuroplasticity

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Genomic and Epigenetic Determinants of Circulating Cell-Free DNA Release in Cancer

edited by

Federica Maione

submission deadline 30 Apr 2026 | Viewed by 23 | Submission Open

Keywords: genomic alterations; epigenetic modifications; chromosomal instability; aneuploidy and DNA fragmentation; tumor cell-derived cell-free DNA release; chromosome methylation; liquid biopsy; gene-gene interactions; cell death

(This special issue belongs to the Section Molecular Oncology)

Nanoscale Materials for Advanced Electrocatalysts

edited by

Safia Khan

submission deadline 30 Apr 2026 | Viewed by 22 | Submission Open

Keywords: nanomaterials; electrocatalysis; electrocatalysts; energy conversion; fuel cells

(This special issue belongs to the Section Molecular Nanoscience)

From Molecule to Mind: Neuropharmacology of Psychoactive Alkaloids and Next-Generation Neuroactives

edited by Kyoko Koshibu

submission deadline 30 Apr 2026 | Viewed by 21 | Submission Open

Keywords: psychoactive alkaloids; neuropharmacology; bioactive compounds; performance enhancement; addiction; translational research; cognitive modulation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Emerging Targeted Therapies and Evolving Treatment Paradigms in Non-Small Cell Lung Cancer

edited by Luis E. Raez

submission deadline 30 Apr 2026 | Viewed by 20 | Submission Open

Keywords: non-small cell lung cancer (NSCLC); targeted therapies; human epidermal growth factor receptor 2 (HER2); mesenchymal-epithelial transition factor (MET); anaplastic lymphoma kinase (ALK); C-ROS oncogene 1 receptor tyrosine kinase (ROS1); rearranged during transfection (RET); neurotrophic tyrosine receptor kinase (NTRK); B-Raf proto-oncogene serine/threonine kinase V600 mutation (BRAFv600); Kirsten rat sarcoma viral oncogene homolog (KRAS); epidermal growth factor receptor (EGFR)

(This special issue belongs to the Section Molecular Oncology)

Bioactive Phenolic Compounds in Human Health and Disease: Second Edition

edited by

Andrei Lobiuc

submission deadline 30 Apr 2026 | Viewed by 19 | Submission Open

Keywords: novel sources; synthesis; biological activity; molecular interactions; pharmacodynamics; pharmacokinetics; assay development; microbiota; sources and intake

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Recent Advances in Sperm Physiology and Genetics

edited by Jordi Ribas-Maynou and Ariadna Delgado Bermudez

submission deadline 30 Apr 2026 | Viewed by 19 | Submission Open

Keywords: sperm; DNA; chromatin; physiology; reproduction

(This special issue belongs to the Section Molecular Genetics and Genomics)

Interdisciplinary Molecular Design: Catalysis, Therapeutics, and Biomaterials

edited by

Zhiwei Yang

submission deadline 30 Apr 2026 | Viewed by 17 | Submission Open

Keywords: intelligent molecular design; computational catalysis; antibody and protein engineering; biomaterials design; molecular dynamics simulations; AI in drug discovery

(This special issue belongs to the Section Molecular Biophysics)

Molecular Mechanisms and Treatment Strategies in Diabetic Kidney Disease

edited by

Érika Bevilaqua Rangel

submission deadline 30 Apr 2026 | Viewed by 17 | Submission Open

Keywords: diabetic kidney disease; oxidative stress; autophagy; inflammation; fibrosis; cell therapy; SGLT2 inhibitors and GLP-1 agonists; mesenchymal stem cells; gene therapy; translational nephrology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Lupus Erythematosus and Lupus Nephritis: Pathogenesis, Biomarkers and Treatments, 2nd Edition

edited by

Chi Chiu Mok

submission deadline 30 Apr 2026 | Viewed by 14 | Submission Open

Keywords: lupus erythematosus; lupus nephritis; SLE; LN; organ damage; pathogenesis; biomarkers; genomic; transcriptomic; metabolomic; treatments; therapeutic

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances on Gut Microbiota in Human Health

edited by

Sanda Cretoiu

submission deadline 30 Apr 2026 | Viewed by 14 | Submission Open

Keywords: gut microbiota; dysbiosis; metabolomics; host– microbe interaction; molecular pathways; inflammation; personalized medicine

(This special issue belongs to the Section Molecular Microbiology)

Molecular and Physiological Effects of Exercise in Cachexia

edited by

Marilia Seelaender

and

Fábio Santos Lira

submission deadline 30 Apr 2026 | Viewed by 13 | Submission Open

Keywords: cachexia; skeletal muscle mass; skeletal muscle strength; exercise; muscle metabolism

(This special issue belongs to the Section Molecular Biology)

Molecular Crosstalk Between Allergens, Microbes, and the Mucosal Immune System

edited by Stefanie Gilles

submission deadline 30 Apr 2026 | Viewed by 13 | Submission Open

Keywords: allergens and innate immunity; mucosal immune signaling; epithelial barrier and inflammation; pathogen-allergen crosstalk; bioaerosol exposure; allergen recognition mechanisms; environmental immunology

(This special issue belongs to the Section Molecular Immunology)

Insight in Reproductive Immunology

edited by Ruben Motrich

submission deadline 30 Apr 2026 | Viewed by 12 | Submission Open

Keywords: reproductive immunology; immune tolerance; male reproductive tract; female reproductive tract; fertility disorders; inflammation; pregnancy complications; immunoregulation

(This special issue belongs to the Section Molecular Immunology)

Dietary Interventions for Type 2 Diabetes: Current Evidence and Emerging Perspectives on Underlying Molecular Mechanisms

edited by Caterina Formichi

submission deadline 30 Apr 2026 | Viewed by 12 | Submission Open

Keywords: type 2 diabetes; nutritional intervention; dietary strategies; nutrients; personalized nutrition; diet; metabolic health

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Emerging Biological Markers and Molecular Targets in Bladder Cancer

edited by Stanislav Žiaran

submission deadline 30 Apr 2026 | Viewed by 10 | Submission Open

Keywords: bladder cancer; biomarkers; urothelial carcinoma; molecular pathways; liquid biopsy; extracellular matrix; omics profiling; precision medicine; tissue engineering; translational urology

(This special issue belongs to the Section Molecular Oncology)

Artificial Intelligence, Machine Learning, and Bioinformatics in Molecular Mechanisms of Human Health and Disease

edited by

Santosh Anand

submission deadline 30 Apr 2026 | Viewed by 10 | Submission Open

Keywords: artificial intelligence; machine learning; bioinformatics; molecular mechanisms; human health; human disease; multi-omics data; molecular pathways; personalized medicine; disease biomarkers

(This special issue belongs to the Section Molecular Informatics)

Advances on Viral Immunology and Pathogenesis of Viral Infections

edited by Yeong-Bin Baek

submission deadline 30 Apr 2026 | Viewed by 10 | Submission Open

Keywords: viral immunology; viral pathogenesis; innate sensing and interferon; cytokine networks and inflammasomes; adaptive immunity (T- and B-cell quality); immunometabolism and lipid signaling; host-directed antiviral strategies; transcriptomics and spatial omics; mechanism of action and target engagement; complex bioactive modulators

(This special issue belongs to the Section Molecular Microbiology)

Neural Circuit Mechanisms of Brain Disorders

edited by

Yun Li

submission deadline 30 Apr 2026 | Viewed by 7 | Submission Open

Keywords: dynamic wiring; brain network; brain connectivity; neuropathology; neuromodulation; neuroplasticity; circuit mapping

(This special issue belongs to the Section Molecular Neurobiology)

Metabolomics as a Window into Human Disease Mechanisms

edited by

Paolo Iadarola

submission deadline 30 Apr 2026 | Viewed by 7 | Submission Open

Keywords: biomarker discovery; metabolomics; disease mechanisms

(This special issue belongs to the Section Molecular Informatics)

Electrochemical Detection: A Molecular-Level Perspective

edited by Katarzyna Fendrych and

Joanna Smajdor-Baran

submission deadline 30 Apr 2026 | Viewed by 2 | Submission Open

Keywords: electrochemical detection; molecular sensing; biosensors; nanostructured electrodes; biomolecular interactions; electroanalytical chemistry; molecular electrochemistry

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Design, Synthesis and Development of Anticancer Drugs Targeting the Tumor Microenvironment

edited by

Yoshihiro Uto

submission deadline 30 Apr 2026 | Viewed by 1 | Submission Open

Keywords: anticancer drugs; tumor microenvironment; in vivo model; cancer-associated fibroblast; tumor-associated macrophage; tumor hypoxia; tumor endothelial cells

(This special issue belongs to the Section Molecular Oncology)

Radiobiology: New Challenges and Advances

edited by Lorenzo Manti and

Pavel Bláha

submission deadline 30 Apr 2026 | Viewed by 1 | Submission Open

Keywords: strategies for overcoming cancer radioresistance and normal-tissue damage mitigation; combined approaches: BNCT; proton– boron capture therapy; radioimmunotherapy; emerging technologies and novel temporal regimes: FLASH RT mechanisms and radiobiology of laser-accelerated particles; radiobiology of new ions and of novel dose-delivery modalities in particle radiotherapy; limphopoenia in radiotherapy and biomarkers of radiation response; three-dimensional models; microdosimetry: standardising measurements; DNA damage/repair; tumour microenvironment: autophagy; ferroptosis; fibroblast activation protein; non-cancer effects and non-targeted effects

(This special issue belongs to the Section Molecular Biology)

The Role of Complement Regulation in Kidney Disease

edited by Jasmina Marković Lipkovski

submission deadline 30 Apr 2026 | Submission Open

Keywords: complement system; kidney disease; glomerulonephritis; C3 glomerulopathy; membranous nephropathy; complement regulation; innate immunity; molecular pathology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Stem Cells for Biomedical Applications

edited by

Sorina Dinescu

submission deadline 30 Apr 2026 | Submission Open

Keywords: stem cells biology; stem cells differentiation; stem cell-based regenerative therapies; stem cells exosomes; personalized medicine; stem cell-based 3D models

(This special issue belongs to the Section Molecular Biology)

Bioactive Food Components in Human Health

edited by

Kamila Rachwał

and Klaudia Gustaw

submission deadline 30 Apr 2026 | Submission Open

Keywords: bioactive compounds; functional food; phytochemicals; bioactive peptides; health-promoting foods; food chemistry; polyphenols; natural products; human health; prebiotic compounds; bioavailability; nutraceuticals; bioaccessibility

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Regenerative Medicine: Biomaterials and Stem Cell Research: 2nd Edition

edited by Silvia María Díaz-Prado

submission deadline 30 Apr 2026 | Submission Open

Keywords: regenerative medicine; stem cell; biomaterial; bioprinting; tissue engineering; tissue and organ transplant; organ scarcity

(This special issue belongs to the Section Materials Science)

Research Advances in Plant Interactions with Bacteria and Fungi: From Molecular to Ecological Perspectives

edited by

Jessie Fernandez

submission deadline 30 Apr 2026 | Submission Open

Keywords: plant-microbe interactions; plant-bacteria interactions; plant-fungi interactions; biocontrol; beneficial microbes; endophytes; microbiome; plant growth-promoting microbes; synthetic microbial communities

(This special issue belongs to the Section Molecular Plant Sciences)

Composites of Cellulose and Cellulose Derivatives: Engineering and Applications

edited by

Omar A. El Seoud

submission deadline 30 Apr 2026 | Submission Open

Keywords: cellulose composites: engineering and applications; composites of cellulose esters: engineering and applications; composites of cellulose ethers: engineering and applications; molecular interactions within cellulose and its derivatives; molecular interactions within composites of cellulose and its derivatives

(This special issue belongs to the Section Macromolecules)

New Advance in Xenobiotic Toxicology

edited by Marcelo Arbo

submission deadline 30 Apr 2026 | Submission Open

Keywords: xenobiotics; toxicity tests; biotransformation; drug effects; signal transduction; environmental pollutants; chemically induced- injury; toxicogenomics; biomarkers; risk assessment

(This special issue belongs to the Section Molecular Toxicology)

Insulin Resistance Mechanisms: From Epigenetics to Receptor-Mediated Signaling Pathways

edited by

Angélica Rueda

and

Jesús Alberto Olivares-Reyes

submission deadline 30 Apr 2026 | Submission Open

Keywords: epigenetics; insulin receptor; insulin resistance; inflammation; metabolic syndrome; protein phosphorylation; cardiometabolic syndrome

(This special issue belongs to the Section Molecular Genetics and Genomics)

Cutting Edge Advances in Wound Healing

edited by Fui Ping Lim

submission deadline 30 Apr 2026 | Submission Open

Keywords: wound repair; molecular pathways; regenerative biology; tissue remodelling; inflammation modulation

(This special issue belongs to the Section Molecular Biology)

Molecular Basis of Plant Traits Associated with Responses to Biotic and Abiotic Stress

edited by Nobuhiro Suzuki

submission deadline 30 Apr 2026 | Submission Open

Keywords: molecular mechanisms ; biotic and abiotic stress ; plant trait ; signaling

(This special issue belongs to the Section Molecular Plant Sciences)

Inflammatory Bowel Disease: Molecular Advances in Pathogenesis and Therapies, 2nd Edition

edited by

Rafał Filip

submission deadline 30 Apr 2026 | Submission Open

Keywords: Crohn’ s disease; inflammatory bowel disease; immunologic and molecular mechanisms; therapies in IBD; ulcerative colitis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Perspectives in Cardiovascular Disease: From Molecular Mechanisms to Clinical Innovations

edited by

Yunglung Chen

submission deadline 30 Apr 2026 | Submission Open

Keywords: cardiovascular disease; molecular mechanisms; biomarkers; atrial fibrillation; translational medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

mRNA Vaccines Against Viral Infectious Diseases: Progress and Prospects

edited by

Barbara Ridolfi

, Maria Teresa Maggiorella and

Ivan Schietroma

submission deadline 30 Apr 2026 | Submission Open

Keywords: viruses; mRNA vaccines; mRNA structure; mRNA platform technologies; lipid nanoparticle (LNP) delivery; immunization strategies; adjuvants; preclinical trials; clinical trials; germline-targeting; broadly neutralizing antibodies; humoral immune response; cellular immune response; host– vaccine interactions

(This special issue belongs to the Section Molecular Microbiology)

From Molecular Insights to Novel Therapies: Neurological Diseases

edited by

Margarita Neganova

submission deadline 20 May 2026 | 17 articles | Viewed by 62504 | Submission Open

Keywords: neurological diseases; neurodegenerative diseases; epilepsy; mental illness; transgenic animal models; molecular pathways; metabolism disabilities; mitochondrial dysfunction; oxidative stress; disturbances in epigenetic regulation

(This special issue belongs to the Section Molecular Neurobiology)

Targeted Therapy for Immune Diseases

edited by

Alexey Sarapultsev

submission deadline 20 May 2026 | 15 articles | Viewed by 46589 | Submission Open

Keywords: targeted therapy; immune diseases; biologics; immunotherapy; precision medicine; nanoparticles; biomarkers

(This special issue belongs to the Section Molecular Immunology)

Fascial Anatomy and Histology: Advances in Molecular Biology

edited by

Carla Stecco

submission deadline 20 May 2026 | 4 articles | Viewed by 27521 | Submission Open

Keywords: fascia; connective tissue; myofascial pain; collagen; hyaluronan

(This special issue belongs to the Section Molecular Biology)

Natural Compounds in Cancer Therapy and Prevention, 2nd Edition

edited by

Federica Finetti

and

Lorenza Trabalzini

submission deadline 20 May 2026 | 6 articles | Viewed by 24272 | Submission Open

Keywords: cancer therapy cancer prevention; natural compounds; metastasis; immunomodulation; adjuvant therapy; preventive therapy; drug discovery; natural drugs

(This special issue belongs to the Section Molecular Pharmacology)

Advances in Anti-Inflammatory Activity of Natural Products of Plant Origin

edited by Radoslaw Zajdel

submission deadline 20 May 2026 | 2 articles | Viewed by 22466 | Submission Open

Keywords: anti-inflammatory; phytochemicals; natural products; medicinal plants; inflammation; cytokines; NF-κ B pathway; cyclooxygenase inhibitors; flavonoids; terpenoids; polyphenols; molecular mechanisms; drug discovery; ethnopharmacology; metabolomics

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Omics Science and Research in Human Health and Disease

edited by Elisa De Paolis

submission deadline 20 May 2026 | 7 articles | Viewed by 16559 | Submission Open

Keywords: genomics; transcriptomics; proteomics; metabolomics; single-cell analysis; spatial transcriptomics; bioinformatics; multi-omics

(This special issue belongs to the Section Molecular Biology)

Innovative Nanomaterials from Functional Molecules

edited by Xiaoming Zhang and

Yi Jia

submission deadline 20 May 2026 | 5 articles | Viewed by 16509 | Submission Open

Keywords: functional materials; molecular design; molecular assembly; medicine; catalysis; battery; supercapacitor; sensing

(This special issue belongs to the Section Molecular Nanoscience)

102nd Anniversary of Neurotransmitter Discovery: Cholinergic Pathways in Physiology and Pathophysiology

edited by

Sumonto Mitra

submission deadline 20 May 2026 | 4 articles | Viewed by 13538 | Submission Open

Keywords: acetylcholine; physiological functions; pathological alterations; cholinergic pathways

(This special issue belongs to the Section Biochemistry)

Advances in Melanoma and Skin Cancers: 2nd Edition

edited by

Domenico Mallardo

Debora Basile

and Maria Grazia Vitale

submission deadline 20 May 2026 | 6 articles | Viewed by 12841 | Submission Open

Keywords: melanoma; immunotherapy; biomarkers; translational research; drug repurposing; clinical outcome; prognostic markers; predictive markers; combination immunotherapy

(This special issue belongs to the Section Molecular Oncology)

The Roles of Photodynamic Therapy in Tumors and Cancers

edited by Jianyong Liu

submission deadline 20 May 2026 | 4 articles | Viewed by 10866 | Submission Open

Keywords: photodynamic therapy; PDT; photodetection; photosensitizers; photosensitizing agents; reactive oxygen species; molecular mechanisms; cell necrosis; apoptosis; singlet oxygen; synergetic therapy; combination therapy; delivery vehicles; immunophototherapy; nano-photosensitizer

(This special issue belongs to the Section Molecular Oncology)

The Role of Oxidative Stress and Antioxidants in Human Disease

edited by

Federica Mannino

submission deadline 20 May 2026 | 7 articles | Viewed by 10858 | Submission Open

Keywords: oxidative stress; free radicals; antioxidants; reactive oxygen species (ROS); polyphenols

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Liver Fibrosis: Molecular Pathogenesis, Diagnosis and Treatment

edited by Manuel Morales-Ruiz

submission deadline 20 May 2026 | 5 articles | Viewed by 10706 | Submission Open

Keywords: liver fibrosis; cirrhosis; hepatic stellate cells; collagen; fibrogenic pathways; diagnosis of fibrosis; therapeutic strategies for liver disease; extracellular matrix remodeling; cell-to-cell interactions; fibrosis complications

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 2801-2850 on page 57 of 67.

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