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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Recent Molecular Research in Neuroimmunology
edited by Mireya Fernández-Fournier
submission deadline 20 Mar 2026 | Viewed by 161 | Submission Open
Keywords: neuroimmunology; antibodies; virus; multiple sclerosis; progression
(This special issue belongs to the Section Molecular Neurobiology)
Advances in Aging and Alzheimer’s Disease Research: From Molecular Mechanisms to Therapeutics—2nd Edition
edited by Lilach Soreq
submission deadline 20 Mar 2026 | Viewed by 155 | Submission Open
Keywords: aging; Alzheimer’ s disease; bioinformatics; RNA-seq; Parkinson’ s disease
(This special issue belongs to the Section Molecular Neurobiology)
New Advances in Food Allergenicity: From Molecular Mechanisms to Innovative Mitigation Strategies submission deadline 20 Mar 2026 | Viewed by 151 | Submission Open
Keywords: food allergenicity; food allergen detection; biosensors; mass spectrometry; immunoassays; allergen reduction; hypoallergenic food alternatives; personalized nutrition approaches
(This special issue belongs to the Section Bioactives and Nutraceuticals)
CD8+ T Cells in the Cancer Immunity Cycle: Mechanisms, Barriers, and Therapeutic Opportunities
edited by Wael Traboulsi
submission deadline 20 Mar 2026 | Viewed by 151 | Submission Open
Keywords: CD8+ T cell; cancer immunotherapy; checkpoint inhibitor; CAR-T cell therapy; CD8 differentiation; epigenetic regulation; metabolism; exhaustion; dysfonctional CD8+ T cell
(This special issue belongs to the Section Molecular Immunology)
Plant Senescence Under Environmental Stresses submission deadline 20 Mar 2026 | Viewed by 150 | Submission Open
Keywords: plant senescence; environmental stresses; phytohormones
(This special issue belongs to the Section Molecular Plant Sciences)
Activation of the Blood–Brain Barrier and Neurological Dysfunction: 2nd Edition
edited by
submission deadline 20 Mar 2026 | Viewed by 146 | Submission Open
Keywords: blood– brain barrier; neuro-infectious diseases; microbes; traumatic brain injury; Alzheimer’ s disease; Parkinson’ s disease; schizophrenia; cerebral vasculature; vascular heterogeneity; white matter; gray matter; therapeutic delivery; opening the BBB; neuro vascular unit
(This special issue belongs to the Section Molecular Neurobiology)
Advances in the Molecular Biology of Lipids and Mitochondria
edited by
submission deadline 20 Mar 2026 | Viewed by 139 | Submission Open
Keywords: lipids; lipid transport mechanisms; lipid peroxidation; mitochondrial integrity; bioenergetics; mitochondrial phospholipid
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Advances in Molecular Research on Candida Resistance
edited by
submission deadline 20 Mar 2026 | Viewed by 135 | Submission Open
Keywords: Candida resistance; antifungal resistance; biofilm; drug repurposing; novel therapies; molecular mechanisms; antifungal agents; Candida albicans; Candida auris; host– pathogen interactions
(This special issue belongs to the Section Molecular Microbiology)
Molecular Insights into Pediatric Cancer: Advances in Hematopoietic Stem Cell Research
edited by
submission deadline 20 Mar 2026 | Viewed by 119 | Submission Open
Keywords: bone marrow; microenvironment; precursor; hematopoietic stem cells; pediatric hematological malignancies
(This special issue belongs to the Section Molecular Oncology)
Bee Products and Their Flavonoids: Recent Advances in Molecular Mechanisms, Therapeutic Applications, and Innovative Delivery Systems submission deadline 20 Mar 2026 | Viewed by 117 | Submission Open
Keywords: honeybee products; flavonoids; bioactive compounds; biological activity; pharmacological activity; health benefits; side effects; disease prevention; antioxidant activity; apitherapy; nutritional properties; innovative technical approaches
(This special issue belongs to the Section Molecular Biology)
Omega-6 and Omega-3 Fatty Acid Imbalance: Roles in Human Health and Pathogenesis of Diseases
edited by
submission deadline 20 Mar 2026 | Viewed by 117 | Submission Open
Keywords: omega-6/omega-3 ratio; omega-6 fatty acids; omega-3 fatty acids; omega-6/omega-3 imbalance; lipid metabolism; inflammation; chronic diseases; cardiovascular disease; cancer; metabolic syndrome; neurodegenerative diseases; autoimmune diseases; nutritional interventions; polyunsaturated fatty acids (PUFAs); molecular mechanisms; disease pathogenesis; disease management; health promotion
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Skin Diseases: From Molecular Mechanisms to Pathology, 2nd Edition submission deadline 20 Mar 2026 | Viewed by 113 | Submission Open
Keywords: skin diseases; immunology; genetics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
HPV Infection and Immune Escape Mechanisms
edited by and Elisa Lepore
submission deadline 20 Mar 2026 | Viewed by 110 | Submission Open
Keywords: HPV; persistence; natural molecules; vaccination; genotypes; anal infection; oral infection; co-infection
(This special issue belongs to the Section Molecular Immunology)
Arthritis: From Molecular Basis to Therapy
edited by Cinzia Rotondo
submission deadline 20 Mar 2026 | Viewed by 108 | Submission Open
Keywords: comorbidities; biomarkers; inflammation; autoimmune disease; systemic disease; arthritis; autoimmune disease; psoriasis; axial involvement; biological drugs; target synthetic DMARDs; pathogenesis; rheumatoid arthritis; spondyloarthritis; psoriatic arthritis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Innovative Biomaterials for Advanced Applications in Regenerative Medicine and Drug Delivery
edited by
submission deadline 20 Mar 2026 | Viewed by 101 | Submission Open
Keywords: biomaterials; drug delivery; regenerative medicine; stimuli-responsive polymers; 3D scaffolds; micro-nanocarriers
(This special issue belongs to the Section Materials Science)
Genetic Diversity, Founder Effects, and Migration in Neurodegeneration: Molecular and Population Perspectives submission deadline 20 Mar 2026 | Viewed by 100 | Submission Open
Keywords: neurodegeneration; population genetics; founder effects; genetic diversity; migration and disease risk; spinocerebellar ataxia; Alzheimer’ s disease; Parkinson’ s disease; genetic epidemiology; underrepresented populations
(This special issue belongs to the Section Molecular Neurobiology)
Current Research on Colloidal Emulsions: Preparation and Applications
edited by Alexander Djerdjev
submission deadline 20 Mar 2026 | Viewed by 85 | Submission Open
Keywords: emulsion formulation and stability; nano-; micro-; and high-internal-phase emulsions; drug delivery; aerogels; pickering emulsions; food emulsions; oil– water interface; surfactants; zeta potential at hydrophobic interfaces; advances in emulsion technology
(This special issue belongs to the Section Materials Science)
Musculoskeletal Development and Skeletal Pathophysiologies, 3rd Edition submission deadline 20 Mar 2026 | Viewed by 75 | Submission Open
Keywords: musculoskeletal development; growth plate; endochondral ossification; intramembranous ossification; osteoporosis; osteoarthritis; bone; cartilage; osteoblast; osteoclast; chondrocyte
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Drug Discovery and Preclinical Pharmacology for Cognitive and Neuropsychiatric Disorders in Aging
edited by
submission deadline 20 Mar 2026 | Viewed by 73 | Submission Open
Keywords: aging brain; neural aging; neurodegeneration; neuropsychiatric disorders; late-life psychiatric disorders; dementia syndromes
(This special issue belongs to the Section Molecular Neurobiology)
Application of Biomaterials in Human Diseases
edited by
submission deadline 20 Mar 2026 | Viewed by 72 | Submission Open
Keywords: implant; bone substitute material; titanium; zirconia; biomaterials; in vitro; in vivo
(This special issue belongs to the Section Materials Science)
Molecular Toxicology of Nano- and Microplastics: Mechanisms of Cellular Disruption and Biochemical Pathways
edited by Ioannis Alexandros Charitos
submission deadline 20 Mar 2026 | Viewed by 72 | Submission Open
Keywords: nanoplastics; microplastics (NMP); toxicology; toxicological impact; human health; human microbiota; metabolome
(This special issue belongs to the Section Molecular Toxicology)
Cytokines in Inflammatory Signaling: 3rd Edition
edited by and
submission deadline 20 Mar 2026 | Viewed by 70 | Submission Open
Keywords: cytokines; inflammation; autoimmune diseases; immune homeostasis; signaling pathway; immunotherapy
(This special issue belongs to the Section Molecular Immunology)
Molecular Research Advances in Common and Rare Pediatric Diseases submission deadline 20 Mar 2026 | Viewed by 66 | Submission Open
Keywords: pediatric diseases; diagnosis; therapeutic targets; molecular mechanisms; pediatric pathology; signaling pathways
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Advances in Dry Eye Syndrome, Second Edition
edited by Maria Jesus Giráldez-Fernández
submission deadline 20 Mar 2026 | Viewed by 64 | Submission Open
Keywords: dry eye disease; tear film osmolarity; tear film; artificial tear substitutes; biological tear substitutes; tear fluid biomarkers; tear film lipid layer; meibomian gland dysfunction; evaporative dry eye; aqueous deficiency dry eye; ocular surface inflammation; cytokines; histological analysis; pharmacological treatment
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Autoimmune Diseases: A Swing Dance of Immune Cells, 3rd Edition
edited by
submission deadline 20 Mar 2026 | Viewed by 63 | Submission Open
Keywords: autoimmune diseases; antigens/autoantigens; post-translational modifications; antigen processing and presentation; shared epitopes; molecular mimicry; autoantibodies; immune signaling; animal models; therapeutic agents
(This special issue belongs to the Section Molecular Immunology)
Liver Disease and Primary Liver Cancer: Translational Advances and Therapeutic Perspectives
edited by
submission deadline 20 Mar 2026 | Viewed by 47 | Submission Open
Keywords: liver disease; hepatocellular carcinoma; cholangiocarcinoma; molecular mechanisms; translational research; 3D models and organoids; biomarkers and therapeutic strategies; MASH/MASLD: pathogenesis; diagnosis; and management; primary liver cancer: pathogenesis; detection; and treatment; inflammation in liver disease; 3D liver models; microbiota and liver disease; mechanisms of damage and repair: ischemia-reperfusion injury; cellular pathology in acute and chronic liver damage of different origin; biomarkers in liver disease: emerging methods and potential applications; immunology in the liver— from homeostasis to disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Role of Long Non-Coding RNAs in Cancer Metastasis and Drug Resistance submission deadline 20 Mar 2026 | Viewed by 45 | Submission Open
Keywords: long non-coding RNAs (lncRNAs); cancer metastasis; drug resistance; epithelial– mesenchymal transition (EMT); tumor microenvironment; chemoresistance mechanisms; RNA-based therapeutics; gene regulation; functional genomics; biomarkers in cancer
(This special issue belongs to the Section Molecular Oncology)
Molecular Insights into Genetic and Epigenetic Alterations in Age-Related Diseases submission deadline 25 Mar 2026 | Viewed by 559 | Submission Open
Keywords: genomics; epigenetic modifications; age-related pathologies; neurodegeneration; dysmetabolism; spatial omics; 3D genome; genetic variants; telomere length; mitochondrial DNA; biomarkers
(This special issue belongs to the Section Molecular Neurobiology)
Advances in Nasopharyngeal Carcinoma Immunology, Epigenetics, and Therapy
edited by
submission deadline 25 Mar 2026 | Viewed by 113 | Submission Open
Keywords: nasopharyngeal carcinoma (NPC); epstein– barr virus (EBV); cancer epigenomics; virus– host interaction; tumor microenvironment (TME); immunotherapy; targeted therapy; biomarker; metastasis; radiotherapy resistance  
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Glial Cells in Brain and Eye: Emerging Mechanisms and Functions in Health and Disease
edited by
submission deadline 25 Mar 2026 | Viewed by 111 | Submission Open
Keywords: glial cells; brain & eye (retina); health & disease; neuronal regulation; therapeutic strategies; CNS; glia biology; cellular interactions
(This special issue belongs to the Section Molecular Biology)
Molecular Engineering of Antimicrobial Agents: From Structure-Function Insights to Combinatorial Therapies
edited by Mingrui Liao
submission deadline 25 Mar 2026 | Viewed by 100 | Submission Open
Keywords: antimicrobial amphiphiles; antimicrobial resistance; structure– activity relationship; synergistic antimicrobial therapy; drug delivery systems
(This special issue belongs to the Section Molecular Biology)
Molecular Research on Central Nervous System Inflammatory Demyelinating Diseases
edited by Yong Guo
submission deadline 25 Mar 2026 | Viewed by 70 | Submission Open
Keywords: central nervous system; autoimmune; demyelination; inflammation; multiple sclerosis; pathology
(This special issue belongs to the Section Molecular Neurobiology)
The Expanding Genetic Landscape of Parkinson's Disease
edited by Christos Koros and
submission deadline 25 Mar 2026 | Viewed by 70 | Submission Open
Keywords: Parkinson’ s disease; monogenic; polygenic risk score; alpha-synuclein
(This special issue belongs to the Section Molecular Neurobiology)
Prostate Cancer: Molecular Mechanisms and Targeting
edited by
submission deadline 25 Mar 2026 | Viewed by 26 | Submission Open
Keywords: prostate cancer; androgen receptor; therapy resistance; epigenetics; tumor microenvironment; molecular signaling; precision oncology
(This special issue belongs to the Section Molecular Oncology)
Pulmonary Fibrosis: Molecular Mechanisms and Therapeutic Strategies
edited by
submission deadline 28 Mar 2026 | Viewed by 134 | Submission Open
Keywords: machine learning; pulmonary fibrosis; interstitial lung diseases; molecular mechanisms; precision medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular-Level Insights into Retinal Vascular Disorders
edited by
submission deadline 28 Mar 2026 | Viewed by 79 | Submission Open
Keywords: retina; retinal neovascularization; diabetic retinopathy; retinopathy of prematurity; VEGF; blood– retinal barrier
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Diagnostic, Prognostic and Predictive Biomarkers in Prostate Cancer
edited by Radka S. Stoyanova
submission deadline 28 Mar 2026 | Viewed by 54 | Submission Open
Keywords: prostate cancer; molecular biomarkers; imaging; non-invasive biomarkers; liquid biopsy
(This special issue belongs to the Section Molecular Oncology)
Advances in Enzyme Inhibitors: Mechanisms, Applications, and Future Perspectives submission deadline 30 Mar 2026 | 5 articles | Viewed by 11685 | Submission Open
Keywords: enzyme inhibitors; drug design; drug discovery; drug therapy; resistance mechanisms; cancer; drug delivery systems; biocatalysts; enzymes in industrial applications
(This special issue belongs to the Section Biochemistry)
Molecular Mechanisms and Therapies of Brain Tumors
edited by Oana Alexandru
submission deadline 30 Mar 2026 | 4 articles | Viewed by 10091 | Submission Open
Keywords: brain tumors; molecular mechanisms; signal transduction; cell proliferation; apoptosis; targeted therapies; chemotherapy; radiotherapy
(This special issue belongs to the Section Molecular Oncology)
Neuroprotective Effects of Food Ingredients submission deadline 30 Mar 2026 | 3 articles | Viewed by 5658 | Submission Open
Keywords: neuroprotection; Parkinson; Alzheimer; bioactive compounds; agri-food by-products; chemical characterization; foodomics; metabolomics; molecular mechanisms
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Diagnostics and Genomics of Tumors, 2nd Edition
edited by
submission deadline 30 Mar 2026 | 1 articles | Viewed by 710 | Submission Open
Keywords: tumor biology; cancer genomics; molecular diagnostics; biomarkers; precision medicine
(This special issue belongs to the Section Molecular Oncology)
Advanced Oxidation Processes and Biodegradation for Emerging Contaminants Treatment: 2nd Edition
edited by
submission deadline 30 Mar 2026 | 1 articles | Viewed by 588 | Submission Open
Keywords: advanced oxidation processes; persistent organic compounds; water pollution control; biodegradation; emerging contaminants; water treatment; wastewater treatment; toxicity assessment
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Role of the Epithelial Mesenchymal Transition in Cancer Development and Invasiveness
edited by
submission deadline 30 Mar 2026 | Viewed by 537 | Submission Open
Keywords: epithelial mesenchymal transition; EMT; cancer; epithelial protein; mesenchymal phenotype; therapeutic approach
(This special issue belongs to the Section Molecular Oncology)
Antitumoral Properties of Natural and Synthetic Compounds submission deadline 30 Mar 2026 | Viewed by 229 | Submission Open
Keywords: anticancer agents; natural compounds; synthetic compounds; molecular mechanisms; translational research
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Mechanisms and Therapeutic Targets in Systemic Vasculitis
edited by Andrés González-García
submission deadline 30 Mar 2026 | 1 articles | Viewed by 197 | Submission Open
Keywords: vasculitis; ANCA-associated vasculitis; EGPA; complement activation; molecular immunopathogenesis; endothelial dysfunction; cytokine signaling; biomarkers; therapeutic targets; autoimmunity
(This special issue belongs to the Section Molecular Immunology)
Metallopharmaceuticals: Current Trends and Future Perspectives in Cancer Immunoediting submission deadline 30 Mar 2026 | Viewed by 197 | Submission Open
Keywords: metal-based drugs; anticancer activity; mechanisms of action; tumor microenvironment; immune cell regulation; cancer immunity; metal– protein interactions; metal– nucleic acid interactions
(This special issue belongs to the Section Molecular Pharmacology)
Domestic Animal Genetics, Genomics, and Molecular Breeding
edited by
submission deadline 30 Mar 2026 | Viewed by 163 | Submission Open
Keywords: genomic selection; molecular breeding; domestic animals; functional genomics; genetic improvement; product quality; reproduction
(This special issue belongs to the Section Molecular Genetics and Genomics)
Obesity: From Molecular Mechanisms to Clinical Aspects—2nd Edition
edited by
submission deadline 30 Mar 2026 | Viewed by 135 | Submission Open
Keywords: food intake; physical activity; adipose tissue; adipokines; gut hormones; nervous system; gut– brain axis; bariatric surgery; inflammation and immune response; genetics and epigenetics
Molecular Pathways to Infertility
edited by
submission deadline 30 Mar 2026 | Viewed by 127 | Submission Open
Keywords: infertility; molecules; meiotic arrest; premature ovarian insufficiency; sperm function; progesterone resistance; mitochondrial dysfunction; epigenetic dysregulation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms and Therapeutic Targets in Inflammation and Cancer Immunity
edited by
submission deadline 30 Mar 2026 | Viewed by 118 | Submission Open
Keywords: immune regulation; inflammation; cancer immunity; immunotherapy; cytokine signaling; therapeutic targets; immune evasion; antibody-based therapy; histamine; drug repositioning
(This special issue belongs to the Section Molecular Immunology)
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