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Application of Biomaterials in Human Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: 31 October 2026 | Viewed by 904

Editor

Special Issue Information

Dear Colleagues,

Artificial restoration of biological functions and the development of matching reconstructive surgery are necessary to maintain acceptable living conditions. In addition to making it possible to choose materials based on application locations and usage durations, the creation of high-performance biomaterials makes a substantial contribution to the growth of regenerative medicine in the medical profession. They are therefore employed as hard tissue substitutes or for long-term implant applications in orthopedics, cardiology, dentistry, and other professions needing mechanical strength and ductility. We hope to gather a variety of insights in these areas to further medical advancement and support the future development of your research field.

Dr. Satoshi Komasa
Guest Editor

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Keywords

  • implant
  • bone substitute material
  • titanium
  • zirconia
  • biomaterials
  • in vitro
  • in vivo

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Published Papers (1 paper)

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Research

17 pages, 14853 KB  
Article
PLGA Nanoparticle-Mediated Sustained Release of Fisetin for Intra-Articular Therapy of Temporomandibular Joint Osteoarthritis
by Ming Zhang, Jun-Ichiro Jo, Yoshiya Hashimoto, Yoshitomo Honda and Aki Nishiura
Int. J. Mol. Sci. 2026, 27(8), 3618; https://doi.org/10.3390/ijms27083618 - 18 Apr 2026
Viewed by 550
Abstract
Temporomandibular joint osteoarthritis (TMJOA) is a degenerative maxillofacial disorder marked by progressive cartilage degradation and subchondral bone resorption, severely compromising patients’ quality of life. Intra-articular injection (IA), a standard route for conservative therapy, offers clinical advantages in safety and efficacy; however, outcomes remain [...] Read more.
Temporomandibular joint osteoarthritis (TMJOA) is a degenerative maxillofacial disorder marked by progressive cartilage degradation and subchondral bone resorption, severely compromising patients’ quality of life. Intra-articular injection (IA), a standard route for conservative therapy, offers clinical advantages in safety and efficacy; however, outcomes remain limited due to short drug retention, poor tissue penetration, and variable agent efficacy, necessitating repeated administration. To overcome these limitations, fisetin-loaded poly (lactic-co-glycolic acid) nanoparticles (FST-PNP) were developed as a localized drug delivery system (DDS) for TMJOA treatment. Physicochemical analyses showed FST-PNP had uniform spherical morphology, excellent dispersibility, stability, high encapsulation efficiency, and substantial drug loading capacity. An in vitro study demonstrated more sustained and stable release from FST-PNP than free fisetin. The in vivo IA administration of FST-PNP preserved mandibular condylar osteochondral structures in TMJOA models. Notably, FST-PNP suppressed the expression of metalloproteinase-13 and a disintegrin and metalloproteinase with thrombospondin motifs-5 (ADAMTS5) as catabolic enzymes and downregulated p16 and p21 as senescence markers, indicating synergistic anti-inflammatory and anti-senescent effects. These findings highlight FST-PNP as a DDS integrating controlled-release with multifaceted therapeutic actions, providing a promising strategy for IA therapy of TMJOA. Full article
(This article belongs to the Special Issue Application of Biomaterials in Human Diseases)
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