Metallopharmaceuticals: Current Trends and Future Perspectives in Cancer Immunoediting
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".
Deadline for manuscript submissions: 30 September 2025 | Viewed by 55
Special Issue Editors
Interests: preclinical investigation of anticancer compounds; antiproliferative and antimetastatic potential evaluation of inflammatory pathways on cancer onset; xenobiotics effetcs on human cells
Special Issues, Collections and Topics in MDPI journals
Interests: ruthenium complexes; platinum complexes; benzodifuran compounds; anticancer drugs; nanosystems; nanomaterials; oligonucleotides; G-quadruplex; aptamers; thrombin binding aptamers
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
We are delighted to announce that the Special Issue entitled “Metallopharmaceuticals: Current Trends and Future Perspectives in Cancer Immunoediting” is now open to receiving paper submissions.
Considering the pivotal role of the tumor microenvironment (TME) for tumor growth and chemotreatment resistance, more and more studies are aimed at assessing the effects of antiproliferative compounds on the basic cellular mechanisms of cancer immunity. In this context, metal-based complexes, thanks to their chemical diversity and versatility, could function as positive immunomodulators for improving antitumor effects by modifying the local tumor microenvironment.
Therefore, in this Special Issue of International Journal of Molecular Sciences (with both regular articles and reviews), we will focus on the most recent advances in the field of metalloimmunotherapy, with a focus on the effects of metal-based complexes in the tumor microenvironment and cancer immunoediting for the identification of new pharmacological targets.
Contributions covering the design, synthesis, and characterization of novel metal-based compounds with biological activities, their mechanisms of action, and innovative metal-based drug delivery systems are welcome.
Topics of interest for this Special Issue include, but are not limited to, the following:
- Chemistry of metal-based anticancer drugs;
- Synthesis/improvement of metal-based complexes;
- Uptake, toxicity, and resistance of metal-based anticancer agents;
- Nanosystem delivery of metal-based complexes;
- Mechanisms of action and biological targets of metal-based complexes;
- Effects of metal-based compounds on the activation of innate immunity with inflammasome-mediated responses;
- Combination immune checkpoint therapy;
- Interactions of metal-based complexes with immune checkpoints and/or proteins.
Dr. Marialuisa Piccolo
Dr. Claudia Riccardi
Guest Editors
Manuscript Submission Information
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Keywords
- metal-based drugs
- anticancer activity
- mechanisms of action
- tumor microenvironment
- immune cell regulation
- cancer immunity
- metal–protein interactions
- metal–nucleic acid interactions
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