Advances in Nasopharyngeal Carcinoma Immunology, Epigenetics, and Therapy
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 25 March 2026 | Viewed by 8
Special Issue Editor
Interests: multi-omics; Epstein–Barr virus; tumor microenvironment; epigenomics; 3D genome; molecular subtyping
Special Issue Information
Dear Colleagues,
This Special Issue, titled "Advances in Nasopharyngeal Carcinoma Immunology, Epigenetics, and Therapy", aims to collate cutting-edge research that contains molecular data, which drives progress against this geographically distinct malignancy. Nasopharyngeal carcinoma (NPC), strongly associated with Epstein–Barr virus (EBV), presents unique challenges and opportunities in understanding its complex pathogenesis and improving therapeutic outcomes. This Special Issue will focus on the following three interconnected pillars:
- Immunology: Exploring the intricate interplay between NPC tumors, EBV, and the host immune system. Key topics include tumor microenvironment characterization, mechanisms of immune evasion, novel immunotherapeutic strategies (checkpoint inhibitors, adoptive cell therapy, and vaccines), and predictive biomarkers.
- Epigenetics: Investigating the pivotal role of EBV-encoded factors and dysregulated host epigenetic modifications (DNA methylation, histone modifications, and non-coding RNAs) in NPC initiation, progression, metastasis, and as targets for therapy or detection.
- Therapy: Highlighting advances in multimodal treatment approaches, including optimization of radiotherapy techniques, novel chemotherapeutic regimens, targeted therapies, and crucially, the integration of immunotherapy and epigenetic-modulating drugs into standard care and combination strategies.
We welcome original research and reviews that deepen our understanding of NPC biology and translate into improved diagnostics, prognostics, and patient outcomes.
We look forward to receiving your contributions.
Dr. Wei Dai
Guest Editor
Manuscript Submission Information
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Keywords
- nasopharyngeal carcinoma (NPC)
- epstein–barr virus (EBV)
- cancer epigenomics
- virus–host interaction
- tumor microenvironment (TME)
- immunotherapy
- targeted therapy
- biomarker
- metastasis
- radiotherapy resistance
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