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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Mechanisms of Toxicity Induced by Engineered Nanomaterials

edited by

Shan Zienolddiny-Narui

submission deadline 31 Jan 2026 | 1 articles | Viewed by 927 | Submission Open

Keywords: toxicity; occupational health; engineered nanomaterials; physical– chemical characteristics; toxicokinetic; toxicodynamic; in vivo; NAMs; NGRA (new-generation risk assessment)

(This special issue belongs to the Section Molecular Toxicology)

Advances in Basic and Translational Research in Colorectal Cancer

edited by

Gina Gheorghe

submission deadline 31 Jan 2026 | 1 articles | Viewed by 923 | Submission Open

Keywords: colorectal cancer; diagnostic and prognostic biomarkers; genetic and epigenetic alterations; MMR/MSI; cytokine profiling; inflammatory mediators; gut microbiota; tumor microenvironment; precision medicine

(This special issue belongs to the Section Molecular Oncology)

Advances in Molecular Target and Anti-Cancer Therapies

edited by Laura Denisa Dragu

submission deadline 31 Jan 2026 | 1 articles | Viewed by 905 | Submission Open

Keywords: cancer; conventional therapy; targeted therapy; immunotherapy; natural compounds; combinatorial therapy; molecular target; molecular mechanism; drug design; drug resistance

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Abiotic Stress in Plants: Physiological and Molecular Responses

edited by Edyta Zdunek-Zastocka

submission deadline 31 Jan 2026 | 1 articles | Viewed by 872 | Submission Open

Keywords: cold; drought; gene expression; heat; heavy metals; oxidative stress; salinity; stress tolerance; stress perception; stress signaling

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Advances in Radiation Oncology: Mechanisms, Immunotherapy and Innovation

edited by Jasna But-Hadžić

submission deadline 31 Jan 2026 | 1 articles | Viewed by 864 | Submission Open

Keywords: molecular radiation oncology; DNA damage response; immunoradiotherapy; radiosensitization; tumor– immune interactions; radiogenomics; predictive biomarkers; combination therapies; translational radiobiology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cell Proliferation and Differentiation in Cancer

edited by

Sérgio Paulo Bydlowski

submission deadline 31 Jan 2026 | 1 articles | Viewed by 852 | Submission Open

Keywords: cell signaling; cell transduction; transcriptional and post-transcriptional pathways; growth factors; second messengers; cell proliferation; cell differentiation; cell metabolism; cell death; cell invasion

(This special issue belongs to the Section Molecular Oncology)

Molecular Insights into Pancreatic Diseases

edited by

Wasif Saif

submission deadline 31 Jan 2026 | 1 articles | Viewed by 831 | Submission Open

Keywords: pancreatic cancer; pancreatic neuroendocrine tumors; KRAS; KRAS inhibitors; KRASG12D inhibitor in pancreatic ductal adenocarcinoma; XPO1 inhibitor; PNET

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Epilepsy: Exploring the Molecular Mechanisms and Potential Medications

edited by

Motohiro Okada

submission deadline 31 Jan 2026 | 1 articles | Viewed by 772 | Submission Open

Keywords: idiopathic epilepsy; genetic epilepsy; transmission; development; signaling; synaptic plasticity; pathophysiology; modulation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Emerging Strategies Targeting Solid Tumors and the Tumor Microenvironment

edited by Emanuela Berrino and

Giuseppina Catanzaro

submission deadline 31 Jan 2026 | 1 articles | Viewed by 748 | Submission Open

Keywords: cancer; tumor microenvironment; medicinal chemistry; drug design; structure– activity relationships; nanotechnologies; antibody– drug conjugates; non-coding RNAs; epigenetic

(This special issue belongs to the Section Molecular Oncology)

Molecular Research in Functional Nanomaterials

edited by

Łukasz Laskowski

submission deadline 31 Jan 2026 | 1 articles | Viewed by 717 | Submission Open

Keywords: functional materials; nanomaterials; molecular structure; molecular materials; functional molecules; nanotechnology; self-assembly methods

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Mechanisms of Plant Virus Infection, Resistance and Control

edited by

Carl Spetz

submission deadline 31 Jan 2026 | 1 articles | Viewed by 713 | Submission Open

Keywords: plant virus; host– pathogen interaction; viral replication; virus movement; RNA silencing; molecular virology; CRISPR; resistance

(This special issue belongs to the Section Molecular Plant Sciences)

Synthesis, Biosynthesis and Implications of Chalcones

edited by

Pal Perjesi

submission deadline 31 Jan 2026 | 1 articles | Viewed by 701 | Submission Open

Keywords: chalcones; biosynthesis; biochemistry

(This special issue belongs to the Section Biochemistry)

Application of Nanomedicine in Cancer Targeting and Treatment

edited by

Kee Siang Lim

submission deadline 31 Jan 2026 | Viewed by 569 | Submission Open

Keywords: nanomedicine; nanoimaging/bioimaging; cancer biology; theranostics; translational nanomedicine

(This special issue belongs to the Section Molecular Nanoscience)

Advances in Angiogenesis: From Molecular Insights to Therapeutic Strategies

edited by

Emanuela Pessolano

submission deadline 31 Jan 2026 | 1 articles | Viewed by 552 | Submission Open

Keywords: angiogenesis; molecular signaling; endothelial cells; tumor microenvironment; pro-angiogenic factors; anti-angiogenic therapy; vascular remodeling; hypoxia; VEGF pathway; translational research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Genetic and Molecular Research on the Malaria Parasite

edited by Hajime Hisaeda and

Takashi Imai

submission deadline 31 Jan 2026 | 1 articles | Viewed by 547 | Submission Open

Keywords: plasmodium; malaria parasite; molecular biology; genomics; gene expression; host– parasite interaction; drug resistance; vaccine development

(This special issue belongs to the Section Molecular Microbiology)

Molecular Research in Protein–Ligand Interactions

edited by

Qiaomei Sun

submission deadline 31 Jan 2026 | 1 articles | Viewed by 542 | Submission Open

Keywords: interaction; protein– ligand; computer simulation; docking; molecular simulation

(This special issue belongs to the Section Biochemistry)

HIV Infection, Pathogenesis and Treatment

edited by

Mudit Tyagi

submission deadline 31 Jan 2026 | 1 articles | Viewed by 537 | Submission Open

Keywords: HIV Infection; HIV; host immune responses; pathogenesis

(This special issue belongs to the Section Molecular Microbiology)

Oral Fibrosis and Oral Cancers: From Molecular Targets to Therapeutics

edited by Ila Pant

submission deadline 31 Jan 2026 | Viewed by 524 | Submission Open

Keywords: OSF; oral cancer; myofibroblast activation; collagen homeostasis; cancer stem cells; immunotherapy; monoclonal antibodies; DNA or RNA based targeted therapy; small molecule inhibitors; targeted nano-delivery systems; resistance to targeted therapies; molecular targets; natural compounds

(This special issue belongs to the Section Molecular Oncology)

The Interactions Between Nutrients and Adipose Tissue

edited by

Junseok Son

submission deadline 31 Jan 2026 | Viewed by 510 | Submission Open

Keywords: adipose tissue; nutrients; metabolic health; insulin resistance; inflammation; energy homeostasis; adipokines; obesity; lipolysis; thermogenesis

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Antitumor Activity of Natural Product

edited by

Fuad Fares

submission deadline 31 Jan 2026 | 1 articles | Viewed by 476 | Submission Open

Keywords: natural products; cancer treatment; cancer prevention; medicinal plants; medicinal mushrooms

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms of Thromboinflammation

edited by Ana B. Arroyo

submission deadline 31 Jan 2026 | Viewed by 463 | Submission Open

Keywords: thromboinflammation; coagulation; inflammation; immune system; sepsis; stroke; autoimmune diseases; cancer; hematology; biomarkers; translational medicine

(This special issue belongs to the Section Molecular Immunology)

The Application of an Electron Microscope in the Study of Cell Structure

edited by

Ivana Bocina

submission deadline 31 Jan 2026 | 1 articles | Viewed by 458 | Submission Open

Keywords: intracellular structure; organelles; cell surface structure; immuno-labeling

(This special issue belongs to the Section Molecular Biophysics)

Molecular Insights into Recent Research in Composite Materials

edited by Aboulfazl Barati

submission deadline 31 Jan 2026 | Viewed by 440 | Submission Open

Keywords: composite materials; molecular-level structure– property relationships; polymer nanocomposites; interfacial interactions; sustainable and biodegradable composites; hybrid organic– inorganic systems

(This special issue belongs to the Section Materials Science)

Plant Responses to Abiotic Stress: Mechanisms and Adaptations

edited by

Shalini Tiwari

and

Lam-Son Phan Tran

submission deadline 31 Jan 2026 | Viewed by 427 | Submission Open

Keywords: salinity stress; heat and cold stress; oxidative stress; signal transduction; stress-responsive genes; antioxidant defence mechanisms; hormonal regulation; molecular adaptation; epigenetic regulation; plant-microbe interaction; crop improvement; stress-resilient plants

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Melanoma Immunotherapy and Molecular Mechanisms of Drug Resistance, Second Edition

edited by Antonino Guerrisi and

Italia Falcone

submission deadline 31 Jan 2026 | Viewed by 425 | Submission Open

Keywords: melanoma; targeted therapy; immunotherapy; precision medicine; biomarkers; omics technologies; tumor microenvironment

(This special issue belongs to the Section Molecular Immunology)

Advances in the Molecular Pathogenesis of Gastrointestinal Malignancies with Implications for Diagnosis and Therapy

edited by Laura Necula

submission deadline 31 Jan 2026 | 1 articles | Viewed by 344 | Submission Open

Keywords: gastrointestinal cancers; biomarkers; early diagnosis; circulating molecules; non-invasive tests

(This special issue belongs to the Section Molecular Oncology)

Novel Mechanisms of Receptor Activation

edited by

Zong-Jie Cui

submission deadline 31 Jan 2026 | Viewed by 299 | Submission Open

Keywords: G protein-coupled receptors; nuclear (steroid) hormone receptors; catalytic receptors; receptor structural motifs important for activation; receptor pharmacophores; structure– function correlates; cellular functions; integrated physiology; compartmentalized GPCRs; receptor pharmacology; aryl hydrocarbon receptor (AHR); “ orphan” GPCRs

(This special issue belongs to the Section Biochemistry)

Advanced Strategies for Melanoma Immunotherapy

edited by

Andrzej Mackiewicz

and

Piotr Rutkowski

submission deadline 31 Jan 2026 | Viewed by 257 | Submission Open

Keywords: melanoma immunotherapy; immune Checkpoint Inhibitors; combination therapies; biomarkers; tumor microenvironment

(This special issue belongs to the Section Molecular Immunology)

Fine-Tuning Proteostasis: Insights into Ubiquitination and Deubiquitination Pathways

edited by

Kwang-Hyun Baek

submission deadline 31 Jan 2026 | Viewed by 254 | Submission Open

Keywords: deubiquitination; homeostasis; posttranslational modification; proteasomal degradation; protein quality control; proteolysis; proteostasis; signaling pathway; small molecule; ubiquitin-proteasome system; ubiquitination

(This special issue belongs to the Section Biochemistry)

Novel Heterocyclic Bioactive Compounds: Design, Synthesis and Biological Evaluation

edited by

Lilia Matei

submission deadline 31 Jan 2026 | Viewed by 233 | Submission Open

Keywords: heterocyclic compounds; drug design; medicinal chemistry; bioactive molecules; structure– activity relationships; synthetic methodologies; molecular mechanisms of action; pharmacological evaluation; therapeutic agents

(This special issue belongs to the Section Biochemistry)

Coordination Chemistry: From Fundamental Principles to Multifunctional Applications

edited by

Kiril B. Gavazov

submission deadline 31 Jan 2026 | Viewed by 212 | Submission Open

Keywords: coordination compounds; metal– ligand interactions; ligand design and synthesis; spectroscopic characterization; coordination geometry; molecular architecture; ion-association complexes; supramolecular chemistry; catalysis and activation mechanisms; functional materials; metal– organic frameworks; magnetism in coordination compounds; redox-active complexes; environmental and green chemistry applications; sensors and molecular devices; bioinorganic chemistry; medicinal coordination chemistry; theoretical and computational coordination chemistry

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Angiogenin: From Molecular Mechanisms to Clinical Implications

edited by

Iogann Tolbatov

submission deadline 31 Jan 2026 | Viewed by 209 | Submission Open

Keywords: angiogenin; angiogenesis; neuroprotection; cancer; neurodegeneration; biomarker; therapeutic target

(This special issue belongs to the Section Biochemistry)

Advances in Research of Estrogen Receptors in Health and Diseases

edited by

Maciej Iek Skrzypczak

submission deadline 31 Jan 2026 | Viewed by 199 | Submission Open

Keywords: estrogen receptors; physiology; pathobiology; cancer; benign diseases and disorders

(This special issue belongs to the Section Biochemistry)

Sphingolipids in Infections, Disorders and Diseases

edited by Elita Avota

submission deadline 31 Jan 2026 | Viewed by 197 | Submission Open

Keywords: sphingolipids; sphingolipid biosynthesis; sphingolipidoses; metabolic disorders; infections; lipidomics; sphingolipid targeting drugs

(This special issue belongs to the Section Biochemistry)

Emerging Therapeutic Potential of Organic Compound in Diseases

edited by

Katarzyna Kotwica-Mojzych

submission deadline 31 Jan 2026 | Viewed by 185 | Submission Open

Keywords: organic compounds; chemical analysis; medicinal chemistry; organic chemistry; organic synthesis; characterization techniques; cancers; chronic diseases; civilization diseases; degenerative and neurodegenerative diseases

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Insights into Nutrition, Genetics, and Biochemistry: From Mechanisms to Therapeutics

edited by

Anna Cieślińska

and

Edyta Sienkiewicz-Szłapka

submission deadline 31 Jan 2026 | Viewed by 184 | Submission Open

Keywords: nutrigenomics and nutrigenetics; molecular nutrition; oxidative stress and redox biology; epigenetics and diet; lipid and glucose metabolism; inflammatory pathways; transcriptomics; metabolomics; proteomics; mitochondrial dysfunction and nutrition; biomarkers of diet-related disease; precision nutrition and molecular therapeutics

(This special issue belongs to the Section Molecular Biology)

Biopolymer-Based Materials: Synthesis, Characterization and Applications for a Sustainable Future

edited by

Agnieszka Feliczak-Guzik

and

Agata Wawrzyńczak

submission deadline 31 Jan 2026 | Viewed by 183 | Submission Open

Keywords: biodegradable polymers; biopolymers; biopolymer-based composite materials; synthesis and characterization of biopolymer materials; applications of biopolymers and biopolymer-based composites

(This special issue belongs to the Section Materials Science)

Research Progress of Fluorescent Proteins in Molecular Biology

edited by Matteo Grenzi

submission deadline 31 Jan 2026 | Viewed by 178 | Submission Open

Keywords: fluorescence microscopy; fluorescence live-cell imaging; quantitative imaging; fluorescent biosensors; in vivo imaging; innovative fluorescence microscopy techniques

(This special issue belongs to the Section Molecular Biology)

Inner Ear Disorders: From Molecular Mechanisms to Treatment

edited by

Srdjan Vlajkovic

submission deadline 31 Jan 2026 | Viewed by 176 | Submission Open

Keywords: hearing loss; balance disorders; stem cell approaches; precision gene therapy; molecular reprogramming; targeted delivery systems; molecular biomarkers; suppression of oxidative stress and inflammation; tissue engineering; immune response and off-target effects

(This special issue belongs to the Section Molecular Immunology)

Integrative Omics Strategies for Biomarker Discovery and Mechanistic Insights into Disease

edited by

Xinxin Song

submission deadline 31 Jan 2026 | Viewed by 166 | Submission Open

Keywords: integrative omics; biomarker discovery; cancer signaling networks; drug resistance; phosphoproteomics; multi-omics integration; systems biology; translational research

(This special issue belongs to the Section Molecular Informatics)

Genetic and Metabolic Molecular Research of Lysosomal Storage Disease: 5th Edition

edited by

Grzegorz Wegrzyn

submission deadline 31 Jan 2026 | Viewed by 163 | Submission Open

Keywords: lysosomal storage diseases; molecular mechanisms of genetic disorders metabolic diseases; accumulation of macromolecules in cells; enzyme replacement therapy; hematopoietic stem cell transplantation gene therapy; substrate reduction therapy; translational research; novel therapies for genetic diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research on Zoonotic Diseases: Current Advances and Perspectives

edited by

Gabriela Goujgoulova

submission deadline 31 Jan 2026 | Viewed by 160 | Submission Open

Keywords: emerging zoonoses; re-emerging zoonoses; zoonotic pathogens; control strategies and measures; animal and public health; worldwide

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Design and Functional Applications of Polysaccharide Composites

edited by

Magdalena Krystyjan

Gohar Khachatryan

and

Karen Khachatryan

submission deadline 31 Jan 2026 | 1 articles | Viewed by 157 | Submission Open

Keywords: polysaccharide composites; molecular design; functional applications

(This special issue belongs to the Section Materials Science)

Advances in Angiogenesis Research: From Novel Compounds to Mechanistic Insights and Therapeutic Strategies

edited by Juliana Luporini Dreyfuss

submission deadline 31 Jan 2026 | Viewed by 156 | Submission Open

Keywords: angiogenesis; vascular endothelial growth factor (VEGF); novel compounds; endothelial cells; drug development; advanced molecular biology; omics technologies; innovation

(This special issue belongs to the Section Molecular Biology)

Advances in the Role of Cytoskeletal Proteins in Diseases

edited by

Urko Del Castillo

submission deadline 31 Jan 2026 | Viewed by 154 | Submission Open

Keywords: cytoskeleton; microtubules; actin filaments; intermediate filaments; neurodegeneration; cancer metastasis; cell migration; cellular mechanotransduction; cytoskeletal remodeling

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Brain Tumor Research and Treatment

edited by

Daniele Armocida

and

Davide Barbagallo

submission deadline 31 Jan 2026 | Viewed by 149 | Submission Open

Keywords: brain tumor; gliomas; brain metastases; translational research; molecular biology

(This special issue belongs to the Section Molecular Oncology)

Long COVID Biology and Epidemiology: Predisposition, Molecular Mechanisms and Diagnostics

edited by Eduardo José Melo dos Santos

submission deadline 31 Jan 2026 | Viewed by 149 | Submission Open

Keywords: long COVID; genetic predisposing; long COVID epidemiology; pathogenesis; immunology of long COVID; long COVID etiology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Animal Nutrition and Muscle Biology

edited by Usuk Jung

submission deadline 31 Jan 2026 | Viewed by 146 | Submission Open

Keywords: animal nutrition; metabolic regulation; molecular biology; molecular mechanisms; skeletal muscle; intramusculuar fat; skeletal muscle fibrosis

(This special issue belongs to the Section Molecular Biology)

Macrophage Metabolic Reprogramming in Inflammation

edited by

Ricardo Sánchez-Rodríguez

and

Roberta Angioni

submission deadline 31 Jan 2026 | Viewed by 144 | Submission Open

Keywords: inflammation; immunometabolism; metabolic rewiring; glycolysis; krebs cycle; glutaminolysis; innate immune response; macrophages

(This special issue belongs to the Section Molecular Immunology)

Unraveling Cell–Cell and Cell–Matrix Interactions: Novel Morphological and Molecular Insights

edited by

José Freni

submission deadline 31 Jan 2026 | Viewed by 143 | Submission Open

Keywords: DGC; sarcoglycans; cell– cell interactions; cell– matrix interactions; morphological analysis; molecular analysis; molecular pathogenesis; translational studies

(This special issue belongs to the Section Molecular Biology)

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