Advances in Basic and Translational Research in Colorectal Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 31 January 2026 | Viewed by 1013
Special Issue Editor
2. Internal Medicine Department, Clinical Emergency Hospital of Bucharest, 105402 Bucharest, Romania
Interests: colorectal cancer; molecular medicine; inflammatory metabolites; proteomics; genomics; cancer outcomes
Special Issue Information
Dear Colleagues,
Colorectal cancer (CRC) remains a leading cause of cancer-related morbidity and mortality worldwide. Despite notable progress in screening, diagnostics, and therapeutics, the molecular, immunological, and clinical heterogeneity of CRC continues to present major challenges in effective disease management. This Special Issue aims to gather high-quality basic and translational research that supports the development of innovative strategies for early detection, risk stratification, and personalized treatment. We welcome original research articles and comprehensive reviews exploring the genetic, epigenetic, transcriptomic, and proteomic landscapes of CRC. Particular emphasis will be placed on host–microbiota interactions, including the role of microbial metabolites, dysbiosis, and immune modulation in colorectal tumorigenesis, progression, and therapeutic response. We also encourage studies focusing on diagnostic and prognostic biomarkers, tumor microenvironment remodeling, immune profiling, mismatch repair (MMR) deficiency, microsatellite instability (MSI), and resistance mechanisms to systemic therapies. This Special Issue provides a platform for interdisciplinary studies that integrate molecular, microbial, and clinical insights, fostering precision medicine approaches for CRC patients.
This Special Issue is supervised by Dr. Gina Gheorghe, with assistance from Dr. Vlad Alexandru Ionescu (University of Medicine and Pharmacy Carol Davila Bucharest & Clinical Emergency Hospital of Bucharest, Email: vladalexandru.ionescu92@gmail.com).
Dr. Gina Gheorghe
Guest Editor
Dr. Vlad Alexandru Ionescu
Guest Editor Assistant
Manuscript Submission Information
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Keywords
- colorectal cancer
- diagnostic and prognostic biomarkers
- genetic and epigenetic alterations
- MMR/MSI
- cytokine profiling
- inflammatory mediators
- gut microbiota
- tumor microenvironment
- precision medicine
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