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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cellular Plasticity and EMT in Cancer and Fibrotic Diseases

edited by

Sabrina Lisi

and

Margherita Sisto

submission deadline 20 Mar 2026 | 5 articles | Viewed by 11063 | Submission Open

Keywords: fibrosis; epithelial– mesenchymal transition; epithelial– mesenchymal plasticity; cancer; fibrotic diseases; inflammation; metastases

(This special issue belongs to the Section Molecular Biology)

Advances in Pathogenesis, Molecular Mechanisms, and Therapeutic Strategies for Neurodegenerative Diseases

edited by

Abdullah Sheikh

submission deadline 20 Mar 2026 | 5 articles | Viewed by 10951 | Submission Open

Keywords: neurodegeneration; molecular pathways; protein aggregation; gene therapy; neuroprotection

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Inflammatory Bowel Disease and Microbiome

edited by Abigail Raffner Basson

submission deadline 20 Mar 2026 | 4 articles | Viewed by 10628 | Submission Open

Keywords: inflammatory bowel disease; Crohn’ s disease; ulcerative colitis; gut microbiota; diet; treatment; pathogenesis; biomarker

(This special issue belongs to the Section Molecular Microbiology)

Molecular Genetics in Ovarian Cancer

edited by

Bruna Scaggiante

submission deadline 20 Mar 2026 | 6 articles | Viewed by 10591 | Submission Open

Keywords: chemotherapy resistance; differential gene expression; genomic structural variation; ovarian cancer mutations; ovarian cancer metastasis; ovarian cancer treatment; novel molecular targets

(This special issue belongs to the Section Molecular Genetics and Genomics)

The Role of SARS-CoV-2 in Immunomodulation—Post-Pandemic Reflection on the Role of Viruses in Human Immunology

edited by

Katarzyna A. Lisowska

submission deadline 20 Mar 2026 | 6 articles | Viewed by 10410 | Submission Open

Keywords: SARS-CoV-2; COVID-19; immunomodulation; T cells; B cells; dendritic cells; monocytes; cytokines

(This special issue belongs to the Section Molecular Immunology)

Advanced Molecular Research on the Diagnosis and Treatment of Chronic Liver Diseases

edited by

Hirayuki Enomoto

submission deadline 20 Mar 2026 | 3 articles | Viewed by 10062 | Submission Open

Keywords: biomarker; genomic research; epigenomic research; molecular mechanisms; viral hepatitis; alcoholic-related liver disease; non-alcoholic fatty liver disease; autoimmune liver diseases; liver cirrhosis; hepatocellular carcinoma

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Density Functional Theory and Related Methods for Molecular Computational Chemistry

edited by Paolo Umari

submission deadline 20 Mar 2026 | 3 articles | Viewed by 10017 | Submission Open

Keywords: density functional theory; quantum chemistry; algorithms; quantum computing; high-performance computing; machine learning; many-body perturbations theory; quantum Monte Carlo

(This special issue belongs to the Section Molecular Informatics)

Vegetable Genetics and Genomics, 3rd Edition

edited by

Yunsong Lai

and

Xixiang Li

submission deadline 20 Mar 2026 | 7 articles | Viewed by 10011 | Submission Open

Keywords: major vegetable crops; genome; variome; genotyping; GWAS; QTL mapping; functional genome; metabolome; breeding target characters; genetic mechanism; functional genes

(This special issue belongs to the Section Molecular Plant Sciences)

Signaling Pathways and Novel Therapies in Heart Disease

edited by

Anindita Das

submission deadline 20 Mar 2026 | 4 articles | Viewed by 9956 | Submission Open

Keywords: heart failure; arrhythmias; ischemic heart disease; myocardial regeneration; inflammation; gene- or cell-based therapy; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Gynecologic Diseases: From Molecular Basis to Therapy

edited by Domenico Baldini

submission deadline 20 Mar 2026 | 2 articles | Viewed by 9935 | Submission Open

Keywords: infertility; sterility; gynecologic desease; genetic; IVF; gynecologic therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research Progress of Skin and Skin Diseases: 2nd Edition

edited by

Ji Hyun Lee

submission deadline 20 Mar 2026 | 5 articles | Viewed by 9276 | Submission Open

Keywords: atopic dermatitis; psoriasis; alopecia; vitiligo; acne; skin cancer; JAK-STAT; inflammatory skin disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Therapies and Strategies in the Treatment of Neurodegenerative Diseases

edited by

Polina Petkova-Kirova

submission deadline 20 Mar 2026 | 3 articles | Viewed by 9179 | Submission Open

Keywords: neurodegenerative diseases; Alzheimer’ s disease; Parkinson’ s disease; Huntington’ s disease; aging; memory; dementia; motor dysfunction

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exploring Biological Mechanisms and Therapeutic Strategies for Substance Use Disorders

edited by Thomas Paparrigopoulos

submission deadline 20 Mar 2026 | 3 articles | Viewed by 9035 | Submission Open

Keywords: addiction; alcohol use disorder; opioid use disorder; substance use disorders; physical exercise; physical activity; molecular mechanisms; neuroendocrine system

(This special issue belongs to the Section Molecular Neurobiology)

Ocular Ischemic Diseases: From Molecular Mechanisms to Therapeutics

edited by

Deokho Lee

submission deadline 20 Mar 2026 | 4 articles | Viewed by 8775 | Submission Open

Keywords: diabetic retinopathy; retinopathy of prematurity; retinal vein occlusion; retinal artery occlusion; pathologic myopia; age-related macular degeneration; glaucoma; ocular ischemic syndrome

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanism in Cardiovascular Pathology

edited by Andrea Marzullo

submission deadline 20 Mar 2026 | 6 articles | Viewed by 8467 | Submission Open

Keywords: cardiovascular diseases; molecular biology; sudden death; cardiomyopathies; heart failure; coronary artery diseases; pericarditis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Chromatin Structure and Dynamics

edited by Stephanie Portillo-Ledesma

submission deadline 20 Mar 2026 | 5 articles | Viewed by 8465 | Submission Open

Keywords: chromatin structure and dynamics; genome architecture; epigenetic regulation

(This special issue belongs to the Section Biochemistry)

Hormone Replacement Therapy

edited by

Marco Antonio Botelho

and

Raouf A. Khalil

submission deadline 20 Mar 2026 | 2 articles | Viewed by 8237 | Submission Open

Keywords: hormone replacement therapy; molecular insights; endocrine signaling; precision medicine; gene expression; epigenetics; non-coding RNAs; personalized regimens

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Toxicity of Metals, Metal-Based Drugs, and Microplastics

edited by

Agnieszka Scibior

Manuel Aureliano

and

Juan Llopis

submission deadline 20 Mar 2026 | 4 articles | Viewed by 8228 | Submission Open

Keywords: metal toxicity and pollution; microplastic toxicity and pollution; metal and microplastic bioaccumulation; metal-based drugs; protein metalation; human health problems; diseases; in vitro/in vivo studies; human studies

(This special issue belongs to the Section Molecular Toxicology)

New Advances in Autoimmune Diseases

edited by

Tsvetelina Velikova

submission deadline 20 Mar 2026 | 4 articles | Viewed by 8185 | Submission Open

Keywords: autoimmunity; autoimmune mechanisms; molecular pathogenesis; immune signalling pathways; cytokine regulation; epigenetics in autoimmunity; molecular biomarkers; gene expression profiling; regulatory T cells; immunogenetics; molecular therapeutics; signal transduction; immunometabolism; microRNA in autoimmunity

(This special issue belongs to the Section Molecular Immunology)

Protein Methyltransferases in Human Health and Diseases

edited by

Byron Baron

submission deadline 20 Mar 2026 | 3 articles | Viewed by 8148 | Submission Open

Keywords: lysine and arginine methylation; mass spectrometry; PTM cross talk; functional proteomics; cancer; neurological disorders

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Applications of Bacteriophages

edited by

Grzegorz Wegrzyn

submission deadline 20 Mar 2026 | 1 articles | Viewed by 8115 | Submission Open

Keywords: bacteriophages; gene cloning; phage display technology; phage

(This special issue belongs to the Section Molecular Biology)

Recent Progress in Advanced Computing Techniques for Molecules and Nanomaterials

edited by

Joonho Bae

submission deadline 20 Mar 2026 | 1 articles | Viewed by 8108 | Submission Open

Keywords: nanomaterials; machine learning; artificial intelligence; computing techniques; modeling; energy storage; catalysis

(This special issue belongs to the Section Molecular Nanoscience)

Pathophysiology and New Therapies of Alopecia

edited by Jong-Hyuk Sung

submission deadline 20 Mar 2026 | 2 articles | Viewed by 7904 | Submission Open

Keywords: alopecia; pathophysiology; novel pharmacological treatments; regenerative medicines; gene therapy; cell therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

MAPK Signaling Cascades in Human Health and Diseases, 2nd Edition

edited by Galia Maik-Rachline

submission deadline 20 Mar 2026 | 2 articles | Viewed by 7793 | Submission Open

Keywords: ERK1/2; p38; JNK; ERK5; MEK; MEKK; raf; stimulated nuclear translocation; targeted therapy; resistance mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Strategies to Improve the Detection of Human Papillomavirus (HPV) Persisting Infections

edited by

Marianna Martinelli

submission deadline 20 Mar 2026 | 4 articles | Viewed by 7738 | Submission Open

Keywords: human papillomavirus; HPV; viral load; genotyping; oncogenic transcripts; biomarkers

(This special issue belongs to the Section Molecular Microbiology)

Protein Aggregation and Proteinopathies

edited by Hongyu Hu

submission deadline 20 Mar 2026 | 2 articles | Viewed by 7631 | Submission Open

Keywords: protein aggregation; inclusion; sequestration; interaction; phase transition; proteostasis; proteinopathy

(This special issue belongs to the Section Molecular Biology)

Understanding Allergy and Asthma at the Molecular Level

edited by

Cenk Suphioglu

submission deadline 20 Mar 2026 | 1 articles | Viewed by 7560 | Submission Open

Keywords: allergy; asthma; allergens; allergic asthma; thunderstorm asthma; cell culture; biomarkers; proteomics; metabolomics; lipidomics; genomics; recombinant allergens; recombinant hypoallergens; signalling; inhibitors; cytokines

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mitochondria: Central Players in Cancer

edited by

Annamaria Piscazzi

and

Domenica Mangieri

submission deadline 20 Mar 2026 | 4 articles | Viewed by 7504 | Submission Open

Keywords: mitochondria; cancer; tumorigenesis; oxidative phosphorylation; glycolysis; Warburg effect; reactive oxygen species (ROS); apoptosis; mitochondrial dysfunction; metabolic reprogram-ming; cancer therapy

(This special issue belongs to the Section Molecular Biology)

Cutting-Edge Research on Nanosensors and Microsensors

edited by

Beata Paczosa-Bator

submission deadline 20 Mar 2026 | 2 articles | Viewed by 7125 | Submission Open

Keywords: nanosensors and microsensors; innovations; nanomaterials; nanotechnology; biomedical devices; point-of-care and point-of-use testing; environmental control

(This special issue belongs to the Section Materials Science)

Virus Engineering and Applications: 3rd Edition

edited by

Laura Menotti

submission deadline 20 Mar 2026 | 3 articles | Viewed by 6962 | Submission Open

Keywords: virus engineering; oncolytic virotherapy; immunovirotherapy; viral biotechnology

(This special issue belongs to the Section Molecular Microbiology)

Mitochondrial Metabolism Alterations in Health and Disease: 2nd Edition

edited by

Vincenza Dolce

Rosita Curcio

and

Graziantonio Lauria

submission deadline 20 Mar 2026 | 2 articles | Viewed by 6958 | Submission Open

Keywords: mitochondrial Metabolism; mitochondrial disorders; cellular processes; dysregulation organisms’ physiology

(This special issue belongs to the Section Biochemistry)

Modulation of the Immune System and Oxidative Stress in Liver Illnesses

edited by

Vlad Pădureanu

and Dan Ionuț Gheonea

submission deadline 20 Mar 2026 | 2 articles | Viewed by 6914 | Submission Open

Keywords: oxidative stress; liver illnesses; immune system; inflammatory

(This special issue belongs to the Section Molecular Immunology)

Advanced Research in Retina: 3rd Edition

edited by

Juan J. Salazar

and

José A. Fernández-Albarral

submission deadline 20 Mar 2026 | 4 articles | Viewed by 6790 | Submission Open

Keywords: glaucoma; age-related macular degeneration; diabetic retinopathy; neurodegenerative diseases; diagnostic techniques; therapeutic strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Induced Pluripotent Stem and Extracellular Vesicles in Biomedicine

edited by

Ylenia Della Rocca

Francesca Diomede

and

Jacopo Pizzicannella

submission deadline 20 Mar 2026 | 2 articles | Viewed by 6204 | Submission Open

Keywords: induced pluripotent stem; embryonic stem cells; extracellular vesicles; tissue development; translational medicine

(This special issue belongs to the Section Molecular Biology)

Molecular Research and Insight into Endocannabinoid System

edited by

Jorge Manzanares

and

Francisco Navarrete

submission deadline 20 Mar 2026 | 3 articles | Viewed by 6162 | Submission Open

Keywords: endocannabinoid system; molecular research; biomarker; translational

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Breeding for Abiotic Stress Tolerance in Crops (Second Edition)

edited by

Mario A. Pagnotta

submission deadline 20 Mar 2026 | 6 articles | Viewed by 6151 | Submission Open

Keywords: plant breeding; advance molecular approach; molecular characterization; environmental stresses plant tolerance; resistant genes; QTLs; drought; salinity; climatic changes

(This special issue belongs to the Section Molecular Plant Sciences)

New Advances in Molecular Research in Leukemia

edited by

Akiyoshi Takami

Jorge Luis Espinoza

and

Carla Di Stefano

submission deadline 20 Mar 2026 | 2 articles | Viewed by 5896 | Submission Open

Keywords: acute lymphoblastic leukemia (ALL); chronic lymphocytic leukemia (CLL); acute myelogenous leukemia (AML); chronic myelogenous leukemia (CML); hairy cell leukemia (HCL); T-cell prolymphocytic leukemia (T-PLL); large granular lymphocytic leukemia; measurable residual disease (MRD)

(This special issue belongs to the Section Molecular Oncology)

Mechanism and Treatment Progress of Liver Disease

edited by Yohei Shirakami

submission deadline 20 Mar 2026 | 3 articles | Viewed by 5883 | Submission Open

Keywords: liver diseases; MASLD; alcoholic liver disease; liver cancer; viral hepatitis; sarcopenia

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Discovery, Extraction, Synthesis, and Application of Natural Products

edited by

Hah Young Yoo

, Kang Hyun Lee and

Taek Lee

submission deadline 20 Mar 2026 | 2 articles | Viewed by 5852 | Submission Open

Keywords: antibiotics; antioxidants; biomass; bioactive molecule; biological activity; biosynthesis; biosensor; biomedicine; biotechnology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Big Data in Multi-Omics

edited by

Dimitrios Vlachakis

and

George P. Chrousos

submission deadline 20 Mar 2026 | 2 articles | Viewed by 5714 | Submission Open

Keywords: data science; big data; omics; data management; data analytics TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian // TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back // This page is in Shona Translate to Simplified Chinese Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh Always translate Shona to Simplified Chinese Never translate Shona Never translate admin.mdpi.com

(This special issue belongs to the Section Molecular Informatics)

Recent Advances and Challenges in Colorectal Cancer: From Molecular Research to Treatment

edited by

Premila Leiphrakpam

submission deadline 20 Mar 2026 | 1 articles | Viewed by 5563 | Submission Open

Keywords: tumor biology; tumor heterogeneity; molecular mechanism involved in cancer initiation; progression; and metastasis; compensatory pathways; cancer screening; cancer biomarkers discovery; tumor molecular profiling methods; early cancer diagnosis; novel therapeutic strategies; targeted therapies; drug resistance

(This special issue belongs to the Section Molecular Oncology)

Blueprints of Enzymatic Function and Structure in Biocatalysis

edited by

Francesco Malatesta

submission deadline 20 Mar 2026 | 2 articles | Viewed by 5543 | Submission Open

Keywords: enzyme; biocatalysis; enzyme structure; enzyme kinetics and thermodynamics; enzyme engineering; synthetic biology applications; sustainable biocatalyst design

(This special issue belongs to the Section Biochemistry)

Parkinson’s Disease and Related Diseases: Mechanisms, Genetic Factors and Treatments

edited by

Stergios Boussios

submission deadline 20 Mar 2026 | 3 articles | Viewed by 5465 | Submission Open

Keywords: Parkinson’ s disease; neurodegenerative disorders; α -synuclein aggregation; neuroinflammation; gene therapy; biomarkers

(This special issue belongs to the Section Molecular Neurobiology)

Exploring the Molecular Basis of Cellular Responses to Microgravity-Induced Oxidative Stress

edited by

Caterina Morabito

and

Simone Guarnieri

submission deadline 20 Mar 2026 | 2 articles | Viewed by 5463 | Submission Open

Keywords: microgravity; reactive oxygen species (ROS); oxidative damage; cellular antioxidant systems; cell metabolism; cell responses; molecular pathways; simulated microgravity; protective countermeasures

(This special issue belongs to the Section Molecular Biology)

Genetic Analysis Based on CRISPR/Cas9 Technology: 2nd Edition

edited by

Yong-Gu Cho

and

Kwon-Kyoo Kang

submission deadline 20 Mar 2026 | 2 articles | Viewed by 5460 | Submission Open

Keywords: gene targeting (GT); homology-directed repair (HDR); homology-directed gene targeting (HGT); CRISPR/Cas; targeted mutagenesis; precision breeding; genetic analysis

(This special issue belongs to the Section Molecular Genetics and Genomics)

New Trends and Challenges in Chronic Diseases

edited by

Guan-Jhong Huang

submission deadline 20 Mar 2026 | 2 articles | Viewed by 5076 | Submission Open

Keywords: chronic diseases; ER stress; oxidative stress; immune regulation; new pathways of pathogenesis; cancer development

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Lymphoma: Molecular Pathologies and Therapeutic Strategies

edited by

Francesco Gaudio

and

Stefano Martinotti

submission deadline 20 Mar 2026 | 2 articles | Viewed by 5021 | Submission Open

Keywords: targeted therapy; molecular pathway; Hodgkin’ s lymphoma; non-Hodgkin’ s lymphoma; hematopathology biomarker; new therapeutic approaches

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms and Pathophysiology of Cystic Fibrosis

edited by

Stefanie Krick

and George M. Solomon

submission deadline 20 Mar 2026 | 2 articles | Viewed by 4987 | Submission Open

Keywords: cystic fibrosis; aging; CF airway disease; CF complications; CF molecular pathogenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cancer Biology and Epigenetic Modifications

edited by

Tamer E. Fandy

submission deadline 20 Mar 2026 | 1 articles | Viewed by 4901 | Submission Open

Keywords: epigenetics; DNA methylation; epigenetic modifiers; histone acetylation; histone methylation; miRNA; ncRNA; chrmoatin remodelling

(This special issue belongs to the Section Molecular Oncology)

Eye Diseases: From Pathophysiology to Novel Therapeutic Approaches

edited by

Tomasz Chorągiewicz

and

Joanna Dolar-Szczasny

submission deadline 20 Mar 2026 | 3 articles | Viewed by 4862 | Submission Open

Keywords: eye diseases; genetic; biochemical; proteomic; cellular and physiological level; innovative therapeutic approaches

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 2151-2200 on page 44 of 70.

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