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Advanced Molecular Research on the Diagnosis and Treatment of Chronic Liver Diseases

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Guest Editor
Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya 663-8501, Hyogo, Japan
Interests: viral hepatitis; liver cirrhosis; portal hypertension; ascites; esophageal varices; liver fibrosis; hepatocellular carcinoma
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Special Issue Information

Dear Colleagues,

Chronic liver diseases develop through a wide range of causes, including hepatitis B virus (HBV) and C virus (HCV) infection, alcoholic-related liver disease, non-alcoholic fatty liver disease (NAFLD), and autoimmune liver diseases. Due to recent advancements in antiviral therapies and lifestyle changes, the clinical importance of non-viral chronic liver diseases is increasing. However, viral hepatitis is still a major cause of chronic liver diseases.

Recent advances in molecular and cellular techniques have succeeded in providing new perspectives related to the diagnosis and treatment of chronic liver diseases.

This Special Issue aims to cover state-of-the-art research on chronic liver diseases, inviting authors to submit original and review articles on recent findings in this area, particularly molecular approaches for the diagnosis and treatment of these diseases. Potential topics include, but are not limited to, the following:

  • Biomarkers for chronic liver diseases;
  • Genomic research for chronic liver diseases, including gene SNPs (single-nucleotide polymorphisms);
  • Molecular mechanisms of chronic liver diseases;
  • Recent advances in the management of chronic liver diseases, including liver cirrhosis;
  • Molecularly targeted therapy for liver cancer.

Dr. Hirayuki Enomoto
Guest Editor

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Keywords

  • biomarker
  • genomic research
  • epigenomic research
  • molecular mechanisms
  • viral hepatitis
  • alcoholic-related liver disease
  • non-alcoholic fatty liver disease
  • autoimmune liver diseases
  • liver cirrhosis
  • hepatocellular carcinoma

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Related Special Issue

Published Papers (1 paper)

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Review

12 pages, 897 KiB  
Review
The Role of Myokines in Liver Diseases
by Hiroki Nishikawa, Soo Ki Kim and Akira Asai
Int. J. Mol. Sci. 2025, 26(3), 1043; https://doi.org/10.3390/ijms26031043 - 25 Jan 2025
Cited by 1 | Viewed by 1191
Abstract
Myokine is a general term for hormones, peptides, and other substances secreted by skeletal muscle. Myokine has attracted much attention in recent years as a key substance for understanding the mechanism of “exercise and health”. Skeletal muscle accounts for about 40% of the [...] Read more.
Myokine is a general term for hormones, peptides, and other substances secreted by skeletal muscle. Myokine has attracted much attention in recent years as a key substance for understanding the mechanism of “exercise and health”. Skeletal muscle accounts for about 40% of the total human weight and is now recognized as an endocrine organ that produces myokines, which have physiological activity. Representative myokines include IL-6, myostatin, irisin, brain-derived neurotropic factor, fibroblast growth factor-21, and decorin. On the other hand, sarcopenia, defined by quantitative and qualitative loss of skeletal muscle, is a condition that has received much attention in recent years because of its close correlation with prognosis. In patients with chronic liver disease (CLD), sarcopenia is a common complication. Mechanisms underlying sarcopenia in CLD patients have been reported to involve protein-energy malnutrition, which is characteristic of patients with cirrhosis, signaling involved in protein synthesis and degradation, myokines such as myostatin and decorin, the ubiquitin-proteasome pathway, sex hormones such as testosterone, dysbiosis, and insulin resistance, etc., in addition to aging. Each of these pathological conditions is thought to be intricately related to each other, leading to sarcopenia. This review will summarize the relationship between CLD and myokines. Full article
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