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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Regulatory Mechanisms of Development and Abiotic Stress Response by Transcriptional Regulators in Plants: 2nd Edition

edited by

Yong-Hwan Moon

submission deadline 20 Dec 2025 | 5 articles | Viewed by 6537 | Submission Open

Keywords: transcriptional regulator; transcription activation; transcription factor; transcription repression; plant development; abiotic stress response; epigenetic regulation; genome-wide analysis

(This special issue belongs to the Section Molecular Plant Sciences)

Cytochrome P450 Mechanism and Reactivity

edited by

Samuel De Visser

submission deadline 20 Dec 2025 | 3 articles | Viewed by 6262 | Submission Open

Keywords: enzyme function; enzyme catalysis; bioengineering; inorganic reaction mechanisms; enzyme inhibition

(This special issue belongs to the Section Biochemistry)

Integrated Approaches, Molecular Mechanism and Therapies in Ocular Surface Diseases

edited by

Caterina Gagliano

Marco Zeppieri

and

Mario Damiano Toro

submission deadline 20 Dec 2025 | 4 articles | Viewed by 6179 | Submission Open

Keywords: ocular surface diseases; dry eye; corneal ulcers; persistent epithelial defects; blood-derived products; blood-based therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Nanomedicine in Gene Therapy and Immunotherapy

edited by

Ruosen Xie

and Ruixuan Gao

submission deadline 20 Dec 2025 | 3 articles | Viewed by 6163 | Submission Open

Keywords: nanomedicine; drug delivery; gene delivery; genome editing; immunotherapy

(This special issue belongs to the Section Molecular Immunology)

Wnt/β-Catenin Signaling in Cancer

edited by

Teresa Catalano

and

Gitana Maria Aceto

submission deadline 20 Dec 2025 | 1 articles | Viewed by 6060 | Submission Open

Keywords: Wnt/β -catenin pathway; tumors; gene expression; molecular targets; tumor microenvironment; carcinogenesis and metastasis; biomarkers; therapeutic approaches

(This special issue belongs to the Section Molecular Oncology)

Nanoparticles in Molecular Pharmaceutics

edited by

Qingxin Mu

submission deadline 20 Dec 2025 | 4 articles | Viewed by 6026 | Submission Open

Keywords: nanoparticles; molecular pharmaceutics; drug delivery; nanomedicine; nanoformulation

(This special issue belongs to the Section Molecular Nanoscience)

Voltage-Gated Ion Channels and Human Diseases

edited by María A. Gandini

submission deadline 20 Dec 2025 | 5 articles | Viewed by 6024 | Submission Open

Keywords: channelopathies; voltage gated-ion channels; human diseases; mutations; calcium; sodium; potassium

(This special issue belongs to the Section Molecular Biophysics)

Therapeutic Targets in Pancreatic Cancer: 2nd Edition

edited by

Dorota Lubgan

Nathalie Britzen-Laurent

and

Benjamin Frey

submission deadline 20 Dec 2025 | 3 articles | Viewed by 5906 | Submission Open

Keywords: pancreatic cancer; translational research; therapeutic targets and novel interventional strategies; mechanisms of anti-tumor reactions; biomarkers

(This special issue belongs to the Section Molecular Oncology)

Anticancer and Chemopreventive Activity of Natural Products and Its Derivatives

edited by

Magdalena Bartnik

submission deadline 20 Dec 2025 | 2 articles | Viewed by 5906 | Submission Open

Keywords: coumarins; coumarin derivatives; anticancer activity; chemopreventive activity; therapy adjuvant; mechanism of action; in vitro and in vivo studies; molecular research; metabolic pathway; phytochemicals; natural products; apoptosis; bioactivity assessment; chemical composition; therapeutic targets

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Insight into Extracellular Vesicles in Proliferative Diseases

edited by Sergio Esquivel-Ruiz

submission deadline 20 Dec 2025 | 2 articles | Viewed by 5842 | Submission Open

Keywords: proliferation; extracellular vesicles; intercellular communication; vesicle cargo; therapeutic applications; biomarkers

(This special issue belongs to the Section Molecular Immunology)

Neuroinflammation: Advancements in Pathophysiology and Therapies (2nd Edition)

edited by

David Martín-Hernández

submission deadline 20 Dec 2025 | 2 articles | Viewed by 5751 | Submission Open

Keywords: neuroinflammation; CNS diseases; pathophysiology; therapeutic strategies; pharmacological treatments; neurological disorders; neurodegenerative diseases; cardiovascular diseases; psychiatric disorders

(This special issue belongs to the Section Molecular Neurobiology)

The Molecular Link Between Nutrition and Obesity

edited by

Elena Azzini

submission deadline 20 Dec 2025 | 2 articles | Viewed by 5688 | Submission Open

Keywords: hormonal regulation; chronic low-grade inflammation; nutrient sensing pathways; gut microbiota

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Targeting Metabolic Reprogramming: From Pathogenesis to Therapeutic Strategies

edited by

Beatriz García-Díaz

Alejandro Escamilla

and

Raquel Sanchez-Varo

submission deadline 20 Dec 2025 | 2 articles | Viewed by 5662 | Submission Open

Keywords: metabolism; therapy; mitochondria; pathogenesis; bioenergetics

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advancing Neurological Disorders via Computational Neuroscience and Neural Networks

edited by

Elnaz Pashaei

submission deadline 20 Dec 2025 | 2 articles | Viewed by 5632 | Submission Open

Keywords: neurological disorders; neuroimaging analysis; biomarker identification; computational neuroscience; machine learning; brain aging

(This special issue belongs to the Section Molecular Informatics)

Preclinical and Translational Research in Thyroid Cancer

edited by

Marialuisa Appetecchia

and

Giulia Puliani

submission deadline 20 Dec 2025 | 2 articles | Viewed by 5534 | Submission Open

Keywords: thyroid cancers; pathogenesis; molecular bases of thyroid cancer; precision medicine; gender medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Research on Antifungal Resistance

edited by Anna Tomova

submission deadline 20 Dec 2025 | 4 articles | Viewed by 5507 | Submission Open

Keywords: antifungal resistance; antifungal therapy; drug discovery; molecular mechanisms

(This special issue belongs to the Section Molecular Microbiology)

Advances in Gastrointestinal Disease: Exploring the Interplay Between Inflammation, Autoimmunity, and Cancer

edited by Spyridon Siakavellas and

Stavros P. Papadakos

submission deadline 20 Dec 2025 | 2 articles | Viewed by 5468 | Submission Open

Keywords: gastrointestinal disease; inflammation; autoimmunity; gut microbiota

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Molecular Insights into Ischemia/Reperfusion: 2nd Edition

edited by

Moo-Ho Won

submission deadline 20 Dec 2025 | 5 articles | Viewed by 5416 | Submission Open

Keywords: vital organs; ischemic injury; cell and organ dysfunction; oxidative stress; inflammation; excitotoxicity

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

A Commemorative Issue in Honor of Professor Peter A. Ward: World Expert in Sepsis

edited by Peter Ward

submission deadline 20 Dec 2025 | 3 articles | Viewed by 5245 | Submission Open

Keywords: sepsis; neutrophils; macrophages; histones; chemical modifications; apoptosis; complement factors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

From Nature to Medicine: Exploring Natural Products for New Therapies

edited by

Alejandro Madrid

submission deadline 20 Dec 2025 | 3 articles | Viewed by 5216 | Submission Open

Keywords: secondary metabolites; flavonoids; terpenes; hemisynthetic compounds; cytotoxic activity; antimicrobial activity; antioxidant activity; natural products; essential oil; resinous exudate

(This special issue belongs to the Section Molecular Pharmacology)

Current Research on Plant Hormones Affecting Crop Yield and Fruit Quality

edited by

María Serrano

and

Daniel Valero

submission deadline 20 Dec 2025 | 1 articles | Viewed by 5204 | Submission Open

Keywords: auxins; gibberellins; citokynis; ethylene; yield; quality; antioxidant; storage

(This special issue belongs to the Section Molecular Plant Sciences)

Allergic Diseases: Molecular Insights into Immunotherapy

edited by Stefania Nicola

submission deadline 20 Dec 2025 | 3 articles | Viewed by 5176 | Submission Open

Keywords: component resolved diagnosis; allergen immunotherapy; molecular diagnostic; basophil activation test; anaphylaxis; allergy diagnosis; in vitro tests; in vivo tests; skin prick test

(This special issue belongs to the Section Molecular Immunology)

Lipid Metabolism and Biomarkers in Neural and Cardiometabolic Health

edited by

Elena Vianello

submission deadline 20 Dec 2025 | 4 articles | Viewed by 5135 | Submission Open

Keywords: lipid species; cardiovascular health; neural health; inflammation; cardiac biomarkers; neural biomarkers

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Systemic Sclerosis: New Insight into Pathogenesis, Molecular and Immune Mechanisms

edited by

Przemysław Kotyla

submission deadline 20 Dec 2025 | 3 articles | Viewed by 4923 | Submission Open

Keywords: systemic sclerosis; autoimmunity; inflammation; fibrosis; pathophysiology and treatment; profibrotic signaling; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Antifungal Drug Discovery: Progresses, Challenges, Opportunities, 2nd Edition

edited by

Bernhard Biersack

submission deadline 20 Dec 2025 | 4 articles | Viewed by 4787 | Submission Open

Keywords: antifungal drugs; fungal infections; drug design; drug discovery; targeted therapy; drug resistance; fungal drug targets; neglected tropical diseases

(This special issue belongs to the Section Molecular Pharmacology)

Antimicrobial Nanomaterials: Approaches, Strategies and Applications

edited by

Andrea Bernardos

submission deadline 20 Dec 2025 | 3 articles | Viewed by 4677 | Submission Open

Keywords: nanotechnology; biocides; antimicrobials; controlled release; drug delivery; antimicrobial agents; antimicrobial resistance; infection; nanoparticles

(This special issue belongs to the Section Materials Science)

Data Science in Cancer Genomics and Precision Medicine: 2nd Edition

edited by

Apostolos Zaravinos

submission deadline 20 Dec 2025 | 2 articles | Viewed by 4642 | Submission Open

Keywords: cancer genomics; big data; tumor immunology; translational oncology; precision medicine; next-generation sequencing; omics; cancer genomic datasets

(This special issue belongs to the Section Molecular Genetics and Genomics)

Biochemistry and Molecular Biology of Coronaviruses

edited by

Shu-Qun Liu

submission deadline 20 Dec 2025 | 3 articles | Viewed by 4572 | Submission Open

Keywords: SARS-CoV; MERS-CoV; COVID-19; RNA viruses; infection; antivirals; vaccines; therapeutics; host-virus interactions

(This special issue belongs to the Section Molecular Microbiology)

Signal Transduction Mechanism in Plant Disease and Immunity: 2nd Edition

edited by

Hideo Nakashita

and

Takumi Nishiuchi

submission deadline 20 Dec 2025 | 2 articles | Viewed by 4567 | Submission Open

Keywords: plant disease resistance; biotic stress; pathogen; plant-microbe interaction; priming; signal transduction; phytohormone; proteomics

(This special issue belongs to the Section Molecular Plant Sciences)

p53—Oncogene, Tumor Suppressor Gene, Guardian of the Genome and the Cell

edited by Przemyslaw Bozko

submission deadline 20 Dec 2025 | 3 articles | Viewed by 4514 | Submission Open

Keywords: p53; oncogene; tumor suppressor gene; tumor formation; anticancer therapy

(This special issue belongs to the Section Molecular Genetics and Genomics)

Biomarkers for Cardiovascular Risk Prediction

edited by

Sanja Stankovic

submission deadline 20 Dec 2025 | 2 articles | Viewed by 4503 | Submission Open

Keywords: biomarker; cardiovascular disease; risk stratification; inflammation; vascular damage; micro-RNA; therapy; artificial intelligence

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Biology of Fish Stress

edited by

Tao Yin

Yong Long

and

Min Jin

submission deadline 20 Dec 2025 | 4 articles | Viewed by 4445 | Submission Open

Keywords: fish stress; molecular biology; omics; apoptosis; inflammation

(This special issue belongs to the Section Molecular Biology)

Advances in Secondary Metabolites in Plants

edited by

Sławomir Dresler

submission deadline 20 Dec 2025 | 4 articles | Viewed by 4404 | Submission Open

Keywords: specialized metabolites; biosynthesis pathways; pharmacological applications; medicinal plants; plant stress resistance; abiotic and biotic elicitors; chemometric analysis; plant biotechnology; therapeutic potential; plant signaling and communication

(This special issue belongs to the Section Molecular Plant Sciences)

The Role of Epigenetics in Genome Maintenance and Its Relationship to Organismal Aging and Age-Related Diseases

edited by Berta Vázquez and Gerardo Ferrer

submission deadline 20 Dec 2025 | 3 articles | Viewed by 4396 | Submission Open

Keywords: chromatin; DNA damage; DNA repair; gene transcription; DNA replication; chromosome segregation; genome integrity; chromosome organization

(This special issue belongs to the Section Molecular Genetics and Genomics)

Recent Advances in Organic Chemistry: Molecule Synthesis and Reactions (2nd Edition)

edited by

José Justicia

and

Rachid Chahboun

submission deadline 20 Dec 2025 | 3 articles | Viewed by 4395 | Submission Open

Keywords: bioactive natural products; organocatalysis; photoredox reactions; free-radical reactions; organometallic reactions; organic synthesis

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Advances in Understanding Molecular Mechanisms Involved in Chronic Kidney Injury and Repair

edited by

Milica Bozic

submission deadline 20 Dec 2025 | 3 articles | Viewed by 4315 | Submission Open

Keywords: kidney disease; ischemic kidney injury; renal fibrosis; obesity; inflammation; oxidative stress; autophagy; senescence; cell death; small ncRNA

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neutrophil Extracellular Traps (NETs) in Immunity and Diseases, 3rd Edition

edited by

Jasmin Knopf

submission deadline 20 Dec 2025 | 3 articles | Viewed by 4307 | Submission Open

Keywords: neutrophils; neutrophil functions; neutrophil extracellular traps (NETs); NET biology; NETs in autoimmune diseases; NETs in immune response; NETs in the development and progression of cancer diseases; NETs in immunothrombosis; degradation of NETs

(This special issue belongs to the Section Molecular Immunology)

Psoriasis: Molecular Research and Novel Therapy

edited by Tsen-Fang Tsai

submission deadline 20 Dec 2025 | 1 articles | Viewed by 4247 | Submission Open

Keywords: psoriasis; pathogenesis; treatment; biologics; novel therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Advances in Cancer Genomics

edited by

Yoshihito Kano

submission deadline 20 Dec 2025 | 3 articles | Viewed by 4233 | Submission Open

Keywords: cancer genomics; biomarker discovery; precision oncology; KRAS and undruggable targets; artificial intelligence in oncology; multi-omics data integration; drug discovery

(This special issue belongs to the Section Molecular Biology)

Pharmacological Treatment of Neuroinflammation

edited by Beatrice Polini

submission deadline 20 Dec 2025 | 2 articles | Viewed by 4221 | Submission Open

Keywords: microglia; neuroinflammation; neurodegeneration; Alzheimer’ s disease; Parkinson’ s disease; therapeutic; natural molecules

(This special issue belongs to the Section Molecular Neurobiology)

Emerging Insights into Phytohormone Signaling in Plants

edited by Meng Zhang

submission deadline 20 Dec 2025 | 5 articles | Viewed by 4171 | Submission Open

Keywords: phytohormone; signal transduction; evolutionary and functional diversity; implications for plant science and agriculture

(This special issue belongs to the Section Molecular Plant Sciences)

Recent Advances in 3D Tumor Models for Cancer Research

edited by

Simona Campora

Francesco Lopresti

and

Alessandra Lo Cicero

submission deadline 20 Dec 2025 | 2 articles | Viewed by 4097 | Submission Open

Keywords: 3D systems; cancer research; spheroids; organoids; organ-on-chip; scaffolds; tissue engineering; biomedical technologies; tumor microenvironment

(This special issue belongs to the Section Molecular Oncology)

Toxicity Mechanism of Emerging Pollutants: 2nd Edition

edited by

Monika Naumowicz

and

Joanna Kotyńska

submission deadline 20 Dec 2025 | 4 articles | Viewed by 4075 | Submission Open

Keywords: emerging pollutant; toxicology; cancer; EDC; pesticides; microplastic; human cell lines; environment; molecular mechanisms

(This special issue belongs to the Section Molecular Toxicology)

Latest Advances in Diabetes Research and Practice

edited by Ezekiel Uba Nwose

submission deadline 20 Dec 2025 | 2 articles | Viewed by 4053 | Submission Open

Keywords: diabetes mellitus; cardiovascular risk; metabolic syndrome; antioxidants; oxidative stress; antiplatelet monitoring; evidence-based medicine; laboratory medicine

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Pathophysiology and Treatment of Alzheimer's Disease

edited by

Jeffrey Fessel

submission deadline 20 Dec 2025 | 1 articles | Viewed by 4024 | Submission Open

Keywords: Alzheimer's disease; Alzheimer’ s dementia; neurodegeneration; AD; pathogenesis; cure for AD

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights: Transitioning Fertility Research from the Laboratory to Clinical Practice

edited by Ekaterini Domali

submission deadline 20 Dec 2025 | 1 articles | Viewed by 3994 | Submission Open

Keywords: IVF/ICSI; male infertility; female infertility; fertility outcomes; endocrine disruptors; oxidative and reductive stress; molecular biology; biomarkers; proteomics; metabolomics; and transcriptomics; cell lines; early pregnancy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Power Up Plant Genetic Research with Genomic Data: 3rd Edition

edited by

Hon-Ming Lam

Sachiko Isobe

and

Man-Wah Li

submission deadline 20 Dec 2025 | 2 articles | Viewed by 3943 | Submission Open

Keywords: genome sequencing; optical mapping; genome editing; population genomics; genome-wide; association mapping; functional genomics; epigenomics; genetic interaction; chromatin; biodiversity

(This special issue belongs to the Section Molecular Genetics and Genomics)

Ovarian Cancer: Pathogenesis, Biomarkers and Treatment

edited by Alessandro Antonio Buda

submission deadline 20 Dec 2025 | 2 articles | Viewed by 3929 | Submission Open

Keywords: ovarian cancer; radiotherapy; diagnosis; prevention; treatment; fertility sparing

(This special issue belongs to the Section Molecular Oncology)

Arthritis: Focus on Pathologies, Symptoms and Therapy

edited by

Katarína Bauerová

submission deadline 20 Dec 2025 | 1 articles | Viewed by 3890 | Submission Open

Keywords: rheumatoid arthritis; autoimmune; pathogenesis; strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Rapeseed: Genetic Breeding, Key Trait Mining and Genome

edited by Hongbo Chao

submission deadline 20 Dec 2025 | 3 articles | Viewed by 3880 | Submission Open

Keywords: rapeseed (Brassica napus L.); genetic breeding; genomic improvement; molecular markers; genome-wide association studies (GWAS); multi-omics integration; CRISPR gene editing; marker-assisted selection (MAS); stress resistance traits; yield and oil content improvement

(This special issue belongs to the Section Molecular Plant Sciences)

Displaying special issue 551-600 on page 12 of 70.

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