Targeting Metabolic Reprogramming: From Pathogenesis to Therapeutic Strategies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: closed (20 May 2025) | Viewed by 826
Special Issue Editors
Interests: myelin; oligodendrocyte; neurodegenerative disease; metabolism
Interests: immunopathology; oncology; haemathology; autoinmune diseases
Interests: Alzheimer’s disease; transgenic models; neuroinflammation; tauopathy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Metabolic reprogramming is a hallmark of cancer cells, but it also occurs in other pathological conditions such as chronic lung diseases, rheumatoid arthritis, cardiovascular diseases, neurodegenerative diseases, and viral pathogenesis, among others.
Despite the increasing interest in this field, the molecular mechanisms underlying metabolic reprogramming in many of the above-mentioned pathologies are still scarce. Metabolic reprogramming might involve changes in glycolysis, the pentose phosphate pathway, glutaminolysis, mitochondrial metabolism, lipid metabolism, amino acid metabolism, or any other biosynthetic and bioenergetic pathways. Therefore, any natural or synthetic compound capable of modifying the activity of any of these pathways altered in the aforementioned diseases might be considered a potential therapeutic candidate to test.
This Special Issue aims to gather a broad collection of any basic and preclinical research that investigates metabolic reprogramming as a key regulator in diverse disease pathogenesis and as a novel target to decipher innovative therapeutic strategies.
Dr. Beatriz García-Díaz
Prof. Dr. Alejandro Escamilla
Prof. Dr. Raquel Sanchez-Varo
Guest Editors
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Keywords
- metabolism
- therapy
- mitochondria
- pathogenesis
- bioenergetics
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