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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Protein Signal Transduction in the Nucleus

edited by Jaekyung Shim

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2147 | Submission Open

Keywords: inner nuclear membrane protein; protein network; LEM-domain proteins; nuclear lamina; signal transcription; transcriptional regulation

(This special issue belongs to the Section Molecular Biology)

The Pathogenesis of Alcohol-Associated Hepatitis and Its Therapies

edited by

Mrigya Babuta

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2095 | Submission Open

Keywords: alcohol-associted hepatitis; acute kidney injury; hepatic encephalopathy; adaptive immune response; innate immune response; neutrophilia

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research on Tumor Suppressor Proteins

edited by Jie Liu

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2046 | Submission Open

Keywords: DNA repair; genome stability; tumor suppressor; BRCA1; BRCA2; PALB2; RAD51C

(This special issue belongs to the Section Molecular Oncology)

Advanced Research on the Physiology and Toxicology of Aquatic Animals

edited by Xin Zhang

submission deadline 20 Jan 2026 | 2 articles | Viewed by 1985 | Submission Open

Keywords: aquatic ecosystem; physiology of aquatic animals; toxicology of aquatic animals; environmental adaptability; environmental pollutants; ecotoxicology; biomarkers; risk assessment

(This special issue belongs to the Section Molecular Biology)

Oxidative Stress in Dermatology, Aesthetics and Regenerative Medicine

edited by

Eugenio Luigi Iorio

submission deadline 20 Jan 2026 | Viewed by 1917 | Submission Open

Keywords: oxidative stress; redox system; antioxidant chemical species; dermatology; aesthetics; regenerative medicine; inflammatory; degenerative skin diseases

(This special issue belongs to the Section Molecular Biology)

Molecular Crosstalk in Breast Cancer Progression and Therapies

edited by Giuseppina Daniela Naimo

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1912 | Submission Open

Keywords: breast cancer; endocrine therapy; drug resistance; breast tumor microenvironment; targeted therapies; personalized therapies; immunotherapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Breeding and Genetic Regulation of Crops, 2nd Edition

edited by

Chiara Biselli

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1884 | Submission Open

Keywords: molecular breeding; genetic regulation; genomics; genome-editing techniques; epigenetic modifications

(This special issue belongs to the Section Molecular Plant Sciences)

Role of Cell Metabolism in Cancer Biology

edited by

Silvia Filippi

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1873 | Submission Open

Keywords: cancer cells metabolism; target therapy; PI3K/Akt/mTOR pathway; hypoxia

(This special issue belongs to the Section Molecular Oncology)

Modulating the Function of the Immune System by Thyrotropin and Thyroid Hormones

edited by Graciela Alicia Cremaschi and Claudia Gabriela Pellizas

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1841 | Submission Open

Keywords: thyrotropin (TSH); thyroid hormones (THs); immune modulation; immunology; immune; autoimmune; immunoendocrinology; hypothalamic-pituitary-thyroid axis; antitumor immune response

(This special issue belongs to the Section Molecular Immunology)

The Impact of Cancer–Immune Cell Crosstalk on Diagnosis, Prognosis and Treatment

edited by Fabricio Figueiro

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1833 | Submission Open

Keywords: protumoral immunity; anticancer immunity; crosstalk; tumor microenvironment; purinergic signaling; immune checkpoints; immunometabolism; extracellular vesicles; RNA communication

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Ozone Therapy

edited by

Francisco Rodríguez-Esparragón

Bernadino Clavo

and

Jacob Lorenzo-Morales

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1688 | Submission Open

Keywords: antioxidant response; cellular stress responses; inflammatory signaling; mitochondrial function; molecular pathways; Nrf2; oxidative stress; ozone therapy; redox regulation; antimicrobial resistance; infectious diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Latest Research in Photocatalysis

edited by

María Teresa Colomer

submission deadline 20 Jan 2026 | 2 articles | Viewed by 1678 | Submission Open

Keywords: design; simulation; synthesis; properties; functionalities; reactions; photocatalysis

(This special issue belongs to the Section Biochemistry)

Advances and Applications in Molecular Enzymology

edited by

Gustavo Molina

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1646 | Submission Open

Keywords: microbial enzymes; biosynthesis and bioengineering; drug development and targets; enzymes in the environment; engineered enzymes; enzymes in agri-food; enzymatic formulations; enzyme engineering; enzymes in biomedical sciences; green chemistry/technology; glycans; molecular evolution; nanocatalyst and nanotechnology; pharma enzymes; recombinant proteins production and purification; system and synthetic biology

(This special issue belongs to the Section Biochemistry)

Molecular Research in Animal Nutrition

edited by Jie Fu

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1621 | Submission Open

Keywords: animal nutrition; animal immunity; epigenetics; m6A methylation; gut microbiota; host– microbiome interaction; metabolic reprogramming

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Insights and Regulation Mechanisms of Tea Quality

edited by

Xujun Zhu

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1617 | Submission Open

Keywords: molecular ecology; spectroscopic techniques; tea quality; tea plant growth

(This special issue belongs to the Section Molecular Plant Sciences)

Gluten/Wheat-Related Disorders: The Role of Nutrition, Gut Barrier, Microbiota, and New Therapeutic Strategies

edited by Lisa Lungaro

submission deadline 20 Jan 2026 | 2 articles | Viewed by 1576 | Submission Open

Keywords: gluten-related disorders; celiac disease; non celiac gluten wheat sensitivity; gluten free diet; microbiota; gut barrier; probiotics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Plant Nematology Research

edited by

Sergei A. Subbotin

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1556 | Submission Open

Keywords: DNA barcoding; Molecular evolution; Genomes; Molecular systematics; Phylogenetics; Plant– nematode interactions; Transcriptomics

(This special issue belongs to the Section Molecular Plant Sciences)

The Role of Extracellular Histones in Patho(physio)logical Hemostasis

edited by Fabrizio Semeraro and

Mauro Coluccia

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1526 | Submission Open

Keywords: extracellular histones; hemostasis; platelets; coagulation; fibrinolysis; thrombosis; inflammation; extracellular traps

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Coagulation Factors and Natural Anticoagulants in Health and Disease

edited by

Zsuzsanna Bereczky

submission deadline 20 Jan 2026 | 2 articles | Viewed by 1465 | Submission Open

Keywords: coagulation factor; natural anticoagulant; hemostasis; thrombosis; molecular studies; molecular interactions; structure; functional studies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Endothelial Cells in Health and Disease

edited by

Alessia Ricci

and

Amelia Cataldi

submission deadline 20 Jan 2026 | 2 articles | Viewed by 1385 | Submission Open

Keywords: endothelial cells; vascular homeostasis; tissue homeostasis; endothelial cell biology; endothelial cells dysfunction; oxidative stress; redox signaling; aging; endothelial regulation of tissue repair

(This special issue belongs to the Section Molecular Biology)

Fibrotic Disease: From Pathophysiology to Treatment

edited by Galina S. Bogatkevich

submission deadline 20 Jan 2026 | Viewed by 1364 | Submission Open

Keywords: lung; liver; heart; kidney; fibrosis; systemic sclerosis; mechanisms; pathophysiology; therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Protein Design and Engineering in Biochemistry

edited by Om Prakash Narayan

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1345 | Submission Open

Keywords: protein engineering; molecular biology; biochemical tools; computational protein design; directed evolution; CRISPR/Cas9; synthetic biology; biomaterials; protein therapeutics; regenerative medicine

(This special issue belongs to the Section Molecular Biology)

Wound Repair: From Basic Biology to Tissue Engineering

edited by

Magdalena Paczkowska-Walendowska

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1343 | Submission Open

Keywords: wound healing; tissue engineering; biomaterials; regenerative medicine; chronic wounds

(This special issue belongs to the Section Molecular Biology)

Research Progress on Oocyte Development

edited by

Ken-ichi Sato

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1319 | Submission Open

Keywords: oocyte maturation; germ cell development; folliculogenesis; oocyte quality; egg cell development; oocyte activation; meiotic progression; fertility

(This special issue belongs to the Section Molecular Biology)

Nanoscience in Plants: Omics Approaches to Elucidate the Role of Nanoparticles

edited by

Setsuko Komatsu

and Zahed Hossain

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1310 | Submission Open

Keywords: nanoparticles; plant; omics-based techniques; bioinformatics; systems biology; nanotoxicology

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Mass Spectrometry-Based Proteomics: From Biomarker Discovery to Translational Applications

edited by

Yanlong Ji

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1299 | Submission Open

Keywords: mass spectrometry; LC-MS method development; phosphoproteomics; glycoproteomics; biomarker discovery; multi-omics data integration

(This special issue belongs to the Section Biochemistry)

Studying Multi-Target Drug Approaches and Posttranslational Modification (PTM) Therapies

edited by

Guo-Ping Zhou

submission deadline 20 Jan 2026 | 2 articles | Viewed by 1282 | Submission Open

Keywords: multi-target therapy; network analysis tools; multi-label proteins; web-server predictor; posttranslational modifications (PTMs); 3D structures; rational drug design

(This special issue belongs to the Section Molecular Informatics)

Research Progress and Therapeutic Targets of Chronic Kidney Disease

edited by

Stefanos Roumeliotis

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1266 | Submission Open

Keywords: blood pressure; cardiovascular disease; chronic kidney disease; diabetes; hypertension; inflammation; oxidative stress; sodium glucose transporter-2; vascular calcification

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular and Immune Mechanisms in Pathogenic Mycobacteria Infections

edited by Fabiana Bigi and Federico Carlos Blanco

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1230 | Submission Open

Keywords: Mycobacterium tuberculosis; virulence; pathogens

(This special issue belongs to the Section Molecular Microbiology)

New Insights into Chronic Inflammatory Demyelinating Polyneuropathy and Neuroimmunological Diseases

edited by

Fumitaka Shimizu

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1204 | Submission Open

Keywords: chronic inflammatory demyelinating polyneuropathy (CIDP); multiple sclerosis (MS); neuromyelitis optica spectrum disorder (NMOSD); myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD); autoimmune encephalitis; paraneoplastic neurological syndrome; Guillain-Barre syndrome (GBS); myositis; blood-brain barrier; blood-nerve barrier

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Studies on Oral Disease and Treatment

edited by

Daniela Adamo

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1202 | Submission Open

Keywords: oral cancer; oral mucosal lesions; chronic pain; temporomandibular joint disorders; periodontal diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Paradigm Iconoclasm

edited by

Vance G. Nielsen

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1196 | Submission Open

Keywords: paradigm shift; biochemistry; cell signaling; coagulation; toxinology

(This special issue belongs to the Section Biochemistry)

Unraveling the Enigma of Colorectal Cancer: From Mechanisms to Therapeutic Advances

edited by Valentina Belli and

Vincenza Ciaramella

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1173 | Submission Open

Keywords: Colorectal cancer; tumour microenvironment; epigenetics; diagnostic molecules; immune evasion; biomarkers; drug resistance; precision medicine; targeted

(This special issue belongs to the Section Molecular Oncology)

Computational Genomics and Bioinformatics in Microbiology

edited by

Andreas Martin Lisewski

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1166 | Submission Open

Keywords: computational microbial genomics; comparative genomics; structural genomics; functional genomics; genomic data bioinformatics

(This special issue belongs to the Section Molecular Informatics)

Tuberculosis: Host Immunity, Diagnosis and Treatment

edited by

Veronica Edith Garcia

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1148 | Submission Open

Keywords: tuberculosis; immune response; diagnosis; treatment; antibiotics; resistance

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Biomarker Discovery for Rare Diseases

edited by

Bridget E. Bax

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1133 | Submission Open

Keywords: biomarker; rare diseases; pathological processes; cystic fibrosis; Duchenne muscular dystrophy; Ehlers-Danlos syndrome; haemophilia; sickle cell disease; primary biliary cholangitis; fabry disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in the Molecular Diagnosis and Treatment of Neurodegenerative Diseases

edited by

Bruno Manadas

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1118 | Submission Open

Keywords: neurodegenerative disorders; biomarkers; treatment; omics; systems biology

(This special issue belongs to the Section Molecular Neurobiology)

Radiolabeled Compounds for Theranostic Applications in Oncology

edited by

Cyril Fersing

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1102 | Submission Open

Keywords: radiopharmaceuticals; theranostic; cancer therapy; targeted radionuclide therapy; molecular imaging; positron emission tomography; single-photon emission tomography; radiolabeling

(This special issue belongs to the Section Molecular Oncology)

Hormonal and Metabolic Markers in Health and Disease

edited by

Rafał Podgórski

and

Kornelia Łach

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1095 | Submission Open

Keywords: hormonal biomarkers; molecular mechanism of endocrine disorders; steroidogenesis; hormonal dysregulation; endocrine disruptors; metabolomics; metabolic regulation

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Biotic and Abiotic Stress Responses of Vegetable Crops

edited by Yongqiang Tian

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1092 | Submission Open

Keywords: vegetable crops; biotic stress; abiotic stress; physiological responses; molecular mechanisms; genetic mechanisms; resistance breeding; resistance biotechnology; management strategies

(This special issue belongs to the Section Molecular Plant Sciences)

Progress in Adipokines Research in Cardiovascular Health and Diseases

edited by

Morris Karmazyn

submission deadline 20 Jan 2026 | 1 articles | Viewed by 972 | Submission Open

Keywords: adipokine receptors and cell signalling; adipokines and heart failure and hypertrophy; adipokines and myocardial ischemia; adipokines and hypertension; adipokines and thrombosis/atherosclerosis; adipokines and vascular/endothelial function; structure; and integrity; adipokines and cardiovascular inflammation; adipokines; adiposity; and cardiovascular disease in obesity

(This special issue belongs to the Section Molecular Biology)

Chemical Tools for Microbial Functionalization: Bridging Organic Chemistry and Biotechnology

edited by Stefania Cicco and

Danilo Vona

submission deadline 20 Jan 2026 | Viewed by 933 | Submission Open

Keywords: organometallic biochemistry; green chemistry; bioorthogonal; living polymers; living functionalization; hybrid materials

(This special issue belongs to the Section Molecular Microbiology)

Microbial Omics: Decoding Microbial Life

edited by

Nicole Hansmeier

submission deadline 20 Jan 2026 | 1 articles | Viewed by 928 | Submission Open

Keywords: omics technologies; omics methodologies; microorganisms; proteomics; genomics; transcriptomics; bioinformatics; artificial intelligence for omics; microbial physiology; microbial adaptation to environmental challenges; interspecies and host-microbe interactions; environmental monitoring

(This special issue belongs to the Section Molecular Microbiology)

Molecular Mechanisms of Sarcoma Initiation and Metastasis

edited by

Shinji Miwa

submission deadline 20 Jan 2026 | 1 articles | Viewed by 915 | Submission Open

Keywords: sarcoma; molecular target; metastasis; apoptosis; angiogenesis; microenvironment

(This special issue belongs to the Section Molecular Oncology)

Hearing Loss: Molecular Biological Insights, 2nd Edition

edited by María Beatriz Durán-Alonso

submission deadline 20 Jan 2026 | 1 articles | Viewed by 909 | Submission Open

Keywords: genetics; microRNA; epigenetics; CRISPR; multi-omics; presbycusis; ototoxicity; development

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Bioactive Natural Products in Human Health

edited by

Eleonora Di Salvo

submission deadline 20 Jan 2026 | 1 articles | Viewed by 900 | Submission Open

Keywords: bioactive compound; human health; functional foods; nutraceutical products; food toxicology; antioxidant properties; anti-inflammation; antimicrobial molecules

(This special issue belongs to the Section Molecular Pharmacology)

The Brain’s Regeneration Potential: The Role of Neural Progenitor Cells in Neuropsychiatric Therapy

edited by

Beatriz Caballero

and

Yaiza Potes

submission deadline 20 Jan 2026 | 1 articles | Viewed by 858 | Submission Open

Keywords: neural stem cells; neural progenitor cells; neuropsychiatric disorders; neurodegeneration; neurogenesis; neuroplasticity; melatonin; psychoactive drugs

(This special issue belongs to the Section Molecular Neurobiology)

Lipid Droplet–Mitochondria Interactions in Health and Disease

edited by Anton Petcherski

submission deadline 20 Jan 2026 | Viewed by 792 | Submission Open

Keywords: mitochondria; lipid droplets; metabolism; lipotoxicity; metabolically active tissue; triacylglycerides; fatty acid oxidation

(This special issue belongs to the Section Biochemistry)

Pathogenesis and Therapy of Oral Carcinogenesis, 3rd Edition

edited by

Marko Tarle

and

Ivica Lukšić

submission deadline 20 Jan 2026 | Viewed by 758 | Submission Open

Keywords: oral cancer; oral premalignant disorders; tumor microenvironment; molecular biomarkers; targeted therapy; oral tumorigenesis

(This special issue belongs to the Section Molecular Oncology)

Chitosan: Structural and Chemical Modification, Properties and Application, 2nd Edition

edited by

Joanna Kluczka

submission deadline 20 Jan 2026 | 1 articles | Viewed by 749 | Submission Open

Keywords: chitosan modification; adsorption removal; membrane separation; food preservation; environmental remediation; wastewater treatment; disease treatment; agricultural production; tissue engineering

(This special issue belongs to the Section Macromolecules)

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