Studying Multi-Target Drug Approaches and Posttranslational Modification (PTM) Therapies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Informatics".
Deadline for manuscript submissions: 30 July 2025 | Viewed by 42
Special Issue Editor
2. National Engineering Research Center for Non-Food Biorefinery, Guangxi Academy of Sciences, Chinese Academy of Agriculture Science, Nanning 530004, China
Interests: structural and dynamic studies of protein and DNA by solution NMR spectroscopy; computer modeling of protein-DNA, protein-drug complex, bioinformatics, as well as interactions of protein-protein, and protein-drug; the studies of introduction of graphic methods into biological systems
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Special Issue Information
Dear Colleagues,
Multi-target therapy is the favoured pathway for achieving desired treatment effects in cancer and nervous system, cardiovascular system, and immune system diseases. Network analysis tools and computational prediction approaches have been incorporated into research of the basic mechanisms of these diseases. These computational approaches are novel, and are closely associated with the identification of the subcellular localization of so-called “multi-label” proteins. Recently, user-friendly web-server predictors have been established, whereby users can easily attain their desired results for multi-label proteins in eukaryotic, human, animal, plant, Gram-positive, and Gram-negative organisms, respectively. Posttranslational modifications (PTMs) are related to a number of diseases. In order to obtain targets’ 3D structures for rational drug design in a timely and accurate manner, both theoretical and experimental approaches of structural biology are used. Certain intermolecular and intramolecular interactions related to the migration and invasion of tumor cells may occur during the PTM process. In this Special Issue, recent advances in studying multi-target therapies and PTM will be collected. These studies may provide new perspectives on drug research and development related to tumor-targeted enzymes.
Prof. Dr. Guo-Ping Zhou
Guest Editor
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Keywords
- multi-target therapy
- network analysis tools
- multi-label proteins
- web-server predictor
- posttranslational modifications (PTMs)
- 3D structures
- rational drug design
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