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Research Progress on Oocyte Development

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 369

Special Issue Editor


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Guest Editor
Faculty of Life Sciences, Kyoto Sangyo University, Kamigamo-Motoyama, Kita-ku, Kyoto 603-8555, Japan
Interests: fertilisation; oogenesis; oocyte maturation; early development; oncogene; membrane microdomain; signal transduction
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Special Issue Information

Dear Colleagues,

The International Journal of Molecular Sciences (IJMS) is pleased to announce this Special Issue, titled “Research Progress on Oocyte Development”. It aims to bring together the latest advances in understanding the molecular mechanisms underlying oocyte development across diverse model organisms. Recent breakthroughs in genomics, proteomics, and advanced imaging technologies have provided unprecedented insights into oocyte growth, maturation, and the regulatory pathways governing meiotic progression. Moreover, we seek to highlight novel findings related to oogenesis, cytoskeletal dynamics, organelle reorganization, molecular signaling, and epigenetic modifications that shape oocyte competence and fertility. We invite original research articles, comprehensive reviews, and cutting-edge methodologies that address fundamental questions and emerging challenges in oocyte biology. Contributions from studies on external fertilization models, such as Xenopus, are especially welcome, as they offer valuable perspectives on comparative oocyte biology. Keywords include oogenesis, meiosis, oocyte maturation, cytoskeleton, organelle dynamics, signaling pathways, epigenetic regulation, and fertilization. Our goal is to provide a platform for researchers to showcase their innovative work, fostering collaboration and advancing our collective understanding of oocyte development in health and disease.

Prof. Dr. Ken-ichi Sato
Guest Editor

Manuscript Submission Information

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Keywords

  • oocyte maturation
  • germ cell development
  • folliculogenesis
  • oocyte quality
  • egg cell development
  • oocyte activation
  • meiotic progression
  • fertility

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Published Papers (1 paper)

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Review

15 pages, 1579 KiB  
Review
Egg Overactivation—An Overlooked Phenomenon of Gamete Physiology
by Alexander A. Tokmakov and Ken-Ichi Sato
Int. J. Mol. Sci. 2025, 26(9), 4163; https://doi.org/10.3390/ijms26094163 - 27 Apr 2025
Viewed by 215
Abstract
In many vertebrates, mature ovulated eggs are arrested at metaphase II prior to fertilization. The eggs exit meiotic arrest after fertilization-induced or parthenogenetic activation, followed by embryo development or egg degradation, respectively. Calcium-dependent activation of meiotically-arrested eggs has been thoroughly investigated in various [...] Read more.
In many vertebrates, mature ovulated eggs are arrested at metaphase II prior to fertilization. The eggs exit meiotic arrest after fertilization-induced or parthenogenetic activation, followed by embryo development or egg degradation, respectively. Calcium-dependent activation of meiotically-arrested eggs has been thoroughly investigated in various species. In addition, several recent studies have detailed the excessive activation of ovulated frog eggs, so-called overactivation. This overview highlights the major events of overactivation observed in mature ovulated eggs of the African clawed frog Xenopus laevis with a focus on similarities and differences between spontaneous, oxidative stress-induced, and mechanical stress-induced overactivation. The dramatically different cell death scenarios that unfold in activated and overactivated eggs are also exposed in the article. Full article
(This article belongs to the Special Issue Research Progress on Oocyte Development)
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