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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Novel Cell Signaling Targets and Mechanism for Effective Individualized Therapies

edited by Kazuyuki Matsushita

submission deadline 30 Nov 2025 | Viewed by 126 | Submission Open

Keywords: novel cell signaling targets; individualized therapies; addiction signal pathway; diagnosis and treatment; cancer; neurodegenerative diseases; cell development

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Current Treatment Models in Hepatocellular Carcinomas

edited by

Michał P. Wasilewicz

submission deadline 30 Nov 2025 | Viewed by 124 | Submission Open

Keywords: hepatocellular carcinoma (HCC); liver tumors; liver cancer; molecular mechanisms; systemic therapies; immunochemotherapy; immunotherapy; adjuvant therapy; neoadjuvant therapy; hepatocellular carcinoma microenvironment; liver resection/liver transplantation in HCC; microwave ablation (MWA); transarterial chemoembolisation (TACE)

(This special issue belongs to the Section Molecular Oncology)

The Role of Natural Products in the Treatment and Prevention of Human Diseases

edited by

Jae-Hyun Kim

submission deadline 30 Nov 2025 | Viewed by 124 | Submission Open

Keywords: natural products; bone metabolism; sarcopenia; osteoporosis; herbal medicine; osteo-sarcopenic obesity; bone– muscle crosstalk; low-molecular-weight compounds

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Natural Product-Inspired Anticancer Drug Development

edited by

Erzsébet Mernyák

submission deadline 30 Nov 2025 | Viewed by 123 | Submission Open

Keywords: anticancer; antiproliferative; cytotoxic; natural product; drug development; semi-synthesis; total synthesis; structure– activity relationship; computational simulation; enzyme inhibition

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Nutrition in Neurodegenerative Diseases: Molecular Perspectives

edited by

Vittorio Emanuele Bianchi

submission deadline 30 Nov 2025 | Viewed by 123 | Submission Open

Keywords: nutrition; neurodegenerative disease; phenols; B vitamins; alpha-tocotrienol; dietary factors; intestinal microbiota; central nervous system

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Insights into Serotonin

edited by Joachim Neumann

submission deadline 30 Nov 2025 | Viewed by 122 | Submission Open

Keywords: serotonin; serotonin receptors; migraine; depression; hypertension; heart failure; arrhythmias

(This special issue belongs to the Section Molecular Biology)

Molecular Advances in Translational Infectious Diseases Research

edited by

Carlo Acierno

submission deadline 30 Nov 2025 | Viewed by 121 | Submission Open

Keywords: translational medicine; molecular pathogenesis; host– pathogen interaction; antimicrobial resistance; immune evasion; microbiome and infection; biomarkers; multi-omics approaches; infectious disease models; personalized infectious disease therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Studies of DNA Strand Exchange

edited by

Masayuki Takahashi

submission deadline 30 Nov 2025 | Viewed by 119 | Submission Open

Keywords: DNA strand exchange; homologous recombination: RecA-family recombinases; drug resistance: drug development against recombinases; evolution

(This special issue belongs to the Section Molecular Biophysics)

Nanobiotechnology: Breaking Barriers in Phytomedicine

edited by

Maria Aparecida Medeiros Maciel

submission deadline 30 Nov 2025 | Viewed by 117 | Submission Open

Keywords: nanotechnology; nanobiotechnology; phytocompounds; phytochemistry; natural products

(This special issue belongs to the Section Molecular Nanoscience)

Ion Regulation in Human Pathophysiology

edited by

Lars Kaestner

submission deadline 30 Nov 2025 | Viewed by 116 | Submission Open

Keywords: ion channels; ion gradients; membrane potential; action potential; ion pumps; uniporter; co-transporter; patch-clamp; ion flux; concentration gradient; ion stores; physiological processes; pathophysiological processes

(This special issue belongs to the Section Molecular Biology)

Roles of Phytochemicals in Molecular Signaling Networks

edited by

Jui-Hung Yen

submission deadline 30 Nov 2025 | Viewed by 112 | Submission Open

Keywords: phytochemicals; molecular signaling pathways; inflammation; apoptosis; chronic diseases; cancer; cardiovascular diseases; structure– activity relationships

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Natural Product Therapies in Cancer

edited by

Domenica Mangieri

submission deadline 30 Nov 2025 | Viewed by 111 | Submission Open

Keywords: natural compounds; phytochemicals; flavonoids; alkaloids; metastasis; epithelial– mesenchymal transition; cancer cell invasion; cell cycle; programmed cell death; signaling pathways

(This special issue belongs to the Section Molecular Pharmacology)

Advancements in Cardiovascular Health Research: Investigating Novel Biomaterials, Cellular Responses, and Therapeutic

edited by Magdalena Wawrzyńska

submission deadline 30 Nov 2025 | Viewed by 111 | Submission Open

Keywords: cardiovascular biomaterials; nanomaterials; surface coatings; drug delivery systems; polymers; biocompatibility; hemocompatibility; molecular response

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Wired for Change: Neurotransmitter Plasticity and Circuit Dynamics in Health and Disease

edited by Alessandra Porcu

submission deadline 30 Nov 2025 | Viewed by 110 | Submission Open

Keywords: neurotransmitter; behavioral neuroscience; neuropsychiatric disorders; neurological disorders; neuroplasticity; neuronal circuit

(This special issue belongs to the Section Molecular Neurobiology)

Viral Infections: Molecular, Cellular, and Systems Perspectives

edited by Arnaldo Caruso and

Francesca Caccuri

submission deadline 30 Nov 2025 | Viewed by 110 | Submission Open

Keywords: virus– host interaction; epidemiology; evolution; innate immunity; computational modeling

(This special issue belongs to the Section Molecular Microbiology)

Immunity and Autoimmunity in Cardiovascular and Respiratory Diseases

edited by

Mizanur Rahman

submission deadline 30 Nov 2025 | Viewed by 108 | Submission Open

Keywords: cardiovascular diseases; respiratory diseases; autoimmune diseases; T cell; B cell; lipid mediators; autoantibodies; genetic variants; mucin

(This special issue belongs to the Section Molecular Immunology)

Advances in Targeted Therapies and Immunometabolic Pathways in Cancer

edited by Medhi Wangpaichitr

submission deadline 30 Nov 2025 | Viewed by 106 | Submission Open

Keywords: immunotherapy; targeted therapy; tumor metabolism pathway; tumor microenvironment; immune checkpoint blockade; immune evasion; glucose/amino acids/lipid metabolism

(This special issue belongs to the Section Molecular Immunology)

New Strategy on Diagnosis and Treatment of Meningioma and Glioma

edited by

Giuseppe Lombardi

submission deadline 30 Nov 2025 | Viewed by 102 | Submission Open

Keywords: meningiomas; gliomas; molecular characterization; biomarker discovery; targeted therapy; neuroimaging; artificial intelligence

(This special issue belongs to the Section Molecular Oncology)

Deciphering Allergies—Structural and Immunological Characterization of Allergenic Proteins and Immunomodulatory Agents: 2nd Edition

edited by

Marija Gavrović-Jankulović

submission deadline 30 Nov 2025 | Viewed by 96 | Submission Open

Keywords: allergen; allergenicity; IgE; innate immunity; exposome; cross-reactivity; B cell epitopes; T cell epitopes; in silico prediction

(This special issue belongs to the Section Molecular Immunology)

Structure and Function of Subcellular Organelle and Protein-Membrane Systems

edited by

Chikara Sato

submission deadline 30 Nov 2025 | Viewed by 95 | Submission Open

Keywords: immuno-electron microscopy; cell signaling; comparative anatomy; diagnosis; molecular recognition; molecular complexes; electro-chemistry; liquid-phase synthesis; metal sedimentation; membrane endoskeleton

(This special issue belongs to the Section Molecular Biophysics)

Artificial Intelligence and Data Science for the Discovery of Anticancer Targets and Decision Support

edited by

Soumia Ziti

submission deadline 30 Nov 2025 | Viewed by 95 | Submission Open

Keywords: artificial intelligence in oncology; data science and decision support in cancer therapy; target discovery and biomarker identification; machine learning and multi-omics integration; predictive modeling in precision medicine

(This special issue belongs to the Section Molecular Informatics)

Molecular Insights into Microbial Adaptations to Marine Plastics

edited by

Matan Oren

submission deadline 30 Nov 2025 | Viewed by 94 | Submission Open

Keywords: plastisphere; marine plastic debris; microbial colonization; biofilms; microbial adaptation; community assembly; quorum sesing; plastic biodegradation; biogeochemical cycling; antibiotic resistance genes; marine microbial ecology; metagenomics; microbe– plastic interactions; microbial succession

(This special issue belongs to the Section Molecular Microbiology)

Signaling in Cells Proliferating in Two- and Three-Dimensional Cultures

edited by Hedwig Sutterluety-Fall

submission deadline 30 Nov 2025 | Viewed by 92 | Submission Open

Keywords: proliferation; signaling; two-dimensional; three-dimensional; cell culturing; in vitro; growth factors

(This special issue belongs to the Section Molecular Biology)

Intestinal Immune System and Anti-Inflammatory Pathways

edited by

Moira Paroni

submission deadline 30 Nov 2025 | Viewed by 92 | Submission Open

Keywords: immune checkpoints; mucosal immunity; gut homeostasis; microbiota-driven inflammation; targeted immunotherapy; im-munomodulatory compounds

(This special issue belongs to the Section Molecular Immunology)

Molecular Mechanism and Therapeutics in Human Cancer

edited by

Rachel Bar-Shavit

submission deadline 30 Nov 2025 | Viewed by 87 | Submission Open

Keywords: oncogenes; Wnt/b-catenin; G-protein-coupled receptors (GPCR); translational means; cancer stem cells; ubiquitination and deubiquitinating in cancer

(This special issue belongs to the Section Molecular Oncology)

Molecular Insights into Rhizospheric Microbial Interactions

edited by

Jelena Lozo

submission deadline 30 Nov 2025 | Viewed by 80 | Submission Open

Keywords: plant– microorganism interactions; rhizosphere community; secretory systems; secondary metabolites; volatile compounds

(This special issue belongs to the Section Molecular Microbiology)

Monovalent Ion-Exchange Membranes for Various Applications

edited by Noor ul Afsar

submission deadline 30 Nov 2025 | Viewed by 79 | Submission Open

Keywords: molecular design; ion-exchange membranes; membrane-based separations; energy and resource recovery

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Host DNA Damage Responses in Virus Propagation and Human Disease

edited by Nimrat Chatterjee

submission deadline 30 Nov 2025 | Viewed by 76 | Submission Open

Keywords: DNA repair; DNA viruses; RNA viruses; translesion synthesis; cancer

(This special issue belongs to the Section Molecular Microbiology)

Novel Molecular Pathways in Oncology, 3rd Edition

edited by

Giovanna Casili

submission deadline 1 Dec 2025 | 10 articles | Viewed by 10560 | Submission Open

Keywords: molecular pathway involved in tumorigenesis; cancer therapy; targeted therapy; anticancer drugs; brain cancer; oral cancer; gastrointestinal cancer

(This special issue belongs to the Section Molecular Oncology)

Gene Editing for Cereal Crops

edited by

Ke Wang

submission deadline 1 Dec 2025 | 1 articles | Viewed by 1460 | Submission Open

Keywords: gene-editing techniques; novel germplasm; quality; nutrition; agronomic traits

(This special issue belongs to the Section Molecular Plant Sciences)

The Current Landscape of Microglia-Glioma Research: From Basic Science to Therapeutic Potential

edited by

Manuel Benedikt Graeber

submission deadline 1 Dec 2025 | Viewed by 430 | Submission Open

Keywords: microglia; glioma; tumor associated macrophages; immunosuppression; epigenetics

(This special issue belongs to the Section Molecular Neurobiology)

Long-COVID and Its Complications

edited by

Alexey Sarapultsev

submission deadline 4 Dec 2025 | 9 articles | Viewed by 35401 | Submission Open

Keywords: acquired immune deficiency; auto-immunity; blood– brain barrier dysfunction; complication; COVID-19; gut microbiome; hypothalamic– pituitary– adrenal axis; immune dysfunction; long COVID; multisystem dysfunction; neurological complications; SARS-CoV-2; systemic inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biology of Oral Cancer

edited by Rafał Pęksa

submission deadline 10 Dec 2025 | 1 articles | Viewed by 1006 | Submission Open

Keywords: oral cancer; molecular mechanisms; biomarkers; tumor microenvironment; therapy resistance; precision medicine; carcinogenesis; oral squamous cell carcinoma; epigenetics; microbiome; immunotherapy; liquid biopsy

(This special issue belongs to the Section Molecular Oncology)

Biophysical Characterization and Molecular Engineering of Multidomain Proteins (4th Edition)

edited by

Koichi Kato

and

Takayuki Uchihashi

submission deadline 10 Dec 2025 | Viewed by 99 | Submission Open

Keywords: multidomain proteins; protein dynamics; domain interactions; allosteric regulation; protein engineering; SAXS; Cryo-EM; protein NMR; computational modeling; protein design

(This special issue belongs to the Section Molecular Biophysics)

Molecular Mechanisms of Obesity and Metabolic Diseases

edited by

Liliya Mihaylova

submission deadline 15 Dec 2025 | 7 articles | Viewed by 22203 | Submission Open

Keywords: molecular pharmacology; molecular mechanisms; obesity; metabolic diseases; metabolic syndrome; type 2 diabetes; atherosclerosis; cardio-metabolic disorders; non-alcoholic fatty liver disease (NAFLD)

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Pathogenesis and Molecular Therapy of Brain Tumor

edited by

Theo Kraus

submission deadline 15 Dec 2025 | 1 articles | Viewed by 1135 | Submission Open

Keywords: brain tumor; glioma; glioblastoma; astrocytoma; oligodendroglioma; epigenetics; precision medicine

(This special issue belongs to the Section Molecular Oncology)

Unveiling Mental Disorders: Molecular Mechanisms and Innovative Therapies

edited by Blerida Banushi

submission deadline 20 Dec 2025 | 7 articles | Viewed by 42233 | Submission Open

Keywords: molecular psychiatry; epigenetics; neurobiology; gene– environment interactions; neuroplasticity; psychopharmacology; neuromodulation; personalized medicine; neuroinflammation

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Retinal Diseases: 2nd Edition

edited by Minzhong Yu

submission deadline 20 Dec 2025 | 9 articles | Viewed by 28352 | Submission Open

Keywords: retina; optic nerve; ocular disorder; retinal disease; genetic mutation; aging; drug side effects; novel mutations/biomarkers; signaling pathways; spectral domain optical coherence tomography; stem cell; gene therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research on Reproductive Physiology and Endocrinology

edited by

Kamil Gill

submission deadline 20 Dec 2025 | 12 articles | Viewed by 24473 | Submission Open

Keywords: reproductive; endocrinology; reproductive hormones; embryology; molecular research; IVF; obesity

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Plant Responses to Biotic and Abiotic Stresses

edited by

Shu Yuan

submission deadline 20 Dec 2025 | 20 articles | Viewed by 24451 | Submission Open

Keywords: plant enzymes and metabolites; abiotic stress; stress response; phytohormones; secondary metabolism; gene regulation network; developmental and environmental adaptation; microbial interactions; biotic stress; pathogen response

(This special issue belongs to the Section Molecular Plant Sciences)

High-Density Lipoproteins in Health and Disease

edited by

Ilaria Zanotti

submission deadline 20 Dec 2025 | 7 articles | Viewed by 23939 | Submission Open

Keywords: omics; protein; lipid; cardiovascular; neurodegenerative disease; inflammation; preclinical studies; therapy

(This special issue belongs to the Section Molecular Biology)

Exosomes and Extracellular Vesicles in Health and Diseases: 3rd Edition

edited by

Manuela Zavatti

and

Francesca Beretti

submission deadline 20 Dec 2025 | 8 articles | Viewed by 21815 | Submission Open

Keywords: exosome; extracellular vesicles; network signals; biomarkers; pathological conditions

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biomimetic Materials Applied in the Analytical and Biomedical Fields

edited by

Iacob Bogdan-Cezar

and

Ede Bodoki

submission deadline 20 Dec 2025 | 6 articles | Viewed by 20470 | Submission Open

Keywords: biomimetics; molecular recognition; imprinted polymers; smart materials; molecular complexes; polymeric biomaterials; biomedical materials; analytical methods; molecular interactions; artificial receptors

(This special issue belongs to the Section Materials Science)

Bacteriophages Biology and Bacteriophage-Derived Technologies

edited by Wilfried Moreira

submission deadline 20 Dec 2025 | 5 articles | Viewed by 20347 | Submission Open

Keywords: bacteriophage; antibiotic resistance; biofilm; molecular biology; genetic engineering; synthetic biology

(This special issue belongs to the Section Biochemistry)

Plant Biodiversity and Molecular Marker Technology: Discovery and Application of DNA Polymorphisms

edited by

Luigi De Masi

submission deadline 20 Dec 2025 | 13 articles | Viewed by 20174 | Submission Open

Keywords: plant biodiversity; plant genetic resources; genetic variability; molecular characterization; biomolecular resources; DNA-based molecular markers; DNA sequencing; next generation sequencing; biosequences; DNA polymorphisms; bioinformatics

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Basis of Neuropsychiatric Disorders: Recent and Future Developments

edited by

Konstantinos Tsamakis

submission deadline 20 Dec 2025 | 5 articles | Viewed by 19803 | Submission Open

Keywords: molecular; schizophrenia; depression; genetic; autism; mechanisms; genetic

(This special issue belongs to the Section Molecular Neurobiology)

The Relationship, Mechanisms, and Treatment Strategies of Diabetes Mellitus and Related Diseases

edited by Maria Kokozidou

submission deadline 20 Dec 2025 | 6 articles | Viewed by 19671 | Submission Open

Keywords: diabetes mellitus; molecular mechanisms; related diseases; genetic basis; microRNAs; incretins; targeted therapies; immunotherapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Natural Bioactives and Inflammation, 2nd Edition

edited by

Juan Gambini

submission deadline 20 Dec 2025 | 6 articles | Viewed by 17476 | Submission Open

Keywords: inflammation; bioactive compounds; polyphenols; nutraceutical; diet; nutrition; pharmacology; health; lifespan; healthspan; aging; inflammaging

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Computational Approaches in Drug Design: Novel Methodologies and Applications

edited by

Serena Vittorio

submission deadline 20 Dec 2025 | 7 articles | Viewed by 16907 | Submission Open

Keywords: drug design; computational approaches; molecular docking; molecular dynamics; pharmacophore modeling; homology modeling; computer aided drug design; ADME/Tox predictions; artificial intelligence

(This special issue belongs to the Section Molecular Informatics)

Novel Molecular Mechanisms Underlying Tumorigenesis and Innovative Therapeutic Approaches for Cancer-Fighting, 3rd Edition

edited by

Annapina Russo

, Giulia Russo and

Annalisa Pecoraro

submission deadline 20 Dec 2025 | 8 articles | Viewed by 16724 | Submission Open

Keywords: cancer; nucleolus; nucleolar stress; tumorigenesis; cancer therapy

(This special issue belongs to the Section Molecular Oncology)

Displaying special issue 451-500 on page 10 of 69.