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Natural Bioactives and Inflammation, 2nd Edition
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Natural Bioactives and Inflammation, 2nd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 20 September 2024 | Viewed by 406

Special Issue Editor

Dr. Juan Gambini

E-Mail Website
Guest Editor
Freshage Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, E46010 Valencia, Spain
Interests: diet; oxidative stress; longevity; aging; polyphenols
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to our Special Issue of the International Journal of Molecular Sciences (IJMS), entitled “Natural Bioactives and Inflammation, 2nd Edition”.

Inflammation is a key physiological process in tissue repair and immunity against infections, trauma, toxins, or allergic reactions. However, chronic inflammation can cause the development of diseases such as cardiovascular disease, autoimmune disease, neurological disease, and cancer. Bioactive compounds, such as polyphenols, omega fatty acids, etc., are molecules that present therapeutic potential by reducing inflammation, thereby decreasing the risk of chronic diseases. As inflammation regulation is one of the keys to longevity, by consuming these bioactive compounds, we could potentially increase both our health- and lifespan.

For this Special Issue, we want to collect recent research topics and current review articles, to report the latest updates on inflammation and how to modulate it using natural bioactive compounds.

Dr. Juan Gambini
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • inflammation
  • bioactive compounds
  • polyphenols
  • nutraceutical
  • diet
  • nutrition
  • pharmacology
  • health
  • lifespan
  • healthspan
  • aging
  • inflammaging

Published Papers (1 paper)

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Research

15 pages, 3119 KiB  
Article
Anti-Neuroinflammatory Effects of Ginkgo biloba Extract EGb 761 in LPS-Activated BV2 Microglial Cells
by Lu Sun, Matthias Apweiler, Ashwini Tirkey, Dominik Klett, Claus Normann, Gunnar P. H. Dietz, Martin D. Lehner and Bernd L. Fiebich
Int. J. Mol. Sci. 2024, 25(15), 8108; https://doi.org/10.3390/ijms25158108 - 25 Jul 2024
Viewed by 151
Abstract
Inflammatory processes in the brain can exert important neuroprotective functions. However, in neurological and psychiatric disorders, it is often detrimental due to chronic microglial over-activation and the dysregulation of cytokines and chemokines. Growing evidence indicates the emerging yet prominent pathophysiological role of neuroinflammation [...] Read more.
Inflammatory processes in the brain can exert important neuroprotective functions. However, in neurological and psychiatric disorders, it is often detrimental due to chronic microglial over-activation and the dysregulation of cytokines and chemokines. Growing evidence indicates the emerging yet prominent pathophysiological role of neuroinflammation in the development and progression of these disorders. Despite recent advances, there is still a pressing need for effective therapies, and targeting neuroinflammation is a promising approach. Therefore, in this study, we investigated the anti-neuroinflammatory potential of a marketed and quantified proprietary herbal extract of Ginkgo biloba leaves called EGb 761 (10–500 µg/mL) in BV2 microglial cells stimulated by LPS (10 ng/mL). Our results demonstrate significant inhibition of LPS-induced expression and release of cytokines tumor necrosis factor-α (TNF-α) and Interleukin 6 (IL-6) and chemokines C-X-C motif chemokine ligand 2 (CXCL2), CXCL10, c-c motif chemokine ligand 2 (CCL2) and CCL3 in BV2 microglial cells. The observed effects are possibly mediated by the mitogen-activated protein kinases (MAPK), p38 MAPK and ERK1/2, as well as the protein kinase C (PKC) and the nuclear factor (NF)-κB signaling cascades. The findings of this in vitro study highlight the anti-inflammatory properties of EGb 761 and its therapeutic potential, making it an emerging candidate for the treatment of neuroinflammatory diseases and warranting further research in pre-clinical and clinical settings. Full article
(This article belongs to the Special Issue Natural Bioactives and Inflammation, 2nd Edition)
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