Intestinal Immune System and Anti-Inflammatory Pathways
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 36
Special Issue Editor
Special Issue Information
Dear Colleagues,
In recent years, significant progress has been made in unraveling the complex interplay between the intestinal immune system, mucosal inflammation, and the gut microbiota. Advances in molecular and cellular immunology have led to the identification of novel immune checkpoints, the regulatory pathways governing intestinal homeostasis, and microbiota-derived factors that shape mucosal immune responses. These discoveries have deepened—though not yet fully clarified—our understanding of how immune tolerance is maintained and how its disruption contributes to varied chronic inflammatory conditions and gut-associated autoimmune disorders.
This Special Issue welcomes original research articles that explore the intestinal immune system and the mechanisms involved in anti-inflammatory responses, including studies addressing the following: (1) New insights into mechanisms triggering mucosal immune dysregulation and pathologic inflammation; (2) The pathways underlying immune checkpoint blockade and immune evasion mediated by dysbiotic microbiota; (3) Innovative strategies for modulating intestinal immunity and restoring immune homeostasis.
This Special Issue will ultimately advance our understanding of the intestinal immune landscape and identify novel targets for treating mucosal inflammation and immune-mediated intestinal diseases.
Dr. Moira Paroni
Guest Editor
Manuscript Submission Information
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Keywords
- immune checkpoints
- mucosal immunity
- gut homeostasis
- microbiota-driven inflammation
- targeted immunotherapy
- im-munomodulatory compounds
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