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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Degradable Polymers: Synthesis, Applications, and Environmental Impact
edited by Ce Sun and
submission deadline 25 Aug 2025 | Viewed by 157 | Submission Open
Keywords: degradable polymer; synthesis; degradation mechanisms; sustainability
(This special issue belongs to the Section Macromolecules)
Metabolic Regulators of Bone Health
edited by
submission deadline 25 Aug 2025 | Viewed by 151 | Submission Open
Keywords: bone; osteoporosis; diabetes; obesity; glucose; insulin; lipids; estrogen; microRNA; osteoblasts
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Advances in the Role of Retinoic Acid-Regulated Genes in Cancer Biology
edited by Fuming Tsai
submission deadline 25 Aug 2025 | Viewed by 97 | Submission Open
Keywords: retinoic acid; retinoic acid receptors; retinoic x receptors; tumorigenesis; metastasis; tumor microenvironment; molecular pathways
(This special issue belongs to the Section Molecular Genetics and Genomics)
Neuromodulatory Effects of Serotonin, 2nd Edition
edited by
submission deadline 25 Aug 2025 | Viewed by 16 | Submission Open
Keywords: neuromodulation; Serotonin; pain research; cognition; emotions; depression; anxiety; GBM
(This special issue belongs to the Section Molecular Neurobiology)
Advances in Lung Cancer: From Genetic Landscape to Treatment
edited by Rossella Bruno
submission deadline 26 Aug 2025 | 2 articles | Viewed by 2944 | Submission Open
Keywords: lung cancer; precision medicine; predictive biomarkers; resistance mechanisms; targeted therapy; immunotherapy; molecular tests; liquid biopsy
(This special issue belongs to the Section Molecular Oncology)
Mechanistic Insights into Pharmacological and Non-Pharmacological Pain Therapies: From Cellular Responses to Therapy Outcomes
edited by
submission deadline 28 Aug 2025 | Viewed by 180 | Submission Open
Keywords: neuromodulation; neural plasticity; glial activation; endogenous pain modulation; neuroinflammation; therapeutic mechanisms
(This special issue belongs to the Section Molecular Pharmacology)
Recent Advances in Molecular Pharmacology of Neurological Diseases
edited by
submission deadline 28 Aug 2025 | Viewed by 172 | Submission Open
Keywords: neurological diseases; neurodevelopmental disorders; neurodegenerative diseases; therapeutic agents; drug discovery; molecular pharmacology
(This special issue belongs to the Section Molecular Pharmacology)
The Neuro and Immune Mechanisms Behind Cannabinoids Effects
edited by
submission deadline 28 Aug 2025 | Viewed by 130 | Submission Open
Keywords: cannabinoids; neuroinflammation; endocannabinoid system (ECS); non-cannabinoid receptors; immune modulation; synaptic plasticity
(This special issue belongs to the Section Biochemistry)
Molecular Biology of Plant Disease Resistance
edited by Heewan Kang
submission deadline 28 Aug 2025 | Viewed by 108 | Submission Open
Keywords: Bacillus subtilis; antifungal activity; amino acids; defense genes; molecular mechanisms
(This special issue belongs to the Section Molecular Plant Sciences)
Immune Regulation During Pregnancy
edited by Sabrina Marie Scroggins
submission deadline 28 Aug 2025 | Viewed by 96 | Submission Open
Keywords: maternal– fetal immunology; multiomics in pregnancy; in utero inflammation; therapeutics; placental biology; neurodevelopment; gestational disorders; epigenetics; microbiome
(This special issue belongs to the Section Molecular Immunology)
Molecular Biomarkers for Assessing Marine Ecosystem Health submission deadline 28 Aug 2025 | Viewed by 73 | Submission Open
Keywords: biodiversity; biomarkers; biomonitoring; marine organisms; pollution; metals; microplastics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Anti-Inflammatory and Anti-Oxidant Effects of Extracts from Plants submission deadline 29 Aug 2025 | 1 articles | Viewed by 996 | Submission Open
Keywords: oxidative stress; inflammation; herbal extracts
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Application and Formulation of Therapeutic Natural Deep Eutectic Solvents
edited by
submission deadline 29 Aug 2025 | Viewed by 124 | Submission Open
Keywords: deep eutectic solvent; ionic liquid drug; eutectic mixture; green solvent; pharmaceutical salts
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Insights into Thrombosis
edited by
submission deadline 30 Aug 2025 | 6 articles | Viewed by 17222 | Submission Open
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Current Research on the Role of the Gut Microbiota in Human Diseases and Health
edited by
submission deadline 30 Aug 2025 | 5 articles | Viewed by 14989 | Submission Open
Keywords: microbiota; microbiome; gut microbiome metabolites; dysbiosis; gut– organ axis; gut microbiota pathogens; diet
(This special issue belongs to the Section Molecular Microbiology)
Molecular Pharmacology in Diabetes, 2nd Edition submission deadline 30 Aug 2025 | 3 articles | Viewed by 10608 | Submission Open
Keywords: diabetes; vascular complications; cancer; neurodegenerative disorders; key molecular players; signaling pathways; molecular biomarkers; pharmacological agents; antioxidants; anti-inflammatory agents
(This special issue belongs to the Section Molecular Pharmacology)
The Role of Extracellular Vesicles in Cancer Diagnosis and Therapy, 2nd Edition
edited by
submission deadline 30 Aug 2025 | 3 articles | Viewed by 7545 | Submission Open
Keywords: extracellular vesicles; exosomes; intercellular communication; liquid biopsy; cancer therapeutics; nanotherapeutics
(This special issue belongs to the Section Molecular Oncology)
From Bench to Bedside: Well-Established and Emerging Preclinical Models in Cardiovascular Research
edited by and Veronica Dusi
submission deadline 30 Aug 2025 | 1 articles | Viewed by 5998 | Submission Open
Keywords: myocardial infarction; organ ischemia and reperfusion injury; hypertension; cardiovascular dysfunction; cardio-renal syndrome; stroke; arrhythmias; heart disease; heart failure; genetic disorders; translational medicine; organoids; bioreactors; organs on a chip; omics sciences; pharmacology; molecular biology; gene therapy; quantum biology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Germline Stem Cells: New Insights
edited by
submission deadline 30 Aug 2025 | 1 articles | Viewed by 4383 | Submission Open
Keywords: signaling pathway; spermatogonia development; oocyte development; microarray analysis; single-cell sequencing; epigenetic mechanisms; germline stem cell
(This special issue belongs to the Section Molecular Biology)
Immunology of Infectious Disease and Transplantation: A Symbiotic Dance submission deadline 30 Aug 2025 | 2 articles | Viewed by 4083 | Submission Open
Keywords: organ transplantation; infectious disease; immune responses; immunology; personalized medicine; transplantation medicine
(This special issue belongs to the Section Molecular Immunology)
Genetic Analysis Based on CRISPR/Cas9 Technology: 2nd Edition
edited by and
submission deadline 30 Aug 2025 | 2 articles | Viewed by 3722 | Submission Open
Keywords: gene targeting (GT); homology-directed repair (HDR); homology-directed gene targeting (HGT); CRISPR/Cas; targeted mutagenesis; precision breeding; genetic analysis
(This special issue belongs to the Section Molecular Genetics and Genomics)
Transition Metal Catalysis: From Synthesis to Late-Stage Functionalization of Aromatics and Heterocycles submission deadline 30 Aug 2025 | 2 articles | Viewed by 3403 | Submission Open
Keywords: transition metal catalysis; homogeneous catalysis; heterogeneous catalysis; cross-couplings; synthesis of aromatics and heteroaromatics; late-stage functionalization; photo-; electro-; flow; mechanochemistry; medicinal chemistry; material sciences; bioinorganic chemistry; industrial processes
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Advances in the Genetics, Epidemiology and Management of Myopathies submission deadline 30 Aug 2025 | 1 articles | Viewed by 3038 | Submission Open
Keywords: myopathies; muscle disorders; muscle weakness; muscle pain; myalgia
(This special issue belongs to the Section Molecular Biology)
Cellular Plasticity and EMT in Cancer and Fibrotic Diseases submission deadline 30 Aug 2025 | 3 articles | Viewed by 2834 | Submission Open
Keywords: fibrosis; epithelial– mesenchymal transition; epithelial– mesenchymal plasticity; cancer; fibrotic diseases; inflammation; metastases
(This special issue belongs to the Section Molecular Biology)
The Transcendental World of Plant Toxic Compounds
edited by
submission deadline 30 Aug 2025 | 2 articles | Viewed by 2518 | Submission Open
Keywords: alcaloids; biotic stress; defence; phenols; phytotoxins; secondary metabolism; terpenes
(This special issue belongs to the Section Molecular Plant Sciences)
Oral Soft Tissue Repair and Oral Diseases: 2nd Edition
edited by
submission deadline 30 Aug 2025 | 2 articles | Viewed by 2423 | Submission Open
Keywords: oral medicine; tissue regeneration; lasers; photobiomodulation; periodontology; implant dentistry
(This special issue belongs to the Section Molecular Biology)
The Extracellular Matrix in Physiopathology
edited by
submission deadline 30 Aug 2025 | 1 articles | Viewed by 2156 | Submission Open
Keywords: extracellular matrix; glycosaminoglycans; matrix metalloproteinases; tissue remodeling; cell interactions; physiopathology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Computer-Aided Drug Design Strategies submission deadline 30 Aug 2025 | 2 articles | Viewed by 1856 | Submission Open
Keywords: computer-aided drug design; artificial intelligence in drug discovery; molecular docking; molecular dynamics simulations; macromolecular systems; quantum mechanics/molecular mechanics (QM/MM); big data analytics in drug development; pharmacokinetics optimization; structure-based drug design (SBDD); ligand-based drug design; virtual screening techniques
(This special issue belongs to the Section Molecular Informatics)
The Role of Cytokines and Autoantibodies Against Cytokines in Health and Disease submission deadline 30 Aug 2025 | 1 articles | Viewed by 1811 | Submission Open
Keywords: cytokine; autoantibodies; cytokine therapy; cytokine inhibition
(This special issue belongs to the Section Molecular Immunology)
Advanced Research in Antioxidant Activity
edited by Demetrios Kouretas and
submission deadline 30 Aug 2025 | 1 articles | Viewed by 1649 | Submission Open
Keywords: xenobiotics; oxidative stress; free radicals; reactive oxygen species; reactive nitrogen species; antioxidants; glutathione; toxicology; redox metabolism; redox imbalance
(This special issue belongs to the Section Biochemistry)
Beyond the Known: Molecular Insights into the World of New Psychoactive Compounds
edited by and
submission deadline 30 Aug 2025 | 1 articles | Viewed by 1507 | Submission Open
Keywords: new psychoactive substances; synthetic drugs; metabolism; toxicology; drug checking; designer drugs
(This special issue belongs to the Section Macromolecules)
New Advances in Plant–Microbe Interaction submission deadline 30 Aug 2025 | 1 articles | Viewed by 1270 | Submission Open
Keywords: biomarkers; molecular biotechnology; cell signalling; microbiota signaling; genetic editing of microbes; plant-microbe stress response; plant-microbe stress mitigation; plant-microbe underlying mechanisms
(This special issue belongs to the Section Molecular Plant Sciences)
Intracellular Trafficking and Catabolism of Free Heme: Physiological Roles and Relevance to Pathological Mechanisms
edited by Junichi Taira
submission deadline 30 Aug 2025 | 1 articles | Viewed by 1215 | Submission Open
Keywords: heme oxygenase; heme metabolism; heme chaperon; free heme (labile heme); cytochrome P450 reductase; reactive oxygen species; carbon monoxide  
(This special issue belongs to the Section Biochemistry)
Plant-Microbe Interaction: Current Status and Future Directions submission deadline 30 Aug 2025 | 1 articles | Viewed by 1053 | Submission Open
Keywords: beneficial micro-organism; climate change; crop productivity; environmental stress; food production; plant growth; stress mitigation; yield
(This special issue belongs to the Section Molecular Plant Sciences)
Plants Redox Biology
edited by
submission deadline 30 Aug 2025 | 1 articles | Viewed by 1034 | Submission Open
Keywords: plant– environment interaction; stress physiology; plant redox signaling; plant hormones; plant– pathogen interaction; reactive oxygen species (ROS); reactive nitrogen species (RNS); ascorbate; flavonoid; glutathione
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Research on Endothelial Cell Injury and Repair submission deadline 30 Aug 2025 | 1 articles | Viewed by 997 | Submission Open
Keywords: endothelial injury; endothelial repair; endotheliopathies; endothelial dysfunction
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Advances in Regenerative Medicine and Therapeutics
edited by
submission deadline 30 Aug 2025 | 1 articles | Viewed by 958 | Submission Open
Keywords: regenerative medicine; morphology; regenerative dentistry; biomaterials; scaffolds; organoids; tissue regeneration
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Innovative Technologies in the Study and Understanding of Colorectal Tumorigenesis: Challenges and Opportunities
edited by
submission deadline 30 Aug 2025 | 1 articles | Viewed by 866 | Submission Open
Keywords: colorectal cancer; genetic analysis; gut microbiome; tumor; circulating components; medicine; immunotherapy; proteomics
(This special issue belongs to the Section Molecular Oncology)
Molecular Mechanism of Sympathetic Nerves in Cardiovascular Diseases and Cancer
edited by
submission deadline 30 Aug 2025 | Viewed by 807 | Submission Open
Keywords: sympathetic nerve activity; adrenergic receptors; renal denervation; heart disease; stroke; atherosclerosis; hypertension; diabetes; metabolic syndrome; cancer
(This special issue belongs to the Section Molecular Neurobiology)
Biodegradable Polymers: From Chemical Synthesis to Biodegradable Mechanism submission deadline 30 Aug 2025 | Viewed by 798 | Submission Open
Keywords: biodegradable polymers; polyolefins; molecular structures; synthesis; chemical modification; hydrolysis kinetics
(This special issue belongs to the Section Macromolecules)
The Latest Molecular Research on Renal Disease
edited by Niels Henrik Buus and Marco Eijken
submission deadline 30 Aug 2025 | 1 articles | Viewed by 734 | Submission Open
Keywords: renal disease; chronic kidney disease; renal regeneration; kidney injury
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Gastrointestinal Microbes: Implications for Health and Disease
edited by Suqin Hang
submission deadline 30 Aug 2025 | 1 articles | Viewed by 729 | Submission Open
Keywords: animal; gut; microbiota; gut hormone; nutrients
(This special issue belongs to the Section Molecular Microbiology)
Novel Approaches for Tissue Repair and Tissue Regeneration
edited by Srinivas Madduri
submission deadline 30 Aug 2025 | 2 articles | Viewed by 718 | Submission Open
Keywords: injuries; tissue repair; tissue regeneration; tissue engineering; tissue bioengineering; bioactive biomaterial; cell and gene therapeutics; hydrogel; immune modulation
(This special issue belongs to the Section Molecular Biology)
Melanoma: Molecular Mechanism and New Agents for Prevention and Therapy
edited by
submission deadline 30 Aug 2025 | 1 articles | Viewed by 704 | Submission Open
Keywords: melanoma; therapy resistance; melanoma microenvironment (MME); melanoma plasticity; epigenetic mechanism; predictive markers; prognostic markers; extracellular vesicles; molecular therapy; natural molecules
(This special issue belongs to the Section Molecular Oncology)
The Plant Cell Wall: Structural Dynamics, Functions, and Future Innovations submission deadline 30 Aug 2025 | 1 articles | Viewed by 648 | Submission Open
Keywords: plant cell wall; biosynthesis; biomass; abiotic stress; biotic stress; renewable resources; biotechnology; climate change
(This special issue belongs to the Section Molecular Plant Sciences)
Trees Genetics, Genomics, and Molecular Breeding
edited by
submission deadline 30 Aug 2025 | 1 articles | Viewed by 634 | Submission Open
Keywords: trees genetics; genomics; molecular; regulatory mechanism; genetic improvement
(This special issue belongs to the Section Molecular Plant Sciences)
Inflammation in Pregnancy and Childbirth
edited by and Maciej Ziętek
submission deadline 30 Aug 2025 | 1 articles | Viewed by 591 | Submission Open
Keywords: pregnancy; labor; eicosanoid; chronic inflammation; cytokines; intestinal dysbiosis; mitogen-activated protein kinase; nuclear factor kappa-light-enhancer-activated B cell; maresins; resolvins and protectins
(This special issue belongs to the Section Molecular Immunology)
Feature Papers in ‘Physical Chemistry and Chemical Physics’: Fourth Edition
edited by
submission deadline 30 Aug 2025 | 3 articles | Viewed by 520 | Submission Open
Keywords: heterogeneous structures; alignment and surface phenomena; quantum theory; mathematical physics; statistical and classical mechanics; molecular structure; chemical kinetics; laser physics; dynamics; kinetics; photochemistry; spectroscopy; exciton dynamics; statistical mechanics; thermodynamics; electrochemistry; catalysis; surface science; quantum mechanics; theoretical developments; fundamental aspects of catalysis; solar energy conversion; polymer dynamics
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Molecular Research on Plant Breeding
edited by , Sandra Correia and
submission deadline 30 Aug 2025 | 1 articles | Viewed by 501 | Submission Open
Keywords: plant breeding; proteomics; metabolomics; epigenomics; gene editing
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Mechanisms of Hemostasis, Thrombosis and Thrombo-Inflammation: 3rd Edition submission deadline 30 Aug 2025 | 1 articles | Viewed by 482 | Submission Open
Keywords: atherosclerosis; coagulation; complement; endothelial cells; extracellular vesicles; fibrinolysis; immune thrombosis; inflammation; leukocytes; platelets; proteomics; red blood cells
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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