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From Bench to Bedside: Well-Established and Emerging Preclinical Models in Cardiovascular Research

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 30 August 2025 | Viewed by 4083

Special Issue Editors


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Guest Editor
Cardiology Research Laboratory, Department of Cardiology, Istituto Auxologico Italiano, IRCCS, 20145 Milan, Italy
Interests: cardiovascular research; neuroinflammation; experimental models; 3R research; bioreactors; quantum biology; laboratory animal science
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Guest Editor
1. Cardiology, Department of Medical Sciences, University of Turin, Turin, Italy
2. Division of Cardiology, Cardiovascular and Thoracic Department, ‘Città della Salute e della Scienza’ Hospital, Turin, Italy
Interests: arrythmias; neuromodulation; autonomic nervous system; channelopathies

Special Issue Information

Dear Colleagues,

As is widely known, cardiovascular diseases are among the leading causes of death worldwide; therefore, advances in technologies concerning preclinical models able to produce translational results are of extreme interest. This Special Issue aims at introducing the most advanced tools currently available to both preclinical researchers and clinicians involved in cardiovascular studies. Original articles and reviews describing all experimental models potentially useful for cardiovascular research are accepted. This will include, among others, in silico procedures, mathematical/experimental models derived from Quantum Biology, Omics sciences, in vivo/in vitro models and the emerging field of the organoids and 2D cultures cultivated on chips and in micro/millifluidic systems.

This Special Issue seeks to focus on both basic science and translational research as well as clinical studies in order to have a complete overview of the latest and advanced study models. Pure clinical studies will not be suitable, but clinical submissions with biomolecular experiments are welcome.

Dr. Laura Calvillo
Dr. Veronica Dusi
Guest Editors

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • myocardial infarction
  • organ ischemia and reperfusion injury
  • hypertension
  • cardiovascular dysfunction
  • cardio-renal syndrome
  • stroke
  • arrhythmias
  • heart disease
  • heart failure
  • genetic disorders
  • translational medicine
  • organoids
  • bioreactors
  • organs on a chip
  • omics sciences
  • pharmacology
  • molecular biology
  • gene therapy
  • quantum biology

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Published Papers (1 paper)

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Review

21 pages, 1614 KiB  
Review
Understanding Vascular Calcification in Chronic Kidney Disease: Pathogenesis and Therapeutic Implications
by Chiara Siracusa, Nicole Carabetta, Maria Benedetta Morano, Marzia Manica, Antonio Strangio, Jolanda Sabatino, Isabella Leo, Alberto Castagna, Eleonora Cianflone, Daniele Torella, Michele Andreucci, Maria Teresa Zicarelli, Michela Musolino, Davide Bolignano, Giuseppe Coppolino and Salvatore De Rosa
Int. J. Mol. Sci. 2024, 25(23), 13096; https://doi.org/10.3390/ijms252313096 - 5 Dec 2024
Cited by 4 | Viewed by 3436
Abstract
Vascular calcification (VC) is a biological phenomenon characterized by an accumulation of calcium and phosphate deposits within the walls of blood vessels causing the loss of elasticity of the arterial walls. VC plays a crucial role in the incidence and progression of chronic [...] Read more.
Vascular calcification (VC) is a biological phenomenon characterized by an accumulation of calcium and phosphate deposits within the walls of blood vessels causing the loss of elasticity of the arterial walls. VC plays a crucial role in the incidence and progression of chronic kidney disease (CKD), leading to a significant increase in cardiovascular mortality in these patients. Different conditions such as age, sex, dyslipidemia, diabetes, and hypertension are the main risk factors in patients affected by chronic kidney disease. However, VC may occur earlier and faster in these patients if it is associated with new or non-traditional risk factors such as oxidative stress, anemia, and inflammation. In chronic kidney disease, several pathophysiological processes contribute to vascular calcifications, including osteochondrogenic differentiation of vascular cells, hyperphosphatemia and hypercalcemia, and the loss of specific vascular calcification inhibitors including pyrophosphate, fetuin-A, osteoprotegerin, and matrix GLA protein. In this review we discuss the main traditional and non-traditional risk factors that can promote VC in patients with kidney disease. In addition, we provide an overview of the main pathogenetic mechanisms responsible for VC that may be crucial to identify new prevention strategies and possible new therapeutic approaches to reduce cardiovascular risk in patients with kidney disease. Full article
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