The Neuro and Immune Mechanisms Behind Cannabinoids Effects
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 28 August 2025 | Viewed by 54
Special Issue Editor
Interests: innate immunity; cannabinoids; cannabis; inflammation; neuroinflammation; immune regulation; microbiome
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The Special Issue titled The Neuro and Immune Mechanisms Behind Cannabinoids Effects will explore the molecular mechanisms through which cannabinoids influence neurobiology and immune responses. While cannabinoids primarily act through the endocannabinoid system (ECS), including receptors like CB1 and CB2, their effects are not limited to these pathways alone. Cannabinoids also interact with a variety of non-cannabinoid receptors, such as transient receptor potential (TRP) channels, peroxisome proliferator-activated receptors (PPARs), and GPR55, which contribute to their diverse biological effects.
At the molecular level, cannabinoids modulate a range of cellular processes, including neurotransmitter release, synaptic plasticity, and immune cell function. In the central nervous system (CNS), cannabinoids affect neuroinflammation, synaptic transmission, and neuroprotection, which are critical in the context of neurodegenerative diseases, pain, and psychiatric disorders. In the immune system, cannabinoids regulate the activation and function of immune cells, influencing both innate and adaptive immune responses.
Recent research has highlighted the potential of cannabinoids to target specific molecular pathways involved in neuroinflammation and immune modulation, offering therapeutic promise for conditions like multiple sclerosis, Alzheimer’s disease, and chronic pain. This Special Issue aims to provide new insights into the molecular underpinnings of cannabinoid effects, including both ECS-dependent and independent mechanisms, and their therapeutic potential
Prof. Dr. Babak Baban
Guest Editor
Manuscript Submission Information
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Keywords
- cannabinoids
- neuroinflammation
- endocannabinoid system (ECS)
- non-cannabinoid receptors
- immune modulation
- synaptic plasticity
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