Advances in Lung Cancer: From Genetic Landscape to Treatment
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 26 August 2025 | Viewed by 1548
Special Issue Editor
Interests: molecular pathology; lung cancer; malignant pleural mesothelioma; precision medicine; predictive biomarkers; molecular tests; next generation sequencing
Special Issue Information
Dear Colleagues,
Precision medicine, including both targeted therapies and immunotherapy, has dramatically changed and improved the clinical practice of lung cancer. To date, different molecular targets have been approved for metastatic advanced non-small cell lung cancer, mainly adenocarcinoma histotype, and more recently also for early-stage tumors. The molecular characterization of targetable alterations is mandatory to assess the best therapeutic approaches. However, in most lung cancer cases, available biological material is scarce, mainly represented by small biopsies or cytological specimens. In this context, liquid biopsy, particularly circulating cell free tumor DNA, has recently acquired great value as a complement of tissue testing. In addition, molecular investigations of lung cancer are warranted to uncover and face resistance mechanisms to therapy, and identify new predictive biomarkers. Therefore, the continuous optimization of next-generation sequencing techniques is crucial for a complete molecular analysis, including a plethora of genetic alterations from gene mutations to gene fusions and gene expression profiling.
This Special Issue of the International Journal of Molecular Sciences welcomes original articles, case reports, reviews and metanalyses on the advances in lung cancer covering the genetic landscape to treatment.
We look forward to receiving your contributions.
Dr. Rossella Bruno
Guest Editor
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Keywords
- lung cancer
- precision medicine
- predictive biomarkers
- resistance mechanisms
- targeted therapy
- immunotherapy
- molecular tests
- liquid biopsy
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