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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Risk Stratification in Sarcomas: Epigenomics in Osteosarcomas
edited by Empar Mayordomo-Aranda
submission deadline 31 Oct 2025 | Viewed by 43 | Submission Open
Keywords: sarcomas; malignant neoplasms; oncogenic pathways; optical genome mapping; epigenomics
(This special issue belongs to the Section Molecular Oncology)
Biological Pathways and Nutraceutical Compounds in Genetic Disease Treatment
edited by
submission deadline 10 Nov 2025 | Viewed by 317 | Submission Open
Keywords: micronutrients; supplements; functional foods; inherited disease; microbiome; RNA expression; protein expression; signaling pathways; DNA methylation; animal models; cell lines; clinical trials
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Systems Genetics of Metabolic Disorders: From Omics Signatures to Molecular Mechanisms
edited by
submission deadline 10 Nov 2025 | Viewed by 123 | Submission Open
Keywords: metabolic syndrome; single-nucleotide polymorphism (SNP); genome-wide association study (GWAS); copy number variation; diet; metabolomics; nutritional genetics; lipid metabolism; omics
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Innovative Approaches in Personalized Medicine: Cancer, Inherited Diseases, and Beyond
edited by Julia Hentschel
submission deadline 10 Nov 2025 | Viewed by 55 | Submission Open
Keywords: personalized medicine; hereditary diseases; pharmacogenomics; proteomics; polygenic factors; molecular pathology; therapeutic approaches; biomarkers
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Mechanism Discovery of the Bioactive Phytochemicals Against Different Diseases Based on Network Pharmacology and Molecular Docking, 2nd Edition
edited by
submission deadline 15 Nov 2025 | 4 articles | Viewed by 3617 | Submission Open
Keywords: molecular mechanism; phytochemicals; network pharmacology; molecular docking; diseases; curing targets; signaling pathway; biological processes
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Advances in the Molecular Biological Effects of Magnetic Fields submission deadline 20 Nov 2025 | 8 articles | Viewed by 22975 | Submission Open
Keywords: magnetoreception magnetoperception alternating magnetic field static magnetic field hypomagnetic field cryptochrome radical-pair mechanism zebrafish Aquatic Species
(This special issue belongs to the Section Molecular Biology)
Cellular and Molecular Progression of Cardiovascular Diseases submission deadline 20 Nov 2025 | 8 articles | Viewed by 17961 | Submission Open
Keywords: cardiovascular diseases; multi-omics data; biomarkers; molecular level; pathophysiology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Regenerative Medicine: Biomaterials and Stem Cell Research
edited by Silvia María Díaz-Prado
submission deadline 20 Nov 2025 | 7 articles | Viewed by 17292 | Submission Open
Keywords: regenerative medicine; stem cell; biomaterial; bioprinting; tissue engineering; tissue and organ transplant; organ scarcity
(This special issue belongs to the Section Materials Science)
Advances in Lupus Erythematosus and Lupus Nephritis: Pathogenesis, Biomarkers and Treatments
edited by
submission deadline 20 Nov 2025 | 7 articles | Viewed by 17234 | Submission Open
Keywords: lupus erythematosus; lupus nephritis; SLE; LN; organ damage; pathogenesis; biomarkers; genomic; transcriptomic; metabolomic; treatments; therapeutic
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms of Pain and Analgesia
edited by and Hee Young Kim
submission deadline 20 Nov 2025 | 3 articles | Viewed by 14074 | Submission Open
Keywords: pain; analgesia; sensory transmission and integration; molecular pathways; pain genes; drug targets
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advanced Research on Lipid Signaling Molecules
edited by Roberta Ottria
submission deadline 20 Nov 2025 | 4 articles | Viewed by 13091 | Submission Open
Keywords: endocannabinoid hydrolytic enzyme inhibitors; endocannabinoids; oxylipins; eicosanoids; lipid signaling (fatty acid derivatives); protectins; maresins; and resolvins
(This special issue belongs to the Section Molecular Biology)
Understanding the Mechanisms of Mitochondrial Stress and Its Association with Human Diseases
edited by
submission deadline 20 Nov 2025 | 5 articles | Viewed by 12630 | Submission Open
Keywords: mitochondrial stress; mitochondrial quality control; mitophagy; mitochondrial unfolded protein response; mitochondrial fission and fusion; mitochondria-related diseases
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Drug Treatment for Bacterial Infections
edited by Janusz Madaj
submission deadline 20 Nov 2025 | 9 articles | Viewed by 12572 | Submission Open
Keywords: bacterial infection; antibiotic-resistant bacteria; new agents in the treatment of bacterial infections; optimization of the use of already registered drugs; single antibacterial agents; combined antibacterial agents; new drug forms
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Mechanism of Circadian Rhythm
edited by Rosângela Vieira de Andrade
submission deadline 20 Nov 2025 | 1 articles | Viewed by 11850 | Submission Open
Keywords: circadian cycle; exercise; aging; clock genes; health
(This special issue belongs to the Section Molecular Biology)
Diet and Oxidative Stress
edited by
submission deadline 20 Nov 2025 | 3 articles | Viewed by 11378 | Submission Open
Keywords: diet; antioxidants; personalized medicine; oxidative stress; health and disease
(This special issue belongs to the Section Biochemistry)
Advances in Plant Metabolite Research
edited by
submission deadline 20 Nov 2025 | 7 articles | Viewed by 11095 | Submission Open
Keywords: metabolomics; regulatory networks; metabolic engineering; plant secondary metabolic defense; phytochemicals; antioxidant properties; mass spectrometry imaging; biotechnological applications; plant biochemistry
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Metabolism of Ameloblasts in Tooth Development
edited by Maiko Suzuki and Yong Hee Patricia Chun
submission deadline 20 Nov 2025 | 6 articles | Viewed by 9326 | Submission Open
Keywords: ameloblasts; amelogenesis; metabolism; gene regulation; amelogenesis imperfecta; SCPP; enamel hypomineralization; tooth epithelial stem cells
(This special issue belongs to the Section Molecular Biology)
Inflammatory Airway Diseases: Diagnosis, Pathology, Molecular Mechanisms and Treatment Options
edited by
submission deadline 20 Nov 2025 | 6 articles | Viewed by 9228 | Submission Open
Keywords: inflammatory airway diseases; asthma; COPD; anti-inflammatory
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advanced Research on Chemokines and Chemokine Receptors
edited by
submission deadline 20 Nov 2025 | 4 articles | Viewed by 8395 | Submission Open
Keywords: chemokines; chemokine receptors; chronic diseases; angiogenesis; fracture; regeneration; chemokine function; expression
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Plant Development and Hormonal Signaling
edited by
submission deadline 20 Nov 2025 | 5 articles | Viewed by 8321 | Submission Open
Keywords: plant growth; reproductive growth; phytohormones; signal transduction; transcription factors; root development; shoot development; floral development; seed development; environmental interactions; regulatory networks; apical dominance
(This special issue belongs to the Section Molecular Plant Sciences)
Inflammatory Bowel Disease: Molecular Advances in Pathogenesis and Therapies
edited by
submission deadline 20 Nov 2025 | 7 articles | Viewed by 8257 | Submission Open
Keywords: Crohn’ s disease; inflammatory bowel disease; immunologic and molecular mechanisms; therapies for IBD; ulcerative colitis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Exploring Abiotic Stress in Plants: Mechanisms, Adaptations, and Mitigation Strategies
edited by
submission deadline 20 Nov 2025 | 7 articles | Viewed by 8080 | Submission Open
Keywords: abiotic stress; plant physiology; stress tolerance; crop resilience; molecular mechanisms; biotechnological interventions
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Insights into Reproductive Biology and Related Diseases submission deadline 20 Nov 2025 | 5 articles | Viewed by 7976 | Submission Open
Keywords: spermatozoa; oocyte; molecular reproduction; infertility
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Abnormal Organelles and Protein Expression in Acute and Chronic Neurodegeneration
edited by
submission deadline 20 Nov 2025 | 3 articles | Viewed by 7595 | Submission Open
Keywords: brain ischemia; epileptic damage; basal ganglia pathology; catecholamine cell damage; excitotoxicity; autophagy; dopamine system norepinephrine system; protein unfolding; protein misfolding; cholinergic system
(This special issue belongs to the Section Molecular Neurobiology)
Omics Science and Research in Human Health and Disease
edited by Elisa De Paolis
submission deadline 20 Nov 2025 | 5 articles | Viewed by 7488 | Submission Open
Keywords: genomics; transcriptomics; proteomics; metabolomics; single-cell analysis; spatial transcriptomics; bioinformatics; multi-omics
(This special issue belongs to the Section Molecular Biology)
Female Infertility and Fertility submission deadline 20 Nov 2025 | 4 articles | Viewed by 7346 | Submission Open
Keywords: infertility; embryo; implantation; placenta; endometrium; gynecological endocrinology; assisted reproduction technology; ovaries; inflammation; endometriosis
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Research in Prebiotics, Probiotics and Postbiotics: 2nd Edition
edited by and Haruki Kitazawa
submission deadline 20 Nov 2025 | 4 articles | Viewed by 7283 | Submission Open
Keywords: probiotics; prebiotics; postbiotics; symbiotics; immunobiotics; functional foods; health improvement; mucosal immunology; microbiota
(This special issue belongs to the Section Molecular Microbiology)
Splice-Switching Antisense Oligonucleotides: 30 Years After Advocating Exon-Skipping Therapy for Duchenne Muscular Dystrophy
edited by
submission deadline 20 Nov 2025 | 3 articles | Viewed by 7242 | Submission Open
Keywords: antisense oligonucleotides; modified nucleic acid; splicing; splicing switch; exon skipping; pseudoexon; N-of-1; precision medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Drug Design and Development for Neurological Diseases submission deadline 20 Nov 2025 | 4 articles | Viewed by 7045 | Submission Open
Keywords: neurological disorders and their therapies; molecular modeling; synthesis and structural analysis; neurotransmitters ligands; mechanism of action; drug repurposing
(This special issue belongs to the Section Molecular Pharmacology)
Astrocyte-Endothelial Interactions at the Blood-Brain Barrier, 2nd Edition
edited by
submission deadline 20 Nov 2025 | 2 articles | Viewed by 6997 | Submission Open
Keywords: blood– brain barrier (BBB); astrocyte– endothelial interactions; cytokine signaling; astrocytic modulation; brain microvascular endothelial cells; chemokine receptors; BBB permeability; BBB dysfunction; BBB pharmacokinetics; cerebrovascular disease; oxidative stress; BBB models
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Advances in Antimicrobial Nanoparticles submission deadline 20 Nov 2025 | 1 articles | Viewed by 6870 | Submission Open
Keywords: nanotechnology; antimicrobial agents; nanoparticle synthesis; biomedical applications; targeted delivery; mechanisms of action
(This special issue belongs to the Section Molecular Nanoscience)
Medicinal Plants and Natural Compounds in Health and Disease: Progresses, Challenges, Opportunities, 2nd Edition submission deadline 20 Nov 2025 | 2 articles | Viewed by 6791 | Submission Open
Keywords: medicinal plants; phytochemicals; vitamins; oxidative stress; gene expression; protein expression; cellular signaling; ethnopharmacology
(This special issue belongs to the Section Molecular Pharmacology)
Signaling and Stress Adaptation in Plants
edited by and
submission deadline 20 Nov 2025 | 7 articles | Viewed by 6763 | Submission Open
Keywords: plants; environmental stress; stress signaling; reactive oxygen/nitrogen species; calcium; protein kinases; stress resistance; adaptive mechanisms
(This special issue belongs to the Section Molecular Plant Sciences)
Physiology and Molecular Medicine of Molecular Hydrogen
edited by and John Nagi Kheir
submission deadline 20 Nov 2025 | 2 articles | Viewed by 6721 | Submission Open
Keywords: molecular hydrogen; reactive oxygen species; nitric oxide; inflammation; cardiovascular disease
(This special issue belongs to the Section Molecular Biology)
Insights in Reproductive Immunology and Placental Pathology, 2nd Edition
edited by
submission deadline 20 Nov 2025 | 4 articles | Viewed by 6657 | Submission Open
Keywords: gamete immunology; in vitro fertilization; infertility; immunocontraception; implantation; placentation; immunotolerance; reproductive immunology; inflammation; cytokine network; placenta-derived stem cells; placental development; placental insufficiency; endometriosis; immunopathology of pregnancy; sex hormones
(This special issue belongs to the Section Molecular Immunology)
From Biomolecules to Therapies: Bridging the Gap with Molecular Mechanisms, Computational Design, and Drug Delivery submission deadline 20 Nov 2025 | 3 articles | Viewed by 6537 | Submission Open
Keywords: biomolecules; molecular mechanisms; computational studies; drug delivery; xenobiotics
(This special issue belongs to the Section Molecular Informatics)
Cheminformatics in Drug Discovery and Green Synthesis
edited by
submission deadline 20 Nov 2025 | 5 articles | Viewed by 6493 | Submission Open
Keywords: cheminformatics; drug discovery; databases; in silico methods; green chemistry
(This special issue belongs to the Section Molecular Informatics)
New Insights into Mitochondria in Health and Diseases submission deadline 20 Nov 2025 | 4 articles | Viewed by 6449 | Submission Open
Keywords: mitochondrial bioenergetics; reactive oxygen species; apoptosis; aging; immune function; mtDNA mutations; mitochondrial dysfunction; mitochondria-targeted therapies
(This special issue belongs to the Section Biochemistry)
Cardiovascular Disease and Diabetes: A New Challenge in Treatment and Management
edited by Graziano Riccioni
submission deadline 20 Nov 2025 | 3 articles | Viewed by 6414 | Submission Open
Keywords: hypertension; atherosclerosis; congestive heart failure; diabetes mellitus; therapy; hypercholesterolemia; coronary artery disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Exploring the Molecular Mechanisms of Chronic Kidney Disease submission deadline 20 Nov 2025 | 3 articles | Viewed by 6267 | Submission Open
Keywords: chronic kidney disease; hereditary renal disease; renal hypertension; diabetic nephropathy; secondary hyperparathyroidism; cardiovascular disease; renal osteodystrophy; peritoneal dialysis; hemodialysis; anemia; metabolic acidosis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Editorial Board Members’ Collection Series: “Molecular Dynamics” submission deadline 20 Nov 2025 | 3 articles | Viewed by 6089 | Submission Open
Keywords: quantum mechanics; classical mechanics; hybrid QM/MM; molecular dynamics at the atomic level; steered molecular dynamics; coarse-graining; docking(protein– protein; protein– ligand); the molecular dynamics of protein– ligand interactions; drug design; virtual screening
(This special issue belongs to the Section Molecular Biophysics)
Cardiovascular Diseases: From Pathology to Therapeutics
edited by
submission deadline 20 Nov 2025 | 4 articles | Viewed by 6063 | Submission Open
Keywords: cardiovascular diseases; pathologies; cardiac progenitor cells; molecular pathways; regenerative medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Research of Natural Products from Microalgae and Cyanobacteria
edited by
submission deadline 20 Nov 2025 | 3 articles | Viewed by 5836 | Submission Open
Keywords: marine and fresh water microalgal and cyanobacterial bioactive compounds; microalgal and cyanobacterial carotenoids; vitamins; phenolics; and phycobiliproteins; microalgal and cyanobacterial alkaloids; microalgal and cyanobacterial polysaccharides; microalgal and cyanobacterial peptides; microalgal and cyanobacterial polyphenols; microalgal and cyanobacterial antioxidants; microalgal and cyanobacterial pharmaceuticals; microalgal and cyanobacterial nutraceuticals; microalgal and cyanobacterial anti-inflammatory compounds; microalgal and cyanobacterial antimicrobial compounds; microalgal and cyanobacterial anticancer compounds; microalgal and cyanobacterial neuroprotective compounds; microalgal and cyanobacterial antiviral compounds; microalgal and cyanobacterial-derived anti-aging compounds; microalgal and cyanobacterial extracts
(This special issue belongs to the Section Biochemistry)
Recent Advances in Gastrointestinal Tract Oncology: Pathology, Diagnostics and Therapy
edited by and Mariusz Gryko
submission deadline 20 Nov 2025 | 6 articles | Viewed by 5753 | Submission Open
Keywords: gastrointestinal cancer; esophageal cancer; gastric (stomach) cancer; colorectal cancer; liver cancer; pancreatic cancer; gallbladder and biliary tract cancer; genetic alterations; molecular subtyping; tumor microenvironment; innovative therapies; targeted therapies; tumor biomarkers
(This special issue belongs to the Section Molecular Oncology)
Microbial Infections and Novel Biological Molecules for Treatment
edited by Matthew Cheesman
submission deadline 20 Nov 2025 | 8 articles | Viewed by 5723 | Submission Open
Keywords: microbial infections; infectious diseases; new antibiotics; antimicrobial resistance (AMR); antimicrobial drugs; active substance; bacterial; virus
(This special issue belongs to the Section Molecular Microbiology)
Molecular Mechanisms and Therapies of Colorectal Cancer: 4th Edition submission deadline 20 Nov 2025 | 6 articles | Viewed by 5688 | Submission Open
Keywords: transforming growth factor beta (TGF-β ) signaling; genetic alterations; molecular targeted therapy precision medicine
(This special issue belongs to the Section Molecular Oncology)
The Role of Autophagy in Disease and Cancer submission deadline 20 Nov 2025 | 3 articles | Viewed by 5637 | Submission Open
Keywords: autophagy; autophagy-related proteins; target therapy; cancer; neurodegenerative disease; infections; aging; metabolic disease; autoimmunity
(This special issue belongs to the Section Molecular Biology)
Bacteriophage—Molecular Studies (6th Edition)
edited by
submission deadline 20 Nov 2025 | 4 articles | Viewed by 5545 | Submission Open
Keywords: bacteriophage biodiversity; regulation of bacteriophage development; molecular processes in bacteriophages; bacteriophage-based biotechnology; phage therapy
(This special issue belongs to the Section Biochemistry)
The Role of miRNA in Human Diseases
edited by and Seeun Ha
submission deadline 20 Nov 2025 | 3 articles | Viewed by 5344 | Submission Open
Keywords: miRNA; diabetes; obesity; fatty liver disease; gastrointestinal disease
(This special issue belongs to the Section Molecular Genetics and Genomics)
Skeletal Muscle Function and Metabolism: Molecular Mechanisms and Treatment—2nd Edition
edited by
submission deadline 20 Nov 2025 | 4 articles | Viewed by 5231 | Submission Open
Keywords: skeletal muscle; metabolism; mitochondria; epigenetics; exercise; signalization
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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