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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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MicroRNAs as Biomarkers and Therapeutic Targets in Human Diseases
edited by Elena V. Bichenkova
submission deadline 30 Sep 2025 | 2 articles | Viewed by 1867 | Submission Open
Keywords: microRNA biomarkers; diagnostic profiling; expression patterns; miRNA therapeutics; antimiRs; miRNA mimics; hybridisation; sequence-specificity; miRNA knockdown
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Natural Products for Neuroprotection and Neurodegeneration
edited by
submission deadline 30 Sep 2025 | 3 articles | Viewed by 1840 | Submission Open
Keywords: natural products; bioactive compounds; neuroprotection; neurodegeneration
(This special issue belongs to the Section Molecular Neurobiology)
Innovative Approaches for Investigations on Protein Interactions submission deadline 30 Sep 2025 | 1 articles | Viewed by 1696 | Submission Open
Keywords: protein– protein and protein– ligand interactions; proteomics; innovative approaches; LC-MS/MS; immunometric techniques; interactome; drug discovery and development
(This special issue belongs to the Section Biochemistry)
Molecular Mechanism and Breeding of Abiotic and Biotic Stress Tolerance in Crops submission deadline 30 Sep 2025 | 1 articles | Viewed by 1447 | Submission Open
Keywords: crop production; abiotic stress; biotic stress; genetic mechanism; molecular markers; crop variety improvement
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Insights into Hepatocellular Carcinoma: From Carcinogenesis to Liver Transplantation
edited by
submission deadline 30 Sep 2025 | 2 articles | Viewed by 1359 | Submission Open
Keywords: hepatocarcinogenesis; molecular pathogenesis; tumor microenvironment; metabolic dysfunction-associated fatty liver disease (MAFLD); metastasis; genetic and epigenetic alterations; biomarkers; precision oncology; targeted therapy; immunotherapy; therapy resistance; immune escape; tumor recurrence; transplant oncology
(This special issue belongs to the Section Molecular Oncology)
Molecular Insights and Treatments for Gynecological Cancers submission deadline 30 Sep 2025 | 1 articles | Viewed by 1330 | Submission Open
Keywords: gynecological cancers; cancers; endometrial cancers; cervical cancer; tumor microenvironment
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Current Trends in Redox Physiology Research
edited by Fotios Tekos
submission deadline 30 Sep 2025 | Viewed by 1293 | Submission Open
Keywords: redox biology; oxidative stress; antioxidant mechanisms; redox signaling; cellular homeostasis; inflammation and redox; nutritional redox modulation; environmental toxicology and redox; mitochondrial dysfunction; oxidative stress biomarkers
(This special issue belongs to the Section Biochemistry)
Research Advances in Retinal Neurodegeneration and Neuroprotection Strategies
edited by and
submission deadline 30 Sep 2025 | Viewed by 1251 | Submission Open
Keywords: retinal neurodegeneration; retinal neuroprotection; retinal pigment epithelium dysfunction; electrophysiology; molecular targets; drug delivery
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Insights into Rare Diseases: From Pathogenesis to Innovative Therapies
edited by Grażyna Gromadzka
submission deadline 30 Sep 2025 | 2 articles | Viewed by 1249 | Submission Open
Keywords: rare diseases; orphan disorders; orphan drugs; gene therapy; precision medicine; biomarkers in rare diseases; gene therapy; CRISPR therapy; CRISPR-mediated DNA editing; CRISPR technology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Therapies, Pathogenetic and Inflammatory Mechanisms in Thrombosis
edited by
submission deadline 30 Sep 2025 | 2 articles | Viewed by 1219 | Submission Open
Keywords: thromboinflammation; endothelial dysfunction; antithrombotic therapies; oxidative stress; thrombosis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advancing Regenerative Medicine: Basic Research and Translation in Clinics
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1202 | Submission Open
Keywords: regenerative medicine; stem cells; tissue engineering; exosomes; orthobiologics
(This special issue belongs to the Section Molecular Biology)
Advances in Epigenetics of Mental Disorders
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1153 | Submission Open
Keywords: mental disorders; epigenetic; epigenomic; gene– environment interactions
(This special issue belongs to the Section Molecular Neurobiology)
New Advances in Platelet Biology and Functions: 3rd Edition
edited by
submission deadline 30 Sep 2025 | 2 articles | Viewed by 1091 | Submission Open
Keywords: platelet microparticles; thrombosis; inflammation; oxidative stress; antiplatelet drug; signal transduction; immunity; tumor growth
(This special issue belongs to the Section Molecular Biology)
Emerging Biomaterials for Cartilage Regeneration
edited by
submission deadline 30 Sep 2025 | Viewed by 1075 | Submission Open
Keywords: osteoarthritis; glycosaminoglycans; biomaterials; cartilage regeneration; mesenchymal cells; chondrocytes
(This special issue belongs to the Section Biochemistry)
Mitochondrial Functions and Dynamics
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1069 | Submission Open
Keywords: bioenergetics; mitochondrial biogenesis; mitochondrial morphology; apoptosis; mitophagy; reactive oxygen species; calcium homeostasis; cardiovascular diseases; neurodegenerative diseases; in vitro; cellular; and animal models; myopathies; mitochondria and immune system
(This special issue belongs to the Section Molecular Biology)
Molecular Research in Obesity and Obesity Related Disorders: 3rd Edition
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1010 | Submission Open
Keywords: biochemistry and molecular medicine; molecular and cellular mechanisms of disease pathogenesis; pathogenesis of metabolic disorders; the role of interaction between genetic and environmental factors in the pathogenesis of non-communicable diseases; atherosclerosis; obesity; obesity-related metabolic diseases and cancers
(This special issue belongs to the Section Molecular Biology)
Bone and Cartilage Injury and Repair: Molecular Aspects
edited by Silvia María Díaz-Prado
submission deadline 30 Sep 2025 | 2 articles | Viewed by 985 | Submission Open
Keywords: bone and cartilage repair; regenerative medicine; inflammation and immune response; stem cell therapy; extracellular matrix remodeling; biomaterials; drug delivery systems; therapeutic targets; biomarkers
(This special issue belongs to the Section Molecular Biology)
Advances in Microbial Genomics: Insights from Whole Genomes and Metagenomes submission deadline 30 Sep 2025 | 2 articles | Viewed by 873 | Submission Open
Keywords: microbial evolution; whole-genome sequencing; metagenomics; horizontal gene transfer; antimicrobial resistance; computational genomics
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Insights into Glioblastoma Pathogenesis and Therapeutics submission deadline 30 Sep 2025 | 2 articles | Viewed by 850 | Submission Open
Keywords: glioblastoma; proteomics; immunopeptidomics; genomics; extracellular vesicles; biomarkers; molecular mechanisms; i-knife mass spectrometry; intra-operative imaging; cancer stem cells; cancer progression; neurosurgery; radiomics; personalized medicine
(This special issue belongs to the Section Molecular Oncology)
Molecular Mechanisms of Antimicrobial Resistance and Host–Pathogen Interactions: From Genes to Therapeutics
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 849 | Submission Open
Keywords: antimicrobial resistance; host– pathogen interaction; MDR pathogens; biofilm; immune evasion; pharmacodynamics; sepsis; critical care infections; quorum sensing; immunoparalysis
(This special issue belongs to the Section Molecular Immunology)
Neurogenesis and Neurodegeneration: Insights into Regeneration and the Impact of Neurotrophins submission deadline 30 Sep 2025 | 1 articles | Viewed by 833 | Submission Open
Keywords: neurogenesis; neurodegeneration and regeneration; neurotrophins; brain plasticity
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Mechanisms and Functions of Extracellular Vesicles
edited by and Jameel M. Inal
submission deadline 30 Sep 2025 | 1 articles | Viewed by 830 | Submission Open
Keywords: extracellular vesicles; molecular mechanisms; biomarkers; liquid biopsy; cell-communication; cellular function; pathobiology; clinical
(This special issue belongs to the Section Molecular Biology)
Osteoblast Differentiation in Human Health and Disease
edited by Younho Han
submission deadline 30 Sep 2025 | 1 articles | Viewed by 818 | Submission Open
Keywords: osteoblast differentiation; bone remodeling; mesenchymal stem cells; skeletal diseases; osteogenesis; bone mineralization; osteoporosis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Role of Natural Products in Treating Human Diseases
edited by Luís R. Silva
submission deadline 30 Sep 2025 | Viewed by 783 | Submission Open
Keywords: natural products; phytochemicals; biological potential; pharmacological activity; health promoters; chronic diseases
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Advancements in Molecular Science, Material Analysis, and Surface Treatments: Paving the Way for Future Technological Innovations
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 727 | Submission Open
Keywords: materials; surface treatments; corrosion; nanomaterials; coatings; molecular interactions; deposition
(This special issue belongs to the Section Materials Science)
Calcium Homeostasis of Cells in Health and Disease: Third Edition submission deadline 30 Sep 2025 | 1 articles | Viewed by 706 | Submission Open
Keywords: Ca2+; calcium homeostasis; calcium-binding proteins; aging; disease
(This special issue belongs to the Section Biochemistry)
Natural Compounds in Cancer Therapy: Molecular Mechanisms and Translational Potential submission deadline 30 Sep 2025 | 1 articles | Viewed by 687 | Submission Open
Keywords: natural compounds; cancer research; oxidative stress
(This special issue belongs to the Section Molecular Oncology)
Molecular Microbiology in the Omics Era: Genomics, Metagenomics and Computational Insights
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 684 | Submission Open
Keywords: microbial genomics; metagenomics; computational biology; antimicrobial resistance; host– microbe interactions; multi-omics integration; bioinformatics tools; machine learning in microbiology
(This special issue belongs to the Section Molecular Microbiology)
Heat Shock Proteins (HSPs): Biological Functions and Mechanisms of Actions submission deadline 30 Sep 2025 | 1 articles | Viewed by 640 | Submission Open
Keywords: heat shock proteins; apoptosis; immune cell activation; stress responses; misfolded proteins; cellular chaperones; cell signaling
(This special issue belongs to the Section Biochemistry)
Emerging Viral Epidemics
edited by Nikolaos Siafakas
submission deadline 30 Sep 2025 | 1 articles | Viewed by 636 | Submission Open
Keywords: emerging viruses; diagnostic virology; viral epidemiology; viral evolution; zoonotic infections; public health; surveillance
(This special issue belongs to the Section Molecular Microbiology)
New Developments in Chronic Myeloid Leukemia
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 624 | Submission Open
Keywords: CML; small molecule inhibitors; biologicall treatment; prognostic markers
(This special issue belongs to the Section Molecular Immunology)
Natural Active Substances in Human Diseases
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 614 | Submission Open
Keywords: natural active substances; bioactive compounds; molecular mechanisms; traditional medicine; metabolic disorders; inflammatory diseases; neurodegenerative diseases
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Recent Advances in Urological Cancer
edited by Andrea Zivi and Sara Merler
submission deadline 30 Sep 2025 | 1 articles | Viewed by 589 | Submission Open
Keywords: genitourinary oncology; urologic surgery; urologic radiotherapy innovations; translational research; emerging therapies
(This special issue belongs to the Section Molecular Oncology)
Molecular Mechanisms of Various Diseases and Drugs Involved in Vascular Tone Regulation in Cardiovascular Disease
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 557 | Submission Open
Keywords: vasoconstriction; vasodilation; calcium; protein kinase C; Rho-kinase; hypertension; nitric oxide
(This special issue belongs to the Section Molecular Biology)
Lung Cancer: From Molecular Mechanisms to Novel Therapeutics: 2nd Edition submission deadline 30 Sep 2025 | 1 articles | Viewed by 541 | Submission Open
Keywords: lung cancer; oncogene; targeted therapy; immunotherapy; predictive biomarkers; liquid biopsy
(This special issue belongs to the Section Molecular Oncology)
Inflammatory Bowel Disease: Molecular Insights—2nd Edition
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 540 | Submission Open
Keywords: genomic sequencing; microbiome; dysbiosis; commensal flora; omics; immunobiology; colitis; Crohn’ s disease; ulcerative colitis; multiomics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Biomarkers in Diabetes Mellitus: From Discovery to Clinical Application submission deadline 30 Sep 2025 | 1 articles | Viewed by 537 | Submission Open
Keywords: diabetes mellitus; biomarkers; diabetes complications; omics technologies; risk stratification; therapeutic response; personalized medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Drug Repurposing: Emerging Approaches to Drug Discovery (2nd Edition)
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 524 | Submission Open
Keywords: repurposed drugs; network medicine; systems medicine; drug design; therapeutic strategies; drug repurposing in the era of artificial intelligence; drug repositioning; machine learning
(This special issue belongs to the Section Molecular Pharmacology)
Optical Materials: Molecular Advances of Their Synthesis, Properties and Medical Applications submission deadline 30 Sep 2025 | Viewed by 500 | Submission Open
Keywords: optical materials; luminescence; luminescence thermometry; laser materials; phosphors; biocompatible optical materials; optical imaging; fluorescent nanoparticles; rare-earth ion-doped nanomaterials; hard and soft tissue engineering; laser imaging systems
(This special issue belongs to the Section Materials Science)
Molecular Research in Natural Products
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 478 | Submission Open
Keywords: synaptic plasticity regulation; bioactive compounds; signal transduction pathways; gene expression regulation; molecular neurobiology
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Bioactive Compound Delivery Systems and Microbiome Interactions submission deadline 30 Sep 2025 | Viewed by 458 | Submission Open
Keywords: bioactive compounds; delivery systems; gut microbiome; personalized nutrition; bioavailability; encapsulation technologies; microbiome– bioactive interactions; targeted delivery; precision nutrition; synergistic interactions
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Mechanism of VCP/p97 in Health and Diseases
edited by
submission deadline 30 Sep 2025 | Viewed by 416 | Submission Open
Keywords: AAA ATPase; VCP/p97/cdc48/TER ATPase; AAA ATPase; protein unfolding; protein degradation; protein quality control; ERAD; mitochondria-associated degradation; lysosome degradation; ribosome-associated degradation; membrane fusion and trafficking; ubiquitin; TDP43; inclusion body myopathy (IBM); paget disease (PD); frontotemporal dementia (FD); MSP1; amyotrophic lateral sclerosis (ALS); charcot-marie-tooth disease 2Y; Parkinson’ s disease; intellectual development disabilities (IDDs); lysosomal diseases; tauopathies
(This special issue belongs to the Section Molecular Biology)
X-Linked Disorders: Epigenetic and Environmental Modulation of Phenotypes
edited by Yoram Chaiter and
submission deadline 30 Sep 2025 | Viewed by 415 | Submission Open
Keywords: X-linked disorders; epigenetics; environmental factors; gene expression; clinical manifestations
(This special issue belongs to the Section Molecular Genetics and Genomics)
Advances in Novel Therapeutic Strategies for Cancers submission deadline 30 Sep 2025 | 1 articles | Viewed by 389 | Submission Open
Keywords: precision medicine; molecular targeted therapies; kinase inhibitors; PROTAC; CAR-T cell therapy; tumor microenvironment; host microbiota; resistance mechanisms; biomarkers; immunotherapy
(This special issue belongs to the Section Molecular Oncology)
Advances in Laboratory Animal Research for Precision Medicine in Cardiovascular Diseases
edited by Conrado Calvo
submission deadline 30 Sep 2025 | Viewed by 385 | Submission Open
Keywords: cardiovascular disease; experimental models and research; arrhythmias and cardiac electrophysiology; molecular science and imaging techniques; myocardial ischemia and heart failure; cardiac fibrillation and sudden cardiac death; circulation and blood vessels; diabetes and metabolic disorders; experimental datasets for precision medicine; data-driven in silico approaches
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research in Triple-Negative Breast Cancer: 2nd Edition
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 373 | Submission Open
Keywords: triple negative breast cancer; lymph node metastasis; PMP22; prediction model using deep learning
(This special issue belongs to the Section Molecular Oncology)
Lipid Emulsion and Other Treatment in Drug Toxicity
edited by
submission deadline 30 Sep 2025 | Viewed by 372 | Submission Open
Keywords: lipid emulsions; toxicity; toxic drug; anesthetic drug
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Insights into the Precision Medicine on Neoplastic Diseases: Challenges, Perspectives and Opportunities
edited by
submission deadline 30 Sep 2025 | Viewed by 371 | Submission Open
Keywords: cancer; molecular biology; precision medicine; targeted therapy
(This special issue belongs to the Section Molecular Oncology)
Molecular Pharmacology and Interventions in Cardiovascular Disease: 2nd Edition submission deadline 30 Sep 2025 | 1 articles | Viewed by 349 | Submission Open
Keywords: cardiovascular pharmacology; cardiovascular interventions; cardioprotection; myocardial ischemia and infarction; heart failure
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Advances in Macroporous, Mesoporous, and Microporous Materials submission deadline 30 Sep 2025 | 1 articles | Viewed by 346 | Submission Open
Keywords: functional materials; nanomaterials; nanostructures; molecular systems; porous materials
(This special issue belongs to the Section Materials Science)
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