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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Recognition and Biosensing
edited by
submission deadline 20 Dec 2025 | 4 articles | Viewed by 10595 | Submission Open
Keywords: molecular recognition; biosensor; nanomaterials; aptamer; nucleic acids; sensitivity
(This special issue belongs to the Section Biochemistry)
Understanding and Treating Amyotrophic Lateral Sclerosis and Related Motor Neuron Diseases
edited by
submission deadline 20 Dec 2025 | 3 articles | Viewed by 10450 | Submission Open
Keywords: neurodegenerative; ALS; motor neuron; genetics; molecular pathways; biomarkers; models; treatments
(This special issue belongs to the Section Molecular Neurobiology)
Nonalcoholic Liver Disease: Mechanisms, Prevention, and Treatment submission deadline 20 Dec 2025 | 3 articles | Viewed by 10219 | Submission Open
Keywords: MAFLD; MASH; metabolic syndrome; steatosis; lipid droplets; SNPs; GWAS; therapeutc target; fatty liver; steatohepatitis; HCC; EpigEnetics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Lymphatic Disorders: From Molecular Mechanisms to Therapies
edited by
submission deadline 20 Dec 2025 | 4 articles | Viewed by 10122 | Submission Open
Keywords: lymphoedema; lipedema; matrix; vascular disorder; ultrasound; lacteal; microbiota; intersitial fluid
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
High Resolution Mass Spectrometry in Molecular Sciences: 2nd Edition
edited by
submission deadline 20 Dec 2025 | 4 articles | Viewed by 10077 | Submission Open
Keywords: antibodies; astrobiology; biomarkers; drug discovery; drug development; drug metabolism; Fourier transform; glycomics; imaging; ion cyclotron resonance; ion mobility; lipids; lipidomics; mass spectrometry; metabolomics; nucleic acids; Orbitrap; organometallics; polymers; peptides; proteins; proteomics; structural biology; structure elucidation; tandem mass spectrometry; time-of-flight
(This special issue belongs to the Section Biochemistry)
Genetic Research in Neurological Diseases
edited by
submission deadline 20 Dec 2025 | 2 articles | Viewed by 9903 | Submission Open
Keywords: neurodegenerative diseases; genetic risk factor; next-genetation sequencing; genome-wide association studies; disease models
(This special issue belongs to the Section Molecular Neurobiology)
Advanced Research on Nucleic Acids: Therapeutic Potential and Applications, 2nd Edition submission deadline 20 Dec 2025 | 5 articles | Viewed by 9901 | Submission Open
Keywords: aptamer; decoy; DNAzyme; ribozyme; siRNA; miRNA; antisense oligonucleotide; antigene strategy; G-quadruplex; triplex
(This special issue belongs to the Section Biochemistry)
Diabetes: Advances in Molecular Research submission deadline 20 Dec 2025 | 3 articles | Viewed by 9877 | Submission Open
Keywords: type 1 diabetes; type 2 diabetes; retinopathy; nephropathy; neuropathy; molecular pharmacology; cardiovascular disease; cerebrovascular disease; normal physiology; counter-regulatory hormones; hypoglycemia   TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian   //   TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back //     This page is in English   Translate to Simplified Chinese         Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh   Always translate English to Simplified Chinese Never translate English Never translate admin.mdpi.com
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Innovative Therapeutic Approaches in Neuropsychiatric Disorders
edited by Marta Pardo
submission deadline 20 Dec 2025 | 2 articles | Viewed by 9773 | Submission Open
Keywords: neuropsychiatric disorders; pharmacogenomics; pathophysiology; molecular treatment mechanisms; molecular targets for novel drug development; neurotransmitters; synaptic plasticity; epigenetics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Latest Reviews in Molecular Plant Science 2025
edited by and
submission deadline 20 Dec 2025 | 4 articles | Viewed by 9654 | Submission Open
Keywords: gene cloning and gene functional analysis; gene editing; QTL mapping; multi-omics integration analysis; agronomically characteristics; plant development; metabolic pathway; biotic and abiotic stresses
(This special issue belongs to the Section Molecular Plant Sciences)
Insights into Redox Homeostasis and Oxidative Stress
edited by , Zoi Vasiliki Skaperda and
submission deadline 20 Dec 2025 | 4 articles | Viewed by 9412 | Submission Open
Keywords: oxidative stress; redox homeostasis; redox signaling; reactive oxygen species; oxidative damage; diseases
(This special issue belongs to the Section Molecular Pharmacology)
New Perspective on Inflammatory Diseases: Role of Natural Compounds submission deadline 20 Dec 2025 | 4 articles | Viewed by 8956 | Submission Open
Keywords: natural compounds; immunomodulatory activity; anti-inflammatory activity; synergistic effect; nanotechnologies; delivery systems; bioinformatic analysis
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Innovations in Polymeric Materials: Exploring Advancements and Applications
edited by
submission deadline 20 Dec 2025 | 3 articles | Viewed by 8815 | Submission Open
Keywords: eco-friendly polymers; nanocomposites; biodegradable polymers; smart materials; polymer recycling; drug delivery systems; biocompatible polymers; food industry; wastewater treatment
(This special issue belongs to the Section Materials Science)
Cancer Drug Treatment and Cancer Cell Drug Resistance submission deadline 20 Dec 2025 | 3 articles | Viewed by 8766 | Submission Open
Keywords: cellular plasticity; heterogeneity; combinational chemotherapy; metastasis; tumor relapse; novel targets; drug delivery
(This special issue belongs to the Section Molecular Pharmacology)
Advances in Synaptic Transmission and Plasticity
edited by
submission deadline 20 Dec 2025 | 4 articles | Viewed by 8566 | Submission Open
Keywords: synaptic transmission; synapse; neurotransmitters; synaptic plasticity; memory; learning; neurodegenerative diseases; neuropsychiatric diseases
(This special issue belongs to the Section Molecular Neurobiology)
Integrated Approaches, Molecular Mechanism and Therapies in Ocular Surface Diseases
edited by , and
submission deadline 20 Dec 2025 | 4 articles | Viewed by 8558 | Submission Open
Keywords: ocular surface diseases; dry eye; corneal ulcers; persistent epithelial defects; blood-derived products; blood-based therapies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Type 2 Diabetes: Molecular Pathophysiology and Treatment
edited by
submission deadline 20 Dec 2025 | 3 articles | Viewed by 8154 | Submission Open
Keywords: type 2 diabetes mellitus and comorbidity; bioinformatics; molecular pathways; genetic background; biomarkers; novel therapies
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Research of Dystonia and Parkinson’s Disease
edited by
submission deadline 20 Dec 2025 | 4 articles | Viewed by 8064 | Submission Open
Keywords: dystonia; Parkinson’ s disease; molecular mechanism; molecular pathology; cell biology; genetic predisposition to disease; physiopathology; neural plasticity; animal models; biomedical translational science
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cellular and Molecular Mechanisms of Plant Responses to Light (Second Edition) submission deadline 20 Dec 2025 | 4 articles | Viewed by 7957 | Submission Open
Keywords: celluar mechanism; light; molecular mechanism; plant growth; plant development; gene expression; primary and secondary metabolites; photomorphogenesis; photoperiod response; stress resistance; nutrient uptake
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Basis and Advances of Targeted Therapy for Breast Cancer: Second Edition submission deadline 20 Dec 2025 | 4 articles | Viewed by 7827 | Submission Open
Keywords: breast cancer; targeted therapy; cancer therapy; resistance; epigenetic modulations
(This special issue belongs to the Section Molecular Oncology)
The Role of Neurons in Human Health and Disease—3rd Edition
edited by
submission deadline 20 Dec 2025 | 5 articles | Viewed by 7666 | Submission Open
Keywords: brain; nervous system; neurons; immune system; human health and disease
(This special issue belongs to the Section Molecular Neurobiology)
Nanoparticles in Molecular Pharmaceutics
edited by
submission deadline 20 Dec 2025 | 5 articles | Viewed by 7655 | Submission Open
Keywords: nanoparticles; molecular pharmaceutics; drug delivery; nanomedicine; nanoformulation
(This special issue belongs to the Section Molecular Nanoscience)
Advances in Targeting Macrophages in Immunotherapy
edited by Vinod Nadella
submission deadline 20 Dec 2025 | 1 articles | Viewed by 7387 | Submission Open
Keywords: tumor-associated macrophages; tumor microenvironment; tumor immunology; carcinogenesis; macrophage repolarization; checkpoint inhibitor; immunotherapy; nanomaterials; metabolic reprogramming; epigenetics
(This special issue belongs to the Section Molecular Immunology)
Regulatory Mechanisms of Development and Abiotic Stress Response by Transcriptional Regulators in Plants: 2nd Edition
edited by
submission deadline 20 Dec 2025 | 5 articles | Viewed by 7379 | Submission Open
Keywords: transcriptional regulator; transcription activation; transcription factor; transcription repression; plant development; abiotic stress response; epigenetic regulation; genome-wide analysis
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Insights into Multiple Sclerosis
edited by Yoshio Bando
submission deadline 20 Dec 2025 | 4 articles | Viewed by 6996 | Submission Open
Keywords: multiple sclerosis; molecular mechanism; pathogenesis; biomarkers; therapeutic targets
(This special issue belongs to the Section Molecular Neurobiology)
Therapeutic Targets in Pancreatic Cancer: 2nd Edition submission deadline 20 Dec 2025 | 3 articles | Viewed by 6757 | Submission Open
Keywords: pancreatic cancer; translational research; therapeutic targets and novel interventional strategies; mechanisms of anti-tumor reactions; biomarkers
(This special issue belongs to the Section Molecular Oncology)
Nanomedicine in Gene Therapy and Immunotherapy
edited by and Ruixuan Gao
submission deadline 20 Dec 2025 | 3 articles | Viewed by 6691 | Submission Open
Keywords: nanomedicine; drug delivery; gene delivery; genome editing; immunotherapy
(This special issue belongs to the Section Molecular Immunology)
Cytochrome P450 Mechanism and Reactivity
edited by
submission deadline 20 Dec 2025 | 3 articles | Viewed by 6598 | Submission Open
Keywords: enzyme function; enzyme catalysis; bioengineering; inorganic reaction mechanisms; enzyme inhibition
(This special issue belongs to the Section Biochemistry)
Voltage-Gated Ion Channels and Human Diseases
edited by María A. Gandini
submission deadline 20 Dec 2025 | 5 articles | Viewed by 6501 | Submission Open
Keywords: channelopathies; voltage gated-ion channels; human diseases; mutations; calcium; sodium; potassium
(This special issue belongs to the Section Molecular Biophysics)
Anticancer and Chemopreventive Activity of Natural Products and Its Derivatives
edited by
submission deadline 20 Dec 2025 | 2 articles | Viewed by 6407 | Submission Open
Keywords: coumarins; coumarin derivatives; anticancer activity; chemopreventive activity; therapy adjuvant; mechanism of action; in vitro and in vivo studies; molecular research; metabolic pathway; phytochemicals; natural products; apoptosis; bioactivity assessment; chemical composition; therapeutic targets
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Targeting Metabolic Reprogramming: From Pathogenesis to Therapeutic Strategies submission deadline 20 Dec 2025 | 2 articles | Viewed by 6272 | Submission Open
Keywords: metabolism; therapy; mitochondria; pathogenesis; bioenergetics
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Neuroinflammation: Advancements in Pathophysiology and Therapies (2nd Edition) submission deadline 20 Dec 2025 | 3 articles | Viewed by 6182 | Submission Open
Keywords: neuroinflammation; CNS diseases; pathophysiology; therapeutic strategies; pharmacological treatments; neurological disorders; neurodegenerative diseases; cardiovascular diseases; psychiatric disorders
(This special issue belongs to the Section Molecular Neurobiology)
A Commemorative Issue in Honor of Professor Peter A. Ward: World Expert in Sepsis
edited by Peter Ward
submission deadline 20 Dec 2025 | 3 articles | Viewed by 6131 | Submission Open
Keywords: sepsis; neutrophils; macrophages; histones; chemical modifications; apoptosis; complement factors
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Lipid Metabolism and Biomarkers in Neural and Cardiometabolic Health
edited by
submission deadline 20 Dec 2025 | 4 articles | Viewed by 6089 | Submission Open
Keywords: lipid species; cardiovascular health; neural health; inflammation; cardiac biomarkers; neural biomarkers
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
The Molecular Link Between Nutrition and Obesity
edited by
submission deadline 20 Dec 2025 | 2 articles | Viewed by 6084 | Submission Open
Keywords: hormonal regulation; chronic low-grade inflammation; nutrient sensing pathways; gut microbiota
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Advancing Neurological Disorders via Computational Neuroscience and Neural Networks
edited by
submission deadline 20 Dec 2025 | 2 articles | Viewed by 6061 | Submission Open
Keywords: neurological disorders; neuroimaging analysis; biomarker identification; computational neuroscience; machine learning; brain aging
(This special issue belongs to the Section Molecular Informatics)
New Molecular Insights into Ischemia/Reperfusion: 2nd Edition
edited by
submission deadline 20 Dec 2025 | 5 articles | Viewed by 6029 | Submission Open
Keywords: vital organs; ischemic injury; cell and organ dysfunction; oxidative stress; inflammation; excitotoxicity
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Insight into Extracellular Vesicles in Proliferative Diseases
edited by Sergio Esquivel-Ruiz
submission deadline 20 Dec 2025 | 2 articles | Viewed by 6015 | Submission Open
Keywords: proliferation; extracellular vesicles; intercellular communication; vesicle cargo; therapeutic applications; biomarkers
(This special issue belongs to the Section Molecular Immunology)
Advances in Gastrointestinal Disease: Exploring the Interplay Between Inflammation, Autoimmunity, and Cancer
edited by Spyridon Siakavellas and
submission deadline 20 Dec 2025 | 2 articles | Viewed by 5957 | Submission Open
Keywords: gastrointestinal disease; inflammation; autoimmunity; gut microbiota
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Research on Antifungal Resistance
edited by Anna Tomova
submission deadline 20 Dec 2025 | 4 articles | Viewed by 5889 | Submission Open
Keywords: antifungal resistance; antifungal therapy; drug discovery; molecular mechanisms
(This special issue belongs to the Section Molecular Microbiology)
Allergic Diseases: Molecular Insights into Immunotherapy
edited by Stefania Nicola
submission deadline 20 Dec 2025 | 3 articles | Viewed by 5720 | Submission Open
Keywords: component resolved diagnosis; allergen immunotherapy; molecular diagnostic; basophil activation test; anaphylaxis; allergy diagnosis; in vitro tests; in vivo tests; skin prick test
(This special issue belongs to the Section Molecular Immunology)
Antifungal Drug Discovery: Progresses, Challenges, Opportunities, 2nd Edition
edited by
submission deadline 20 Dec 2025 | 4 articles | Viewed by 5566 | Submission Open
Keywords: antifungal drugs; fungal infections; drug design; drug discovery; targeted therapy; drug resistance; fungal drug targets; neglected tropical diseases
(This special issue belongs to the Section Molecular Pharmacology)
Biomarkers for Cardiovascular Risk Prediction
edited by
submission deadline 20 Dec 2025 | 3 articles | Viewed by 5342 | Submission Open
Keywords: biomarker; cardiovascular disease; risk stratification; inflammation; vascular damage; micro-RNA; therapy; artificial intelligence
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Systemic Sclerosis: New Insight into Pathogenesis, Molecular and Immune Mechanisms submission deadline 20 Dec 2025 | 3 articles | Viewed by 5319 | Submission Open
Keywords: systemic sclerosis; autoimmunity; inflammation; fibrosis; pathophysiology and treatment; profibrotic signaling; biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Current Research on Plant Hormones Affecting Crop Yield and Fruit Quality submission deadline 20 Dec 2025 | 1 articles | Viewed by 5281 | Submission Open
Keywords: auxins; gibberellins; citokynis; ethylene; yield; quality; antioxidant; storage
(This special issue belongs to the Section Molecular Plant Sciences)
Antimicrobial Nanomaterials: Approaches, Strategies and Applications
edited by
submission deadline 20 Dec 2025 | 3 articles | Viewed by 5201 | Submission Open
Keywords: nanotechnology; biocides; antimicrobials; controlled release; drug delivery; antimicrobial agents; antimicrobial resistance; infection; nanoparticles
(This special issue belongs to the Section Materials Science)
p53—Oncogene, Tumor Suppressor Gene, Guardian of the Genome and the Cell
edited by Przemyslaw Bozko
submission deadline 20 Dec 2025 | 3 articles | Viewed by 5150 | Submission Open
Keywords: p53; oncogene; tumor suppressor gene; tumor formation; anticancer therapy
(This special issue belongs to the Section Molecular Genetics and Genomics)
Data Science in Cancer Genomics and Precision Medicine: 2nd Edition submission deadline 20 Dec 2025 | 2 articles | Viewed by 5036 | Submission Open
Keywords: cancer genomics; big data; tumor immunology; translational oncology; precision medicine; next-generation sequencing; omics; cancer genomic datasets
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Biology of Fish Stress
edited by , and
submission deadline 20 Dec 2025 | 4 articles | Viewed by 5036 | Submission Open
Keywords: fish stress; molecular biology; omics; apoptosis; inflammation
(This special issue belongs to the Section Molecular Biology)
Recent Advances in 3D Tumor Models for Cancer Research submission deadline 20 Dec 2025 | 3 articles | Viewed by 5013 | Submission Open
Keywords: 3D systems; cancer research; spheroids; organoids; organ-on-chip; scaffolds; tissue engineering; biomedical technologies; tumor microenvironment
(This special issue belongs to the Section Molecular Oncology)
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