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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Biology of 3D Cell and Tissue Culture Systems: Benefits to Research and Disease Diagnostics

edited by

Thomas J. Goodwin

submission deadline 20 Jun 2026 | 2 articles | Viewed by 902 | Submission Open

Keywords: 3D physiological relevance vs. 2D biology; 3D research; and diagnostic systems; evolving 3D “ omics” applications; research and clinical medicine; drug applications; toxicity evaluations; “ Omics” ; spatial biology of 3D

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Multifaceted Roles of Extracellular Vesicles in Cancer and Other Diseases

edited by

Eleni Myrto Trifylli

submission deadline 20 Jun 2026 | 1 articles | Viewed by 882 | Submission Open

Keywords: extracellular vesicles; exosomes; cancer diagnostics; non-invasive tests; liquid biopsy; cancer therapy; biomarker discovery; nanotechnology; EV engineering; drug delivery; neurodegenerative diseases; cardiovascular diseases; infectious diseases; autoimmune diseases; precision diagnostics

(This special issue belongs to the Section Molecular Oncology)

Molecular Research on Actinomycetes-Derived Natural Products

edited by Fong Tian Wong

submission deadline 20 Jun 2026 | 1 articles | Viewed by 832 | Submission Open

Keywords: actinomycetes; natural products; actinobacterial; genome mining; omics; secondary metabolites; genetic engineering; discovery; structural diversity

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Natural Antioxidants—Sources, Characteristics, and Biological Activity

edited by

Maciej Spiegel

submission deadline 20 Jun 2026 | 1 articles | Viewed by 806 | Submission Open

Keywords: natural antioxidants; oxidative stress; reactive oxygen species; inflammation; free radicals; structure– activity relationship; nutraceuticals; synergistic effects; plant-derived compounds; drug discovery

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Precision Cancer Medicine: Molecular Insights, Biological Events and Clinical Perspectives

edited by

Dimitrios H. Roukos

submission deadline 20 Jun 2026 | Viewed by 789 | Submission Open

Keywords: multi-omics at bulk level; single-cell multi-omics; precision oncology; precision immune-oncology; tumor molecular profiling

(This special issue belongs to the Section Molecular Oncology)

Natural Products and Drug Delivery Systems in Dental Diseases

edited by

Rafael Scaf De Molon

submission deadline 20 Jun 2026 | 1 articles | Viewed by 730 | Submission Open

Keywords: periodontitis; natural products; anti-inflammatory therapy; local drug delivery; gingival inflammation; regenerative periodontics; nanotechnology in dentistry; herbal medicine; antimicrobial agents; oral microbiome modulation; signaling pathways

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advancements in Inflammatory and Oxidative Disease Research

edited by

Sandra Barbalho

submission deadline 20 Jun 2026 | 1 articles | Viewed by 689 | Submission Open

Keywords: diabetes; cancer; neurological diseases; inflammation; oxidative stress; endocrinology; gastroenterology; pulmonology; rheumatology; cardiology; neurology; nephrology; dermatology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

RNA in Biology and Medicine (2nd Edition)

edited by

Roberto Patarca

and William A. Haseltine

submission deadline 20 Jun 2026 | 1 articles | Viewed by 666 | Submission Open

Keywords: noncoding RNAs; coding RNAs; RNA-based therapy; RNA vaccine; RNA structure; RNA function

(This special issue belongs to the Section Molecular Biology)

Cutting-Edge Advances in Natural Bioactive Compounds

edited by

Joachim Storsberg

submission deadline 20 Jun 2026 | Viewed by 645 | Submission Open

Keywords: natural bioactive compounds; phytochemicals; fungal metabolites; antioxidant activity; anti-inflammatory agents; antimicrobial compounds; anti-cancer compounds

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advancing Research on Alexander Disease

edited by

Ming-Der Perng

submission deadline 20 Jun 2026 | Viewed by 639 | Submission Open

Keywords: Alexander disease; astrocyte dysfunction; intermediate filaments; GFAP; astrogliosis; neurodegeneration; leukodystrophy; rare disease; rosenthal fibers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Diabetes: Genetics and Genomics, Hormone Regulation, and Metabolic Control

edited by Maria Stathopoulou

submission deadline 20 Jun 2026 | Viewed by 618 | Submission Open

Keywords: type 1 diabetes; type 2 diabetes; monogenic diabetes; polygenic risk factors; gestational diabetes (GDM); maturity-onset diabetes of the young (MODY); latent autoimmune diabetes in adults (LADAs); genome-wide association studies (GWASs); single nucleotide polymorphisms (SNPs); epigenetic modifications in diabetes; insulin production regulation; hormone action and metabolic control; β -cell dysfunction; gene-environment interactions in diabetes; precision medicine in diabetes treatment; genetics; genomics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Yeast Engineering and Stress Responses

edited by

Joaquin Ariño

and

Pau Ferrer

submission deadline 20 Jun 2026 | 2 articles | Viewed by 618 | Submission Open

Keywords: stress tolerance; cellular adaptation; nutrient limitation; gene expression; metabolic engineering; synthetic biology; strain robustness; fermentation efficiency; bioprocess optimization

(This special issue belongs to the Section Molecular Microbiology)

Molecular Dynamics Techniques in the Artificial Intelligence Era

edited by

Luciano Tavares Costa

Andrew S. Paluch

and Itamar Borges Junior

submission deadline 20 Jun 2026 | Viewed by 614 | Submission Open

Keywords: molecular dynamics; machine learning; force field; free energy; statistical mechanics; algorithm development; artificial intelligence

(This special issue belongs to the Section Molecular Informatics)

Molecular Mechanisms of Gastrointestinal Immunity: Balancing Homeostasis and Pathological States

edited by Mihai Danciu and Gabriel Becheanu

submission deadline 20 Jun 2026 | Viewed by 603 | Submission Open

Keywords: gastrointestinal immunity; mucosal barrier function; immune signaling pathways; gut microbiota; inflammatory bowel disease (IBD); colorectal cancer; cytokines and chemokines; immunopathology; targeted immunotherapy; biomarkers of gut inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Developmental Origins of Kidney Disease: Renal Programming

edited by Hyung-Eun Yim

submission deadline 20 Jun 2026 | 1 articles | Viewed by 592 | Submission Open

Keywords: air pollution; chronic kidney disease; congenital anomalies of the kidneys and urinary tract; high-risk pregnancy; nephrogenesis; renal programming; renin angiotensin system

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Chitosan Biomaterials: Advances and Challenges, 3rd Edition

edited by

Lacramioara Popa

Mihaela Violeta Ghica

and Cristina Elena Dinu-Pirvu

submission deadline 20 Jun 2026 | 1 articles | Viewed by 587 | Submission Open

Keywords: chitosan; chitosan biomaterials; chitosan derivatives; drug delivery; wound healing; tissue regeneration; dentistry; smart biomaterials

(This special issue belongs to the Section Materials Science)

T-Cell Lymphoma: From Basic Science to Novel Therapeutics

edited by

Daniele Caracciolo

and

Andrea Duminuco

submission deadline 20 Jun 2026 | Viewed by 584 | Submission Open

Keywords: T-cell lymphoma; targeted therapy; immunotherapy; translational research; real-world experience

(This special issue belongs to the Section Molecular Oncology)

Cancer-Associated Stromal Cells

edited by Krisztián Németh and Balazs Mayer

submission deadline 20 Jun 2026 | 1 articles | Viewed by 581 | Submission Open

Keywords: cancer; microenvironment; tumor-associated stromal cells; cancer-associated fibroblast; mesenchymal stem cell; tumor-associated adipocyte; pericyte; cancer immunology; angiogenesis; metastasis; targeted cancer therapy; checkpoint inhibitor; CAR T cells; immunotherapy; signal transduction; small molecules

(This special issue belongs to the Section Molecular Oncology)

Leukemia: Molecular Immune Mechanisms

edited by

Mohammad Hojjat-Farsangi

submission deadline 20 Jun 2026 | Viewed by 579 | Submission Open

Keywords: leukemia; immune system; Genetic Mutations and Alterations; Immune Evasion Mechanisms; Immune Cell Dysfunction; Cytokine Networks; Bone Marrow Microenvironment; immunotherapy strategies

(This special issue belongs to the Section Molecular Immunology)

Hepatocellular Carcinoma: From Pathophysiology to Innovative Therapeutic Approaches

edited by Andrea Martini

submission deadline 20 Jun 2026 | Viewed by 549 | Submission Open

Keywords: liver carcinogenesis; tumor microenvironment; immune surveillance; fibrogenesis; inflammation

(This special issue belongs to the Section Molecular Oncology)

Role of Mesenchymal Stem/Stromal Cells (MSCs) in Human Diseases and Their Treatment

edited by

Mirjana Jerkic

submission deadline 20 Jun 2026 | Viewed by 523 | Submission Open

Keywords: mesenchymal stem/stromal cells (MSCs); MSC homing; MSC properties; immune cells; macrophages; injury; inflammation; cell therapy

(This special issue belongs to the Section Molecular Immunology)

Brain Stroke Across the Lifespan: Mechanisms, Models, Translational Advances and Impacts Beyond the Brain

edited by

Gabriele Deidda

submission deadline 20 Jun 2026 | 1 articles | Viewed by 518 | Submission Open

Keywords: stroke; brain; cerebral injury; post-stroke recovery; systemic physiology; models; therapeutic strategies

(This special issue belongs to the Section Molecular Neurobiology)

Toxicity of Animal Venoms and the Components: Molecular Mechanisms of Action

edited by

Tianfang Wang

submission deadline 20 Jun 2026 | 1 articles | Viewed by 482 | Submission Open

Keywords: venom toxicity; biochemical activity; toxin biology; cellular targets; peptide; protein; structure– function relationships

(This special issue belongs to the Section Molecular Biology)

The Current Landscape of Microglia-Glioma Research: From Basic Science to Therapeutic Potential

edited by

Manuel Benedikt Graeber

submission deadline 20 Jun 2026 | Viewed by 474 | Submission Open

Keywords: microglia; glioma; tumor associated macrophages; immunosuppression; epigenetics

(This special issue belongs to the Section Molecular Neurobiology)

Unveiling the Functional Microbiomes of the Ocean: From Genes to Ecosystem Services

edited by

Sergey Dobretsov

and

Daniel Rittschof

submission deadline 20 Jun 2026 | 1 articles | Viewed by 471 | Submission Open

Keywords: microbiome; symbiosis; community organization; functional diversity; communication; microbial functions; metagenomics; metabolomics; transcriptomics; proteomics; biogeochemical cycling; biofouling; ocean health; marine biotechnology; microbial ecology

(This special issue belongs to the Section Molecular Microbiology)

The Roles of AI in Disease Diagnosis and Treatment

edited by

Miguel Souto-Bayarri

submission deadline 20 Jun 2026 | 1 articles | Viewed by 470 | Submission Open

Keywords: artificial intelligence; radiomics; machine learning; deep learning; diagnosis; treatment; cancer

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Machine Learning Approaches in Drug Molecule Design

edited by

Bing Niu

submission deadline 20 Jun 2026 | 1 articles | Viewed by 458 | Submission Open

Keywords: machine learning; drug design; deep learning; virtual screening; QSAR; molecular property prediction; de novo drug design; pharmacokinetics; computational chemistry; drug discovery

(This special issue belongs to the Section Molecular Informatics)

Molecular Mechanisms and Performances of Photocatalysis

edited by

Shaojun Yuan

submission deadline 20 Jun 2026 | Viewed by 450 | Submission Open

Keywords: photocatalytic materials; photocatalysis; energy conversion; environmental remediation; carbon dioxide reduction; organic synthesis

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Molecular-Scale Design and Applications of Food Packaging: Eco-Friendly Materials and Technologies

edited by

Xi Yu

and

Tian Zhong

submission deadline 20 Jun 2026 | Viewed by 422 | Submission Open

Keywords: sustainable packaging; biodegradable materials; smart packaging; active packaging; food safety; environmental impact

(This special issue belongs to the Section Materials Science)

Molecular and Cellular Aspects of Autoimmune and Inflammatory Rheumatic Diseases: Second Edition

edited by Marzena Helena Olesińska and Magdalena Szmyrka

submission deadline 20 Jun 2026 | Viewed by 401 | Submission Open

Keywords: autoimmune rheumatic diseases; inflammatory rheumatic diseases; arthritis; connective tissue diseases

(This special issue belongs to the Section Molecular Immunology)

Allosteric Modulation of Kinases in Cancer Therapeutic Strategies and Challenges

edited by

Nidhi Joshi

submission deadline 20 Jun 2026 | Viewed by 363 | Submission Open

Keywords: kinase signaling; allosteric modulators; cancer therapy; drug resistance; molecular mechanisms; protein– protein interactions; targeted therapy; conformational changes; ATP-competitive inhibitors; drug design

(This special issue belongs to the Section Molecular Biology)

Bioactive Compounds in Cancers: Second Edition

edited by

Patrícia M. A. Silva

Hassan Bousbaa

and

Honorina Cidade

submission deadline 20 Jun 2026 | 1 articles | Viewed by 358 | Submission Open

Keywords: anticancer strategies; bioactive compounds; natural products; synthetic products; medicinal chemistry; drug repurposing; drug delivery systems

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Research on Aging: How Can We Live Beyond 100 Years?

edited by

Shin Murakami

submission deadline 20 Jun 2026 | Viewed by 357 | Submission Open

Keywords: aging; biomarkers; centenarians; longevity interventions; stress resistance and metabolism; age-related diseases

(This special issue belongs to the Section Molecular Biology)

Molecular Insights into the Pathophysiology of Placenta Accreta Spectrum

edited by Jessian L. Munoz

submission deadline 20 Jun 2026 | Viewed by 354 | Submission Open

Keywords: placenta accreta; invasive placenta; trophoblasts; placenta; high-risk pregnancy; placenta previa; in vitro fertilization; biomarkers; multi-omics research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Metabolic Reprogramming in Health and Aging-Related Diseases

edited by

Hung-Yao Ho

submission deadline 20 Jun 2026 | Viewed by 345 | Submission Open

Keywords: aging; degenerative diseases; lifestyle intervention; metabolic reprogramming; metabolic syndromes; metabolome; metabolomics; neurodegenerative diseases; omics

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Computational Cancer Genomics and Molecular Profile in Breast Cancer

edited by Daniel Guimarães Tiezzi and

Stefano Maria Pagnotta

submission deadline 20 Jun 2026 | 1 articles | Viewed by 340 | Submission Open

Keywords: breast cancer; computational biology; genomics; molecular biology

(This special issue belongs to the Section Molecular Informatics)

Telomeres in Development, Senescence and Genome Instability: 2nd Edition

edited by Michal Zalzman

submission deadline 20 Jun 2026 | Viewed by 314 | Submission Open

Keywords: telomere disorders and cell death; telomere factors as therapeutic targets in cancer; telomeres and genome stability; telomeres in aging and senescence

(This special issue belongs to the Section Molecular Genetics and Genomics)

New Insights into Intercellular Communication and Signal Transduction

edited by

Dongki Yang

submission deadline 20 Jun 2026 | Viewed by 314 | Submission Open

Keywords: intercellular communication; signal transduction; extracellular vesicles (EVs); exosomes; tunneling nanotubes (TNTs); cytokines; hormonal signaling; neurotransmitters; mechanotransduction; immune signaling

(This special issue belongs to the Section Molecular Biology)

Urothelial Cancer: From Translational Medicine to Recent Innovations in Therapeutic Management

edited by Alessio Bruni

submission deadline 20 Jun 2026 | Viewed by 309 | Submission Open

Keywords: urothelial cancer; bladder cancer; radiation therapy; trimodality approach; immunotherapy

(This special issue belongs to the Section Molecular Oncology)

Macrophage Plasticity: Beyond the M1–M2 Paradigm

edited by

Håkan Eriksson

submission deadline 20 Jun 2026 | Viewed by 298 | Submission Open

Keywords: macrophage; plasticity; microenvironment; polarization; epigenetic modulation; phagocytosis

(This special issue belongs to the Section Molecular Immunology)

Valorization of Lignocellulosic Biomass: 2nd Edition

edited by

Haishun Du

submission deadline 20 Jun 2026 | Viewed by 292 | Submission Open

Keywords: lignocellulosic biomass; biorefinery; biomass conversion; bioenergy; biofuels; bioproducts; platform chemicals; cellulose nanomaterials; lignin nanoparticles; functional materials

(This special issue belongs to the Section Materials Science)

Innovations in Photodynamic Therapy: New Horizons in Breast Cancer Care

edited by Sandeep Surendra Panikar

submission deadline 20 Jun 2026 | Viewed by 291 | Submission Open

Keywords: noninvasive therapy; tumor targeting; breast cancer therapy; oncology; photosensitizers; theranostics; precision medicine

(This special issue belongs to the Section Molecular Oncology)

Organoid Models in Host–Pathogen Interactions and Disease Pathogenesis

edited by

Apichai Tuanyok

submission deadline 20 Jun 2026 | 1 articles | Viewed by 283 | Submission Open

Keywords: organoids; host– pathogen interaction; infectious disease models; mucosal immunity; tissue engineering; microbial pathogenesis; immune organoids; 3D culture systems

(This special issue belongs to the Section Molecular Biology)

Innovative Advances and Applications in Medical and Molecular Virology

edited by

Vincent T. K. Chow

and

Julian W. Tang

submission deadline 20 Jun 2026 | Viewed by 275 | Submission Open

Keywords: medical virology; molecular virology; molecular diagnostics; genomics; metagenomics; interactomics; integrative omics

(This special issue belongs to the Section Molecular Microbiology)

Structural and Functional Insights into Chemokines and Chemokine Receptors in Immune Pathologies

edited by

Nidhi Joshi

submission deadline 20 Jun 2026 | Viewed by 274 | Submission Open

Keywords: chemokines; chemokine receptors; immune pathologies; signaling mechanisms; therapeutic targeting

(This special issue belongs to the Section Molecular Immunology)

Regulation of Brown Adipose Function

edited by

Stephen F. Vatner

and

Shinsuke Nirengi

submission deadline 20 Jun 2026 | Viewed by 274 | Submission Open

Keywords: brown adipose tissue; metabolic disorders; thermogenesis; endocrine function; cellular signaling

(This special issue belongs to the Section Biochemistry)

Molecular Crosstalk in Stress-Induced Psychopathology

edited by Ilaria Demori and

Natalia V. Gulyaeva

submission deadline 20 Jun 2026 | 1 articles | Viewed by 255 | Submission Open

Keywords: Depression; Anxiety; Post-traumatic stress disorder; Early life stress; Microbiota– gut– brain axis; Blood– brain barrier; Neurotransmission; Neuroinflammation; Eating disorders; Addiction; Psychoneuroendocrineimmunology; Allostasis

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms of Parasitic Diseases

edited by Rajendranath Ramasawmy

submission deadline 20 Jun 2026 | 1 articles | Viewed by 252 | Submission Open

Keywords: parasites; molecular mechanisms; pathogenesis; genetics; symptomatics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Characterization of Glioblastoma: Implications for Diagnosis and Personalized Treatment

edited by Madan Mohan Kwatra

submission deadline 20 Jun 2026 | Viewed by 250 | Submission Open

Keywords: glioblastoma; diagnosis; molecular characterization; personalized treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Contemporary Perspective of Cardio-Kidney Metabolic Syndrome: From Prevention to Management

edited by Alberto Palazzuoli,

Francesco Fedele

and

Anna Mattioli

submission deadline 20 Jun 2026 | Viewed by 238 | Submission Open

Keywords: cardiovascular risk factors; metabolic syndrome; chronic kidney disease; heart failure; endothelial dysfunction

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 3101-3150 on page 63 of 68.

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