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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Atomic-Scale Design of Li-Ion Battery Materials

edited by

Saiful Islam

submission deadline 30 May 2026 | Viewed by 116 | Submission Open

Keywords: lithium-ion batteries; atomic-scale design; electrode– electrolyte interface; electrolyte engineering; defect chemistry; solid-state batteries

(This special issue belongs to the Section Materials Science)

Anticancer, Anti-Inflammatory and Antioxidant Properties of Active Substance and Natural Products

edited by Emira D’Amico

submission deadline 30 May 2026 | Viewed by 94 | Submission Open

Keywords: anticancer activity; anti-inflammatory activity; oxidative stress; immunomodulation; drug discovery; natural products; active substance; plant extracts; phytochemicals

(This special issue belongs to the Section Molecular Biology)

Oral Diseases and Oral Soft Tissue Repair

edited by Diana Russo

submission deadline 30 May 2026 | Viewed by 87 | Submission Open

Keywords: oral medicine; tissue regeneration; photobiomodulation; periodontology; implant dentistry

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Nanostructured Strategies for Bioactive Compounds

edited by

Karen Khachatryan

submission deadline 30 May 2026 | Viewed by 81 | Submission Open

Keywords: nanostructure-bioactive interaction; molecular encapsulation mechanisms; metallic nanoparticles (bioactivity); carbon-based nanocarriers; nano/microcapsule delivery systems; bioactive compound stabilisation; structure-activity relationships; molecular release kinetics

(This special issue belongs to the Section Molecular Biology)

Cytokines and Inflammatory Diseases

edited by

Pio Conti

submission deadline 30 May 2026 | Viewed by 76 | Submission Open

Keywords: inflammation; cytokines; interleukin-6; immune diseases; immune signaling; autoimmunity; brain inflammation

(This special issue belongs to the Section Molecular Immunology)

Hormetic Responses of Plants to Environmental Stress

edited by

Michael Moustakas

submission deadline 30 May 2026 | Viewed by 64 | Submission Open

Keywords: hormesis; environmental stress; dose– response; molecular mechanisms

(This special issue belongs to the Section Molecular Plant Sciences)

Extracellular Matrix Signalling in Health and Disease

edited by

Helen L. Birch

submission deadline 30 May 2026 | Viewed by 60 | Submission Open

Keywords: extracellular; matrix; mechano-transduction; biochemical signalling; cell– matrix interactions; outside-in signalling; matrix remodelling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Unraveling Immunometabolism in Sepsis: From Cellular Reprogramming to Therapeutic Targets

edited by

Marcello Candelli

submission deadline 30 May 2026 | Viewed by 56 | Submission Open

Keywords: sepsis; immunometabolism; metabolic reprogramming; cellular bioenergetics; innate and adaptive immunity; mitochondrial dysfunction; inflammatory signaling; metabolic biomarkers; therapeutic modulation; host– pathogen interactions

(This special issue belongs to the Section Molecular Immunology)

Oxidative Stress and the Kidney: From Physiological Homeostasis to Pathophysiology and Nutraceutical Interventions

edited by

Daniele La Russa

and

Daniela Pellegrino

submission deadline 30 May 2026 | Viewed by 52 | Submission Open

Keywords: oxidative stress; nutraceuticals; CVD risk; CKD; antioxidant

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Retinal Degeneration: From Pathophysiology to Therapeutic Approaches—4th Edition

edited by

Jan Wijnholds

submission deadline 30 May 2026 | Viewed by 47 | Submission Open

Keywords: hereditary retinal disease; retinal inflammation; retinal gene augmentation; editing; optogenetics and splice modulation therapy; natural history studies of the retina; human iPSC-derived retinal organoids and retinal pigment epithelium; retinal iPSC-derived cell therapy; retinal pathology; pre- and clinical gene therapy; animal models for retinal dystrophy; retinal imaging; retina-on-a-chip

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Engineering Cell-Derived Nanostructures for Therapeutic Delivery

edited by

Tania Limongi

submission deadline 30 May 2026 | Viewed by 38 | Submission Open

Keywords: extracellular vesicles (EVs); cell membrane-coated nanoparticles; plant-derived nanostructures (PDNSs); bacterial extracellular vesicles (bEVs); drug delivery; nanomedicine; nano-biointerfaces; bioinspired engineering; biomanufacturing; translational nanotechnology

(This special issue belongs to the Section Molecular Nanoscience)

Recent Progress in Regenerative Therapy Using Blood-Derived Biomaterials: 2nd Edition

edited by

Tomoyuki Kawase

Takashi Ushiki

and Tomoharu Mochizuki

submission deadline 30 May 2026 | Viewed by 38 | Submission Open

Keywords: blood-derived biomaterial; platelet-rich plasma; autologous protein solution; mechanism; platelet; coagulation

(This special issue belongs to the Section Materials Science)

Research on the Molecular Mechanisms Related to Exercise

edited by Kayvan Khoramipour

submission deadline 30 May 2026 | Viewed by 34 | Submission Open

Keywords: exercise; molecules; disease

(This special issue belongs to the Section Molecular Biology)

Atherosclerosis: From Molecular Biology to Therapeutic Perspective: 7th Edition

edited by

Ida Daniela Perrotta

submission deadline 30 May 2026 | Viewed by 28 | Submission Open

Keywords: atherosclerosis; vascular smooth muscle cells; inflammation; endothelium; cell senescence; apoptosis; lipid metabolism; oxidative stress; nitric oxide; exosomes; vascular calcification; cytokines; growth factors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Oral Cancer: From Molecular Mechanisms to Therapeutics

edited by Diana Russo

submission deadline 30 May 2026 | Viewed by 25 | Submission Open

Keywords: oral cancer; molecular mechanisms; carcinogenesis; therapeutic strategies; biomarkers; immunotherapy; tumor microenvironment; drug resistance; precision medicine; head and neck oncology

(This special issue belongs to the Section Molecular Oncology)

New Perspectives on Fish Nutrition, Physiology and Molecular Regulatory Networks

edited by Linghong Miao

submission deadline 30 May 2026 | Viewed by 25 | Submission Open

Keywords: fish nutrition; feed ingredients; intestinal physiology; molecular regulation; stress response and welfare; genetic mechanisms; aquaculture sustainability; omics technologies

(This special issue belongs to the Section Molecular Biology)

Design and Application of Biocatalysts: Emerging Advances in Enzyme Technology

edited by

Salvadora Ortega-Requena

submission deadline 30 May 2026 | Viewed by 21 | Submission Open

Keywords: biocatalysis; enzyme engineering; green chemistry; directed evolution; computational design; industrial enzymes; nano-biocatalysts

(This special issue belongs to the Section Biochemistry)

Decoding Parkinson’s: Molecular Symphonies and Dysregulated Pathways

edited by Hortensia Alonso-Navarro

submission deadline 30 May 2026 | Viewed by 19 | Submission Open

Keywords: Parkinson’ s disease; neuropharmacology; movement disorders

(This special issue belongs to the Section Molecular Neurobiology)

Recent Research on Metabolomics and Cancer Pathogenesis

edited by

Danuta Dudzik

submission deadline 30 May 2026 | Viewed by 17 | Submission Open

Keywords: cancer metabolomics; metabolic reprogramming; biomarkers; tumor microenvironment; systems biology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Novel Therapeutic Strategies for Hepatocellular Carcinoma

edited by

Soon Kyu Lee

submission deadline 30 May 2026 | Viewed by 12 | Submission Open

Keywords: hepatocellular carcinoma; immune checkpoint inhibitors; tyrosine kinase inhibitors; radiotherapy; embolization; surgery; transplantation

(This special issue belongs to the Section Molecular Oncology)

Recent Advances in Gastrointestinal Tract Oncology: Pathology, Diagnostics and Therapy (Second Edition)

edited by

Karolina Orywal

submission deadline 30 May 2026 | Viewed by 11 | Submission Open

Keywords: gastrointestinal cancer; esophageal cancer; gastric (stomach) cancer; colorectal cancer; liver cancer; pancreatic cancer; gallbladder and biliary tract cancer; genetic alterations; molecular subtyping; tumor microenvironment; innovative therapies; targeted therapies; tumor biomarkers

(This special issue belongs to the Section Molecular Oncology)

Natural and Synthetic Compounds for Management, Prevention and Treatment of Obesity, 3rd Edition

edited by

Marianna Lauricella

and

Antonella D'Anneo

submission deadline 31 May 2026 | 4 articles | Viewed by 24042 | Submission Open

Keywords: obesity; adipokines; obesogens; genetic predisposition; natural/synthetic compounds; cardiovascular disorders; type II diabetes; non-alcoholic fatty liver disease; cancer

(This special issue belongs to the Section Molecular Pharmacology)

State-of-the-Art Molecular Oncology in Brazil, 3rd Edition

edited by

Tiago Rodrigues

and

Roger Chammas

submission deadline 31 May 2026 | 7 articles | Viewed by 15041 | Submission Open

Keywords: apoptosis; autophagy; calcium; cancer; cell death; chemotherapy; metabolism; mitochondria; drug resistance; oxidative stress

(This special issue belongs to the Section Molecular Oncology)

Molecular and Translational Research on Bone Tumors, 2nd Edition

edited by

Michela Rossi

and

Andrea Del Fattore

submission deadline 31 May 2026 | 2 articles | Viewed by 12937 | Submission Open

Keywords: primary bone tumours; metastatic bone tumour; therapy; biomarkers; epigenetic factors; immune-oncology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Therapeutic Targets for Neuroinflammation and Neurodegeneration

edited by Muhammad Sohail Khan and

Cassie S. Mitchell

submission deadline 31 May 2026 | 4 articles | Viewed by 6268 | Submission Open

Keywords: neurodegenerative diseases; inflammatory response; nervous system; neuroinflammations

(This special issue belongs to the Section Molecular Neurobiology)

Functional Food Ingredients in Immunity Improvement

edited by

Prodromos Skenderidis

submission deadline 31 May 2026 | 1 articles | Viewed by 4813 | Submission Open

Keywords: functional food ingredients; bioactive compounds; health potentials; food processing and immunomodulation; green extraction techniques; molecular mechanisms; nutritional immunology; dietary intervention

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Selected Papers from the 5th International Symposium on Frontiers in Molecular Science (ISFMS)

edited by

Yoshinori Marunaka

Masayuki Takahashi

Yusaku Iwasaki

, Atsushi Shiozaki and Akiyuki Taruno

submission deadline 31 May 2026 | 2 articles | Viewed by 2937 | Submission Open

Keywords: protein structure and function; multidomain proteins; drug design and drug resistance; enzymes; molecular biology of galectins; glycobiophysics; NMR spectroscopy; specific sensory systems; brain and systemic function

(This special issue belongs to the Section Biochemistry)

Artificial Intelligence: Applications in the Field of Immune-Mediated Inflammatory Diseases and Onco-Hematology

edited by

Giuseppe Murdaca

and

Sebastiano Gangemi

submission deadline 31 May 2026 | 1 articles | Viewed by 2677 | Submission Open

Keywords: artificial intelligence; machine learning; immune-mediated diseases; cancers; hematological ma-lignancies

(This special issue belongs to the Section Molecular Immunology)

Advances in Pulmonary Hypertension and Interstitial Lung Diseases: Mechanisms and Treatments

edited by

Katarzyna B. Lewandowska

and

Monika Szturmowicz

submission deadline 31 May 2026 | 2 articles | Viewed by 1624 | Submission Open

Keywords: pulmonary hypertension; interstitial lung disease; lung fibrosis; pulmonary hemodynamics; pulmonary function testing; pathogenesis; prognosis; survival; treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Diversity in Structure, Function, and Regulation of Calcium-Permeable Channels

edited by

Lucie Parent

submission deadline 31 May 2026 | Viewed by 659 | Submission Open

Keywords: calcium-permeable channels in health and disease; calcium-permeable channels in calcium cycling; TRP channels; voltage-gated calcium channels; STIM / Orai complexes; intracellular IP3 calcium channels; intracellular RyR calcium channels; posttranslational calcium channel modifications; calcium-permeable channel inhibitors; calcium-permeable channel biophysics; calcium-permeable channel evolution

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Molecules in Infection and Toxicity: Antimicrobial Peptides and Drug-Induced Damage in Disease Models

edited by

Oleksii Skorokhod

submission deadline 31 May 2026 | 1 articles | Viewed by 575 | Submission Open

Keywords: antimicrobial peptides (AMPs); infectious diseases; drug-induced toxicity; disease models; therapeutic strategies; drug delivery systems

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Future of Drug Discovery and Development, 2nd Edition

edited by

William C. (Trey) Putnam

submission deadline 31 May 2026 | Viewed by 434 | Submission Open

Keywords: drug discovery; drug development; biotechnology; target identification; target validation; regulatory affairs; regulatory sciences; drug commercialization; pharmaceutical market access; drug screening; novel nonclinical models/approaches; advanced manufacturing; continuous manufacturing; process analytical technology; adaptive clinical trials; in silico laboratory and clinical development; rolling submissions; accelerated approvals; real-world evidence

(This special issue belongs to the Section Molecular Pharmacology)

Viral Infections and Viral Pathogenesis

edited by

Shymaa E. Bilasy

submission deadline 31 May 2026 | 1 articles | Viewed by 404 | Submission Open

Keywords: viral pathogenesis; viral– host interactions; viral persistence; long COVID; molecular virology; immune dysregulation; diagnosis; vaccines; oncoviruses; antiviral and gene therapy

(This special issue belongs to the Section Molecular Microbiology)

Microbiota-Mediated Regulation of Stem Cells in Cancer Initiation, Progression, and Treatment Response

edited by

Ciro Gargiulo Isacco

submission deadline 31 May 2026 | Viewed by 368 | Submission Open

Keywords: microbiota stem cell cancer

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Natural Products in the Treatment and Prevention of Human Diseases

edited by

Jae-Hyun Kim

submission deadline 31 May 2026 | Viewed by 141 | Submission Open

Keywords: natural products; bone metabolism; sarcopenia; osteoporosis; herbal medicine; osteo-sarcopenic obesity; bone– muscle crosstalk; low-molecular-weight compounds

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Gene Delivery in Cancer Therapy: Next-Generation Platforms and Translational Advances

edited by

Ksenija Božinović

submission deadline 31 May 2026 | Viewed by 116 | Submission Open

Keywords: gene delivery; gene therapy; viral vectors; non-viral vectors; lipid nanoparticles; extracellular vesicles; mRNA therapeutics; CRISPR/Cas genome editing; tumor microenvironment; translational oncology

(This special issue belongs to the Section Molecular Oncology)

Advances in Cancer Epigenetics for Precision Medicine

edited by

Alessandro Lavoro

and

Saverio Candido

submission deadline 31 May 2026 | Viewed by 95 | Submission Open

Keywords: cancer epigenetics; DNA methylation; precision medicine; cancer biomarker; therapeutic target; epidrugs

(This special issue belongs to the Section Molecular Oncology)

Cellular and Molecular Mechanisms of Neuroinflammation

edited by

Maria Anttonietta Panaro

submission deadline 31 May 2026 | Viewed by 95 | Submission Open

Keywords: neuroinflammation; astrocytes; microglia; CNS; cytokines; brain; diseases; immune response

(This special issue belongs to the Section Molecular Neurobiology)

Molecular and Systems Mechanisms of Neural Circuit Function and Plasticity

edited by

Hyunjung Oh

submission deadline 31 May 2026 | Viewed by 91 | Submission Open

Keywords: neural circuits; neuroplasticity; synaptic organization; brain aging; mood disorders; neurodegenerative disorders; cognitive function

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms of Natural Products: Redox Balance, Inflammation Control, and Apoptosis Modulation

edited by Rosanna Avola

submission deadline 31 May 2026 | Viewed by 90 | Submission Open

Keywords: natural antioxidants; inflammation; apoptosis; bioactive natural products; oxidative stress

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in the Pharmacology of Depression and Mood Disorders

edited by

Guillaume Lucas

submission deadline 31 May 2026 | Viewed by 82 | Submission Open

Keywords: new antidepressants; rapid antidepressant action; ketamine in depression; glutamatergic antidepressants; psychedelics in depression; 5-HT receptors as targets for antidepressant research; neu-roplasticity and antidepressant action

(This special issue belongs to the Section Molecular Pharmacology)

Physiological and Molecular Responses of Plants to Drought Stress

edited by

Muhammad Waseem

submission deadline 31 May 2026 | Viewed by 81 | Submission Open

Keywords: drought stress; photosynthesis; stomatal regulation; signal transduction; phytohormones; anti-oxidants

(This special issue belongs to the Section Molecular Plant Sciences)

Characterization and Engineering of Functional Nanomaterials

edited by

P. Sivaprakash

submission deadline 31 May 2026 | Viewed by 75 | Submission Open

Keywords: functional nanomaterials; molecular-level engineering; engineered materials; materials characterization; energy and environmental applications; materials design and performance

(This special issue belongs to the Section Molecular Nanoscience)

Microorganisms and Invertebrates in Molecular Dialogue: Mechanisms, Dynamics, and Applications

edited by

Monika Mioduchowska

submission deadline 31 May 2026 | Viewed by 70 | Submission Open

Keywords: microorganism– invertebrate interactions; symbiosis; stress tolerance; co-evolution; omics approaches; biotechnological applications

(This special issue belongs to the Section Molecular Microbiology)

Functional Materials for Biomedical Applications and Uses

edited by

Magdalena Laskowska

submission deadline 31 May 2026 | Viewed by 69 | Submission Open

Keywords: functional materials; nanomaterials; biomedical applications; molecular engineering

(This special issue belongs to the Section Materials Science)

Molecular Crosstalk in Allergy, Barrier Dysfunction, and Asthma

edited by

Elisa Boni

submission deadline 31 May 2026 | Viewed by 64 | Submission Open

Keywords: barrier dysfunction; asthma; allergy; molecular pathways; molecular crosstalks

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Human Virome and Emerging Viruses: Characterization, Interactions, and Molecular Insights

edited by

Luigi Rosa

and

Pietro Giorgio Spezia

submission deadline 31 May 2026 | Viewed by 56 | Submission Open

Keywords: human virome; molecular virology; functional virology; metagenomics; virus– host interactions; immune modulation; pseudovirus assays; antiviral screening; omics integration; molecular immunology

(This special issue belongs to the Section Molecular Microbiology)

Targeted Molecular Radio-Immuno-Theranostics: From Cancer to other Human Diseases—in Honor of Prof. Dr. Otmar Dieter Wiestler

edited by Michael Philipp Bachmann and Holger Stephan

submission deadline 31 May 2026 | Viewed by 55 | Submission Open

Keywords: molecular diagnostics; radiotherapy; immunotherapy; endoradionuclide therapy; radiodiagnostics; radio-immuno-theranostics; radionuclides; PET/SPECT imaging; nanomaterials; chelators; chimeric antigen receptors (CARs); adapter CAR T cells

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Genetic and Molecular Insights into Aging in Vertebrate Models

edited by

Antonio Palladino

submission deadline 31 May 2026 | Viewed by 52 | Submission Open

Keywords: aging; vertebrate models; molecular mechanisms; cellular senescence; translational medicine

(This special issue belongs to the Section Molecular Biology)

Cryo-EM and Cryo-Tomography in Macromolecular Structure Analysis

edited by

R. Holland Cheng

submission deadline 31 May 2026 | Viewed by 49 | Submission Open

Keywords: macromolecular structure; precision nanomedicine; cryo-electron microscopy (cryo-EM); cryo-electron tomography (cryo-ET); viral capsids; AI/ML in structural analysis; time-resolved imaging; nanoparticle delivery; in-cell tomography; structural dynamics; molecular mechanisms; protein complexes; membrane proteins; macromolecular assemblies; conformational changes; integrative structural biology; cellular structural biology; drug delivery systems; therapeutic design

(This special issue belongs to the Section Macromolecules)

Displaying special issue 2901-2950 on page 59 of 67.

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