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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Innovative Strategies in the Design and Development of Anticancer Agents
edited by Sanjay Kumar
submission deadline 20 Jan 2026 | 2 articles | Viewed by 2806 | Submission Open
Keywords: chemotherapy; biomimetic; natural product analogs; prodrugs; nanodrugs; drug release
(This special issue belongs to the Section Molecular Pharmacology)
Gluten/Wheat-Related Disorders: The Role of Nutrition, Gut Barrier, Microbiota, and New Therapeutic Strategies
edited by Lisa Lungaro
submission deadline 20 Jan 2026 | 2 articles | Viewed by 2805 | Submission Open
Keywords: gluten-related disorders; celiac disease; non celiac gluten wheat sensitivity; gluten free diet; microbiota; gut barrier; probiotics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Structure, Function and Dynamics in Proteins: 3rd Edition
edited by
submission deadline 20 Jan 2026 | 2 articles | Viewed by 2790 | Submission Open
Keywords: protein structure and dynamics; protein– protein and protein– DNA interactions; protein folding and misfolding; protein aggregation processes; intermediate/misfolded states; conformational equilibria; DNA and ligand recognition mechanisms; membrane receptors; enzyme dynamics; metal-binding proteins; intrinsically disordered proteins; cell signaling; phase separation mechanims; solution- and solid-state NMR; molecular dynamics simulations; time-resolved X-ray; NMR relaxation; in-/on-cell NMR; cryo-EM; fluorescence polarization; surface plasmon resonance; static and dynamic light scattering; isothermal titration calorimetry; microscale thermophoresis; protein– fragment complementation assay; cross-linking; protein microarray
(This special issue belongs to the Section Molecular Biology)
The Multiple Faces of Non-Small Cell Lung Cancer: Targeted Therapies and Recent Developments
edited by Angelo Delmonte and Alberto Verlicchi
submission deadline 20 Jan 2026 | 1 articles | Viewed by 2727 | Submission Open
Keywords: non-small cell lung cancer; tyrosine-kinase inhibitors; next generation sequencing; immunoconjugates; targeted therapies 
(This special issue belongs to the Section Molecular Oncology)
Latest Advances in Nanoparticles for Modern Biomedicine (2nd Edition) submission deadline 20 Jan 2026 | 2 articles | Viewed by 2724 | Submission Open
Keywords: nanoparticles; nanotherapeutics; nanomedicine; biomedicine; selective targeting of nanoparticles
(This special issue belongs to the Section Molecular Nanoscience)
Autophagy and Kidney Diseases
edited by Francesco Reggiani
submission deadline 20 Jan 2026 | 1 articles | Viewed by 2711 | Submission Open
Keywords: autophagy; kidney diseases; cellular homeostasis; molecular signaling; autophagy biomarkers; renal homeostasis; autophagy modulators
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Research in Alzheimer’s Disease: Advances and Perspectives
edited by
submission deadline 20 Jan 2026 | 2 articles | Viewed by 2657 | Submission Open
Keywords: neuroinflammation; synaptic dysfunction; oxidative stress; neurofibrillary tangles; mitochondrial dysfunction; biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Advances in Molecular Mechanisms of Bacterial Resistance and Antibiotic Therapy
edited by
submission deadline 20 Jan 2026 | 2 articles | Viewed by 2646 | Submission Open
Keywords: bacterial resistance; antibiotics; antimicrobials; “ superbugs” ; clinical strains; laboratory induced-bacteria; antimicrobial peptides; antimicrobial combinations; hybrid antibiotics; repurposing drugs; anti-virulence agents; immune modulators; toxin neutralizers
(This special issue belongs to the Section Molecular Microbiology)
Protein Networks and Their Signaling submission deadline 20 Jan 2026 | 1 articles | Viewed by 2599 | Submission Open
Keywords: protein-protein interaction; chromatin/nucleosome; signaling; protein structure; drug design
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms of Bone Injury and Bone Tissue Regeneration
edited by Nasim Golafshan
submission deadline 20 Jan 2026 | 1 articles | Viewed by 2519 | Submission Open
Keywords: bone formation; osteoblast diffrentiation; cell-based materials
(This special issue belongs to the Section Materials Science)
Precision Medicine Approaches to Antifibrotic Therapy
edited by Karim Daliri
submission deadline 20 Jan 2026 | 1 articles | Viewed by 2448 | Submission Open
Keywords: fibrotic diseases; antifibrotic therapy; antifibrotic drug; multi-omics data; precision medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advanced Research on the Physiology and Toxicology of Aquatic Animals
edited by Xin Zhang
submission deadline 20 Jan 2026 | 2 articles | Viewed by 2361 | Submission Open
Keywords: aquatic ecosystem; physiology of aquatic animals; toxicology of aquatic animals; environmental adaptability; environmental pollutants; ecotoxicology; biomarkers; risk assessment
(This special issue belongs to the Section Molecular Biology)
Protein Signal Transduction in the Nucleus
edited by Jaekyung Shim
submission deadline 20 Jan 2026 | 1 articles | Viewed by 2287 | Submission Open
Keywords: inner nuclear membrane protein; protein network; LEM-domain proteins; nuclear lamina; signal transcription; transcriptional regulation
(This special issue belongs to the Section Molecular Biology)
Role of Cell Metabolism in Cancer Biology
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 2270 | Submission Open
Keywords: cancer cells metabolism; target therapy; PI3K/Akt/mTOR pathway; hypoxia
(This special issue belongs to the Section Molecular Oncology)
Wound Repair: From Basic Biology to Tissue Engineering submission deadline 20 Jan 2026 | 2 articles | Viewed by 2229 | Submission Open
Keywords: wound healing; tissue engineering; biomaterials; regenerative medicine; chronic wounds
(This special issue belongs to the Section Molecular Biology)
The Pathogenesis of Alcohol-Associated Hepatitis and Its Therapies
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 2199 | Submission Open
Keywords: alcohol-associted hepatitis; acute kidney injury; hepatic encephalopathy; adaptive immune response; innate immune response; neutrophilia
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms of Ozone Therapy submission deadline 20 Jan 2026 | 1 articles | Viewed by 2199 | Submission Open
Keywords: antioxidant response; cellular stress responses; inflammatory signaling; mitochondrial function; molecular pathways; Nrf2; oxidative stress; ozone therapy; redox regulation; antimicrobial resistance; infectious diseases
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research on Tumor Suppressor Proteins
edited by Jie Liu
submission deadline 20 Jan 2026 | 1 articles | Viewed by 2162 | Submission Open
Keywords: DNA repair; genome stability; tumor suppressor; BRCA1; BRCA2; PALB2; RAD51C
(This special issue belongs to the Section Molecular Oncology)
Molecular Crosstalk in Breast Cancer Progression and Therapies
edited by Giuseppina Daniela Naimo
submission deadline 20 Jan 2026 | 1 articles | Viewed by 2142 | Submission Open
Keywords: breast cancer; endocrine therapy; drug resistance; breast tumor microenvironment; targeted therapies; personalized therapies; immunotherapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Endothelial Cells in Health and Disease submission deadline 20 Jan 2026 | 2 articles | Viewed by 2099 | Submission Open
Keywords: endothelial cells; vascular homeostasis; tissue homeostasis; endothelial cell biology; endothelial cells dysfunction; oxidative stress; redox signaling; aging; endothelial regulation of tissue repair
(This special issue belongs to the Section Molecular Biology)
Modulating the Function of the Immune System by Thyrotropin and Thyroid Hormones
edited by Graciela Alicia Cremaschi and Claudia Gabriela Pellizas
submission deadline 20 Jan 2026 | 1 articles | Viewed by 2095 | Submission Open
Keywords: thyrotropin (TSH); thyroid hormones (THs); immune modulation; immunology; immune; autoimmune; immunoendocrinology; hypothalamic-pituitary-thyroid axis; antitumor immune response
(This special issue belongs to the Section Molecular Immunology)
Molecular Breeding and Genetic Regulation of Crops, 2nd Edition
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 2021 | Submission Open
Keywords: molecular breeding; genetic regulation; genomics; genome-editing techniques; epigenetic modifications
(This special issue belongs to the Section Molecular Plant Sciences)
The Impact of Cancer–Immune Cell Crosstalk on Diagnosis, Prognosis and Treatment
edited by Fabricio Figueiro
submission deadline 20 Jan 2026 | 1 articles | Viewed by 1972 | Submission Open
Keywords: protumoral immunity; anticancer immunity; crosstalk; tumor microenvironment; purinergic signaling; immune checkpoints; immunometabolism; extracellular vesicles; RNA communication
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Oxidative Stress in Dermatology, Aesthetics and Regenerative Medicine submission deadline 20 Jan 2026 | Viewed by 1937 | Submission Open
Keywords: oxidative stress; redox system; antioxidant chemical species; dermatology; aesthetics; regenerative medicine; inflammatory; degenerative skin diseases
(This special issue belongs to the Section Molecular Biology)
Latest Research in Photocatalysis submission deadline 20 Jan 2026 | 2 articles | Viewed by 1862 | Submission Open
Keywords: design; simulation; synthesis; properties; functionalities; reactions; photocatalysis
(This special issue belongs to the Section Biochemistry)
Molecular Research in Animal Nutrition
edited by Jie Fu
submission deadline 20 Jan 2026 | 1 articles | Viewed by 1820 | Submission Open
Keywords: animal nutrition; animal immunity; epigenetics; m6A methylation; gut microbiota; host– microbiome interaction; metabolic reprogramming
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Insights and Regulation Mechanisms of Tea Quality
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 1797 | Submission Open
Keywords: molecular ecology; spectroscopic techniques; tea quality; tea plant growth
(This special issue belongs to the Section Molecular Plant Sciences)
Advances in Plant Nematology Research
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 1760 | Submission Open
Keywords: DNA barcoding; Molecular evolution; Genomes; Molecular systematics; Phylogenetics; Plant– nematode interactions; Transcriptomics
(This special issue belongs to the Section Molecular Plant Sciences)
Advances and Applications in Molecular Enzymology
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 1759 | Submission Open
Keywords: microbial enzymes; biosynthesis and bioengineering; drug development and targets; enzymes in the environment; engineered enzymes; enzymes in agri-food; enzymatic formulations; enzyme engineering; enzymes in biomedical sciences; green chemistry/technology; glycans; molecular evolution; nanocatalyst and nanotechnology; pharma enzymes; recombinant proteins production and purification; system and synthetic biology
(This special issue belongs to the Section Biochemistry)
Coagulation Factors and Natural Anticoagulants in Health and Disease
edited by
submission deadline 20 Jan 2026 | 2 articles | Viewed by 1673 | Submission Open
Keywords: coagulation factor; natural anticoagulant; hemostasis; thrombosis; molecular studies; molecular interactions; structure; functional studies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Role of Extracellular Histones in Patho(physio)logical Hemostasis
edited by Fabrizio Semeraro and
submission deadline 20 Jan 2026 | 1 articles | Viewed by 1623 | Submission Open
Keywords: extracellular histones; hemostasis; platelets; coagulation; fibrinolysis; thrombosis; inflammation; extracellular traps
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Studies on Oral Disease and Treatment
edited by
submission deadline 20 Jan 2026 | 2 articles | Viewed by 1527 | Submission Open
Keywords: oral cancer; oral mucosal lesions; chronic pain; temporomandibular joint disorders; periodontal diseases
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Protein Design and Engineering in Biochemistry
edited by Om Prakash Narayan
submission deadline 20 Jan 2026 | 1 articles | Viewed by 1514 | Submission Open
Keywords: protein engineering; molecular biology; biochemical tools; computational protein design; directed evolution; CRISPR/Cas9; synthetic biology; biomaterials; protein therapeutics; regenerative medicine
(This special issue belongs to the Section Molecular Biology)
Advances in Mass Spectrometry-Based Proteomics: From Biomarker Discovery to Translational Applications
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 1487 | Submission Open
Keywords: mass spectrometry; LC-MS method development; phosphoproteomics; glycoproteomics; biomarker discovery; multi-omics data integration  
(This special issue belongs to the Section Biochemistry)
Studying Multi-Target Drug Approaches and Posttranslational Modification (PTM) Therapies
edited by
submission deadline 20 Jan 2026 | 2 articles | Viewed by 1467 | Submission Open
Keywords: multi-target therapy; network analysis tools; multi-label proteins; web-server predictor; posttranslational modifications (PTMs); 3D structures; rational drug design
(This special issue belongs to the Section Molecular Informatics)
Research Progress and Therapeutic Targets of Chronic Kidney Disease submission deadline 20 Jan 2026 | 1 articles | Viewed by 1464 | Submission Open
Keywords: blood pressure; cardiovascular disease; chronic kidney disease; diabetes; hypertension; inflammation; oxidative stress; sodium glucose transporter-2; vascular calcification
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Research Progress on Oocyte Development
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 1458 | Submission Open
Keywords: oocyte maturation; germ cell development; folliculogenesis; oocyte quality; egg cell development; oocyte activation; meiotic progression; fertility
(This special issue belongs to the Section Molecular Biology)
Nanoscience in Plants: Omics Approaches to Elucidate the Role of Nanoparticles
edited by and Zahed Hossain
submission deadline 20 Jan 2026 | 1 articles | Viewed by 1408 | Submission Open
Keywords: nanoparticles; plant; omics-based techniques; bioinformatics; systems biology; nanotoxicology
(This special issue belongs to the Section Molecular Plant Sciences)
Fibrotic Disease: From Pathophysiology to Treatment
edited by Galina S. Bogatkevich
submission deadline 20 Jan 2026 | Viewed by 1390 | Submission Open
Keywords: lung; liver; heart; kidney; fibrosis; systemic sclerosis; mechanisms; pathophysiology; therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Tuberculosis: Host Immunity, Diagnosis and Treatment submission deadline 20 Jan 2026 | 1 articles | Viewed by 1378 | Submission Open
Keywords: tuberculosis; immune response; diagnosis; treatment; antibiotics; resistance
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular and Immune Mechanisms in Pathogenic Mycobacteria Infections
edited by Fabiana Bigi and Federico Carlos Blanco
submission deadline 20 Jan 2026 | 1 articles | Viewed by 1375 | Submission Open
Keywords: Mycobacterium tuberculosis; virulence; pathogens  
(This special issue belongs to the Section Molecular Microbiology)
Radiolabeled Compounds for Theranostic Applications in Oncology
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 1346 | Submission Open
Keywords: radiopharmaceuticals; theranostic; cancer therapy; targeted radionuclide therapy; molecular imaging; positron emission tomography; single-photon emission tomography; radiolabeling
(This special issue belongs to the Section Molecular Oncology)
New Insights into Chronic Inflammatory Demyelinating Polyneuropathy and Neuroimmunological Diseases
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 1334 | Submission Open
Keywords: chronic inflammatory demyelinating polyneuropathy (CIDP); multiple sclerosis (MS); neuromyelitis optica spectrum disorder (NMOSD); myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD); autoimmune encephalitis; paraneoplastic neurological syndrome; Guillain-Barre syndrome (GBS); myositis; blood-brain barrier; blood-nerve barrier
(This special issue belongs to the Section Molecular Neurobiology)
Advances in Biomarker Discovery for Rare Diseases
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 1324 | Submission Open
Keywords: biomarker; rare diseases; pathological processes; cystic fibrosis; Duchenne muscular dystrophy; Ehlers-Danlos syndrome; haemophilia; sickle cell disease; primary biliary cholangitis; fabry disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Unraveling the Enigma of Colorectal Cancer: From Mechanisms to Therapeutic Advances
edited by Valentina Belli and
submission deadline 20 Jan 2026 | 1 articles | Viewed by 1301 | Submission Open
Keywords: Colorectal cancer; tumour microenvironment; epigenetics; diagnostic molecules; immune evasion; biomarkers; drug resistance; precision medicine; targeted  
(This special issue belongs to the Section Molecular Oncology)
Computational Genomics and Bioinformatics in Microbiology submission deadline 20 Jan 2026 | 1 articles | Viewed by 1300 | Submission Open
Keywords: computational microbial genomics; comparative genomics; structural genomics; functional genomics; genomic data bioinformatics
(This special issue belongs to the Section Molecular Informatics)
Hormonal and Metabolic Markers in Health and Disease submission deadline 20 Jan 2026 | 1 articles | Viewed by 1256 | Submission Open
Keywords: hormonal biomarkers; molecular mechanism of endocrine disorders; steroidogenesis; hormonal dysregulation; endocrine disruptors; metabolomics; metabolic regulation
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Advances in the Molecular Diagnosis and Treatment of Neurodegenerative Diseases
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 1255 | Submission Open
Keywords: neurodegenerative disorders; biomarkers; treatment; omics; systems biology
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Paradigm Iconoclasm
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 1255 | Submission Open
Keywords: paradigm shift; biochemistry; cell signaling; coagulation; toxinology
(This special issue belongs to the Section Biochemistry)
Progress in Adipokines Research in Cardiovascular Health and Diseases
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 1221 | Submission Open
Keywords: adipokine receptors and cell signalling; adipokines and heart failure and hypertrophy; adipokines and myocardial ischemia; adipokines and hypertension; adipokines and thrombosis/atherosclerosis; adipokines and vascular/endothelial function; structure; and integrity; adipokines and cardiovascular inflammation; adipokines; adiposity; and cardiovascular disease in obesity
(This special issue belongs to the Section Molecular Biology)
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