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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Obesity and Cancer Risk: Molecular Mechanisms and Perspectives

edited by

Hendrik Lehnert

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1493 | Submission Open

Keywords: epidemiology of obesity and cancer; experimental models of cancer in obesity; genetic and epigenetics of obesity and metabolic dysfunction associated cancer; tumor microenvironment; basis of metastatic spread of cancer in obesity; therapeutic modeling and targeting

(This special issue belongs to the Section Molecular Oncology)

Bioactive Compounds from Foods Against Diseases

edited by Jongbin Lim

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1388 | Submission Open

Keywords: diet-related diseases; bioactive compounds; analytical techniques; functional foods; molecular interaction; health benefits

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Upper and Lower Airway Diseases in Allergy and Immunology: From Bench to Bedside

edited by

Giovanni Paoletti

Giulia Costanzo

and

Enrico Marco Heffler

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1311 | Submission Open

Keywords: unified airway disease; allergic rhinitis; asthma; chronic rhinosinusitis; eosinophilic; airway inflammation; airway epithelial barrier; immune dysregulation; respiratory microbiome; biomarkers; allergy and immunology

(This special issue belongs to the Section Molecular Immunology)

Plant Breeding Strategies: Employment of Plant Adaptation Mechanisms to Biotic and Abiotic Stresses

edited by

Vidmantas Bendokas

submission deadline 20 Jun 2026 | 2 articles | Viewed by 842 | Submission Open

Keywords: marker-assisted selection; molecular breeding; whole-transcriptome analysis; RNA sequencing; DNA sequencing; plant stress response

(This special issue belongs to the Section Molecular Plant Sciences)

Research on System Biology Methods and Tools for Integrating Omics Data

edited by Yuanyan Xiong

submission deadline 20 Jun 2026 | 2 articles | Viewed by 602 | Submission Open

Keywords: systems biology; multi-omics integration; network analysis; computational biology; bioinformatics tools; machine learning; precision medicine

(This special issue belongs to the Section Molecular Informatics)

Leukemia: Molecular Immune Mechanisms

edited by

Mohammad Hojjat-Farsangi

submission deadline 20 Jun 2026 | Viewed by 554 | Submission Open

Keywords: leukemia; immune system; Genetic Mutations and Alterations; Immune Evasion Mechanisms; Immune Cell Dysfunction; Cytokine Networks; Bone Marrow Microenvironment; immunotherapy strategies

(This special issue belongs to the Section Molecular Immunology)

Molecular Research on Actinomycetes-Derived Natural Products

edited by Fong Tian Wong

submission deadline 20 Jun 2026 | Viewed by 525 | Submission Open

Keywords: actinomycetes; natural products; actinobacterial; genome mining; omics; secondary metabolites; genetic engineering; discovery; structural diversity

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Biology of 3D Cell and Tissue Culture Systems: Benefits to Research and Disease Diagnostics

edited by

Thomas J. Goodwin

submission deadline 20 Jun 2026 | 1 articles | Viewed by 429 | Submission Open

Keywords: 3D physiological relevance vs. 2D biology; 3D research; and diagnostic systems; evolving 3D “ omics” applications; research and clinical medicine; drug applications; toxicity evaluations; “ Omics” ; spatial biology of 3D

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular and Cellular Aspects of Autoimmune and Inflammatory Rheumatic Diseases: Second Edition

edited by Marzena Helena Olesińska and Magdalena Szmyrka

submission deadline 20 Jun 2026 | Viewed by 385 | Submission Open

Keywords: autoimmune rheumatic diseases; inflammatory rheumatic diseases; arthritis; connective tissue diseases

(This special issue belongs to the Section Molecular Immunology)

Bioactive Compounds in Cancers: Second Edition

edited by

Patrícia M. A. Silva

Hassan Bousbaa

and

Honorina Cidade

submission deadline 20 Jun 2026 | Viewed by 301 | Submission Open

Keywords: anticancer strategies; bioactive compounds; natural products; synthetic products; medicinal chemistry; drug repurposing; drug delivery systems

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Telomeres in Development, Senescence and Genome Instability: 2nd Edition

edited by Michal Zalzman

submission deadline 20 Jun 2026 | Viewed by 292 | Submission Open

Keywords: telomere disorders and cell death; telomere factors as therapeutic targets in cancer; telomeres and genome stability; telomeres in aging and senescence

(This special issue belongs to the Section Molecular Genetics and Genomics)

Synthesis, Modification, and Functional Characterization of Advanced Biomaterials for Bone Tissue Engineering

edited by

Elisa Boanini

submission deadline 20 Jun 2026 | Viewed by 214 | Submission Open

Keywords: material functionalization; bioactive materials; antimicrobial; antibiofilm; coatings; scaffolds; bone cements; metal nanoparticles; controlled release; biocompatibility

(This special issue belongs to the Section Materials Science)

Molecular Characterization of Glioblastoma: Implications for Diagnosis and Personalized Treatment

edited by Madan Mohan Kwatra

submission deadline 20 Jun 2026 | Viewed by 208 | Submission Open

Keywords: glioblastoma; diagnosis; molecular characterization; personalized treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Research on the Major Histocompatibility Complex (MHC): From Bench to Bedside

edited by Antonio Arnaiz-Villena

submission deadline 20 Jun 2026 | Viewed by 192 | Submission Open

Keywords: HLA; immunology; HLA genetics and pharmacogenetics; immune and other functions of the MHC; classical and nonclassical MHC class I HLA genes; HLA-G; HLA-E; HLA-F; MHC evolution; complement; autoimmunity; immunodeficiency; cancer; HIV

(This special issue belongs to the Section Molecular Immunology)

Molecular Horizons in Pain Therapeutics

edited by Alaa Abd-Elsayed

submission deadline 20 Jun 2026 | Viewed by 192 | Submission Open

Keywords: spinal cord stimulation; peripheral nerve stimulation; stem cell therapy; platelet-rich plasma (PRP) injections; chronic pain management; interventional pain procedure

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Graphene-based Nanocomposites

edited by

Oleksandr Ivasenko

submission deadline 20 Jun 2026 | Viewed by 191 | Submission Open

Keywords: graphite intercalates; graphene; reduced graphene oxide; grafting; vertical heterostructures; nanocomposites; covalent organic frameworks (COFs); 2D nanomaterials; biomimetic interfaces; interfacial engineering

(This special issue belongs to the Section Molecular Nanoscience)

Natural Bioactive Compounds for Human Health, 3rd Edition

edited by

Hongjie Zhang

submission deadline 20 Jun 2026 | Viewed by 166 | Submission Open

Keywords: natural bioactive plant products; biological and pharmacological activity; natural plant drug discovery and development; nutraceuticals; botanical dietary supplement

(This special issue belongs to the Section Molecular Pharmacology)

Progress in Molecular Breeding and Genetic Engineering for Fruit Crop Improvement

edited by

Amelia Salimonti

submission deadline 20 Jun 2026 | Viewed by 164 | Submission Open

Keywords: genetics; GWAS; genome; abiotic and biotic stress; transcriptomic analysis; fruit crop germplasm; breeding

(This special issue belongs to the Section Molecular Plant Sciences)

New Perspectives in Protein Structure

edited by

Csaba Magyar

submission deadline 20 Jun 2026 | Viewed by 139 | Submission Open

Keywords: stability of protein complexes structural; background of protein function; allosteric regulation of proteins; fuzzy complexes; intrinsically disordered proteins; liquid-liquid phase separation; mutual synergistic folding; protein folding; protein structure; protein-protein interactions; transmembrane proteins

(This special issue belongs to the Section Molecular Biophysics)

Molecular Research in Pregnancy-Related Complications

edited by Kallirhoe Kalinderi

submission deadline 25 Jun 2026 | Viewed by 179 | Submission Open

Keywords: preeclampsia; gestetional diabetes mellitus; pregnancy; complications; gene; molecular; pathways; biomarkers; diagnosis; therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Colorectal Cancer: A Molecular Genetics Perspective (2nd Edition)

edited by

Ehsan Gharib

submission deadline 25 Jun 2026 | Viewed by 71 | Submission Open

Keywords: colorectal cancer; chromosomal and microsatellite instability; CpG island methylator phenotype; molecular characteristics; early diagnosis; targeted therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mitochondrial Function in Human Health and Disease: 3rd Edition

edited by

Yumay Chen

submission deadline 25 Jun 2026 | Viewed by 58 | Submission Open

Keywords: mitochondial genesis and disease; mitochondrial function and aging; mitochondrial dysfunction and cancer; mitochondrial function and apoptosis; mitophage; autophage; mitochondrial AKT

(This special issue belongs to the Section Biochemistry)

Functions and Applications of Natural Products: 2nd Edition

edited by

Seung-Hong Lee

submission deadline 25 Jun 2026 | Viewed by 58 | Submission Open

Keywords: natural products; biomedicine/phytomedicine; biologically active extracts and compounds; pharmacological and toxicological mechanisms of action

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Progression of Gut Microbiota—2nd Edition

edited by

Emina Pustijanac

submission deadline 25 Jun 2026 | Viewed by 39 | Submission Open

Keywords: gut microbiota; microbiome; differences in gut microflora; molecular techniques; gut microbiota’ s role and composition; healthy state; dysbiosis

(This special issue belongs to the Section Molecular Microbiology)

Current Research on Cancer Biology and Therapeutics: Fourth Edition

edited by

Rafael Coveñas Rodríguez

submission deadline 29 Jun 2026 | 2 articles | Viewed by 399 | Submission Open

Keywords: cancer and anticancer peptides; substance P/neurokinin-1 receptor system; neurokinin-1 receptor antagonists

(This special issue belongs to the Section Molecular Oncology)

Oxidative Stress Unveiled: Mechanisms and Implications in Cardiac Pathologies

edited by Sukkum Ngullie Chang and Vernat Exil

submission deadline 30 Jun 2026 | Viewed by 370 | Submission Open

Keywords: reactive oxygen species (ROS); electron transport chain (ETC); mitochondrial permeability transition pore (mPTP); endothelial– cardiomyocyte– fibroblast crosstalk; metabolic adaptation; inflammation; cardiovascular disease (CVD)

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biomaterials and Nanotechnology in Cancer Therapy and Regenerative Medicine

edited by Manoochehr Rasekh

submission deadline 30 Jun 2026 | Viewed by 141 | Submission Open

Keywords: biomaterials; nanoparticle drug delivery; cancer therapy; stimuli-responsive nanocarriers; targeted therapeutics; regenerative medicine; tissue engineering; theranostics

(This special issue belongs to the Section Materials Science)

Unraveling Neurodevelopmental Disorders: A Molecular Perspective

edited by Marija Petrinovic

submission deadline 30 Jun 2026 | Viewed by 62 | Submission Open

Keywords: neurodevelopmental disorders; molecular neuroscience; genetics; epigenetics; functional MRI (fMRI); magnetic resonance spectroscopy (MRS); PET imaging; imaging biomarkers; translational neuroscience; precision medicine

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Discoveries in Pharmacogenetics: From Bench to Bedside

edited by

Kumaraswamy Naidu Chitrala

submission deadline 30 Jun 2026 | Viewed by 57 | Submission Open

Keywords: pharmacogenetics; clincial practice; artficial intelligence; bioinformatics; personalized medicine; drug response; genetic variations

(This special issue belongs to the Section Molecular Pharmacology)

Latest Research Progress of Biomaterial Modification

edited by

Manuel José Lis

submission deadline 30 Jun 2026 | Viewed by 48 | Submission Open

Keywords: functionalization of carbohydrates; molecular aggregation; simulation of biopolymers; biopolymeric microcapsules; biopolymeric devices

(This special issue belongs to the Section Materials Science)

Thermogenic Adipocytes and Skeletal Muscle: Novel Molecular Targets for the Treatment of Diabetes and Obesity

edited by

Hiroshi Sakaue

submission deadline 30 Jun 2026 | Viewed by 46 | Submission Open

Keywords: metabolic diseases; obesity; type 2 diabetes; molecular signaling pathway

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Anesthetics and Neurovascular Health: Molecular Pathways

edited by Gabriele Melegari

submission deadline 30 Jun 2026 | Viewed by 2 | Submission Open

Keywords: neurovascular paths; blood– brain barrier (BBB) and anesthesia; neurovascular coupling; perioperative neuroprotection; neuroinflammation; endothelial dysfunction; cerebral autoregulation; cerebral blood flow; perioperative brain health

(This special issue belongs to the Section Molecular Neurobiology)

Interplay Between the Human Microbiome and Diseases

edited by

Tihamer Molnar

and

Zoltán Péterfi

submission deadline 20 Jul 2026 | 6 articles | Viewed by 12022 | Submission Open

Keywords: microbiome; metagenome; gastrointestinal tract; skin; seminal fluid; lung; saliva; oral mucosa; conjunctiva; dysbiosis; fecal microbiota transplantation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Research for Legume Genomics, Genetics, and Breeding, 2nd Edition

edited by

Naoufal Lakhssassi

submission deadline 20 Jul 2026 | 5 articles | Viewed by 9858 | Submission Open

Keywords: legumes; genomics; plant breeding; seed composition; gene function; biotic and abiotic stress; legume pathogen resistance/mechanisms

(This special issue belongs to the Section Molecular Plant Sciences)

Bone Metabolism and Bone Diseases

edited by

Giacomina Brunetti

submission deadline 20 Jul 2026 | 3 articles | Viewed by 3774 | Submission Open

Keywords: bone metabolism; bone diseases; osteoclast; osteoblasts and osteocytes; bone remodelling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Addiction

edited by

Aleksandra Suchanecka

and

Jolanta Chmielowiec

submission deadline 20 Jul 2026 | 2 articles | Viewed by 2352 | Submission Open

Keywords: addiction; dependence; neurobiology; reward; neuroplasticity; biostatistics

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms of Sjögren's Syndrome, 4th Edition

edited by

Biji Theyilamannil Kurien

submission deadline 20 Jul 2026 | 1 articles | Viewed by 1650 | Submission Open

Keywords: autoimmunity; sjö gren’ s syndrome; autoantibodies; salivary gland; lacrimal gland; dry eyes/mouth

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Nanotechnology in Drug Delivery

edited by

Omar Mertins

submission deadline 20 Jul 2026 | 1 articles | Viewed by 1009 | Submission Open

Keywords: smart nanoparticles; hybrid nanomaterial; functionalization; drug targeting; liposome; cubosome; polypeptide; polymers; biomolecules; cancer; vaccine; antimicrobial; antiparasite; antioxidant; immunomodulatory; genetic therapy; nanomedicine

(This special issue belongs to the Section Molecular Nanoscience)

Neuronal Differentiation: From Pathology to Therapeutic Strategies

edited by

Marzia Lecchi

submission deadline 20 Jul 2026 | Viewed by 334 | Submission Open

Keywords: neuronal differentiation; molecular mechanisms of neurodifferentiation; neurodegenerative diseases; ischemic stroke; spinal cord and brain injury; neural tissue recovery; regeneration therapy; stem cells

(This special issue belongs to the Section Molecular Neurobiology)

G Protein-Coupled Receptors: Signaling, Regulation and Therapeutic Opportunities, 2nd Edition

edited by

Joanna Filipowska

submission deadline 20 Jul 2026 | Viewed by 167 | Submission Open

Keywords: GPCR; cell signaling; small-molecule drugs; biased signaling; endosomal signaling; post-translational modification; GPCR internalization; phosphorylation barcode

(This special issue belongs to the Section Molecular Pharmacology)

Recent Molecular Research on Photocatalytic Applications

edited by Hassan Ait Ahsaine

submission deadline 20 Jul 2026 | Viewed by 124 | Submission Open

Keywords: photocatalysis; photocatalytic degradation; molecular catalysts; photocatalysts; functional materials

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Chronic Airway Diseases: Molecular Basis and Advanced Therapeutics

edited by

S. Lorraine Martin

submission deadline 20 Jul 2026 | Viewed by 64 | Submission Open

Keywords: chronic airway diseases; asthma; chronic obstructive pulmonary disease (COPD); cystic fibrosis; bronchiectasis; pulmonary fibrosis; airway remodeling; cytokines; inflammation; immune dysregulation; mucociliary clearance; microbiome; epithelial– mesenchymal transition (EMT); molecular mechanisms; biomarkers; proteases; protease inhibitors; precision medicine; targeted therapeutics; RNA-based and gene therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Natural Compounds in the Prevention and Treatment of Human and Veterinary Diseases

edited by

Fabiana Superti

and

Anna Scotto D'Abusco

submission deadline 20 Jul 2026 | Viewed by 25 | Submission Open

Keywords: bioactive natural substances; nutraceuticals; drug discovery; drug resistance; inflammation; antioxidant; health promotion; prevention; treatment; synergistic effect; molecular mechanism; computational analysis; repurposed molecules

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Evolving Landscape of Cardiovascular Pathophysiology

edited by

Pooja Shivshankar

submission deadline 25 Jul 2026 | Viewed by 22 | Submission Open

Keywords: biomarker discovery in cardiovascular pathophysiology; precision diagnostics-novel contrast agents combined with PET/CT; MRI; machine learning/AI and clinical implementations in cardiology; cardio-metabolic disease; inflammation and immunity in cardiovascular diseases; mechanisms of non-coding RNAs and microRNAs in cardiac diseases; translational research in large animals bridging the rodent re-search with human pathophysiology; targeted therapies- genetic therapies/gene editing approach (CRISPR); stem cell therapies; and therapeutic mRNA and siRNA-based approaches

(This special issue belongs to the Section Biochemistry)

Cancer Drug Resistance and Therapeutic Targets

edited by

Sanjay K. Srivastava

submission deadline 30 Jul 2026 | Viewed by 74 | Submission Open

Keywords: drug resistance; therapeutic targets; efflux transporters’ oncogenic signaling pathways; tumor microenvironment; dna damage/repair; personalized therapies

(This special issue belongs to the Section Molecular Oncology)

Neurobiology Linking Alcohol Addiction to Psychiatry Symptoms

edited by

Jorge Manzanares

and

Francisco Navarrete

submission deadline 30 Jul 2026 | Viewed by 69 | Submission Open

Keywords: alcohol use disorder (AUD); psychiatry; neurobiology; biomarkers; translational

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Bone Homeostasis

edited by

John Kelly Smith

submission deadline 30 Jul 2026 | Viewed by 56 | Submission Open

Keywords: bone remodeling; osteoblasts and osteoclasts; osteoimmunology; osteometabolism; signaling pathways; bone diseases; epigenetic regulation; extracellular vesicles; mechanotransduction; therapeutic targets

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Phytochemicals and Antioxidants on Health and Disease Modulation

edited by Natalia Kurhaluk

submission deadline 30 Jul 2026 | Viewed by 5 | Submission Open

Keywords: phytochemical bioactive compounds; antioxidant mechanisms; oxidative stress modulation; chronic disease prevention; inflammatory signalling pathways; molecular health effects; bioavailability and metabolism; flavonoid biological activity; polyphenol therapeutic potential; disease modulation strategies

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Physiology and Molecular Biology of Plant Stress Tolerance: 3rd Edition

edited by

De-Guo Han

submission deadline 31 Jul 2026 | 1 articles | Viewed by 336 | Submission Open

Keywords: plant– pathogen interactions; biotic and abiotic stress; plant innate immunity; phytohormones; genes

(This special issue belongs to the Section Molecular Plant Sciences)

Fluorescent Nanoparticles: Composition, Properties, and Biomedical Applications

edited by Bonghwan Chon

submission deadline 1 Aug 2026 | Viewed by 77 | Submission Open

Keywords: fluorescent nanoparticles; bioimaging; targeted drug delivery; cancer nanotherapy; quantum dots; surface functionalization; biomedical nanotechnology; theragnostic; fluorescence imaging; deep tissue imaging

(This special issue belongs to the Section Molecular Nanoscience)

Displaying special issue 3351-3400 on page 68 of 69.

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