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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Targeting Oxidative Stress: New Insights into Disease Pathogenesis, Emerging Preventive Strategies and Novel Therapeutic Approaches

edited by Fabio Vivarelli and

Donatella Canistro

submission deadline 30 Aug 2026 | Viewed by 28 | Submission Open

Keywords: metabolism; inflammation; oxidative stress; diabetes; natural oxidative stress modulators; novel preventive/therapeutic strategies; ageing; cardiovascular diseases; regenerative medicine; neurodegeneration; environmental exposure; cancer

(This special issue belongs to the Section Molecular Biology)

Advances in Protein Structure and Dynamics

edited by

Ki Hyun Nam

submission deadline 30 Aug 2026 | Viewed by 12 | Submission Open

Keywords: experimental protein structure determination; structure–function relationships and mechanistic enzymology; molecular dynamics simulations; conformational dynamics; intrinsic disorder; and structural flexibility; protein–ligand and protein–protein interactions; AI-predicted structures with experimental and simulation data; methodological developments in structural and dynamic analysis.

(This special issue belongs to the Section Molecular Biophysics)

Molecular Mechanisms in Glomerular and Renal Diseases

edited by Eleni Stamellou and

Evangelia Dounousi

submission deadline 30 Aug 2026 | Viewed by 4 | Submission Open

Keywords: glomerulonephritis (GN); podocytopathies; IgA (IgAN); chronic kindey disease (CKD); membra-nous nephropathy; focal segmental glomerulosclerosis (FSGS)

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Anti-Inflammatory Strategies and Cell Models for Alzheimer’s Disease

edited by Sophia Lavrentiadou

submission deadline 31 Aug 2026 | 1 articles | Viewed by 3465 | Submission Open

Keywords: Alzheimer’ s disease; neuroinflammation; anti-inflammatory strategies; cell models

(This special issue belongs to the Section Molecular Neurobiology)

The Role of Neuropeptides and Their GPCRs in the Neuroendocrine System

edited by

Hirotaka Sakamoto

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1090 | Submission Open

Keywords: neuropeptides; G-protein-coupled receptors (GPCRs); neuroendocrine system; signal transduction; hypothalamus

(This special issue belongs to the Section Molecular Neurobiology)

Cell Penetrating Peptides: Novel Therapeutic Tools for Drug Delivery

edited by

Betty Revon Liu

submission deadline 31 Aug 2026 | Viewed by 207 | Submission Open

Keywords: cell-penetrating peptides; peptide design; drug delivery; controlled and release; clinical applica-tions; penetration mechanisms

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Neuropathology of Alzheimer’s Disease: Tau, Amyloid-β, and Novel Protein Associations

edited by

José Luna-Muñoz

and Alejandra Morlett-Paredes

submission deadline 31 Aug 2026 | Viewed by 140 | Submission Open

Keywords: tauopathies and protein aggregation; amyloid beta and neurotoxicity; emerging proteins in neurodegeneration; molecular and morphological biomarkers; innovative therapies and experimental targets; artificial intelligence and neuropathological analysis

(This special issue belongs to the Section Molecular Neurobiology)

Lipid Metabolism in Aging and Diseases: From Mechanisms to Therapy

edited by

Dominique Delmas

submission deadline 31 Aug 2026 | Viewed by 100 | Submission Open

Keywords: lipid metabolism; degenerative diseases; cardiovascular pathologies; neurodegeneration; inflammation; autoimmunity; cancer; lipid droplets; bioactive molecules; drug repositioning; oxidative stress; mitochondrial dysfunction; inflammatory processes

(This special issue belongs to the Section Biochemistry)

Animal Models for Neurobiological Diseases

edited by

Hiroki Toyoda

and

Jana Tchekalarova

submission deadline 31 Aug 2026 | Viewed by 82 | Submission Open

Keywords: animal models; mice; zebrafish; Alzheimer's disease; Parkinson's disease; multiple sclerosis; neuropsychiatric conditions

(This special issue belongs to the Section Molecular Neurobiology)

Functional Precision Medicine in Rare Cancers: Organoid Models and Integrated Omics Profiling

edited by Gavin Robert Oliver and Carlton C Barnett

submission deadline 31 Aug 2026 | Viewed by 67 | Submission Open

Keywords: organoids; rare cancer; new approach methodologies; oncology; precision medicine; functional precision medicine; multiomics; genomics; transcriptomics; epigenomics

(This special issue belongs to the Section Molecular Oncology)

Advances in Alzheimer's Disease and Related Dementias: From Pathogenesis to Therapeutics

edited by

Amal Kaddoumi

submission deadline 31 Aug 2026 | Viewed by 66 | Submission Open

Keywords: Alzheimer's disease; cerebral amyloid angiopathy; blood– brain barrier; cerebrovascular dysfunction; neuroinflammation; therapeutic development; translational research

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms in Cardiovascular and Metabolic Diseases: Effective and Potential Treatments

edited by

Alex Cleber Improta-Caria

submission deadline 31 Aug 2026 | Viewed by 63 | Submission Open

Keywords: molecular mechanisms; cardiovascular diseases; metabolic diseases; microRNAs; circRNAs; long non-coding RNAs; epigenetics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular and Nanostructured Materials for Energy, Environmental, and Biomedical Applications

edited by

Balaji Murugan

submission deadline 31 Aug 2026 | Viewed by 49 | Submission Open

Keywords: advanced sustainable materials; molecular engineering; energy conversion and storage (supercapacitor; solar cells; and batteries); electrocatalysis and photocatalysis; environmental remediation; biomedical applications; bio/electrochemical sensing and bioelectronics; molecular surface structure and interface chemistry; in situ/operando spectroscopy

(This special issue belongs to the Section Molecular Nanoscience)

Nanobiomaterials for Medical Research: From Molecular Mechanisms to Clinical Translation

edited by

Carmen Curutiu

Alina Maria Holban

and

Florin Iordache

submission deadline 31 Aug 2026 | Viewed by 39 | Submission Open

Keywords: nanomaterials; biopolymers; medical research; chronic diseases; molecular mechanisms

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Insights in Placental Function and Pregnancy Complications

edited by Jezid Miranda

submission deadline 31 Aug 2026 | Viewed by 34 | Submission Open

Keywords: placental biology; pregnancy complications; preeclampsia; fetal growth restriction; angiogenic markers; maternal– fetal immunity; fetal growth; trophoblast; implementation; precision obstetrics; maternal mortality

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Hydrogen Medicine: From Molecular Insights to Disease Intervention

edited by

Fei Xie

submission deadline 31 Aug 2026 | Viewed by 31 | Submission Open

Keywords: hydrogen medicine; molecular hydrogen; oxidative stress; inflammation; mitochondrial function; gasotransmitters; ischemia– reperfusion injury; clinical trials; signal transduction; bioinformatics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Oral and Esophageal Disorders: Molecular Induction/Promotion, Treatment, and Prevention

edited by

Takanobu Takata

submission deadline 31 Aug 2026 | Viewed by 21 | Submission Open

Keywords: oral disorders; esophageal disorders; stomatitis; esophagitis; lifestyle-related diseases; advanced glycation-end products; modern European medicines; traditional medicines

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Forward in Vasculitis: Genetics and Beyond, 2nd Edition

edited by

Marija Jelusic

submission deadline 31 Aug 2026 | Viewed by 20 | Submission Open

Keywords: systemic vasculitides; ethiopathogenesis; risk factors; genetics; genomics; proteomics; transcriptomics; epigenetics; molecular pathways; novel therapeutic strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Novel Strategies in the Development of New Therapies, Drug Substances and Drug Carriers, 4rd Edition

edited by

Andrzej Kutner

Geoffrey Brown

and Enikö Kallay

submission deadline 31 Aug 2026 | Viewed by 18 | Submission Open

Keywords: drug design and discovery antimicrobial drugs; antiviral drugs; antibiotics; cancer prevention and treatment molecular modeling; molecular mechanisms; crystallography preclinical studies; pharmacokinetics; pharmacodynamics; pharmacognosy drug-protein interactions nuclear receptors; receptor agonists and antagonists; stem cells; activity profiling; vaccines; markers; and diagnostics drug carriers; dosage form; anti-crystal engineering; nanoparticles; dissolution testing

(This special issue belongs to the Section Molecular Pharmacology)

Nutrition, Inflammation and Chronic Kidney Diseases

edited by

Rodolfo A. Valtuille

submission deadline 31 Aug 2026 | Viewed by 17 | Submission Open

Keywords: chronic kidney disease; nutrition; inflammation; bioimpedance; gut-kidney axis; uremic toxins; oxidative stress; protein-energy wasting; precision nutrition; biomarkers

(This special issue belongs to the Section Molecular Immunology)

Developmental Biology: Computational and Experimental Approaches, 3rd Edition

edited by

Mikhail P. Ponomarenko

submission deadline 31 Aug 2026 | Viewed by 14 | Submission Open

Keywords: animal; plant; fungus; biological organization hierarchy; evolutionary limitations; fertilization; zygote; cell cycle; stem cell; meristem; cell layer; tissue; embryo; multicellular organism; ontogenesis; morphogenesis; life cycle; molecular mechanism; signal transduction; gene regulation; gene networks; cellular process; differentiation; migration; segmentation; high-resolution 3D-map; real-time in silico simulator; developmental hourglass; transcriptome ontogenetic switch; developmental abnormality; premature aging; neurodegeneration; tumorigenesis; atherogenesis; autoimmunity; induced pluripotent cell; wound healing; regeneration; assisted reproductive technologies; epigenetic reprogramming; predictive preventive personalized participatory (4P) medicine

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms of Hormone/Receptor System in Human Diseases

edited by Elena Zocchi,

Sonia Spinelli

and

Laura Sturla

submission deadline 31 Aug 2026 | Viewed by 13 | Submission Open

Keywords: hormone; receptor; energy metabolism; mitochondria

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Bacteriophages in the One Health Perspective: From Infection Therapy to Precision Medicine Through Diagnostics

edited by

Alicja Wegrzyn

submission deadline 31 Aug 2026 | Viewed by 13 | Submission Open

Keywords: bacteriophages; one health concept; bacteriophage therapy

(This special issue belongs to the Section Molecular Microbiology)

Lipid Metabolic and Signaling Dysregulations: From Molecular Mechanisms to Disease Pathogenesis

edited by Gergana M. Deevska

submission deadline 31 Aug 2026 | Viewed by 11 | Submission Open

Keywords: lipid signaling; lipid metabolism; lipid homeostasis; metabolic dysregulation; signal transduction; disease pathogenesis

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms, Biomarkers, and Therapeutic Targets in Heart Failure

edited by Celestino Sardu

submission deadline 31 Aug 2026 | Viewed by 9 | Submission Open

Keywords: heart failure; molecular mechanisms; ventricular remodeling; biomarkers; myocardial fibrosis; inflammation; oxidative stress; non-coding RNAs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Neuropharmacology: From Molecular Design to Preclinical Models

edited by

Jana Tchekalarova

and Miroslav A. Rangelov

submission deadline 31 Aug 2026 | Viewed by 7 | Submission Open

Keywords: neuropharmacology; drug discovery; molecular modeling; preclinical models

(This special issue belongs to the Section Molecular Neurobiology)

Sjogren's Disease: Multidimensional Perspectives on Pathogenesis, Clinical Manifestations, and Therapeutic Advancements (2nd Edition)

edited by

Xiang Lin

submission deadline 31 Aug 2026 | Viewed by 6 | Submission Open

Keywords: Sjö gren's disease; diagnosis; therapeutics; bioinformatics; pre-clinical; cytokine; lymphocytes; autoantibodies; exocrine glands

(This special issue belongs to the Section Molecular Immunology)

Contemporary Advancement in Personalized Medicine in Urological Cancers

edited by

Elenko Popov

submission deadline 31 Aug 2026 | Viewed by 5 | Submission Open

Keywords: urological cancers; prostate cancer; bladder cancer; renal/kidney cancer; personalized medicine

(This special issue belongs to the Section Molecular Oncology)

Molecular Research in Bamboo, Tree, Grass, and Other Forest Products—2nd Edition

edited by

Huayu Sun

submission deadline 31 Aug 2026 | Viewed by 1 | Submission Open

Keywords: bamboo; tree; grass; molecular biology; gene function

(This special issue belongs to the Section Molecular Plant Sciences)

Cellular and Molecular Progression of Cardiovascular Diseases: 2nd Edition

edited by

Andrea Borghini

Antonio Rizza

and

Alessandro Tonacci

submission deadline 10 Sep 2026 | Viewed by 33 | Submission Open

Keywords: cardiovascular diseases; multi-omics data; biomarkers; molecular level

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular and Cellular Advances in Coagulation and Bleeding

edited by

Muriel Meiring

submission deadline 10 Sep 2026 | Viewed by 28 | Submission Open

Keywords: thrombosis; haemostasis; inflammation-coagulation cross ralk; proteomics; molecular biomarkers

(This special issue belongs to the Section Molecular Biology)

Nanomaterials for Targeted Therapy and Drug Delivery

edited by Ceren Kimna

submission deadline 10 Sep 2026 | Viewed by 19 | Submission Open

Keywords: nanocarriers ; targeted therapies ; translational nanomedicine ; nano-bio interactions

(This special issue belongs to the Section Molecular Nanoscience)

Inflammation in Chronic Disease: Molecular Mechanisms and Signaling Pathways

edited by

Nadia Lampiasi

submission deadline 20 Sep 2026 | 4 articles | Viewed by 11460 | Submission Open

Keywords: inflammation; neuroinflammation; immune response; inflammation-associated disease; inflammation mediators (proteins; enzymes; ecc); cytokines; macrophages; mast cells; monocytes; dendritic cells; oxidative stress; signaling pathways

(This special issue belongs to the Section Molecular Immunology)

Type 2 Diabetes: Molecular Pathophysiology and Treatment

edited by

Edit Szabó

submission deadline 20 Sep 2026 | 4 articles | Viewed by 9853 | Submission Open

Keywords: type 2 diabetes mellitus and comorbidity; bioinformatics; molecular pathways; genetic background; biomarkers; novel therapies

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Melanin and Other Pigments: Function, Synthesis and Characterization

edited by Koen P. Vercruysse

submission deadline 20 Sep 2026 | 3 articles | Viewed by 6487 | Submission Open

Keywords: melanin; eumelanin; pheomelanin; allomelanin; catechol; indole; phenol

(This special issue belongs to the Section Biochemistry)

Exploring the Complex Interplay Between Metabolic Diseases, MASLD, and Liver Cancer

edited by

Daniela Gabbia

and

Sara De Martin

submission deadline 20 Sep 2026 | 3 articles | Viewed by 5005 | Submission Open

Keywords: hepatocellular carcinoma; MASLD; MASH; obesity; insulin resistance; dyslipidemia; liver cancer

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Antibody Engineering and Therapeutic Applications

edited by

Yong-Seok Heo

submission deadline 20 Sep 2026 | 1 articles | Viewed by 4430 | Submission Open

Keywords: monoclonal antibody (mAb) therapies; antibody engineering; antibody-drug conjugate (ADC); chimeric antigen receptor T cell (CAR-T); bispecific antibody; T-cell engager (TCE); cancer immunotherapy; immunocytokine; AI-driven antibody design; antibody structure and mechanism of action

(This special issue belongs to the Section Molecular Pharmacology)

Ongoing Anticancer Agents

edited by

Mauro Coluccia

submission deadline 20 Sep 2026 | 2 articles | Viewed by 2469 | Submission Open

Keywords: tumorigenesis; anticancer drugs; therapeutic innovation; platinum-based drugs; anticancer therapies

(This special issue belongs to the Section Molecular Oncology)

New Challenges of Parkinson’s Disease, 2nd Edition

edited by

Franca Rosa Guerini

and

Cristina Agliardi

submission deadline 20 Sep 2026 | 2 articles | Viewed by 2294 | Submission Open

Keywords: Parkinson’ s disease; neurodegeneration; synuclein; diagnosis; genetics; epigenetics; extracellular vesicles; biomarkers; treatments; rehabilitation

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms of the Aging Process: 2nd Edition

edited by

Giuseppe Coppotelli

and

Jaime M. Ross

submission deadline 20 Sep 2026 | 1 articles | Viewed by 2066 | Submission Open

Keywords: aging process; molecular mechanisms; epigenetic clock; cancer; metabolic disease

(This special issue belongs to the Section Molecular Biology)

Inner Ear Disorders: From Molecular Mechanisms to Treatment

edited by

Srdjan Vlajkovic

submission deadline 20 Sep 2026 | 2 articles | Viewed by 1992 | Submission Open

Keywords: hearing loss; balance disorders; stem cell approaches; precision gene therapy; molecular reprogramming; targeted delivery systems; molecular biomarkers; suppression of oxidative stress and inflammation; tissue engineering; immune response and off-target effects

(This special issue belongs to the Section Molecular Immunology)

Abiotic Stress in Plants: Physiological and Molecular Responses

edited by Edyta Zdunek-Zastocka

submission deadline 20 Sep 2026 | 3 articles | Viewed by 1920 | Submission Open

Keywords: cold; drought; gene expression; heat; heavy metals; oxidative stress; salinity; stress tolerance; stress perception; stress signaling

(This special issue belongs to the Section Molecular Plant Sciences)

Advanced Research in Veterinary Drugs

edited by Jianyong Li

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1808 | Submission Open

Keywords: veterinary drug; target; chemical structure; mechanism; medicinal chemistry; toxicity; pharmacodynamics; pharmacokinetics; residues

(This special issue belongs to the Section Molecular Pharmacology)

The Regulation of Microorganisms on Human Endocrine and Metabolic Systems

edited by Thi Phuong Nam Bui and Valentina Tremaroli

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1620 | Submission Open

Keywords: human gut microbiome; endocrine signaling; metabolism; obesity; type 2 diabetes; cardiometabolic diseases

(This special issue belongs to the Section Molecular Microbiology)

Plant Cell/Organ Structure and Function Research

edited by

Bartosz Płachno

submission deadline 20 Sep 2026 | 2 articles | Viewed by 1225 | Submission Open

Keywords: leaf development; root development; plant cell ultrastructure; plant morphogenesis; plant organs and bacteria; fungi and animal interactions

(This special issue belongs to the Section Molecular Plant Sciences)

New Trends in Alzheimer’s Disease Research: From Molecular Mechanisms to Therapeutics: 3rd Edition

edited by

Ramón Cacabelos

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1220 | Submission Open

Keywords: Alzheimer’ s disease; pathogenic mechanisms; genomics; epigenetics; biomarkers; prevention; treatment; pharmacogenetics

(This special issue belongs to the Section Molecular Neurobiology)

Genetic and Molecular Research on the Malaria Parasite

edited by Hajime Hisaeda and

Takashi Imai

submission deadline 20 Sep 2026 | 1 articles | Viewed by 905 | Submission Open

Keywords: plasmodium; malaria parasite; molecular biology; genomics; gene expression; host– parasite interaction; drug resistance; vaccine development

(This special issue belongs to the Section Molecular Microbiology)

Molecular Research on Prostate Cancer, 2nd Edition

edited by

Yaser Gamallat

submission deadline 20 Sep 2026 | 1 articles | Viewed by 861 | Submission Open

Keywords: prostate cancer; molecular biology; genomics; biomarkers; signaling pathways; precision medicine; treatment resistance; epigenetics; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research on Zoonotic Diseases: Current Advances and Perspectives

edited by

Gabriela Goujgoulova

submission deadline 20 Sep 2026 | 1 articles | Viewed by 756 | Submission Open

Keywords: emerging zoonoses; re-emerging zoonoses; zoonotic pathogens; control strategies and measures; animal and public health; worldwide

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Collagen-Based Biomaterials in Tissue Engineering and Regenerative Medicine

edited by Martin Braun,

Selestina Gorgieva

and

Eva Filova

submission deadline 20 Sep 2026 | Viewed by 520 | Submission Open

Keywords: collagen; tissue engineering; advanced biomaterials; biodegradable composites; scaffolds; protein structure; biochemical analysis; material characterization; medical application; gelatine

(This special issue belongs to the Section Macromolecules)

Displaying special issue 3201-3250 on page 65 of 67.

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