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Advances in Neuropharmacology: From Molecular Design to Preclinical Models

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 31 August 2026 | Viewed by 7

Special Issue Editors


E-Mail Website
Guest Editor

E-Mail Website
Guest Editor
Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 1000 Sofia, Bulgaria
Interests: computational chemistry; medicinal design; phytochemistry

Special Issue Information

Dear Colleagues,

This Special Issue aims to attract the interest of researchers working in design and development of novel compounds with potential applications in the central nervous system. It highlights cutting-edge advances in neuropharmacology, spanning rational drug design, target identification, and validation in preclinical models. The Issue brings together multidisciplinary research that bridges molecular pharmacology, neurobiology, and translational neuroscience, offering insights into innovative therapeutic strategies for neurological and neuropsychiatric disorders.

It is essential to consider the latest research findings and advancements in the field of neuroscience. Focusing on mechanistic innovation, this Special Issue explores recent progress in neuropharmacology, from molecular design and target modulation to functional evaluation in cellular and animal models. Contributions emphasize signaling pathways, receptor dynamics, and disease-modifying mechanisms that advance our understanding of nervous system disorders.

This Special Issue accelerates the translation of molecular discoveries into preclinical validation. By integrating computational design, medicinal chemistry, and in vivo modeling, it highlights emerging drug candidates and experimental paradigms with therapeutic potential for central nervous system diseases.

Dedicated to emerging technologies in neuropharmacology, this Special Issue covers innovations in molecular modeling, high-throughput screening, and advanced preclinical models. The collected works demonstrate how modern experimental and computational approaches are reshaping the development of neurotherapeutics.

Addressing current challenges and future directions, the Issue examines next-generation neuropharmacological strategies, from precision molecular design to sophisticated preclinical models, and aims to foster innovative approaches that bridge basic research and therapeutic development.

Dr. Jana Tchekalarova
Dr. Miroslav A. Rangelov
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neuropharmacology
  • drug discovery
  • molecular modeling
  • preclinical models

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Published Papers

This special issue is now open for submission.
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