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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Non-Coding RNA in Physiology and Pathophysiology: Second Edition

edited by Maria Rosaria Tumolo

submission deadline 20 Feb 2026 | 3 articles | Viewed by 5867 | Submission Open

Keywords: microRNA; long non-coding RNA; circular RNA; epigenetics; musculoskeletal pain; cardiovascular disease; metabolic disease; nervous system disorders; cancer; aging

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanism of Extracellular Vesicles in Human Diseases

edited by Eszter Ágnes Tóth

submission deadline 20 Feb 2026 | 2 articles | Viewed by 5848 | Submission Open

Keywords: extracellular vesicles; intercellular communication; disease pathophysiology; biomarkers; nanoscience; biomolecular interactions

(This special issue belongs to the Section Molecular Biology)

Sperm Oxidative Stress and Male Infertility

edited by

Kamil Gill

submission deadline 20 Feb 2026 | 3 articles | Viewed by 5801 | Submission Open

Keywords: oxidative stress; antioxidant system; free radical scavengers; sperm DNA oxidation; sperm DNA fragmentatio; antioxidant therapy; male infertility; male oxidative stress infertility

(This special issue belongs to the Section Molecular Biology)

Omics-Driven Unveiling of the Structure and Function of Nanoparticles

edited by

Elva Morretta

submission deadline 20 Feb 2026 | 4 articles | Viewed by 5706 | Submission Open

Keywords: nanoparticles; nanotechnology; drug delivery; protein corona; proteomics; nano-proteomics; matabolomics; lipidomics

(This special issue belongs to the Section Molecular Biophysics)

Roles of Lipid Rafts in the Regulation of Cellular Processes and Diseases

edited by

Kohji Kasahara

submission deadline 20 Feb 2026 | 1 articles | Viewed by 5681 | Submission Open

Keywords: lipid rafts; glycosphingolipid; ganglioside; sphingomyelin; cholesterol; GPI-anchored proteins; caveolae; detergent-resistant membrane; signal transduction; disease

(This special issue belongs to the Section Biochemistry)

Cutting-Edge Innovations in Molecular and Nanoscale Engineering for Energy Applications

edited by

Mohammad R. Thalji

and

Farzaneh Mahmoudi

submission deadline 20 Feb 2026 | 2 articles | Viewed by 5588 | Submission Open

Keywords: nanostructured electrode materials; energy storage; energy conversion; energy materials

(This special issue belongs to the Section Materials Science)

Marine Natural Compounds: Biotechnological Potential and Pharmacological Targets

edited by

Elena Leychenko

submission deadline 20 Feb 2026 | 3 articles | Viewed by 5551 | Submission Open

Keywords: marine natural compounds; structure elucidation; biologic activity; structure-activity relationships; biosynthesis; biotechnology; pharmacology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Advances in Metabolic Engineering and Synthetic Biology of Yeasts

edited by

Justyna Ruchała

submission deadline 20 Feb 2026 | 1 articles | Viewed by 5525 | Submission Open

Keywords: yeast metabolic engineering; synthetic biology; CRISPR-Cas9; metabolic pathways; bio-based chemicals; bioprocess engineering; yeast strain optimization; industrial biotechnology

(This special issue belongs to the Section Molecular Microbiology)

Research on Gene Mutations in Cancer and Chronic Diseases

edited by Adam Szpechciński

submission deadline 20 Feb 2026 | 2 articles | Viewed by 5516 | Submission Open

Keywords: germline and somatic mutation; pathogenesis of cancer and chronic diseases; molecular techniques for gene mutation detection; biomarkers; molecular diagnostics; bioinformatics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Mechanisms of Neutrophil Extracellular Traps (Nets) in Human Diseases

edited by Eisuke F. Sato

submission deadline 20 Feb 2026 | 1 articles | Viewed by 5510 | Submission Open

Keywords: neutrophil extracellular traps (NETs); neutrophils; inflammation; autoimmune diseases; cardiovascular diseases; tumor metastasis; thrombosis; molecular mechanisms; disease progression; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Inflammation in Pregnancy and Childbirth

edited by

Małgorzata Szczuko

and Maciej Ziętek

submission deadline 20 Feb 2026 | 2 articles | Viewed by 5486 | Submission Open

Keywords: pregnancy; labor; eicosanoid; chronic inflammation; cytokines; intestinal dysbiosis; mitogen-activated protein kinase; nuclear factor kappa-light-enhancer-activated B cell; maresins; resolvins and protectins

(This special issue belongs to the Section Molecular Immunology)

Essential Molecules in Life: Regulation, Defense, and Longevity, 2nd Edition

edited by

Eva E. Rufino Palomares

Amalia Pérez-Jiménez

and

José Antonio Lupiáñez

submission deadline 20 Feb 2026 | 3 articles | Viewed by 5445 | Submission Open

Keywords: glucose metabolism and its regulation; enzimology and kinetics; metabolism and evolution; cell growth; protein synthesis and degradation; cell proliferation and apoptosis; cancer; metastasis and angiogenesis; oxidative stress; genomic; proteomic and metab

(This special issue belongs to the Section Molecular Immunology)

The Extracellular Matrix in Physiopathology

edited by

Eric Huet

submission deadline 20 Feb 2026 | 4 articles | Viewed by 5388 | Submission Open

Keywords: extracellular matrix; glycosaminoglycans; matrix metalloproteinases; tissue remodeling; cell interactions; physiopathology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Brain-Body Interactions in Mental Disorders: Molecular Mechanisms and Therapeutics

edited by Yan-Xue Xue

submission deadline 20 Feb 2026 | 1 articles | Viewed by 5151 | Submission Open

Keywords: mental disorders; brain– body interactions; neural mechanisms; therapeutics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Advances in Cervical Cancer and Its Therapy

edited by Ilaria Cuccu and

Violante Di Donato

submission deadline 20 Feb 2026 | 1 articles | Viewed by 5090 | Submission Open

Keywords: cervical cancer; cervical cancer surgery; fertility-sparing techniques; targeted therapy; immunotherapy; immune checkpoint inhibitors; DNA damage repair inhibitors; antibody– drug conjugates; precision medicine; oncological outcomes

(This special issue belongs to the Section Molecular Oncology)

Osteoimmunology: Interactions of the Bone and Immune System

edited by

Galliera Emanuela Rita

submission deadline 20 Feb 2026 | 1 articles | Viewed by 5087 | Submission Open

Keywords: osteoimmunology markers; bone infection; inflammation and bone; immune response and bone; diagnostic and prognostic markers; bone remodeling; osteoclasts; immune-mediated bone diseases; bone– immune interface

(This special issue belongs to the Section Molecular Immunology)

Drug Therapy of Systemic Lupus Erythematosus

edited by Dionysis Nikolopoulos

submission deadline 20 Feb 2026 | 3 articles | Viewed by 5073 | Submission Open

Keywords: systemic lupus erythematosus; treatment; drugs; tailored strategies; precision medicine; biologics; cell therapy; randomized clinical trials

(This special issue belongs to the Section Molecular Pharmacology)

Advances in Structural and Functional Properties of G-Quadruplexes and Aptamers

edited by

Antonella Virgilio

Veronica Esposito

and

Aldo Galeone

submission deadline 20 Feb 2026 | 5 articles | Viewed by 5035 | Submission Open

Keywords: G-quadruplex structure; aptamer; DNAzyme; catalytic G-quadruplexes

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Osteoarthritis Pathways and Biomarker Research

edited by

Előd Ernő Nagy

submission deadline 20 Feb 2026 | 5 articles | Viewed by 4853 | Submission Open

Keywords: osteoarthritis; low-grade inflammation; cartilage chondrocyte; synovial membrane; synovial fluid; subchondral bone; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Immune Mechanisms and Biomarkers in Systemic Lupus Erythematosus—Second Edition

edited by

Ioannis Parodis

submission deadline 20 Feb 2026 | 3 articles | Viewed by 4791 | Submission Open

Keywords: systemic lupus erythematosus; lupus nephritis; neuropsychiatric lupus; autoimmunity; biomarkers; B lymphocyte; interferons

(This special issue belongs to the Section Molecular Immunology)

Microbiome-Immunity Crosstalk and Its Role in Health and Disease

edited by

Ana Isabel Beltrán-Velasco

and Sara Uceda

submission deadline 20 Feb 2026 | 4 articles | Viewed by 4724 | Submission Open

Keywords: gut microbiota; immune system; nutrition; inflammatory processes; dysbiosis; neurodegenerative diseases

(This special issue belongs to the Section Molecular Microbiology)

CRISPR/Cas Systems and Genome Editing—3rd Edition

edited by

Dmitry Karpov

submission deadline 20 Feb 2026 | 4 articles | Viewed by 4694 | Submission Open

Keywords: CRISPR/Cas; bacterial argonauts; transcription regulation; genome editing; genome editing tools

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Research on Micropollutants in Various Enviroments

edited by

Anna Lenart-Boroń

submission deadline 20 Feb 2026 | 4 articles | Viewed by 4680 | Submission Open

Keywords: airborne microorganisms; antibiotics; antibiotic resistance; circular economy of water; environmental bacteria and fungi; wastewater treatment; waterborne microorganisms; water quality

(This special issue belongs to the Section Molecular Toxicology)

Molecular and Cellular Aspects of Breast Cancer Metastasis

edited by

Hideki Furuya

submission deadline 20 Feb 2026 | 2 articles | Viewed by 4622 | Submission Open

Keywords: precision medicine; omics-based discovery research (genomics; proteomics; transcriptomics; and radiomics); non-invasive test; liquid biopsy; first-in-class medications

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Melanoma: Molecular Mechanism and New Agents for Prevention and Therapy

edited by

M. Letizia Motti

submission deadline 20 Feb 2026 | 3 articles | Viewed by 4513 | Submission Open

Keywords: melanoma; therapy resistance; melanoma microenvironment (MME); melanoma plasticity; epigenetic mechanism; predictive markers; prognostic markers; extracellular vesicles; molecular therapy; natural molecules

(This special issue belongs to the Section Molecular Oncology)

Aging: From Molecular Mechanisms and Pathophysiology to Novel Therapeutic Approaches (3rd Edition)

edited by

Darío Acuña-Castroviejo

submission deadline 20 Feb 2026 | 5 articles | Viewed by 4469 | Submission Open

Keywords: human aging; molecular clock; aging genes; epigenetics; nutrigenomics; inflammaging; stem cells; telomeres; mitochondria; brain-gut axis; brain-muscle axis; gut microbiota; chronodisruption

(This special issue belongs to the Section Molecular Biology)

Functional Genomics of Insects: Unraveling Genetic Mechanisms and Applications

edited by

Bin Li

submission deadline 20 Feb 2026 | 4 articles | Viewed by 4459 | Submission Open

Keywords: genomics; comparative genomics; gene regulation networks; developmental biology; metamorphosis; vector biology; insecticide resistance mechanisms; insect– plant interactions; environmental adaptation

(This special issue belongs to the Section Molecular Genetics and Genomics)

Progress in the Use of Graphene and Graphene-Like Materials in Various Applications

edited by Piotr Kamedulski

submission deadline 20 Feb 2026 | 2 articles | Viewed by 4421 | Submission Open

Keywords: graphene; porous carbons; carbon-based materials; 3D graphene; graphene exfoliation; nanotubes; nanomaterials; N-rich nano-porous carbon matrixes; N-rich activated carbons; carbon molecular sieves; hybrid materials; medical applications

(This special issue belongs to the Section Materials Science)

Antimicrobial Resistology: A New Approach in the Fight Against Antimicrobial Resistance

edited by

Ziad Daoud

submission deadline 20 Feb 2026 | 2 articles | Viewed by 4348 | Submission Open

Keywords: antimicrobial resistance; resistology; ESBL; AmpC; carbapenem resistance; one health

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Mechanisms and Targeted Regulation of Autoimmune Diseases

edited by

Davide Raineri

submission deadline 20 Feb 2026 | 3 articles | Viewed by 4338 | Submission Open

Keywords: autoimmunity; autoimmune diseases; multiple sclerosis; rheumatoid arthritis; lupus; type 1 diabetes; inflammatory bowel disease; biomarkers; immune cells; signaling molecules

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Modulating the Niche: Targeting the Tumor Microenvironment for Enhanced Therapy

edited by

Dong Min Lee

submission deadline 20 Feb 2026 | 2 articles | Viewed by 4209 | Submission Open

Keywords: microenvironment dynamics; immune modulation; biomarker discovery; tumor microenvironment; extracellular matrix; cancer therapy

(This special issue belongs to the Section Molecular Oncology)

Advances in Stem Cell-Based Regenerative Medicine for Renal Disorders

edited by In-Yong Kim

submission deadline 20 Feb 2026 | 1 articles | Viewed by 4132 | Submission Open

Keywords: chronic kidney disease; acute kidney injury; stem cells; regenerative medicine; stem cell therapy; cellular reprogramming; cell transplantation

(This special issue belongs to the Section Molecular Biology)

Environmental Contributors to Oxidative Stress: Mechanisms and Effects

edited by Halina Tkaczenko and

Natalia Kurhaluk

submission deadline 20 Feb 2026 | 1 articles | Viewed by 4090 | Submission Open

Keywords: oxidative stress; environmental pollution; climate change; antioxidants; biological effects; toxicology; health risks; reactive oxygen species (ROS); public health; mitigation strategies; cellular damage in human and animal disorders; environmental stressors in human and animal health

(This special issue belongs to the Section Molecular Biology)

Molecular Associations Between Adipose Tissue and Diseases

edited by

Roberto Cannataro

Erika Cione

and

Maria Cristina Caroleo

submission deadline 20 Feb 2026 | 2 articles | Viewed by 4061 | Submission Open

Keywords: lipedema; adipose tissue; adipocyte; adipose organ; body fat; miRNA; ketogenic diet

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Mechanisms Study of Functional Foods and Nutrients in Human Health Interventions

edited by

Rui Jiao

submission deadline 20 Feb 2026 | 1 articles | Viewed by 4053 | Submission Open

Keywords: functional foods; molecular mechanisms; nutrient bioavailability; chronic disease prevention; health interventions

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Forensics and the Genetic Foundations of Forensic Biology

edited by

Laura Caine

submission deadline 20 Feb 2026 | 2 articles | Viewed by 4032 | Submission Open

Keywords: molecular forensics; forensic genetics; epigenetics; biological fluid identification; forensic microbiology; sexual assault

(This special issue belongs to the Section Molecular Biology)

New Advances in Neuroscience: Molecular Biological Insights

edited by

Palsamy Periyasamy

submission deadline 20 Feb 2026 | 1 articles | Viewed by 3985 | Submission Open

Keywords: neurodegenerative diseases; neurodevelopmental disorders; neurohiv; drug abuse; neuropharmacology; epigenetics; exosomes; inflammasomes; biomarkers; gene therapy; stem cell therapy; deep brain stimulation; Alzheimer’ s disease; Parkinson’ s disease; Huntington’ s disease; autism spectrum disorder; ADHD; dyslexia; neuroinflammation

(This special issue belongs to the Section Molecular Neurobiology)

Erythrocyte Cell Death: Molecular Insights

edited by

Anton Tkachenko

submission deadline 20 Feb 2026 | 3 articles | Viewed by 3938 | Submission Open

Keywords: cell death signaling; eryptosis; erythrocyte senescence; erythrocytes; necroptosis; regulated cell death

(This special issue belongs to the Section Molecular Biology)

Molecular Biology of Periodontal Disease and Periodontal Pathogens

edited by Yago Leira and

João Botelho

submission deadline 20 Feb 2026 | 4 articles | Viewed by 3920 | Submission Open

Keywords: periodontitis; general medicine; inflammation; bacteraemia; education

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Molecular Network, Key Biomarkers, and Therapeutic Targets in Colorectal Cancer

edited by

Katharina M. Robertson

submission deadline 20 Feb 2026 | 2 articles | Viewed by 3886 | Submission Open

Keywords: inflammation; metabolism; tumor-associated macrophages; tumor microenvironment; early-onset colorectal cancer; colorectal neoplasms; obesity; immunotherapy; epigenetics; cytokines; microbiome

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Current Developments in Glioblastoma Research and Therapy: 2nd Edition

edited by

Aleksandra Majchrzak-Celińska

submission deadline 20 Feb 2026 | 2 articles | Viewed by 3875 | Submission Open

Keywords: diagnostic; prognostic and predictive biomarkers of glioblastoma; ways to target glioma stem cells; targeting glioblastoma-related signaling pathways; epigenetics of glioblastoma; treatment resistance mechanisms; novel treatment options for glioblastoma; combinatorial therapies; immunotherapy; nanotherapy; the application of CRISPR/Cas9 in glioma research; molecular testing of long-term glioblastoma survivors

(This special issue belongs to the Section Molecular Neurobiology)

Crop Stress Biology and Molecular Breeding: 5th Edition

edited by

Youxiong Que

submission deadline 20 Feb 2026 | 3 articles | Viewed by 3822 | Submission Open

Keywords: biotic and abiotic stress; variety improvement; crop stress biology; molecular breeding; biological basis; signal transduction pathway; agronomic traits; excellent germplasm

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Studies of Bone Biology and Bone Tissue: 2nd Edition

edited by

Giovanna Iezzi

submission deadline 20 Feb 2026 | 4 articles | Viewed by 3774 | Submission Open

Keywords: bone; stem cells; immunomodulation; biomaterials; bone regeneration; bone repair; bone diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Redox Systems in Humans, Animals, Plants and Aquatic Ecosystems and Their Microbiomes

edited by

Eugenio Luigi Iorio

submission deadline 20 Feb 2026 | 1 articles | Viewed by 3701 | Submission Open

Keywords: redox systems; aging and disease; nutraceuticals; probiotics; animals; plants; aquatic ecosystems; microbiomes

(This special issue belongs to the Section Molecular Biology)

Molecular Advances in Adsorbing Materials

edited by Mounia Achak

submission deadline 20 Feb 2026 | 4 articles | Viewed by 3654 | Submission Open

Keywords: adsorption process; adsorbing materials; bio-based adsorbents; regeneration and reusability; pollutant removal; wastewater treatment; industrial and environmental applications

(This special issue belongs to the Section Materials Science)

Editorial Board Member's Collection Series: The Memory of the Immune Cells

edited by

Malgorzata Kloc

and

Jacek Z. Kubiak

submission deadline 20 Feb 2026 | 2 articles | Viewed by 3486 | Submission Open

Keywords: immunological memory; innate immune memory; dendritic cells; natural killer cells; macrophage memory

(This special issue belongs to the Section Molecular Immunology)

Acute Kidney Injury: Molecular Mechanism and Targeted Therapeutic Approaches

edited by

Bin Yang

submission deadline 20 Feb 2026 | 3 articles | Viewed by 3485 | Submission Open

Keywords: kidney injury; repair; immunoresponse; biomarker; targeted therapy; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Drug-Induced Neurotoxicity and Neurodegeneration: Mechanisms, Models and Implications

edited by

Daniel José Barbosa

and

Renata Silva

submission deadline 20 Feb 2026 | 2 articles | Viewed by 3468 | Submission Open

Keywords: drugs of abuse; pharmaceutical drugs; environmental toxins; drug exposure; neurotoxicity; neurodegeneration; brain health; substance use disorders; therapeutic interventions; in vivo models; in vitro models; in silico models; biomarkers of damage; translational studies

(This special issue belongs to the Section Molecular Neurobiology)

Intestinal 3D Culture, Organoids and Gut-on-Chip in Intestinal Disorders

edited by

Vanessa D’Antongiovanni

and

Carolina Pellegrini

submission deadline 20 Feb 2026 | 2 articles | Viewed by 3439 | Submission Open

Keywords: 3D cultures; gut-on-chip; intestinal organoids; spheroids; organotypic cultures; morphological studies; pharmacological studies; intestinal cancer; inflammatory bowel disease; intestinal functional disorders

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Micro(nano) Plastics as Endocrine Disruptors in Human Diseases

edited by

Anna Maria Giuseppina Poma

submission deadline 20 Feb 2026 | 1 articles | Viewed by 3406 | Submission Open

Keywords: micro(nano) plastics; estrogens; endocrine disruptors; female reproductive system; breast; colon

(This special issue belongs to the Section Molecular Biology)

Displaying special issue 251-300 on page 6 of 67.

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