Gene Regulatory Networks in Hematologic Malignancies and Cancer
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Human Genomics and Genetic Diseases".
Deadline for manuscript submissions: 15 August 2026 | Viewed by 138
Special Issue Editor
Special Issue Information
Dear Colleagues,
Gene regulatory networks (GRNs) are central to controlling gene expression, governing cell fate decisions, differentiation, and responses to both internal and external cues. Dysregulation of these networks is a hallmark of hematological malignancies and other cancers, contributing to disease initiation, progression, therapeutic resistance, and tumor heterogeneity. Recent advances in high-throughput sequencing, single-cell profiling, and integrative multi-omics approaches now allow systematic reconstruction and functional analysis of GRNs at unprecedented resolution.
Hematological malignancies provide an especially informative model for studying gene regulatory networks, given their well-defined developmental hierarchies, dynamic clonal evolution, and accessibility to molecular and cellular analysis. Alterations in transcription factors, epigenetic modifiers, chromatin architecture, non-coding RNAs, and signaling pathways can remodel normal regulatory circuits, promoting malignant transformation. Insights gained from these diseases often reveal regulatory principles that extend to solid tumors and other cancer types.
In this Special Issue, original research articles and reviews are welcome. Research areas may include (but not limited to) the following: Transcriptional and epigenetic regulation in normal and malignant hematopoiesis, network remodeling during tumorigenesis and disease progression, single-cell and spatial approaches for regulatory network inference, computational and systems biology frameworks, and the identification of network-based biomarkers or therapeutic targets.
We look forward to receiving your contributions.
Dr. Renee M. Demarest
Guest Editor
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Keywords
- gene regulatory networks
- hematologic malignancies
- cancer genomics
- transcriptional regulation
- epigenetic regulation
- hematopoiesis
- single-cell sequencing
- systems biology
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