Genetics and Genomics of Neurological Disorders

Dear Colleagues,

Neurological disorders span a broad and heterogeneous group of conditions due to perturbations across metabolic, genomic, and molecular networks. Advances in high-throughput sequencing, multi-omics technologies, and computational biology have transformed our understanding of how genetic variation ranging from single-gene defects to complex polygenic architectures shapes and reshapes neurodevelopment, neural function, and neurodegeneration. This Special Issue, ‘Genetics and Genomics of Neurological Disorders’, brings together original research and comprehensive reviews that illustrate the mechanisms underlying a wide spectrum of neurological diseases, including rare monogenic disorders, complex neurodevelopmental conditions, and later-onset neurodegenerative diseases.

Contributions highlight emerging insights into gene regulation, epigenetics, mitochondrial and metabolic pathways, and gene–environment interactions, as well as advances in diagnostic approaches, disease modeling, and precision therapies. This integration of genomic discovery with functional and translational perspectives allows this Special Issue to bridge basic science and clinical practice, leading to a deeper understanding of neurological disease biology seen through various lenses and accelerating the development of targeted interventions.

Dr. Andrea L. Gropman
Guest Editor

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