Genetics and Treatment in Neurodegenerative Diseases

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Neurogenomics".

Deadline for manuscript submissions: 15 September 2025 | Viewed by 326

Special Issue Editors


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Guest Editor
Department of Neurology, Clinical Hospital Centre Rijeka, Rijeka, Croatia
Interests: Parkinson’s disease; neurodegeneration; neurogenetike; microglia; neuroimmunology

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Guest Editor
Clinical Institute of Genomic Medicine, University Medical Center Ljubljana, Ljubljana, Slovenia
Interests: tandem repeat expansion disorders; hereditary ataxia; Huntington’s disease; whole genome sequencing; next-generation sequencing; RNA sequencing; Parkinson’s disease; neurodegenerative disorders

Special Issue Information

Dear Colleagues,

The Special Issue "Genetics and Treatment in Neurodegenerative Diseases" invites original research articles and comprehensive reviews exploring genetic determinants and therapeutic strategies in neurodegeneration. Manuscripts that focus on genetic factors contributing to diseases such as Alzheimer's, Parkinson's, amyotrophic lateral sclerosis (ALS), and Huntington's disease are welcome, with an emphasis on insights that inform therapeutic innovation and personalized medicine. Submissions may include genetic association studies, pharmacogenomics, gene-editing therapies, biomarker identification, and translational research connecting genetics to clinical interventions, as well as novel genetic therapies. This issue aims to foster understanding of disease mechanisms, promote early diagnosis, and accelerate the development of targeted treatments, ultimately improving patient outcomes in neurodegenerative conditions.

Dr. Valentino Rački
Dr. Gaber Bergant
Guest Editors

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Keywords

  • neurodegeneration
  • genetics
  • Alzheimer’s disease
  • Parkinson’s disease
  • gene therapy
  • pharmacogenomics
  • precision medicine

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Published Papers (1 paper)

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Research

17 pages, 35398 KiB  
Article
Hwanhon Decoction Ameliorates Cognitive Impairment and Suppresses Neuroinflammation in a Chronic Cerebral Hypoperfusion Mouse Model: Involvement of Key Genes Identified by Network Pharmacology
by Sieun Kang, Chiyeon Lim, Sehyun Lim, Kyoung-Min Kim and Suin Cho
Genes 2025, 16(7), 746; https://doi.org/10.3390/genes16070746 - 26 Jun 2025
Viewed by 222
Abstract
Background: With an aging population, dementia prevalence is increasing in Korea. Vascular dementia (VaD), often caused by cerebrovascular disease (CVD), is more common in Korea compared to Western countries. Hwanhon decoction, a traditional medicine containing Ephedrae Herba, Armeniacae Semen, and Glycyrrhizae Radix et [...] Read more.
Background: With an aging population, dementia prevalence is increasing in Korea. Vascular dementia (VaD), often caused by cerebrovascular disease (CVD), is more common in Korea compared to Western countries. Hwanhon decoction, a traditional medicine containing Ephedrae Herba, Armeniacae Semen, and Glycyrrhizae Radix et Rhizoma, is traditionally used for CVD-related loss of consciousness. This study aimed to assess the cognitive improvement and anti-inflammatory effects of Hwanhon decoction extract (HHex) in a mouse model of VaD caused by chronic cerebral hypoperfusion (CCH). Methods: Key pharmacologically active ingredients of Hwanhon decoction were identified using network pharmacology analysis. VaD was induced in C57Bl/6 male mice through bilateral common carotid artery stenosis (BCAS). Mice were divided into sham surgery, BCAS control, low-dose HHex (L-HHex), and high-dose HHex (H-HHex) groups (n = 5/group). After CCH induction, L-HHex or H-HHex was administered thrice weekly for six weeks. Cognitive function, inflammatory markers, and RNA sequencing data were analyzed. Results: HHex administration reduced cognitive impairment and mitigated CCH-induced astrocyte activation. Inflammatory responses mediated by reactive astrocytes were suppressed, and network pharmacology predicted central proteins influencing HHex’s activity. Conclusions: HHex alleviated cognitive dysfunction and reduced inflammation in a VaD mouse model, suggesting its potential as a therapeutic agent for vascular dementia associated with impaired cerebral blood flow. Full article
(This article belongs to the Special Issue Genetics and Treatment in Neurodegenerative Diseases)
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