Genomic and Molecular Determinants of HPV-Related Reproductive Health

Dear Colleagues,

This Special Issue focuses on the genomic, epigenomic and molecular mechanisms that shape Human Papillomavirus (HPV) infection and its consequences for reproductive health. We welcome studies exploring host genetic susceptibility, viral genomic diversity and the molecular basis of host–virus interactions. Particular emphasis is placed on multi-omics approaches—including epigenomics, transcriptomics, proteomics and metabolomics—to identify biomarkers linked to HPV persistence, disease progression and fertility outcomes. Research on vaginal and intestinal microbiome composition, metabolic alterations and oxidative stress pathways is also encouraged, given their emerging roles in HPV-related pathophysiology. In addition, contributions addressing genomic determinants of infertility in both women and men, as well as immune–genetic factors influencing HPV vaccine response, are of high interest. Studies integrating artificial intelligence, machine learning or precision-medicine frameworks to enhance diagnostics and risk stratification are particularly welcomed. This Special Issue aims to advance comprehensive, systems-level insights into HPV biology and reproductive health.

Dr. Nektaria Zagorianakou
Dr. Efthalia Moustakli
Guest Editors

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