Epigenomic and Genomic Studies of Cancers
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Epigenomics".
Deadline for manuscript submissions: 20 August 2026 | Viewed by 129
Special Issue Editor
Special Issue Information
Dear Colleagues,
Genomic alterations are fundamental drivers of the hallmarks of cancer and represent critical targets for precision treatment. Multiple mutation-specific targeted therapies have received FDA approval for clinical cancer treatment, including inhibitors targeting KRAS G12C and EGFR T790M/L858R mutations, highlighting the therapeutic value of genomic profiling. Beyond genetic alterations, epigenetic regulation has emerged as a central layer controlling gene expression and cellular identity in cancer. Advances in 3D epigenomics have further expanded this field by revealing how higher-order chromatin architecture regulates enhancer–promoter interactions and transcriptional programs. Consistent with this mechanistic understanding, several epigenetic-targeted therapies, including DNA methyltransferase (DNMT) inhibitors, histone deacetylase (HDAC) inhibitors, and EZH2 inhibitors, have been approved for cancer treatment, demonstrating the translational potential of epigenomic discoveries. Rapid advances in next-generation sequencing, single-cell multi-omics, and spatial genomics technologies continue to accelerate discoveries in cancer genomics and epigenomics, enabling systematic interrogation of tumor heterogeneity, clonal evolution, and tumor–microenvironment interactions.
This Special Issue aims to highlight recent advances in understanding the functional roles of genomic alterations, epigenomic dysregulation, and 3D genome organization in tumor initiation, progression, and therapeutic response. We welcome submissions of both articles and review papers in cancer genomics and epigenomics.
Dr. Yuxiang Wang
Guest Editor
Manuscript Submission Information
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Keywords
- cancer
- mutation
- amplification
- deletion
- epigenetics
- 3D epigenetics
- next-generation sequencing
- ChIP-seq
- Hi-C
- DamID
- sequential FISH
- SPRITE
- GAM
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