Application of Bioinformatics in Complex Traits
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Bioinformatics".
Deadline for manuscript submissions: 20 January 2026
Special Issue Editor
Interests: statistical and computational methods for complex traits; multi-omics data integration (genomics, transcriptomics, epigenomics, proteomics); bioinformatics approaches for precision medicine; machine learning and deep learning for phenotype prediction and biomarker discovery; longitudinal and high-dimensional data modeling in biomedical research; design and analysis of biomarker-guided clinical trials; translational systems biology for clinical applications
Special Issue Information
Advances in bioinformatics have revolutionized the study of complex traits by enabling the integration and analysis of large-scale multi-omics data, including genomics, transcriptomics, epigenomics, proteomics, and metabolomics. This Special Issue aims to highlight innovative computational methods, statistical models, and machine learning approaches that dissect the genetic architecture and elucidate the molecular mechanisms underlying complex, multifactorial traits and diseases such as cancer, diabetes, obesity, cardiovascular disease, and substance addiction. We welcome submissions that address methodological and practical challenges in identifying gene–environment interactions, predicting polygenic risk, conducting causal inference using integrative omics, and performing network-based analysis of biological pathways.
Applications may span a broad spectrum of traits, from metabolic and behavioral phenotypes to neuropsychiatric conditions or agriculturally important traits in plants and animals. By bringing together cutting-edge research in bioinformatics, systems biology, and integrative data science, this issue will foster interdisciplinary dialog, advance our understanding of the biology of complex traits, and accelerate translational efforts in precision medicine and molecular design breeding.
Please kindly note that research articles require biological verification.
Dr. Xiang-Yang Lou
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- complex traits
- bioinformatics
- multi-omics integration
- gene–environment interactions
- polygenic risk scores
- machine learning
- systems biology
- network analysis
- statistical genetics
- causal inference
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