The CranioFacial Biology Group at the University of Adelaide Collection: Genetic, Epigenetic and Environmental Factors in Complex Adaptive Systems, Multilayer Complex Interactive Networks, and Multiple Models During Oral Development

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Human Genomics and Genetic Diseases".

Deadline for manuscript submissions: 5 June 2025 | Viewed by 1228

Special Issue Editors


E-Mail Website
Guest Editor
1. Adelaide Dental School, University of Adelaide, Adelaide, SA 5000, Australia
2. Barts & London Dental Institute, Queen Mary University of London, London, UK
Interests: dental development; genetics; epigenetics; complex adaptive systems; interactive networks
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Annenberg School of Communication, University of Pennsylvania, Philadelphia, PA 19104, USA
Interests: communication; artificial intelligence; computational linguistics; data analysis; complex systems; networks

Special Issue Information

Dear Colleagues,

The main purpose of this Special Issue is to present a range of research works exploring how the use of complex systems, network science, and multiple-model approaches to the interactions between genetic, epigenetic, and environmental factors can increase our understanding of oro-facial development.

The CranioFacial Biology group at the University of Adelaide has a long history of innovative research and international collaborations. This is reflected in the editorship and authorship of the papers in this Special Issue. A substantial collection of research material has been gathered, providing the basis for studies on twins, different ethnic groups, and individuals with different development patterns. Innovations in measurement techniques have led to detailed new findings.

A particular emphasis of this Special Issue is on interrogating and integrating the new knowledge acquired in order to increase our understanding of the developmental processes of the teeth, dental arches, palate, and facial profile. This is achieved using complex systems, networks, and multiple-model approaches.

For all the papers submitted to this Special Issue, an Editorial Board member for Genes who has no conflicts of interest with the CranioFacial Biology group at the University of Adelaide will be invited to make decisions, to avoid any ethical issues. All papers included in this Special Issue will undergo the full review process established for the journal Genes.

Publisher’s notice:

As stated above, the central purpose of this Special Issue is to present research from the CranioFacial Biology group at the University of Adelaide. Given this purpose, the Guest Editors’ contribution to this Special Issue may be greater than standard Special Issues published by MDPI. Further details on MDPI's Special Issue guidelines can be found here: https://www.mdpi.com/special_issues_guidelines. The Editorial Office and Editor-in-Chief of Genes has approved this and MDPI’s standard manuscript editorial processing procedure (https://www.mdpi.com/editorial_process) will be applied to all submissions. As per our standard procedure, Guest Editors are excluded from participating in the editorial process for their submission and/or for submissions from persons with whom a potential conflict of interest may exist. More details on MDPI’s Conflict of Interest policy for reviewers and editors can be found here: https://www.mdpi.com/ethics#_bookmark22.

Dr. Alan H. Brook
Dr. Matthew Brook O'Donnell
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oral development
  • genetics
  • epigenetics
  • complex adaptive systems
  • multilayer complex interactive networks
  • multiple models

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

18 pages, 3504 KiB  
Article
Fluctuating Genetic Influences at Three Different Stages of Development of Dental Arches: A Complex System
by Toby Hughes, Zuliani Mahmood, Jamal Giri, Grant Townsend and Alan Henry Brook
Genes 2025, 16(2), 189; https://doi.org/10.3390/genes16020189 - 3 Feb 2025
Viewed by 970
Abstract
Background/Objectives: The development of dental arches is a complex adaptive system with interactions between genetic and environmental factors. At different developmental stages, the relative contribution of these factors varies. The aims of this project were to identify the longitudinal changes of dental [...] Read more.
Background/Objectives: The development of dental arches is a complex adaptive system with interactions between genetic and environmental factors. At different developmental stages, the relative contribution of these factors varies. The aims of this project were to identify the longitudinal changes of dental arches in the primary, mixed and permanent dentition stages, using curve fitting methods on serial dental casts, and to investigate the contribution of the genotype to dental arch development. Methods: Longitudinal dental records from 125 monozygotic same-sex twin pairs, 89 dizygotic same-sex twin pairs, and 49 opposite-sex dizygotic twin pairs were used. Standardized model photographs were collected, and key landmarks were digitized. Fourth-order orthogonal polynomials were applied to the Cartesian data. Descriptive statistics were calculated, and structural equation models were developed to analyze the individual polynomial coefficients. The final models employed a genetic simplex framework, enabling the evaluation of how genetic and environmental influences changed over time. These changes were examined both quantitatively (e.g., variations in heritability) and qualitatively (e.g., the influence of different genes at various stages). Results: In the primary dentition, arches were typically parabolic, while in the permanent dentition, they tended to be more square-shaped. Asymmetry made a minor contribution to variation across all stages of development. Genetic analysis revealed that a core group of genes influenced arch shape over time, though their impact varied. Additionally, some genes were specific to certain developmental stages, with their relative contributions differing significantly. Notably, there was evidence of sexual heterogeneity in arch shape, particularly in the permanent dentition. Heritability was consistently high, both at individual developmental stages and throughout the overall developmental process. Conclusions: The degree of genetic influence at each developmental stage was substantial but it fluctuated between the primary, mixed, and permanent dentition stages. Full article
Show Figures

Graphical abstract

Back to TopTop