Genetic Epidemiology of Multifactorial Diseases
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: 25 January 2026 | Viewed by 953
Special Issue Editors
Interests: genetic epidemiology; genetic association studies; diabetic nephropathy; gene ontology
Special Issue Information
Dear Colleagues,
Multifactorial diseases, such as cardiovascular disease, diabetes, neurodegenerative disorders, autoimmune diseases and many others, are driven by a combination of multiple environmental and genetic factors. Due to their high prevalence, multifactorial diseases represent a substantial burden for public health systems. Advances in high‑throughput genotyping, whole‑genome sequencing and multi‑omics integration have transformed our ability to dissect the genetic architecture of multifactorial diseases. Understanding their genetic causes and pathophysiological mechanisms are essential for developing novel therapies to target specific diseases. This Special Issue of Genes, titled “Genetic Epidemiology of Multifactorial Diseases”, will address the genetic architecture of multifactorial diseases. We welcome original research articles, brief reports, reviews and methodological papers that address (but are not limited to) the following topics:
- Genetic association studies (GWASs and candidate gene studies);
- Polygenic risk scoring and risk prediction models;
- Gene–environment and gene–gene interactions;
- Population and statistical genetics methods;
- Functional genomics and multi‑omics integration;
- Causal inference and Mendelian randomization studies;
- Translational applications, precision medicine and public health impacts.
Dr. Maria Tziastoudi
Prof. Dr. Ioannis Stefanidis
Guest Editors
Manuscript Submission Information
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Keywords
- genetic association studies
- polygenic risk scores
- functional genomics
- causal inference
- mendelian randomization
- translational applications
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