Genetic Biomarkers in Cancer: From Discovery to Clinical Application
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Human Genomics and Genetic Diseases".
Deadline for manuscript submissions: 10 December 2025 | Viewed by 161
Special Issue Editor
Interests: cancer; tumor biology; biomarkers; cancer therapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Genetic biomarkers play a pivotal role in the advancement of precision oncology, enabling early cancer detection, prognosis, and personalized treatment strategies. This review explores the journey of genetic biomarker development, from initial discovery through genomic and transcriptomic profiling to their validation and integration into clinical practice. Key technologies such as next-generation sequencing and bioinformatics tools have accelerated biomarker identification, revealing critical mutations, gene expression patterns, and epigenetic alterations linked to tumorigenesis. Despite significant progress, challenges persist in translating biomarkers from bench to bedside, including issues of reproducibility, cost, and regulatory approval. Notable successes, such as BRCA1/2 in breast cancer and EGFR mutations in non-small-cell lung cancer, highlight the transformative potential of genetic biomarkers in guiding targeted therapies and improving patient outcomes. Continued interdisciplinary collaboration and innovation are essential for expanding the clinical utility of genetic biomarkers across diverse cancer types.
Dr. Evangelos Koustas
Guest Editor
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Keywords
- cancer
- tumor biology
- biomarkers
- cancer therapy
- targeted therapy
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