Diagnostic Innovations in Endodontics and Regenerative Dental Medicine

Dear Colleagues,

The fields of endodontics and regenerative dental medicine are undergoing a profound transformation, driven by innovations in diagnostics that enable earlier, more accurate, and biologically informed decision-making. Advances in high-resolution and functional imaging—such as MRI, CBCT, optical coherence tomography, and contrast-enhanced techniques—are refining our ability to visualize microanatomy, vascularization, and healing dynamics. Concurrently, the integration of molecular diagnostics, including biomarker detection and genomic/proteomic profiling, offers unprecedented insights into pulpal vitality, inflammatory states, and regenerative potential. Furthermore, artificial intelligence is enhancing diagnostic precision through automated image analysis, predictive modeling, and personalized outcome assessment.

This Special Issue invites the submission of original research and comprehensive reviews that explore cutting-edge diagnostic technologies and their clinical translational impact. We welcome contributions focused on novel imaging modalities, biomarker validation, AI-driven diagnostic systems, and integrative approaches that bridge diagnosis with tailored treatment strategies in endodontic therapy and pulp–dentin regeneration.

Dr. Paulo J. Palma
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.