Precision Diagnosis and Management of Breast Cancer

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Clinical Diagnosis and Prognosis".

Deadline for manuscript submissions: 31 August 2026 | Viewed by 334

Special Issue Editors


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Guest Editor
The London Breast Institute, Princess Grace Hospital, 42-52 Nottingham Place, London W1U 5NY, UK
Interests: breast cancer; stem cells; gene profiling; autophagy; liquid biopsy; microRNA
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Surgical Biotechnology, University College London, London WC1E 6BT, UK
Interests: cancer diagnostics; breast cancer management; plastic surgery

Special Issue Information

Dear Colleagues,

Advances in breast cancer diagnostics have transformed risk stratification and therapeutic decision-making, enabling more precise and individualised management strategies. Integration of imaging, pathology, molecular profiling, and minimally invasive biomarkers now supports risk-adapted treatment optimisation aimed at improving quality of life without compromising oncological outcomes. A key focus of this Special Issue is the role of diagnostic innovation in facilitating the safe de-escalation of breast cancer treatment, including surgical, radiation, and systemic therapies.

We invite original research articles, reviews, and perspectives that explore emerging diagnostic tools such as liquid biopsy, gene expression and microRNA profiling, advanced imaging, and biomarker-driven algorithms that guide treatment intensity. Submissions addressing tumour biology, cancer stem cells, autophagy-related pathways, and mechanisms of treatment response or resistance are encouraged, particularly where diagnostic insights inform individualised escalation or de-escalation strategies. Clinically oriented studies evaluating omission or reduction in surgery, radiotherapy, or systemic therapy in well-defined patient populations are especially welcome.

This Special Issue aims to provide a multidisciplinary platform highlighting how precision diagnostics can optimise breast cancer care while maintaining excellent clinical outcomes and enhancing patient quality of life.

Prof. Dr. Kefah Mokbel
Dr. Jajini Varghese
Guest Editors

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Keywords

  • breast cancer
  • precision diagnostics
  • risk-adapted treatment
  • treatment de-escalation
  • surgery
  • radiotherapy
  • systemic therapy
  • liquid biopsy

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Published Papers (1 paper)

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Research

11 pages, 531 KB  
Article
Circulating Tumor Cells Enhance Prognostic Stratification Beyond ER Assessment by Biopsy or FES-PET in Endocrine-Treated Metastatic Breast Cancer
by Bertha Eisses, Lindsay Angus, Evelien J. M. Kuip, C. Willemien Menke-van der Houven van Oordt, Bert van der Vegt, Andor W. J. M. Glaudemans, Adrienne H. Brouwers, Daniela E. Oprea-Lager, Wim J. G. Oyen, Jasper Emmering, Anieta M. Sieuwerts, Agnes Jager, Jaco Kraan, John W. M. Martens, Elisabeth G. E. de Vries, Stefan Sleijfer and Carolina P. Schröder
Diagnostics 2026, 16(8), 1197; https://doi.org/10.3390/diagnostics16081197 - 17 Apr 2026
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Abstract
Background/Objectives: Outcome prediction in patients with estrogen (ER)-positive metastatic breast cancer (MBC) remains challenging. We investigated whether circulating tumor cell (CTC) count adds prognostic value in ER-positive MBC using immunohistochemical (IHC) or 16α-[18F]-fluoro-17β-estradiol (FES)-PET imaging. Methods: Patients with newly diagnosed [...] Read more.
Background/Objectives: Outcome prediction in patients with estrogen (ER)-positive metastatic breast cancer (MBC) remains challenging. We investigated whether circulating tumor cell (CTC) count adds prognostic value in ER-positive MBC using immunohistochemical (IHC) or 16α-[18F]-fluoro-17β-estradiol (FES)-PET imaging. Methods: Patients with newly diagnosed non-rapidly progressive MBC receiving first-line endocrine monotherapy, with ER-positive IHC (biopsy) or FES-PET and available CTC count, were included. Associations of CTC count and CTC-ER status based on ESR1 mRNA expression with progression-free survival (PFS) and overall survival (OS) were analyzed, and the added prognostic value of CTC count (<5 vs. ≥5/7.5 mL) beyond a positive ER result was assessed. Results: In patients with ER-positive IHC (n = 98) or FES-PET (n = 99) out of 106 endocrine-treated patients, ≥5 CTCs were associated with shorter PFS (HR 1.86; p = 0.0047 and 1.75; p = 0.011) and OS (HR 3.19 and 3.22; both p < 0.01), respectively, compared with <5 CTCs. Adding CTC count to ER-positive IHC or FES-PET improved prognostic accuracy for PFS (p = 0.006 and 0.012) and OS (both p < 0.001). CTC-ER status (ESR1 RNA) was not associated with outcomes. Conclusions: CTC count adds prognostic value to PET- or biopsy-based ER analysis in endocrine-treated MBC. Full article
(This article belongs to the Special Issue Precision Diagnosis and Management of Breast Cancer)
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